Clinical trials: sponsored by Columbia University
Obsessive-Compulsive Symptoms, Cognitive Control
Brain Function and Cognitive Control Training in Children With Obsessive-Compulsive Symptoms
The goal of this clinical trial is to learn about brain function and cognition in children ages 8-12 who have subclinical obsessive-compulsive symptoms (OCS), such as unwanted thoughts or repetitive behaviors.
- Trial name
- AKILI - OCS (NCT07839013)
- Testing
- Cognitive Control Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Columbia University
Asthma
CAMP Air: Efficacy and Cost-effectiveness in Urban Adolescents
This study will test the efficacy and cost-effectiveness of Controlling Asthma Program for Adolescents (CAMP Air), an e-health intervention, among urban predominately Black and Hispanic adolescents with uncontrolled asthma.
- Trial name
- NCT05091034
- Testing
- Controlling Asthma Program for Adolescents (CAMP Air), Attention Control Asthma Education Intervention
- Where
- United States
- Volunteers
- 374 people
- Sponsor
- Columbia University
Shoulder Dislocation
Conservative Versus Operative - First Time Shoulder Dislocations
There is no consensus regarding whether rehabilitation or surgical stabilization leads to optimized outcomes for treatment of primary anterior shoulder dislocations.
- Trial name
- NCT05532150
- Testing
- Arthroscopic Bankart repair, Physical therapy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
ACL Tear
Anterior Cruciate Ligament (ACL) Reconstruction With Bone Tendon Bone Autograft With Versus Without Internal Bracing
There is no consensus regarding the best surgical management of primary ACL tears. Recent evidence suggests that internal brace augmentation may increase load failure and therefore stabilize the graft in-situ at the time of ACL…
- Trial name
- NCT05532189
- Testing
- ACL reconstruction with BTB autograft with internal brace augmentation (suture tape), ACL reconstruction with BTB autograft without internal brace augmentation (suture tape), Standardized Rehabilitation Protocol
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Early Onset Genetic Conditions With Near Complete Penetrance
Genomic Uniformed-Screening Against Rare Disease In All Newborns
The goal of this study is to learn how genomic sequencing technology can be used to effectively expand the conditions screened on newborn screening.
- Trial name
- GUARDIAN (NCT05990179)
- Testing
- Genome sequencing-based newborn screening
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Patella Dislocation
Conservative Versus Operative - First Time Patella Dislocations
There is no consensus regarding whether rehabilitation or surgical management is best for the management of a primary patellar dislocation.
- Trial name
- NCT05533671
- Testing
- medial patellofemoral reconstruction, Non-operative group
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
COVID-19, Households
ARMOR-Household: Characterizing Transmission of COVID-19 in Households of SARS-CoV-2 Index Cases
The goal of this project is to understand the household level transmission dynamics and factors that predict transmission of SARS-COV-2 between pediatric and adults in the household.
- Conditions
- COVID-19, Households, SARS CoV 2 Infection
- Trial name
- NCT05467917
- Where
- United States
- Volunteers
- 374 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cancer in Adolescence
Needs Navigation for Caregivers of AYAs
The overall aim of the study is to address unmet health-related social needs and reduce outcome disparities among AYA (adolescent and young adult) cancer survivors.
- Trial name
- Cope-CAYAC (NCT06296641)
- Testing
- Needs navigation intervention
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Columbia University
Alcohol and Substance-Related Mental Disorders
Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia
This is a randomized controlled trial (RCT) evaluating the effectiveness of a screening, brief intervention, and referral to treatment (SBIRT) stepped-care system in reducing unhealthy AOD use among Congolese refugees and the…
- Trial name
- NCT05471921
- Testing
- SBIRT, Treatment as usual
- Where
- 2 sites in United States, Zambia
- Volunteers
- 400 people
- Sponsor
- Columbia University
Suicidal Ideation and Behavior
Adapting Youth Nominated Support Team (YST) to Prevent Suicide
The goal of this study is to conduct a pilot test of a mental health support program called the Youth-Nominated Support Team - Probation (YST-P) for young people ages 12-17 on probation, experiencing suicidal ideation and…
- Trial name
- NCT07559955
- Testing
- Youth-Nominated Support Team for Probation
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Columbia University
Cancer in Adolescence
Navigating Financial and Health-Related Social Needs in Adolescent and Young Adult Cancer Survivors (AYA-NAV)
Aim 1: Refine the HRSN navigation model to integrate a digital platform (Findhelp.org) to meet the needs of AYAs. The investigators will conduct iterative co-design sessions with AYAs and caregivers to understand their views on…
- Trial name
- AYA-NAV (NCT06950983)
- Testing
- AYA-NAV
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV, Infant Morbidity
Mitigating Infectious Morbidity and Growth Deficits in HIV Exposed Uninfected infanTs With Human Milk Oligosaccharides
Primary Objective: To evaluate the effects of synbiotics on infectious morbidity and growth while it is in place from 4 to 24 weeks of age.
- Conditions
- HIV, Infant Morbidity, Breast Feeding
- Trial name
- MIGH-T MO (NCT05282485)
- Testing
- Synbiotic, Maltodextrin
- Where
- South Africa
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Columbia University
Adolescent Idiopathic Scoliosis, Neuromuscular Scoliosis
Kids With Iron Deficiency and Scoliosis
This study is a randomized controlled trial of preoperative oral iron supplementation, to identify whether iron deficiency is a modifiable risk factor for adverse surgical outcomes such as red blood cell transfusion and…
- Conditions
- Adolescent Idiopathic Scoliosis, Neuromuscular Scoliosis, Perioperative/Postoperative Complications, Iron Deficiencies
- Trial name
- KIDS (NCT06042699)
- Testing
- Oral ferrous sulfate
- Where
- United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Columbia University
HIV/AIDS
MyPEEPS Mobile Plus: A Multi-Level HIV Prevention Intervention for Young MSM
MyPEEPS Mobile Plus, a multi-level intervention for improving HIV prevention outcomes in YMSM, is a novel and evidence-driven approach using mobile technology to deliver HIV prevention information specifically developed for YMSM.
- Trial name
- NCT06741618
- Testing
- MyPEEPS Mobile, Electronic PrEP peer navigation
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Columbia University
Brain Neoplasms, Primary Malignant
Topotecan by Intracerebral Clysis for Recurrent Primary Malignant Brain Tumors
This study will evaluate the safety and efficacy of a chemotherapeutic drug (topotecan) as it is given directly into brain tumors by a delivery technique called convection-enhanced delivery.
- Trial name
- NCT00308165
- Testing
- Convection-Enhanced Delivery, Topotecan
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Columbia University
Clinical High Risk, Early Psychosis
Digital Strategies to Advance Help-Seeking - Aim 3
This proposal aims to establish a Digital Laboratory focused on advancing help-seeking and expediting treatment initiation in youth ages 12-29 who are at Clinical High-Risk (CHR) for developing psychosis.
- Conditions
- Clinical High Risk, Early Psychosis, First Episode Psychosis
- Trial name
- NCT06774417
- Testing
- Digital nudge
- Where
- United States
- Volunteers
- 25,000 people
- Sponsor
- Columbia University
Sickling Disorder Due to Hemoglobin S
131I-apamistamab-based Conditioning for Hematopoietic Stem Cell Transplant (HSCT) in Advanced Sickle Cell Disease (SCD)
The purpose of this study is to find the smallest amount of the 131 I-apamistamab needed for preparing patients with severe sickle cell disease (SCD) for a bone marrow transplant.
- Trial name
- NCT07015684
- Testing
- 131I-apamistmab, Sirolimus, Campath
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Columbia University
Child Development, Mother-Infant Interaction
Mother-infant Bonding During COVID-19
This study will assess whether the promotion of emotional exchange between mother and infant during the first four months of life improves primarily mother-child early relational health (ERH) and secondarily child…
- Conditions
- Child Development, Mother-Infant Interaction, Relation, Parent-Child
- Trial name
- NCT04531618
- Testing
- Emotional Exchange (EE), Newborn Care (NC)
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Columbia University
Acute Lymphoblastic Leukemia, Brain Tumor
European Prospective Investigation Into Childhood Cancer
Over the last decades, research has shown that poor nutritional status can adversely impact prognosis and increase toxicities during treatment for childhood cancer.
- Trial name
- EPICkids (NCT05375617)
- Testing
- Observational
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- Columbia University
Asthma Attack, Lung Function
Cost Effective Air Filtration Intervention in Low-Income Housing to Reduce Asthma Morbidity
This project will investigate the effectiveness of HEPA air cleaners in reducing indoor air pollution and improving asthma morbidity in children living in East Harlem, New York City (NYC).
- Conditions
- Asthma Attack, Lung Function, Airway Inflammation
- Trial name
- NCT07116460
- Testing
- Austin Air Cleaner
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Columbia University