Clinical trials: Pemetrexed
Cervical Cancer
Pemetrexed Disodium in Treating Patients With Recurrent Cancer of the Cervix
RATIONALE: Drugs used in chemotherapy, such as pemetrexed disodium, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00087113
- Testing
- pemetrexed disodium
- Where
- 22 sites in United States
- Sponsor
- Gynecologic Oncology Group
Trophoblastic Neoplasms, Uterine Neoplasms
A Trial for Patients With Gestational Trophoblastic Disease
This phase II study is evaluating the activity of Pemetrexed in patients diagnosed with low risk Gestational Trophoblastic Tumor (GTT) that have failed prior treatment.
- Conditions
- Trophoblastic Neoplasms, Uterine Neoplasms, Hydatidiform Mole, Choriocarcinoma
- Trial name
- NCT00190918
- Testing
- Pemetrexed
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Eli Lilly and Company
Pulpotomies Primary Teeth, Dental Pulp Disease
Comparative Evaluation of Three Different Pulpotomy Agents in Primary Molars
Comparative Evaluation of Mineral Trioxide Aggregate (MTA), Ferric Sulfate, and Chitosan Hydrogel for Primary Molar Pulpotomy: An 18-Month Randomized Controlled Trial Why is this study being done? When a child's tooth has a deep…
- Conditions
- Pulpotomies Primary Teeth, Dental Pulp Disease, Primary Teeth
- Trial name
- MTA (NCT07541976)
- Testing
- 2% Chitosan Hydrogel, MTA, Ferric Sulfate
- Where
- Iraq
- Volunteers
- 165 people
- Sponsor
- Al-Mustansiriyah University
Reversible Pulpitis
Direct Pulp Capping Agent on Human Pulp Tissue
This in- vivo study was conducted to evaluate the response of human pulp tissue following direct pulp capping using four different pulp capping agents in premolars scheduled for extraction in patients undergoing orthodontic…
- Trial name
- NCT06435065
- Testing
- Biodentine, Mineral Tri-Oxide Aggregate, THERACAL LC
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- DR SURINDER SACHDEVA
Carious Exposure of Pulp
Evaluation of MTA Versus Biodentine as Pulpotomy Agents in Immature First Permanent Molars
Aim of the study: To compare the clinical and radiographic outcomes of mineral trioxide aggregate (MTA) and Biodentine as vital pulp therapy materials (pulpotomy) of cariously exposed vital immature mandibular first permanent…
- Trial name
- NCT03838094
- Testing
- Biodentine, MTA
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gihan M Abuelniel ,PhD
Dental Pulp Capping, Dental Caries Extending to Pulp
Long-term Evaluation of Direct Pulp Capping
Calcium hydroxide and mineral trioxide aggregate have been used in vital pulp therapy with variable outcomes recorded by different study.
- Trial name
- NCT03403985
- Testing
- Calcium Hydroxide (Ca(OH)2), Mineral Trioxide Aggregate
- Where
- Jordan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Dentin Bridge, Pulpitis
Partial Pulpotomy on Caries Free Human Teeth
The purpose of this study is to compare the human pulp response to partial pulpotomy using White ProRoot MTA or iRoot BP in the terms of dentinal bridge formation and inflammation.
- Trial name
- NCT01420718
- Testing
- MTA, iRoot BP
- Where
- Iran
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Pulpitis, Pulpotomy
Clinical and Radiographic Evaluation of Laser Photobiomodulation Pulpotomy of Primary Molars in Children
This study aimed to evaluate the clinical and radiographic outcomes of photobiomodulation pulpotomy compared to MTA pulpotomy in primary molars in children.
- Trial name
- NCT05850780
- Testing
- Photobiomodulation, MTA
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Aliaa Hamouda
Pulp Exposure, Dental, Pulp Disease, Dental
The Effect of Genetic Polymorphisms on the Success of Vital Pulp Therapy
This study employs saliva-based DNA analysis to investigate the effect of genetic polymorphisms, particularly SNPs in MMP, TIMP, TNF-α, and BMP genes, on the success of vital pulp therapy in permanent teeth with pulpitis…
- Conditions
- Pulp Exposure, Dental, Pulp Disease, Dental, Pulp Caping, Pulpitis
- Trial name
- NCT07130214
- Testing
- Biodentine
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Ataturk University
Solid Tumors, Lung Adenocarcinoma
IBI188 Combination Therapy in Solid Tumors
A Phase Ib study aim to evaluate the efficacy, safety, and tolerability of IBI188 combination therapy in subjects with advanced malignancies
- Conditions
- Solid Tumors, Lung Adenocarcinoma, Osteosarcoma
- Trial name
- NCT04861948
- Testing
- IBI188, GM-CSF, Cisplatin/Carboplatin
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Ewing Sarcoma, Colorectal Adenocarcinoma
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
This is a first-in-human, open-label, non-randomized, three-part phase 1 trial of INBRX-109, which is a recombinant humanized tetravalent antibody targeting the human death receptor 5 (DR5).
