Clinical trials: sponsored by Ruijin Hospital
Acute Respiratory Distress Syndrome (ARDS), Microbiome Dysbiosis
Multi-Omics Integrative Analysis of Serum and Sputum to Uncover Key Determinants of Prognosis in Patients With ARDS
This study is a prospective observational investigation designed to systematically characterize key microbial signatures, metabolite profiles, and gene-expression features in serum and sputum from patients with acute respiratory…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Microbiome Dysbiosis, Multiomics Analysis, Metabolomics
- Trial name
- NCT07380997
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Lung Nodule
Single-lumen Endotracheal Intubation in ENB-guided Localization and Resection of Pulmonary Nodules
The goal of this clinical study is to evaluate the practicality, safety, and feasibility of a 'one-stop' single-lumen (SL) endotracheal intubation strategy for patients undergoing wedge resection of early-stage lung nodules with…
- Trial name
- NCT07288255
- Testing
- Single lumen, single-lumen to double-lumen
- Where
- China
- Volunteers
- 375 people
- Sponsor
- Ruijin Hospital
Lymphoma, Cohort
Shanghai Lymphoma Clinical Cohort
The aim of this study is to prospectively collect clinical information on patients with lymphoma, and to explore the best therapeutic strategies in the real-world population.
- Trial name
- NCT07285174
- Testing
- No interventions need to be specified for this study
- Volunteers
- 1,000 people
- Sponsor
- Ruijin Hospital
ALL (Acute B-Lymphoblastic Leukemia), CAR-T Cell Therapy
A Real-world Study on the Treatment of Adult B-cell Acute Lymphoblastic Leukemia With CNCT-19
This clinical study is a retrospective, observational, and multicenter post marketing real-world study aimed at evaluating the efficacy and safety of CNCT-19 in the treatment of Chinese adult B-cell acute lymphoblastic leukemia…
- Trial name
- NCT07269587
- Testing
- CNCT-19
- Where
- China
- Volunteers
- 275 people
- Sponsor
- Ruijin Hospital
Acute Lymphoblastic Leukaemia, Acute Lymphoblastic Leukaemias (ALL)
A Multi-center Retrospective Study of INO Treating B-ALL
This multi-center retrospective study aims to evaluate the efficacy and safety of inotuzumab ozogamicin in adults B-ALL of different subgroups. This study is a retrospective study.
- Conditions
- Acute Lymphoblastic Leukaemia, Acute Lymphoblastic Leukaemias (ALL), Inotuzumab Ozogamicin, Venetoclax
- Trial name
- NCT07238907
- Testing
- Inotuzumab Ozogamicin
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Ruijin Hospital
Mantle Cell Lymphoma (MCL)
Orelabrutinib and Rituximab With Optional Autologous Hematopoietic Stem Cell Transplantation in MCL Treatment
This multicenter, open-label, trial aims to evaluate the efficacy and safety of orelabrutinib in combination with rituximab with optional autologous hematopoietic stem cell transplantation in patients with non-high-risk mantle…
- Trial name
- NCT07199296
- Testing
- Orelabrutinib, Rituximab (R), BEAM (carmustine (BCNU), etoposide, cytarabine, melphalan)
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Ruijin Hospital
Lymphoma Cns
A Clinical Study on the Efficacy and Safety of Methotrexate (MTX) or Thiotepa (for MTX Intolerance) or Temozolomide (TMZ) Combined With Orelabrutinib and Selinexor in Relapsed/Refractory Primary or Secondary Central Nervous System Lymphoma（SELINA）
Clinical Study on the Efficacy and Safety of Methotrexate (MTX) or Thiotepa (for MTX intolerance) or Temozolomide (TMZ) Combined with Orelabrutinib and Selinexor in the Treatment of Relapsed/Refractory Primary or Secondary…
- Trial name
- SELINA (NCT07191431)
- Testing
- Selinexor+Orelabrutinib+Methotrexate/Thiotepa/Temozolomide
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Ruijin Hospital
Ischemic Stroke
Predictive Role of KLK10 and Other Neuroinflammatory Molecules on Clinical Outcomes of AIS
This study aims to investigate the dynamic changes and differential expression characteristics of neuroinflammatory molecules such as kallikrein-related peptidase 10 (KLK10), soluble triggering receptor expressed on myeloid cells…
- Trial name
- NCT06549972
- Testing
- Acute Ischemic Stroke
- Where
- China
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Relapse Leukemia
Efficacy and Safety of VAH as a Bridging Regimen to Allo-HCT in Relapsed/Refractory AML
Allogeneic hematopoietic cell transplantation (allo-HCT) is the only treatment that offers a possible cure for relapsed/refractory AML.
- Trial name
- NCT07091006
- Testing
- VAH
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Ruijin Hospital
MDS
Reduced Intensity Conditioning for MDS
Allogeneic hematopoietic cell transplantation (allo-HCT) is the only potential cure for Myelodysplastic syndrome (MDS). Currently, the conditioning regimen for MDS allogeneic transplantation still follows AML, and there are fewer…
- Trial name
- NCT07085156
- Testing
- Fludarabine; melphalan; busulfan
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Ruijin Hospital
Acute Lymphoblastic Leukemia
Inaticabtagene Autoleucel (Inati-cel; CNCT19) Treatment for MRD-Positive B-ALL Patients in CR1
This investigator-initiated, prospective, single-arm, open-label, single-center clinical study aims to evaluate the efficacy and safety of Inaticabtagene autoleucel (Inati-cel;CNCT19)CD19 CAR-T theraphy in adults B-ALL that are…
- Trial name
- NCT06718244
- Testing
- single dose of Inaticabtagene autoleucel
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ruijin Hospital
AML, MDS
Molecular Genetics Guide the Maintenance Therapy After Allogeneic Hematopoietic Stem Cell Transplantation
This study is a prospective, multicenter, open-label umbrella clinical study planned to enroll 126 subjects with acute myeloid leukemia/myelodysplastic syndromes undergoing allogeneic hematopoietic stem cell transplantation.
- Trial name
- NCT06972641
- Testing
- Decitabine, Sorafenib (BAY-43-9006)，giritinib, Avastinib
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Ruijin Hospital
Sarcoma
BIOmarker Driven Trial of VEGFR2 Inhibitor in Advanced or Metastatic Sarcoma
The aim of this study is to evaluate the efficacy and safety of Apatinib monotherapy for relapsed or refractory advanced bone and soft tissue sarcoma with VEGFR-2 (KDR) 604A>G polymorphism as predictive biomarker
- Trial name
- BIOVAS (NCT04072042)
- Testing
- Apatinib monotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Ruijin Hospital
Acute Graft-versus-Host Disease
A Study of iMSC for the Prevention of Acute Graft-versus-host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
An open-label, randomized, controlled clinical trial to explore the efficacy and safety of iMSC in preventing the development of acute graft-versus-host disease of degree III-IV in patients after allogeneic hematopoietic stem…
- Trial name
- NCT06949267
- Testing
- iMSC, conventional aGVHD prophylaxis
- Volunteers
- 56 people
- Sponsor
- Ruijin Hospital
Osteosarcoma Metastatic
A Look Back at How Well Interventional Treatments Work for Bronchopleural Fistulas in Patients With Lung Metastases From Osteosarcoma
Patients with pulmonary metastasis of osteosarcoma complicated with BPF often suffer from massive hemoptysis, refractory pneumothorax and difficult fistula healing due to tumor erosion of bronchial arteries.
- Trial name
- NCT06927596
- Testing
- Interventional therapy
- Volunteers
- 28 people
- Sponsor
- Ruijin Hospital
Food Allergy in Infants
The Role of Bifidobacterium Intervention in Food Allergic Infants
Infant food protein allergy is the most common allergic disease in children, which can lead to infantile-specific dermatitis, intestinal inflammation, and so on.
- Trial name
- NCT05965063
- Testing
- Bifidobacterium M-16V, allergy food avoidance
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Dyspepsia, Child
Influence of Shenqu Xiaoshi Oral Liquid on Intestinal Microbiome of Children With Functional Dyspepsia
It has been confirmed that treatment with Shenqu Xiaoshi Oral liquid (SXOL) effectively improves dyspeptic symptoms and is well tolerated.
- Trial name
- NCT05515887
- Testing
- Shenqu Xiaoshi Oral liquid
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Ruijin Hospital
Allogeneic Hematopoietic Stem Cell Transplantation
Acupoint Application With Herbal Fumigation and Wash for Preventing Diarrhea-induced Perianal Infection in Allo-HSCT Patients
The goal of this clinical trial is to evaluate whether the combination of herbal fumigation and acupoint application can effectively prevent diarrhea in patients undergoing allogeneic hematopoietic stem cell transplantation…
- Trial name
- NCT06912347
- Testing
- Intervention Group, control group
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Ruijin Hospital
CNS Lymphoma
Methotrexate or Thiotepa Combined With R-CHOP and Orelabrutinib in CNSL Patients
This study is designed as an open-label, prospective, single-arm, single-center trial aimed at evaluating the efficacy and safety of MTX or Thiotepa combined with Orelabrutinib and standard chemotherapy regimens in the treatment…
- Trial name
- NCT06901999
- Testing
- Orelabrutinib, RCHOP+MTX or Thiotepa
- Volunteers
- 23 people
- Sponsor
- Ruijin Hospital
Health, Children
A Study on the Changes and Prognosis of Intestinal Microbiota and Function in Infants With Food Allergies
Microorganisms maintain a complex interrelationship with the human body, influencing each other. In recent years, people have gradually realized that the formation of the pediatric microecosystem is closely related to the…
- Conditions
- Health, Children, Gut Microbiota
- Trial name
- NCT06854536
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital