Clinical trials: sponsored by Duke University
Type 1 Diabetes, Eating Disorders
Study Comparing Acceptance and Commitment Therapy to Supportive Diabetes Counseling and a Waitlist Control for Eating Disorders in Type 1 Diabetes
The goal of this clinical trial is to test whether a new intervention works to treat eating disorders in type 1 diabetes. Participants are assigned to one of the following: (1) Acceptance and Commitment Therapy (ACT), (2)…
- Conditions
- Type 1 Diabetes, Eating Disorders, Disordered Eating Behaviors, Purging (Eating Disorders)
- Trial name
- NCT05540704
- Testing
- ACT, Supportive Diabetes Counseling
- Where
- 2 sites in United States
- Volunteers
- 235 people
- Sponsor
- Duke University
Epilepsy Intractable
Sleep Disruption Pattern - Epilepsy Monitoring Unit
Epilepsy affects millions worldwide, with 40% of patients experiencing uncontrolled seizures despite medication. Comprehensive epilepsy centers recommend continuous video-electroencephalography monitoring to define seizure type…
- Trial name
- NCT06581133
- Testing
- Alarm system
- Volunteers
- 75 people
- Sponsor
- Duke University
Neisseria Gonorrheae Infection
Master Protocol for Evaluating Multiple Infection Diagnostics for Ciprofloxacin-Resistant Neisseria Gonorrhoeae
The goal of this study is to learn if a few investigational tests can correctly find the gene mutation (mutant allele gyrA 91F) that predicts ciprofloxacin resistance in clinical specimens that harbor Neisseria gonorrhoeae.
- Trial name
- MASTERMINDRING (NCT06815536)
- Testing
- Investigational Reflex Test 1, Investigational Reflex Test 2, Investigational Reflex Test 3
- Where
- 8 sites in United States
- Volunteers
- 2,627 people
- Sponsor
- Duke University
Pompe Disease, Pompe Disease (Late-onset)
Developing a Management Approach for Patients With "Late-Onset" Pompe Disease
This is an observational study with no study related treatment of interventions. The purpose of the study is to investigate and document disease specific clinical symptoms in newborns, infants and children with Pompe disease…
- Conditions
- Pompe Disease, Pompe Disease (Late-onset), GAA Deficiency
- Trial name
- NCT03694561
- Testing
- Observational
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
COVID-19
Duke COVID-19 Shared Data and Specimen Repository
The purpose of this data repository is to provide a secure and centralized storage location and resource for the collection of essential data and medical specimens, across COVID-19 related protocols at Duke.
- Trial name
- NCT04368234
- Where
- United States
- Volunteers
- 100,000 people
- Sponsor
- Duke University
Eating Disorders, Body Image
FlexED: Full Threshold ED Substudy
The purpose of this study is to test whether a new digital intervention decreases eating disorder symptoms in young women with eating disorders by changing how they experience thoughts and feelings about their body.
- Trial name
- NCT07732829
- Testing
- FlexED
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Duke University
Health Care, Pediatrics
Hospital-to-Home Transitional Care Interventions (H2H-TCI) Children/Youth With Special Health Care Needs (CYSHCN)
Aim 1: Compare the effectiveness of focused dose vs extended dose hospital-to-home Transitional Care Interventions (H2H-TCI) on health service use and parent-reported confidence for hospitalized CYSHCN.
- Conditions
- Health Care, Pediatrics, Transitional Care, Comparative Effectiveness
- Trial name
- H2H-CYSHCN (NCT06428175)
- Testing
- Focused Dose Hospital-to-Home Transitional Care Interventions, Extended Dose Hospital-to-Home Transitional Care Interventions
- Where
- 2 sites in United States
- Volunteers
- 480 people
- Sponsor
- Duke University
Eye Diseases
Widefield Confocal Scanning Laser Ophthalmoscope Optimized for Pediatric and Neonatal Imaging
The goal of this observational study is to test the use of a novel Widefield Confocal Scanning Laser Ophthalmoscope (WiSLO) Optimized for Pediatric and Neonatal Imaging in pediatric and adult subjects who are undergoing clinical…
- Trial name
- WiSLO (NCT06177639)
- Testing
- WiSLO, Volk Pictor Plus™
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Duke University
Gaucher Disease
A Long-term Follow-up Study of Gaucher Disease
The study aims are to: a) identify the long-term natural history of Gaucher disease, b) evaluate long-term treatment efficacy of enzyme replacement therapy (ERT) and substrate reduction therapy (SRT), and c) identify potential…
- Trial name
- NCT03190837
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Eating Disorders, Body Image
A Randomized Controlled Trial Testing a Digital, Gamified Early Intervention for Eating Disorders ("FlexED")
The goal of this clinical trial is to test whether a new digital intervention decreases eating disorder symptoms in young women and girls at risk by changing how they experience thoughts and feelings about their body.
- Trial name
- NCT07632248
- Testing
- FlexED, Educational Control
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Duke University
Atherosclerosis, Wounds and Injuries
Machine Learning for Handheld Vascular Studies
The use of handheld arterial 'stethoscopes' (continuous wave Doppler devices) are ubiquitous in clinical practice. However, most users have received no formal training in their use or the interpretation of the returned data.
- Trial name
- DopplerZAM (NCT02932176)
- Testing
- Non-invasive vascular testing, machine-learning algorithm
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Duke University
COPD (Chronic Obstructive Pulmonary Disease)
Photon-counting CT in Chest Imaging
Purpose and objective: This project aims to evaluate photon-counting computed tomography (PCCT) quantitative accuracy using COPDGene subjects.
- Trial name
- NCT07031336
- Testing
- Photon-counting CT, Energy-integrating CT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Prenatal; Postnatal
Navigation Study: Durham
The purpose of this RCT is to evaluate the implementation and impact of a new, community-wide prevention program, "Community Navigation", on maternal and child health and well-being.
- Trial name
- NCT04438031
- Testing
- Navigation Intervention Version 1.0 (discontinued, modified to Version 2.0. Data will not be used), Control Intervention, Navigation Intervention Version 2.0
- Where
- United States
- Volunteers
- 815 people
- Sponsor
- Duke University
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Overactive Bladder, Overactive Bladder Syndrome
Yoga for Treatment of Overactive Bladder in Pediatric Patients
The goal of this pilot study is to assess the impact of yoga as a treatment modality in pediatric patients age 8-18 diagnosed with idiopathic overactive bladder as measured by validated questionnaires and urinary biomarkers.
- Conditions
- Overactive Bladder, Overactive Bladder Syndrome, Overactive Detrusor
- Trial name
- NCT05895045
- Testing
- Yoga
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Duke University
Unspecified Child Maltreatment, Suspected, Unspecified Child Maltreatment, Confirmed
Durham Connects RCT Evaluation
The aim of this randomized controlled trial (RCT) is to evaluate the impact and mechanisms of the Durham Connects (DC) brief universal nurse home-visiting program to prevent child maltreatment and improve child well-being.
- Trial name
- NCT01406184
- Testing
- Durham Connects
- Where
- United States
- Volunteers
- 2,329 people
- Sponsor
- Duke University
Unspecified Child Maltreatment, Suspected, Unspecified Child Maltreatment, Confirmed
Durham Connects RCT Evaluation II
The aim of this randomized controlled trial (RCT) is to conduct a second, independent evaluation the implementation and impact of the Durham Connects (DC) brief universal nurse home-visiting program to prevent child maltreatment…
- Trial name
- NCT01843036
- Testing
- Durham Connects
- Where
- United States
- Volunteers
- 1,650 people
- Sponsor
- Duke University
Pediatric Obesity, Implementation
Parks & Pediatrics Fit Together
The proposed project will test an implementation strategy (the "TrailGuide") for delivering an existing model of pediatric obesity treatment ("Fit Together") that has demonstrated ability to meet published recommendations for…
- Trial name
- NCT05455190
- Testing
- Fit Together, Educational materials
- Where
- 3 sites in United States
- Volunteers
- 209 people
- Sponsor
- Duke University
Single-ventricle, Infant Conditions
PK/PD of Digoxin in Infants With SVHD
The primary participant will be an infant with single ventricle heart disease. This is a research study to learn more about how the medication digoxin, which is routinely prescribed to infants and children with heart disease in…
- Conditions
- Single-ventricle, Infant Conditions, Infant, Newborn, Diseases, Infant, Premature, Diseases
- Trial name
- Digoxin R01 (NCT06613477)
- Testing
- PK/PD Model Based Dosing of Digoxin in Infants with Single Ventricle Heart Disease
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Acute Kidney Injury
A Study of Facilitators and Barriers to Improve Acute Kidney Injury in Children Through Mobile Health Intervention
The purpose of this study is to improve patient-centered care for acute kidney injury (AKI) in order to decrease the adverse health outcomes associated with this common condition.
- Trial name
- NCT04403633
- Testing
- mobile health educational tool
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University