- Trial name
- NCT03715933
- Testing
- INBRX-109, Irinotecan, Temozolomide
- Where
- 37 sites in United States, France and 4 more
- Volunteers
- 411 people
- Sponsor
- Inhibrx Biosciences, Inc
Reversible Pulpitis
Direct Pulp Capping With MTA and Calcium Hydroxide.
Aim of the study was to evaluate and compare clinical and radiographic success with MTA and calcium hydroxide as direct pulp capping materials in cariously exposed mandibular molars.
- Trial name
- NCT03284697
- Testing
- Direct Pulp Capping with Ca(OH)2, Direct Pulp Capping With MTA
- Volunteers
- 64 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Root Perforation at the Bifurcation Area
Comparative Study Between Biodentine and Mineral Trioxide Aggregate in Sealing Root Perforations
This is a study aimed to compare two materials: (1) Biodentine and (2) MTA. These two materials are going to be tested in sealing accidental root perforations at the bifurcation areas.
- Trial name
- NCT02805101
- Testing
- Biodentine, MTA
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Damascus University
Pretreated Pleural Mesothelioma
Multicenter Single-Arm Study of Ivonescimab (AK112) Combined with Chemotherapy in Pretreated Pleural Mesothelioma
This study is a prospective, multicenter, single-arm, Phase II clinical trial evaluating the efficacy and safety of ivonescimab (AK112) combined with chemotherapy in patients with pleural mesothelioma who failed prior…
- Trial name
- NCT06875076
- Testing
- Ivonescimab Combined With Chemotherapy
- Where
- China
- Volunteers
- 25 people
- Sponsor
- The First Hospital of Jilin University
Dental Caries in Children
Experimental Research on Deep Carious Lesion Treatment of Molars
Maintaining dental pulp vitality is crucial for tooth preservation and functionality. Untreated dental caries may lead to pulp necrosis and infection, affecting children's growth and well-being.
- Trial name
- VITAPULP (NCT03626740)
- Testing
- TheraCal, MTA
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Extensive Decay in Primary Molars
Comparison of The Success Rates of Four Different Pulpotomy Techniques
This randomized clinical trial was conducted to examine and compare the effectiveness of pulpotomy in primary molars treated with calcium silicate based materials including Biodentine and two different mineral trioxide aggregate…
- Trial name
- NCT03135626
- Testing
- Biodentine, ProRoot (Aggregate), MTA Plus
- Volunteers
- 38 people
- Sponsor
- Istanbul University
Ovarian Cancer, Peritoneal Cancer
A Study of Single Agent Pemetrexed Disodium in Treating Patients With Recurrent or Persistent Ovarian or Primary Peritoneal Cancer
The primary purpose of this trial is to estimate the drug effect on tumors in patients with ovarian or primary peritoneal cancers. Patients will receive Pemetrexed every 21 days until disease progression or unacceptable toxicity.
- Trial name
- NCT00461786
- Testing
- pemetrexed
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Eli Lilly and Company
Advanced Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma
Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)
This phase II/III Lung-MAP trial studies how well immunotherapy treatment with N-803 (ALT-803) and pembrolizumab working in treating patients with non-small cell lung cancer that has spread to other places in the body (advanced).
- Conditions
- Advanced Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8
- Trial name
- NCT05096663
- Testing
- Cobalamin, Dexamethasone, Docetaxel
- Where
- 350 sites in United States
- Volunteers
- 82 people
- Sponsor
- SWOG Cancer Research Network
Apexification, Apexogenesis
Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma
Children often damage their front teeth. In approximately 6% of cases, the nerve inside the affected tooth dies (becomes 'non-vital') and natural root development stops.
- Conditions
- Apexification, Apexogenesis, Pulp Necrosis, MTA
- Trial name
- NCT01817413
- Testing
- Mineral trioxide aggregate, Revascularisation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Liverpool
Non-Small Cell Lung Cancer Metastatic
Almonertinib With Chemotherapy in mEGFR NSCLC
The reason for the study is to find out if an experimental combination of an oral medication called Almonertinib when used in combination with chemotherapy is more effective for the treatment of locally advanced or metastatic…
- Trial name
- NCT04646824
- Testing
- Almonertinib Pemetrexed/Cisplatin
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital