Clinical trials: sponsored by Sun Yat-sen University
Breast Cancer Invasive, Hormone-receptor-positive Breast Cancer
Neoadjuvant Pyrotinib in HR-positive and HER2-low High-risk Early Breast Cancer
This is a multi-center, open-lable, prospective, randomized phase III clinical trial to further validate the efficacy and safety of neoadjuvant pyrotinib combined with chemotherapy in HR-positive/HER2-low (IHC 2+/FISH-negative)…
- Conditions
- Breast Cancer Invasive, Hormone-receptor-positive Breast Cancer, HER2 Low Breast Carcinoma, Early-stage Breast Cancer
- Trial name
- NCT06144944
- Testing
- Pyrotinib, epirubicin or doxorubicin, cyclophosphamide, paclitaxel, Epirubicin or doxorubicin, cyclophosphamide, paclitaxel
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Ulcerative Colitis (Disorder)
Objective Disease Control and Treatment Strategies in Ulcerative Colitis
This multicenter longitudinal observational cohort study aims to characterize objective disease-control trajectories, treatment adaptation, and long-term clinical outcomes among adults with ulcerative colitis receiving routine…
- Trial name
- CONTROL-UC (NCT07877636)
- Testing
- Routine Clinical Care
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Inflammatory Bowel Diseases (IBD), Crohn Disease
Longitudinal Registry of Difficult-to-Treat Inflammatory Bowel Disease
Difficult-to-treat inflammatory bowel disease (DTT-IBD) represents a heterogeneous group of patients with treatment-refractory, structurally complicated, postoperative, perianal, pouch-related, or psychosocially complex disease.
- Conditions
- Inflammatory Bowel Diseases (IBD), Crohn Disease, Colitis, Ulcerative
- Trial name
- DTT-IBD (NCT07877649)
- Testing
- Routine IBD Management and Advanced-Therapy Exposure
- Volunteers
- 2,000 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Refractive Errors
Consistency of an Automated Subjective Refraction Program Between Personnel With Diverse Professional Backgrounds and Senior Optometrists
This study aims to evaluate the performance of automated subjective refraction performed by operators with different professional backgrounds.
- Trial name
- NCT07891884
- Testing
- Nurse-Operated Automated Subjective Refraction, Village Doctor-Operated Automated Subjective Refraction, Lay Personnel-Operated Automated Subjective Refraction
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Refractive Errors
Evaluation of the Agreement Between Automated Program-Operated Phoropter Subjective Refraction and Optometrist-Performed Subjective Refraction
This study aims to evaluate the performance of an automated subjective refraction system that operates a digital phoropter. By comparing its results with those obtained through conventional subjective refraction performed by an…
- Trial name
- NCT07891897
- Testing
- Automated Program-Controlled Subjective Refraction, Optometrist-Performed Subjective Refraction
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Pediatric Anesthesia, Airway Management
Effective Dose of Alfentanil Combined With Propofol for Laryngeal Mask Airway Insertion in Children
This study uses a prospective, up-and-down sequential allocation method to determine the median effective dose (ED50) and 95% effective dose (ED95) of alfentanil combined with propofol for successful laryngeal mask airway (LMA)…
- Conditions
- Pediatric Anesthesia, Airway Management, General Anesthesia, LMA
- Trial name
- NCT07581665
- Testing
- Alfentanil
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Autoimmune Encephalitis, Anti-NMDAR Encephalitis
Clinical Evaluation of a Novel DAB Chromogenic Tissue-Based Assay for Detecting Anti-GABABR Antibodies
This multicenter, blinded, cross-sectional study aims to evaluate the clinical performance of a novel DAB chromogenic tissue-based assay (TBA) for detecting anti-GABAB receptor (anti-GABABR) antibodies.
- Conditions
- Autoimmune Encephalitis, Anti-NMDAR Encephalitis, Anti-GABABR Encephalitis
- Trial name
- GREAT (NCT07858175)
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Medulloblastoma
Arsenic Trioxide Combined With Chemotherapy for Relapsed SHH-Activated and/or TP53-Mutant Medulloblastoma
This prospective, open-label, single-arm, multicenter study will evaluate the efficacy and safety of arsenic trioxide (ATO) combined with chemotherapy in pediatric patients with relapsed or refractory SHH-activated…
- Trial name
- NCT07856069
- Testing
- Arsenic Trioxide (ATO), ETOPOSIDE - Study, Cisplatin
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Respiratory Hypersensitivity, Perioperative Respiratory Adverse Events
Inhaling Penehyclidine to Prevent Perioperative Respiratory Adverse Events in Children at Risk Undergoing Sevoflurane Anesthesia
This randomized controlled study is to evaluate the effectiveness of inhaling penehyclidine hydrochloride in reducing perioperative respiratory adverse events in children at risk undergoing minor elective surgery.
- Conditions
- Respiratory Hypersensitivity, Perioperative Respiratory Adverse Events, Anticholinergics, Inhalation Therapy; Complications
- Trial name
- PEPSI (NCT06624696)
- Testing
- Penehyclidine hydrochloride, Normal Saline
- Where
- 2 sites in China
- Volunteers
- 204 people
- Sponsor
- Sun Yat-sen University
Peripheral Venous Cannulation for Contrast-enhanced CT/MRI Examination, Peripheral Venous Access Establishment
Venipuncture Via Nurse-AI Collaboration
The goal of this clinical trial is to learn if AI-assisted site selection plus human-machine coordinated puncture improves the quality and safety of peripheral venous access for contrast-enhanced imaging in patients of all ages…
- Trial name
- NCT07854626
- Testing
- AI-assisted human-machine coordinated peripheral venipuncture, Conventional routine peripheral venipuncture
- Where
- China
- Volunteers
- 3,500 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Obesity & Overweight, Diabete Type 2
Traditional Chinese Medicine Fasting Therapy, Ketone Levels, and Metabolic Improvements
This is a retrospective study using existing medical records. The purpose is to learn how Traditional Chinese Medicine (TCM) fasting therapy affects metabolism.
- Conditions
- Obesity & Overweight, Diabete Type 2, Metabolic Syndrome
- Trial name
- NCT07840807
- Testing
- Traditional Chinese Medicine Fasting Therapy
- Where
- China
- Volunteers
- 1,149 people
- Sponsor
- The Seventh Affiliated Hospital of Sun Yat-sen University
Tic Disorder, Provisional Tic Disorder
Let It TiC in Childhood Provisional Eye Tic
Clarify the effectiveness and safety of "Reduced-Attention Intervention Therapy" in treating children with Provisional tic disorder （PTD） who mainly exhibit abnormal blinking behavior
- Trial name
- LETITTIC (NCT07838428)
- Testing
- Reducing Attentional Interventions Therapy Treatment, Continue with the previous treatment plan
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Smoking Cessation, Early-Stage Cancer
Multi-Theory Model-Based AI Agent Intervention for Smoking Cessation in Early-Stage Cancer Patients
The goal of this clinical trial is to evaluate the effectiveness of a Multi-Theory Model (MTM)-based AI agent intervention for smoking cessation in early-stage cancer patients (clinical stage cTNM 0~II) who currently smoke.
- Conditions
- Smoking Cessation, Early-Stage Cancer, AI Agent
- Trial name
- NCT07827066
- Testing
- MTM-Based AI Agent for smoking cessation, Counseling
- Volunteers
- 156 people
- Sponsor
- Sun Yat-sen University
Nephrotic Syndrome
Super Chinese Nephrotic Syndrome Registration System (SUCCESS)
The investigators are registering all nephrotic syndrome (NS) patients regardless of the primary causes and developing a NS database in China.
- Trial name
- NCT03001934
- Testing
- No intervention
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Sun Yat-sen University
Lupus Nephritis
High Quality Evidence of Chinese Lupus Nephritis (HELP)
The investigators are registering LN patients at recruited hospitals and developing a LN database in China. Patients will be follow-up every year, and both baseline and follow-up information will be entered into the registration…
- Trial name
- NCT03001973
- Testing
- No Intervention
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Sun Yat-sen University
IgA Nephropathy
IgA Nephropathy Registration Initiative of High Quality (INSIGHT)
The investigators are registering all biopsy-proven primary IgA nephropathy (IgAN) patients at recruited hospitals and developing a IgAN database in China.
- Trial name
- NCT03001947
- Testing
- No intervention
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Sun Yat-sen University
Keratoconus, Stable
Perceptual Learning Improve Visual Function in Patients With Keratoconus
This project aims at non-progressive keratoconus patients with unsatisfactory visual acuity corrected by spectacles, and explores the effectiveness and maintenance of visual acuity improved by perceptual learning.
- Trial name
- KPL (NCT05220904)
- Testing
- spectacles, perceptual learning
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Neuroblastoma
Apatinib Mesylate Combined With IT Regimen for the Treatment of Recurrent or Refractory Neuroblastoma: A Single-arm, Phase I/II，Multi-center, Clinical Study.
The survival rate of recurrent and refractory neuroblastoma is low and the prognosis is poor. Apatinib mesylate is a highly selective small-molecule vasoendothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor.
- Trial name
- NCT05027386
- Testing
- Apatinib, Irinotecan, Temozolomide
- Where
- China
- Volunteers
- 125 people
- Sponsor
- Sun Yat-sen University
Wound
EpiSC-Enhanced Composite Grafts for Skin Reconstruction
This randomized controlled trial evaluated a single-stage treatment for full-thickness skin defects using an autologous epidermal stem cell (EpiSC)-enriched cell suspension prepared during surgery.
- Trial name
- NCT02070809
- Testing
- EpiSC-Enhanced Composite Grafting, Standard Composite Grafting
- Where
- China
- Volunteers
- 232 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Youth Mental Health, Psychological Distress in Adolescents and Young Adults
VIPeerAgent for Adolescent Mental Health
This three-arm parallel randomized controlled trial aims to evaluate the effectiveness of VIPeerAgent, a virtual peer support agent, in improving mental health outcomes among adolescents and young adults aged 14-25 years…
- Conditions
- Youth Mental Health, Psychological Distress in Adolescents and Young Adults, Early Intervention
- Trial name
- NCT07778758
- Testing
- Virtual Peer Agent Intervention, Human peer mentor
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Sun Yat-sen University