Clinical trials: open to volunteers, sponsored by Institut National de la Santé Et de la Recherche Médicale, France
- Lead sponsor (exact) Institut National de la Santé Et de la Recherche Médicale, France
- Status Open to volunteers
- Age group Children (under 18)
Intergenerational Trauma
Child Cognitive-Affective Resilience Following 13-11 Event : A Pluridisciplinary Study of Intergenerational Transmission of a Traumatic Event
CARE 13-11 study explores the transmission of trauma within families. Exposure to a traumatic event can have an impact on those directly exposed, but also on their family.
- Trial name
- CARE 13-11 (NCT07203443)
- Testing
- MRI, Psychological assessment, Cognitive assessment
- Where
- France
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Autism Disorder, ASD
GENES AND AUTISM - Induced Pluripotent Stem Cells
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction and verbal and non-verbal communication (DSM-5, 2013), affecting approximately 2% of the general population.
- Trial name
- IPSC (NCT07311213)
- Testing
- Blood Sample : isolation of peripheral blood mononuclear cells (PBMCs)
- Where
- France
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Alport Syndrome
Eurbio-Alport (RaDiCo Cohort) (RaDiCo Eurbio-Alport)
Alport syndrome is a rare, inherited condition characterized by a combination of glomerular nephropathy progressing to kidney failure, deafness, and eye involvement.
- Trial name
- Eurbio-Alport (NCT05927467)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cystinosis
European Cystinosis Cohort 2
This European observational cohort follows patients with cystinosis, a rare lysosomal storage disease caused by CTNS mutations leading to cystine accumulation and multisystem involvement.
- Trial name
- RaDiCo-ECYSCO2 (NCT07680751)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Hemianopsia, Virtual Reality
Effectiveness of a Visual Telerehabilitation Program on Visual Perception in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour
Evaluate the efficiency of audiovisual stimulation in virtual reality for improving the visual perception of children, adolescents, and young adults with hemianopia resulting from pediatric brain tumors.
- Conditions
- Hemianopsia, Virtual Reality, Visual Rehabilitation, Pediatric Brain Tumor
- Trial name
- REVIIH-BT (NCT07558395)
- Testing
- Visual Stimulation, standard of care
- Where
- 8 sites in Austria, Denmark and 5 more
- Volunteers
- 120 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson Disease
French Parkinson's Disease Cohort - NS-PARK
The aim of NS-PARK cohort are to describe the natural history of Parkinson's disease (PD), and to propose patients stratification models based on PD pathophysiological mechanisms.
- Trial name
- NS-PARK (NCT04888364)
- Where
- France
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Neoplasms
Health Effects of CArdiac FluoRoscopy and MOderN RadIotherapy in PediatriCs - Radiotherapy
The goal of the HARMONIC-RT study is to evaluate late health and social outcomes of contemporary techniques of external beam radiotherapy in paediatric patients, based on the setting-up of a European, long-term registry…
- Trial name
- HARMONIC-RT (NCT04746729)
- Testing
- No intervention
- Where
- 5 sites in Belgium, Denmark and 2 more
- Volunteers
- 2,670 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Bronchiolitis Obliterans
Bronchial Epithelium of Children With Post-infectious Bronchiolitis Obliterans
Bronchiolitis obliterans (BO) is an irreversible chronic obstructive pulmonary pathology leading to obstruction and/or obliteration of the small airways.
- Trial name
- e-PIBO (NCT06140901)
- Testing
- Study morphological and functional of respiratory epithelium
- Where
- France
- Volunteers
- 450 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Respiratory Tract Infections (RTI), Influenza -Like Illness
Virological Surveillance of Acute Respiratory Infection in Primary Health Care in Metropolitan France
Every year in the fall and winter, numerous respiratory viruses (such as influenza viruses, SARS-CoV-2 (COVID-19), RSV, rhinovirus, and metapneumovirus) circulate in mainland France, causing acute respiratory infections (ARIs).
- Conditions
- Respiratory Tract Infections (RTI), Influenza -Like Illness, Influenza, COVID - 19
- Trial name
- RS-viro IRA (NCT07599449)
- Testing
- saliva sampling, Nasopharyngeal swab
- Where
- France
- Volunteers
- 25,000 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Childhood Solid Tumor
French Childhood Cancer Survivor Study
The FCCSS is a multicentric national large-scale collaborative population-based study of children treated for a solid tumor before 2000 in France and before the age of 19 years.
- Trial name
- FCCSS (NCT01620372)
- Where
- 36 sites in France
- Volunteers
- 18,000 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Congenital Heart Disease, Cyanotic Congenital Heart Disease
Prenatal Maternal Mental Health and Neurodevelopment in Congenital Heart Disease
Congenital heart disease (CHD) is the leading cause of congenital malformations, representing 1% of live births. Progress in surgical care have led to the dramatic increase in the population of children and adults living with…
- Conditions
- Congenital Heart Disease, Cyanotic Congenital Heart Disease, d-Transposition of the Great Arteries, Hypoplastic Left Heart Syndrome
- Trial name
- Neuro-Moms (NCT06711666)
- Where
- 5 sites in France
- Volunteers
- 174 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cystinosis
European Cystinosis Cohort
Cystinosis is a generalized lysosomal storage disease with a reported incidence of about 1:180,000 live births. There are estimated 110-140 cases in France (approximately 500 in Western Europe).
- Trial name
- RaDiCo-ECYSCO (NCT05901077)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Anophthalmia, Microphthalmia
National Cohort on Congenital Defects of the Eye
Congenital malformations of the eye comprise various developmental defects including microphthalmia, anophthalmia, aniridia, and anterior segment anomalies (such as Peters and Axenfeld-Rieger anomalies).
- Conditions
- Anophthalmia, Microphthalmia, Aniridia, Anterior Segment Dysgenesis 6, Peters Anomaly Subtype
- Trial name
- RaDiCoACOEIL (NCT05954403)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Infectious Disease
Genetic Susceptibility to Severe Infections
Only a fraction of individuals infected with microbes develop clinical disease. This observation raises fundamental questions about the pathogenesis of infectious diseases.
- Trial name
- PREDISPOSITI (NCT06102070)
- Testing
- Blood samples drawing, Skin biopsy
- Where
- France
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Developmental Language Disorder
MOLECULAR BASIS OF LANGUAGE DEVELOPMENT AND ASSOCIATED DISORDERS
Developmental Language Disorder (DLD) refers to children who present with language difficulties that are not due to a known biomedical condition or associated with autism spectrum disorder (ASD) or intellectual disability.
- Trial name
- TSLO (NCT06660108)
- Testing
- blood draw
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Type 1 Diabetes
BeAT1D: Benign Autoimmunity and Type 1 Diabetes
National multi-center non-interventional case-control cohort study with collection of biological samples to characterize the autoimmune T and B lymphocytes involved in the development of type 1 diabetes.
- Trial name
- BeAT1D (NCT05139784)
- Testing
- Biosampling
- Where
- 17 sites in France
- Volunteers
- 1,160 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Patency of the Ductus Arteriosus Acetaminophen Extreme Prematurity
Long Term Follow-up of the TREOCAPA Study (TREOCAPA-LT)
The ductus arteriosus (DA) is a large channel connecting the main pulmonary trunk with the descending aorta. In extremely preterm infants, the DA frequently fails to close and this results in a condition called patent ductus…
- Trial name
- TREOCAPA-LT (NCT06064825)
- Testing
- 2 year follow-up of neurodevelopment using a parental questionnaire
- Where
- 8 sites in France
- Volunteers
- 500 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Type1diabetes
Crosstalk Between Mucosal-Associated Invariant T (MAIT) Cells and the Gut Microbiota and Mucosa in the Development of Type 1 Diabetes in Children
To investigate in a prospective way changes in Mucosal-Associated Invariant T (MAIT) cells frequency, phenotype and function in link with the gut microbiota, gut integrity and the presence of Coxsackie virus B in two cohorts of…
- Trial name
- MAIT-DT1 (NCT05054361)
- Testing
- MAIT cells analysis, MAIT cytokines production analysis, Lactulose/Mannitol Test
- Where
- 2 sites in France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Inflammatory Disease, Genetic Disease
Molecular Diagnosis of Systemic Autoinflammatory Diseases
Systemic autoinflammatory diseases (SAIDs) are a set of rare clinically and genetically heterogeneous conditions. The project proposes to identify novel genes and specific signatures in subgroups of patients with SAIDs.
- Conditions
- Inflammatory Disease, Genetic Disease, Somatic Mutation, Molecular Sequence Variation
- Trial name
- SAIDiag (NCT05364294)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
TBI (Traumatic Brain Injury)
Brain Development in Young Children Following Mild Traumatic Brain Injury - Pilot Study
Concussions (also known as mild traumatic brain injury) are common in young children. In some children, they can lead to short- and long-term difficulties.
- Trial name
- KAOUENN (NCT06024122)
- Testing
- IRM exam
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France