Clinical trials: Tranexamic Acid
Traumatic Brain Injury
Clinical Randomisation of an Antifibrinolytic in Significant Head Injury
The CRASH-3 trial will provide reliable evidence about the effect of tranexamic acid on mortality and disability in patients with traumatic brain injury.
- Trial name
- CRASH-3 (NCT01402882)
- Testing
- Tranexamic Acid
- Where
- Georgia
- Volunteers
- 12,737 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Abortion, Dilation and Evacuation
Effect of Prophylactic Tranexamic Acid on Bleeding Outcomes for Dilation and Evacuation
Prophylactic tranexamic acid has shown been shown to reduce maternal mortality from postpartum hemorrhage with no adverse effects, but has not been studied to reduce bleeding complications with dilation and evacuation (D\&E).
- Conditions
- Abortion, Dilation and Evacuation, Hemorrhage, Blood Loss
- Trial name
- NCT04651166
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
This Study Will Evaluate Whether TXA Reduces Pain
Effect of Tranexamic Acid (TXA) Administered Prior to Shoulder Arthroscopy on Postoperative Pain Medication Usage: A Randomized Controlled Trial
To our knowledge, no studies examining the use of TXA after shoulder arthroscopy in an outpatient setting have been published. This study will evaluate whether TXA reduces pain as measured by opioid consumption and a visual…
- Trial name
- NCT06920264
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- St. Louis Joint Replacement Institute
Arthroplasty Complications, Total Knee Arthroplasty
Is Self-transfusion Safe After Total Knee Arthroplasty in Terms of Nephrotoxicity of Gentamicin From Bone Cement?
Considering that the high local concentration of antibiotic from bone cement is delivered intravenously through the self-transfusion process, systematic toxicity has never been evaluated.
- Trial name
- NCT04505748
- Testing
- Self-transfusion device
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University Hospital, Alexandroupolis
Le Fort, Pain, Postoperative
Anesthetic Optimization in Pediatric LeFort Surgeries
This study will propose and evaluate a standardized LeFort osteotomy anesthetic protocol for pediatric patients at Johns Hopkins Hospital.
- Trial name
- NCT05260320
- Testing
- Standardized Anesthetic Course from Premedication to Induction
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Total Hip Arthroplasty
Two Different Administration Methods of Tranexamic Acid on Perioperative Blood Loss During Total Hip Arthroplasty
To compare the two administration methods of tranexamic acid for patients undergoing the first unilateral THA, to explore the effects of tranexamic acid on perioperative blood loss from the aspects of dominant blood loss, hidden…
- Trial name
- NCT03157401
- Testing
- intravenous infusion group, intra-articular injection group, control group
- Volunteers
- 90 people
- Sponsor
- Tengzhou Central People's Hospital
Scoliosis Idiopathic, Scoliosis; Adolescence
Tranexamic Acid in Pediatric Idiopathic Scoliosis Surgery
This study will evaluate whether tranexamic acid (TXA), a medication used to reduce bleeding, is effective and safe in children undergoing surgery for idiopathic scoliosis.
- Trial name
- NCT07581457
- Testing
- Tranexamic Acid Bolus Plus Infusion, Sodium Chloride 0.9% Inj, Tranexamic Acid Bolus Only
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Poznan University of Medical Sciences
Arthropathy of Knee
Alteration of Thrombelastography and Coagulation Function in Patients Undergoing Total Knee Arthroplasty With Intra-articular Tranexamic Acid Administration
The main aim and scope of this study is making comparison about the thrombelastography and coagulation function in patients before and after the total knee arthroplasty with intra-articular tranexamic acid administration.
- Trial name
- NCT05490160
- Testing
- Tranexamic acid
- Volunteers
- 54 people
- Sponsor
- RenJi Hospital
Post Partum Hemorrhage
Prevention of Postpartum Haemorrhage
Use of Tranexamic Acid for prevention of Postpartum hemorrhage in high risk patients: Randomized Control Trial
- Trial name
- NCT04463966
- Testing
- Tranexamic acid injection
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Bleeding
The Effectiveness Of Intravenous TXA on Reducing Perioperative Blood Loss For Patients Undergoing PAO
In this research study the investigators want to learn more about how a medication called tranexamic acid (TXA) could help reduce bleeding during Periacetabular Osteotomy (PAO) surgery.
- Trial name
- NCT03823417
- Testing
- Tranexamic Acid, Normal saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Uterine Fibroid
The Efficacy and Safety of Preoperative Misoprostol in Blood-loss Reduction During Myomectomy.
Open myomectomy remains the principal treatment for symptomatic fibroids in sub-Saharan countries irrespective of fertility desires.
- Trial name
- MM (NCT03509168)
- Testing
- Misoprostol Pfizer Brand, Non-insertion of Misoprostol Pfizer Brand
- Where
- Uganda
- Volunteers
- 46 people
- Sponsor
- Makerere University
Vaginal Hysterectomy
Do Patients Who Received Tranexamic Acid in Vaginal Hysterectomy Loose Les Blood, Comparing to Patients Who Did Not?
This is a randomized control, double-blind study in which women who are about to go an elective vaginal hysterectomy are offered to participate.
- Trial name
- NCT05921071
- Testing
- Tranexamic acid
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Osteoarthritis, Knee
HTO and Tranexamic Acid Study
The purpose of the study is to assess the effect of Tranexamic acid (TXa), a commonly used medication to prevent bleeding, in reducing blood loss during High Tibial Osteotomy (HTO).
- Trial name
- NCT07825350
- Testing
- Tranexamic Acid, Routine medial opening wedge high tibial osteotomy
- Volunteers
- 200 people
- Sponsor
- Western University, Canada
Endobronchial Bleeding, Hemoptysis
The Efficacy of Tranexamic Acid and Adrenaline to Control Endobronchial Bleeding
During bronchoscopy (a procedure using a thin, flexible camera to look inside the airways), doctors sometimes take small tissue samples (biopsies) to diagnose lung conditions. This can cause bleeding in the airway.
- Trial name
- CATER (NCT07759089)
- Testing
- Adrenaline, Tranexamic Acid
- Where
- Pakistan
- Volunteers
- 76 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Abnormal Uterine Bleeding
Management of Abnormal Uterine Bleeding
Abnormal uterine bleeding "AUB" describes all abnormal forms of menstrual bleeding which may result from several causes including anovulation, problems related to pregnancy, infections, vaginal and cervical abnormalities, uterine…
- Trial name
- NCT06369012
- Testing
- Mefenamic acid 500 mg
- Where
- Egypt
- Volunteers
- 130 people
- Sponsor
- Egymedicalpedia
Congenital Heart Disease
Pharmacokinetics of Tranexamic Acid (TXA) in Children Undergoing Repair of Congenital Heart Defects Utilizing Cardiopulmonary Bypass
The purpose of this study is to measure blood levels of TXA in children having cardiac surgery which requires cardiopulmonary bypass. TXA is used to reduce bleeding during surgery.
- Trial name
- NCT01045356
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
ACL Injury, ACL Tears
Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction
This is a prospective, multi-center, randomized, double-blind, placebo-controlled trial evaluating the efficacy of oral tranexamic acid (TXA) in improving postoperative outcomes following anterior cruciate ligament reconstruction…
- Conditions
- ACL Injury, ACL Tears, ACL Surgery
- Trial name
- NCT07115056
- Testing
- Tranexamic Acid (TXA)
- Where
- 6 sites in United States
- Sponsor
- Campbell Clinic
Postpartum Hemorrhage, Delivery Complication
Trends in the Administration of Tranexamic Acid for Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is the global leading cause of maternal death, with 20-30% of maternal deaths in Thailand linked to hemorrhage.
- Conditions
- Postpartum Hemorrhage, Delivery Complication, Cesarean Section Complications, Perinatal Problems
- Trial name
- NCT07278037
- Testing
- Tranexamic acid
- Where
- Thailand
- Volunteers
- 648 people
- Sponsor
- Mahidol University
Lumbar Disc Degeneration, Surgical Procedure, Unspecified
Evaluation of Topical and Intravenous Tranexamic Acid in Surgical Treatment of Lumbar Degenerative Disease
Evaluation of Topical and Intravenous Tranexamic Acid in Surgical Treatment of Lumbar Degenerative Disease
- Trial name
- NCT02496364
- Testing
- Observational
- Sponsor
- Vinicius Magno da Rocha, MD, MSc
Total Hip Arthroplasty, Tranexamic Acid Administration
Combined Tranexamic Acid Use in Total Hip Replacement Surgery
This prospective study evaluates whether combined intravenous and topical administration of tranexamic acid (TXA) can safely reduce blood loss in patients undergoing primary total hip replacement surgery.
- Conditions
- Total Hip Arthroplasty, Tranexamic Acid Administration, Perioperative Blood Loss, Coagulation Monitoring Using ROTEM
- Trial name
- NCT07610863
- Testing
- Intravenous Tranexamic Acid, Combined Intravenous and Intraarticular Tranexamic Acid
- Where
- Czechia
- Volunteers
- 58 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic