Clinical trials: sponsored by Unity Health Toronto
Stress, Psychological, Compassion Fatigue
Achieving Resilience in Acute Care Nurses (ARISE).
Nurses are exposed to myriad stressors, both in the workplace and in their everyday lives, which can lead to adverse personal and professional outcomes.
- Trial name
- NCT03017469
- Testing
- ARISE
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency
Assessing Diaphragm Muscle Inactivity in Mechanically Ventilated ICU Patients
Background: Mechanical ventilation is a life saving intervention in patients with acute respiratory failure, for instance, due to infection or trauma.
- Trial name
- DIVIP (NCT02434016)
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency
Effect of Sleep Disruption on the Outcome of Weaning From Mechanical Ventilation
Mechanically ventilated patients in the Intensive Care Unit (ICU) are highly susceptible to sleep disruption. Several studies in the last 15 years have demonstrated an extremely poor sleep quality and abnormal sleep pattern…
- Trial name
- SLEEWE (NCT02464735)
- Testing
- Polysomnography
- Where
- 3 sites in Canada
- Volunteers
- 44 people
- Sponsor
- Unity Health Toronto
Acute Respiratory Distress Syndrome
Validation of a Simple Approach to Estimate Alveolar Recruitability in ARDS Patients
This study will test the validity of a new approach to assess alveolar recruitability at the bedside in comparison to direct measurements of lung volume and derecruitment.
- Trial name
- NCT02457741
- Where
- 3 sites in Canada, China and 1 more
- Volunteers
- 45 people
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency
Monitoring Intercostal Muscles After Extubation
Mechanical ventilation is a life-saving treatment for critically ill patients who are unable to breathe on their own. At the time of recovery, separation from the ventilator is performed without difficulty for the majority of…
- Trial name
- MIME (NCT02853201)
- Where
- Canada
- Volunteers
- 124 people
- Sponsor
- Unity Health Toronto
Colorectal Cancer
Colonoscopic Skill Acquisition and Transfer Via Simulated Curriculum of Progressive Training
It is hypothesized that a progressive simulated learning strategy will result in better global clinical performance (e.g., technical, communication) and transfer of endoscopic skill, as compared with a high-fidelity simulation…
- Trial name
- NCT02000180
- Testing
- Progressive Group
- Where
- Canada
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Hypercholesterolemia, Cardiovascular Risk Factor
The Effect of Psyllium Fibre on LDL-C, Non-HDL-C, and Apolioprotein-B: A Systematic Review and Meta-analysis
Serum cholesterol is a major modifiable risk factor for cardiovascular disease, which despite considerable reduction in prevalence, remains the leading cause of premature mortality worldwide.
- Trial name
- NCT03346733
- Testing
- Psyllium Fibre
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Critically Ill
Screening Frequency Trial to Identify Weaning Candidates
During weaning the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time on ventilators is spent weaning.
- Trial name
- RELEASE (NCT02001220)
- Testing
- Once daily screening, At least twice daily screening
- Where
- 8 sites in Canada
- Volunteers
- 53 people
- Sponsor
- Unity Health Toronto
Diabetes Mellitus
The Effect of NVFS on GC in Individuals With DM: SR & MA of RCTs
Purpose of Study (The Effect of Non-Viscous Fibre Supplementation on Glycemic Control (NVFS \& GC) in Individuals with Diabetes Mellitus.
- Trial name
- NVFS&GC (NCT03259724)
- Where
- Canada
- Volunteers
- 514 people
- Sponsor
- Unity Health Toronto
Overweight and Obesity, T2DM (Type 2 Diabetes Mellitus)
Effect of Viscous Soluble Fibres on Body Weight
Abstract: Background: Obesity is a global pandemic affects all age groups and is independent risk factors for most chronic diseases. Dietary intervention is an essential component of obesity management.
- Conditions
- Overweight and Obesity, T2DM (Type 2 Diabetes Mellitus), General Population
- Trial name
- NCT03257449
- Testing
- Viscous Fibre
- Where
- Canada
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acute Respiratory Distress Syndrome
Respiratory Mechanics Registry for ARDS Patients
This registry was proposed to investigate the epidemiology of respiratory mechanics in patients with ARDS through collecting data from a QI project which was constituted with systematic assessments of respiratory mechanics and…
- Trial name
- NCT02623192
- Testing
- Patients who have performed the ARDS pulmonary function test
- Where
- 2 sites in Canada, Italy
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Endoscopy Simulation
Impact of a Simulation-based Training Curriculum of Non-technical Skills on Colonoscopy Performance
The investigators aim to test a curriculum of non-technical skills (NTS) training for simulation-based training of colonoscopy. There is no known literature to date on the optimal approach on how to teach NTS in endoscopy.
- Trial name
- NCT02877420
- Testing
- Non-Technical Skills Training Curriculum, Conventional Simulation Training Group
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
HIV Positive Pregnant Women
Positive Pregnancy Program
The Positive Pregnancy Program is an innovative, unique, interprofessional model of care for HIV-positive pregnant women. This program has been in place at St. Michael's Hospital for five years.
- Trial name
- P3 (NCT03073421)
- Testing
- Qualitative interview
- Volunteers
- 25 people
- Sponsor
- Unity Health Toronto
Education, Medical, Critical Care Ultrasonography
Focused Cardiac and Lung Ultrasound in Anesthesia/Critical Care - The Role of Self-directed Simulation-assisted Training Compared to a Traditional Supervised Approach
The purpose of this study is to determine whether a self-directed and simulation-based lung ultrasound (LUS) and focused cardiac ultrasound (FCU) curriculum is efficacious on anesthesia trainees' image acquisition skills and…
- Trial name
- NCT01972698
- Testing
- Self-directed and simulation-assisted training, Traditional apprenticeship training
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
LDL Cholesterol
Effect of Viscous Soluble Fibers on Serum Cholesterol Levels
Research over the past several decades have linked the intake of dietary fiber with lower blood cholesterol levels. The distinction between soluble and insoluble fiber fractions emerged shortly after and there is now a general…
- Trial name
- CHOL-META (NCT02068248)
- Testing
- Soluble Fibre
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
End Stage Renal Disease
The Use of Furosemide in Patients on Dialysis
Patients often begin dialysis taking diuretics (stimulate the kidney to excrete salt and water). Once on dialysis, these drugs are often continued.
- Trial name
- NCT01815892
- Testing
- Withdrawal of furosemide, furosemide administration
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Unity Health Toronto
Self-regulation, Forethought
Exploring Self-regulatory Processes in Anesthesiologists During Massive Transfusion
The purpose of the project is to investigate the function of self-regulatory processes in anesthesiologists and how application of these processes influence performance in a crisis situation.The investigators intend to explore…
- Conditions
- Self-regulation, Forethought, Performance
- Trial name
- NCT02199210
- Testing
- Prompting forethought
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Blood Pressure
Effect of High-carbohydrate or High-monounsaturated Fat on Blood Pressure: Meta-analysis of Randomized Clinical Trials
High saturated fat acids diets are associated with elevated blood pressure which is associated with cardiovascular morbidity and mortality.
- Trial name
- CHO-MUFA (NCT02626325)
- Testing
- High-carbohydrate or High-monounsaturated fat diets
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Type 2 Diabetes Mellitus
ALA on Glycemic Control in T2DM Participants
With the emerging worldwide epidemic of type 2 diabetes, dietary recommendations to improve diabetes management have been emphasized in the scientific community.
- Trial name
- NCT02701894
- Testing
- Alpha-Linolenic Acid
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Blood Pressure
Effect of Ginseng on Blood Pressure
To determine the effect of ginseng on blood pressure control.
- Trial name
- NCT01913210
- Testing
- Ginseng
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto