Clinical trials: sponsored by Thomas Jefferson University
Hypertension, Portal
SHAPE of Portal Hypertension in Children
Early diagnosis of portal hypertension is difficult as symptoms rarely manifest until the later stages of liver disease. Both cirrhotic and non-cirrhotic portal hypertension can result in life-threatening complications, the most…
- Trial name
- NCT04720456
- Testing
- SHAPE measurement using the ultrasound contrast agent Sonazoid (perfluorobutane microbubbles), SHAPE measurement using the ultrasound contrast agent Lumason (sulfur hexafluoride lipid-type A microspheres)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Thomas Jefferson University
Cesarean Delivery, Postpartum Comfort
Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks.
- Conditions
- Cesarean Delivery, Postpartum Comfort, Postpartum Pain, Post-operative Pain
- Trial name
- PACESS (NCT07102641)
- Testing
- Acetaminophen, NSAID (Ketorolac/Ibuprofen)
- Where
- United States
- Volunteers
- 825 people
- Sponsor
- Thomas Jefferson University
Prostate Carcinoma
Enhanced Genetic Awareness and Genetic Evaluation for Men Through Technology, ENGAGEMENT Study
This study assesses perceived usefulness of a web-based virtual prostate cancer genetics board for providers across academic, community, and veteran affairs settings to discuss prostate cancer genetics cases, precision treatment…
- Trial name
- NCT04789018
- Testing
- Educational Intervention, Survey Administration, Interview
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Thomas Jefferson University
Nonimmune Fetal Hydrops, Nonimmune Hydrops in Neonate
Whole Exome Sequencing and Whole Genome Sequencing for Nonimmune Fetal/Neonatal Hydrops
Brief Summary: Nonimmune hydrops fetalis (NIHF) is a potentially fatal condition characterized by abnormal fluid accumulation in two or more fetal compartments.
- Conditions
- Nonimmune Fetal Hydrops, Nonimmune Hydrops in Neonate, Genetic Disorders
- Trial name
- NCT03911531
- Testing
- Whole Exome Sequencing, Whole Genome Sequencing
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Thomas Jefferson University
IUD Insertion Complication
Postplacental LNG-IUD Ultrasound Use Study
This study will enroll women planning to have an intrauterine device (IUD) placed for contraception immediately following a vaginal delivery.
- Trial name
- PLUS (NCT04474548)
- Testing
- Ultrasound use
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Spinal Dural Arteriovenous Fistula
Spinal Dural Arteriovenous Fistula International Data and Outcomes Registry
Given the lack of large multicenter datasets in the context of Spinal arteriovenous fistula, the strength of the evidence surrounding this rare disease is limited.
- Trial name
- SPIDER (NCT07574645)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Thomas Jefferson University
COVID-19
COVID Booster in Pregnancy and Lactation
This is a prospective longitudinal cohort study to evaluate the impact of COVID-19 vaccination and booster on maternal and infant immunity against COVID-19 variants over time.
- Trial name
- NCT05543993
- Testing
- Bivalent COVID-19 Booster
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Preeclampsia
Antenatal Platelet Response On Aspirin and Correlation With HDP (Hypertensive Disorders of Pregnancy)
This proposal has three aims to characterize the relationship between aspirin therapy, platelet function response, and prevention of hypertensive disorders of pregnancy (HDP) through a prospective, cohort study using…
- Trial name
- APROACH (NCT04295850)
- Testing
- Aspirin 81 mg
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Thomas Jefferson University
Covid19
COVID-19 Pregnancy Related Immunological, Clinical and Epidemiological Factors and Perinatal Outcomes
This is a prospective cohort study of pregnant patients at an urban academic center diagnosed with perinatal COVID-19 infection, followed up to 6 weeks postpartum.
- Trial name
- COVID-PRICE (NCT04659759)
- Testing
- COVID-19 exposure, COVID-19 vaccine
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Thomas Jefferson University
Acute Myeloid Leukemia With FLT3/ITD Mutation, Acute Myeloid Leukemia With Gene Mutations
Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in With High-Risk Hematologic Malignancies
This phase II trial studies reduced-intensity conditioning before donor stem cell transplant in treating patients with high-risk hematologic malignancies.
- Conditions
- Acute Myeloid Leukemia With FLT3/ITD Mutation, Acute Myeloid Leukemia With Gene Mutations, Acute Myeloid Leukemia With Inv(3) (q21.3;q26.2); GATA2, MECOM, Acute Myeloid Leukemia With t(6;9) (p23;q34.1); DEK-NUP214
- Trial name
- NCT01760655
- Testing
- Fludarabine phosphate, Busulfan, Total-Body Irradiation
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Hot Flashes, Prostate Carcinoma
Vitamin B6 in Reducing Hot Flashes in Participants With Prostate Cancer Undergoing Antiandrogen Therapy
This pilot phase II trial studies how well vitamin B6 works in reducing hot flashes in participants with prostate cancer undergoing antiandrogen therapy.
- Trial name
- NCT03580499
- Testing
- Vitamin B6, Questionnaire Administration
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Preterm Birth, Preeclampsia
Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH)
Aspirin is recommended in high risk patients to reduce the risk of preeclampsia and preterm birth, which are leading causes of both maternal and neonatal morbidity and mortality, but up to 20% will have these adverse outcomes…
- Trial name
- DASH (NCT06826859)
- Testing
- Daily aspirin (ASA), Split dose aspirin (ASA)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Thomas Jefferson University
Lung Carcinoma
Improving Lung Cancer Screening Adherence by Overcoming Barriers for Vulnerable Populations
This study investigates multi-level barriers to lung cancer screening uptake and adherence to lung cancer screening. Identifying cost- and convenience-related barriers to lung cancer screening may help researchers develop…
- Trial name
- NCT04969341
- Testing
- Survey Administration, Electronic Health Record Review
- Where
- United States
- Volunteers
- 947 people
- Sponsor
- Thomas Jefferson University
Prostate
Virtual Reality Education Module in Reducing Anxiety and Increasing Knowledge in Patients With Prostate Cancer Undergoing Radiation Therapy
This pilot clinical trial studies a virtual reality education module in reducing anxiety and increasing knowledge in patients with prostate cancer undergoing radiation therapy.
- Trial name
- NCT03318367
- Testing
- Educational Intervention
- Volunteers
- 23 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Skin Basal Cell Carcinoma
Effectiveness of Narrow Margins in Patients With Low-Risk Basal Cell Carcinoma Undergoing Surgery
This clinical trial studies the effectiveness of narrow margins in patients with low-risk basal cell carcinoma undergoing surgery to remove skin lesions on the face.
- Trial name
- NCT02579551
- Testing
- Therapeutic Conventional Surgery
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Breast Cancer
Smart Phone Application in Increasing Physical Activity in Breast Cancer Survivors
This pilot clinical trial studies how well a smart phone application works in increasing physical activity in breast cancer survivors.
- Trial name
- NCT03054025
- Testing
- Smart Phone Monitoring Device
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Geriatric Assessment Screening Tool for the Identification of At-Risk Older Adults Who Are Undergoing Cancer Treatment
This phase II trial investigates how easy it is to incorporate a nursing led geriatric assessment screening tool into a busy oncology practice, in order to identify at-risk older adults being evaluated for cancer treatment.
- Trial name
- NCT04788758
- Testing
- Educational Intervention, Screening Questionnaire Administration, Referral
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Neurologic Diseases, Hemiparesis
NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one…
- Conditions
- Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies
- Trial name
- NCT04798378
- Testing
- Neurosleeve
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Autism Spectrum Disorder
Telehealth Intervention for Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is one of the most frequently occurring childhood-onset neurodevelopmental disorders affecting 1 in every 54 children.
- Trial name
- NCT04832152
- Testing
- OT4ASD
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Preeclampsia
Antenatal Platelet Response on Aspirin: a Pharmacokinetic Study Through Pregnancy
Longitudinal pharmacokinetic and pharmacodynamic study in first and third trimester of pregnancy
- Trial name
- APROACH-PK (NCT04645004)
- Testing
- Aspirin 81Mg Non-enteric coated Tab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Thomas Jefferson University