Clinical trials: Remifentanil
Hemodynamic Instability
The Bolus Dose of Dexmedetomidine (ED50) That Avoids Hemodynamic Compromise in Children
Dexmedetomidine is a sedative drug that has many benefits when given to children under anesthesia, such as improved pain relief and reduced agitation following their surgery.
- Trial name
- DexMED (NCT01498380)
- Testing
- Dexmedetomidine
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Intubating Condition
Remifentanil Requirement for Acceptable Intubating Condition
Ketamine and opioid are known to improve the intubating condition, respectively. Combination of ketamine and opioid potentiate analgesic effect and give hemodynamic stability in complementary manner.
- Trial name
- NCT02655380
- Testing
- Ketamine 1, Ketamine 2, Remifentanil
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Ajou University School of Medicine
Laryngoscopy, Child
Correlation Between Sedation Depth Monitoring and Reflexes During Intravenous Anesthesia With Dexmedetomidine and Remifentanil in Children Undergoing Direct Laryngoscopy for Surgical Procedures
This study evaluates the correlation between sedation depth monitoring obtained by NeuroSENSE ® NS 701 Monitor and reflexes during intravenous anesthesia in children undergoing direct laryngoscopy for surgical procedures.
- Conditions
- Laryngoscopy, Child, Monitoring
- Trial name
- NCT03426579
- Testing
- NeuroSENSE ®in children
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Antwerp
Pupillary Functions, Abnormal
Effects of Volatile and Intravenous Anesthetics on Pupillary Function
To compare of effects of volatile and intravenous anesthetics on pupillary function during general anesthesia in children
- Trial name
- NCT03987529
- Testing
- sevoflurane, propofol
- Where
- South Korea
- Volunteers
- 22 people
- Sponsor
- Seoul National University Hospital
Emergence Delirium (Derlenme Deliryumu)
Brain Monitors to Reduce Child Confusion After Anesthesia
The goal of this clinical trial was to learn if using a brain monitor to adjust anesthesia (sleep medicine) during surgery could prevent emergence delirium (severe confusion and agitation upon waking) in children aged 2 to 12…
- Trial name
- NCT07826559
- Testing
- BIS-Guided Anesthesia, Standard Care Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Baskent University
Used to Induce and Implement General Anesthesia in Combination With Sedative Anesthetics (Such as Propofol)
Pharmacokinetics, Safety and Efficacy of HR020602 Injection in Children Undergoing General Anesthesia
This study is divided into two stages: the first stage is a dose verification trial, with a multicenter, open, single arm trial design, which is planned to enroll 10 children with general anesthesia surgery (all using HR020602…
- Trial name
- NCT04867343
- Testing
- HR020602 injection, fentanyl injection ； remifentanil injection
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Adolescent Idiopathic Scoliosis, Multimodal Analgesia
Propofol + Remifentanil vs. Propofol + Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Having Spine Surgery
Patients with Adolescent Idiopathic Scoliosis may need surgery to correct their scoliosis. General anesthesia is required for this surgery, and a multimodal analgesic regimen using combinations of opioid and non-opioid…
- Conditions
- Adolescent Idiopathic Scoliosis, Multimodal Analgesia, Opioid Induced Hyperalgesia, Remifentanil
- Trial name
- NCT06096181
- Testing
- Remifentanil TIVA, Dexmedetomidine TIVA, Propofol TIVA
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Upper Limb Injury
Efficacy and Safety of Liposomal Bupivacaine and Ropivacaine in Upper Limb Surgery
This clinical trial aims to evaluate the efficacy and safety of liposomal bupivacaine and ropivacaine when used in different brachial plexus blocks and epidural anesthesia for the management of pain associated with burn injuries…
- Trial name
- NCT06779643
- Testing
- General Anesthesia (GA), Continuous Brachial Plexus Block
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiaguang Duan
Anesthesia, Neurotoxicity
A Study to Compare the Long-term Outcomes After Two Different Anaesthetics
There is considerable evidence that most general anaesthetics modulate brain development in animal studies. The impact is greater with longer durations of exposure and in younger animals.
- Conditions
- Anesthesia, Neurotoxicity, Child Development
- Trial name
- TREX (NCT03089905)
- Testing
- Sevoflurane, Remifentanil, Dexmedetomidine
- Where
- 21 sites in United States, Australia and 2 more
- Volunteers
- 450 people
- Sponsor
- Murdoch Childrens Research Institute
Children, Heart Diseases
Study to Evaluate the Optimal Dose of Remifentanil During MRI of the Heart Under General Anaesthesia
What is the optimal maintenance dose of remifentanil to ensure apnoea, during breath hold episodes in children having cardiac MR imaging with general anaesthesia?
- Conditions
- Children, Heart Diseases, Anaesthesia, Magnetic Resonance Imaging
- Trial name
- NCT02481791
- Testing
- Remifentanil and/or propofol, propofol
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Alder Hey Children's NHS Foundation Trust
Opioid Analgesic Adverse Reaction
Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia
Pain is 'a double-edged sword', disturbing daily life of the sufferers and activating the intrinsic protective mechanisms. Transient receptor potential vanilloid 1 (TRPV1), play such role as 'a double agent', transmitting the…
- Trial name
- NCT04553536
- Testing
- Esketamine, Sulfentanil or/and Remifentanil
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Hospital of Shanxi Medical University
Anesthesia
EEG Profiles During General Anesthesia : a Comparative Study Between Sevoflurane and Propofol
A cerebral pharmacodynamic feedback may help the anesthesiologist to adjust anesthetics administration. The BIS, which provides a single number resulting from an algorithm calculated from cortical EEG parameters, may play this…
- Trial name
- NCT02893904
- Testing
- EEG monitoring, Target Controlled Infusion
- Where
- France
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Hôpital Armand Trousseau
Labour Pain, Satisfaction
Remifentanil as Intravenous Patient-controlled Analgesia (IVPCA) During Labour
Remifentanil is a ultra short-acting synthetic opioid. It is rapidly metabolized by non-specific blood and tissue esterases. We wanted to investigate the efficacy and safety of remifentanil used as analgesia during labour.
- Conditions
- Labour Pain, Satisfaction, Adverse Effects
- Trial name
- NCT00202722
- Testing
- Remifentanil
- Where
- Norway
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Sorlandet Hospital HF
Perforated Eardrum
Inhalational Anesthesia vs TIVA in Endoscopic Tympanoplasty
This study aims to prospectively compare surgical field quality and intraoperative blood loss between general inhalational anesthesia to total intravenous anesthesia (TIVA) alone in subjects undergoing endoscopic ear surgery.
- Trial name
- TIVA (NCT05993039)
- Testing
- Isoflurane Inhalant Product, Sevoflurane inhalant product, Propofol injection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Our Lady of the Lake Hospital
Preterm Infants, Mechanical Ventilator Care
Remifentanil in Ventilated Preterm Infants
The purpose of this study is to evaluate efficacy of remifentanil in preterm infants during ventilator care with remifentanil and to analyze pharmacokinetics in preterm infants
- Trial name
- NCT01713127
- Testing
- remifentanil infusion
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Seoul National University Hospital
Mechanical Ventilation
Rapip Study: Clinical Trial on Remifentanyl for Analgesia and Sedation of Ventilated Neonates and Infants
It shall be investigated whether ventilated neonates and infants with a remifentanyl based analgesia and sedation can be extubated faster after discontinuation of the opioid infusion compared to neonates and infants with a…
- Trial name
- NCT00419601
- Testing
- Remifentanyl, Fentanyl
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University of Cologne
Respiratory Distress Syndrome
Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS)
The aim of the study is to compare the intubation conditions among propofol and remifentanil versus midazolam and remifentanil in premature neonates with respiratory distress syndrome.
- Trial name
- NCT00797160
- Testing
- propofol
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Minas Gerais
Post-operative Nausea, Post-operative Vomiting
Study of Anesthesia Techniques to Reduce Nausea and Vomiting After Jaw Corrective Surgery
The purpose of this study is to determine whether a multi-modal anesthesia and pain control protocol reduces post-operative and post-discharge nausea and vomiting (PONV and PDNV) in patients undergoing upper jaw corrective…
- Conditions
- Post-operative Nausea, Post-operative Vomiting, Nausea Persistent
- Trial name
- NCT01592708
- Testing
- Antiemetic anesthesia protocol
- Where
- United States
- Volunteers
- 233 people
- Sponsor
- University of North Carolina, Chapel Hill
Analgesic Adverse Reaction
Psoas Compartment Block (PCB) Versus L.A Infiltration and Remifentanil Infusion During EVAR
Endovascular aneurysm repair (EVAR) was introduced in 1990 for the first time as a minimally invasive procedure instead of the conventional open surgical repair, with the aim to decrease morbidity and mortality .
- Trial name
- NCT03443518
- Testing
- Psoas Compartment Block (PCB), Local Anesthesia infiltration, Normal saline 0.9% IV infusion
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- Dr. Erfan and Bagedo General Hospital
Scoliosis
Effect of Early Morphine Administration on the Development of Acute Opioid Tolerance During Pediatric Scoliosis Surgery
The purpose of this study is to examine if morphine administered by bolus before initiating Remifentanil by infusion decreases the incidence of acute post-operative opioid tolerance as demonstrated by decreased post - operative…
- Trial name
- NCT00737997
- Testing
- Morphine, Saline
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- The Hospital for Sick Children