Clinical trials: completed, sponsored by University Health Network, Toronto
- Lead sponsor (exact) University Health Network, Toronto
- Status Completed
- Age group Children (under 18)
Observational Study
Motion of Kids on Radiation Treatment
At Princess Margaret Cancer Centre, a comprehensive approach to help children stay still during radiation treatment (RT) such as audio-visual distraction (television) is routinely used.
- Trial name
- NCT03995849
- Testing
- Cone Beam CT Scan
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- University Health Network, Toronto
Neuroendocrine Tumors
Lu-DOTATATE Treatment in Patients With 68Ga-DOTATATE Somatostatin Receptor Positive Neuroendocrine Tumors
This is a prospective single arm, multicenter study will evaluate the efficacy and safety of Lutetium-177 Octreotate in patients with neuroendocrine tumors who has positive Somatostatin receptor identified by 68Ga-DOTATATE.
- Trial name
- NCT02743741
- Testing
- Lutetium-177 Octreotate
- Where
- 4 sites in Canada
- Volunteers
- 195 people
- Sponsor
- University Health Network, Toronto
Cerebral Palsy
FES in Young Children With Perinatal Stroke
Every year about 1 out of every 1,600-5,000 infants has a stroke around the time of birth. Many of these children will have lifelong physical problems. For example, the arm muscles are often paralyzed.
- Trial name
- NCT02975180
- Testing
- FES, Conventional
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University Health Network, Toronto
Living Donor Liver Transplantation
PRehab tO PreparE Living Liver Donors for Enhanced Recovery
1. to determine if a Phase III RCT of prehab vs usual care for LLDs is feasible (including rates of recruitment, adherence, adverse events, and attrition); 2.
- Trial name
- PROPELLER (NCT05431361)
- Testing
- Prehabilitation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Prostate Cancer
A Web-based Peer Navigation Program for Men With Prostate Cancer
One in nine Canadian men will be diagnosed with prostate cancer (PC) in their lifetime. Although all treatment options can be effective in controlling the disease, treatment side effects such as problems with erections and…
- Trial name
- NCT05041504
- Testing
- Peer navigation, Active wait list control
- Where
- 3 sites in Canada
- Volunteers
- 184 people
- Sponsor
- University Health Network, Toronto
Cerebral Palsy (CP)
FES Implementation Pediatrics
Physical rehabilitation interventions that promote activity-dependent neuroplasticity are desired for children with CP as this will result in improved motor skill and function.
- Trial name
- NCT06689007
- Testing
- Implementation Intervention
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Lymphoma, Non-Hodgkin's
Obinutuzumab in Combination With GDP Chemotherapy in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma
This is a pilot study to determine the overall survival rate and toxicities of obinutuzumab given with GDP chemotherapy for relapsed or refractory CD20+ aggressive non-Hodgkin lymphoma.
- Trial name
- NCT02750670
- Testing
- Obinutuzumab, Gemcitabine, Dexamethasone
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Chronic Pain
Manage My Pain at Chronic Pain Clinics
The overall objective of this Early Adoption project is to gather evidence for how Managing My Pain Program (MMP), a novel digital pain management application can enable better care at home for chronic pain sufferers in the…
- Trial name
- NCT04762329
- Testing
- Manage My Pain (MMP) digital pain app group
- Where
- Canada
- Volunteers
- 246 people
- Sponsor
- University Health Network, Toronto
Coronavirus
At Home Monitoring for Patients With Covid19
The vast majority of individuals with Covid19 have mild illness that can be managed in the outpatient setting. A small but significant number of these people will deteriorate and require hospitalization.
- Trial name
- NCT04453774
- Testing
- Covidfree@home
- Where
- 2 sites in Canada
- Volunteers
- 432 people
- Sponsor
- University Health Network, Toronto
Impostor Phenomenon
IMPROV-ing The Impostor Phenomenon
The impostor phenomenon refers to feelings of self-doubt and fraudulence in one's own abilities, despite the presence of external evidence to suggest otherwise.
- Trial name
- NCT05230030
- Testing
- Improvisation Workshop
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Oral Cavity Squamous Cell Carcinoma
Biofeedback Rehabilitation to Improve Speaking and Eating in Public
Tongue cancer requires resection and reconstruction that can leave patients disabled with respect to speaking and eating. Impairment of tongue function can have significant impact on social interaction and employment.
- Trial name
- Biofeedback (NCT03650699)
- Testing
- Electropalatography Biofeedback Training
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto
Neuroendocrine Tumors
68Ga-DOTATATE PET for Management of Neuroendocrine Tumors
This is a research study to collect information regarding usefulness of positron emission tomography (PET) scans using a special dye called 68Ga-DOTATATE for patients with neuroendocrine tumours by determining the number of of…
- Trial name
- NCT03873870
- Testing
- 68Ga -DOTATATE PET scans
- Where
- Canada
- Volunteers
- 1,916 people
- Sponsor
- University Health Network, Toronto
Adenocarcinoma of the Prostate
Intensity Modulated Radiation Therapy (IMRT) Pelvic Nodes Prostate
The purpose of this study is to determine the feasibility and late toxicity of dose escalated radiation therapy to the pelvic lymph nodes and prostate and seminal vesicles in the treatment of high risk prostate cancer.
- Trial name
- NCT00915122
- Testing
- Dose Escalated IMRT
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- University Health Network, Toronto
Myeloproliferative Neoplasms (MPN), Polycythemia Vera (PV)
Screening for Asymptomatic Portal Vein Thrombosis and Portal Hypertension in Patients With Philadelphia Negative Myeloproliferative Neoplasms
This study involves screening for portal vein thrombosis and portal hypertension in patients with Philadelphia negative myeloproliferative neoplasms (MPNs).
- Conditions
- Myeloproliferative Neoplasms (MPN), Polycythemia Vera (PV), Essential Thrombocythemia (ET), Myelofibrosis (MF)
- Trial name
- NCT01816256
- Testing
- Upper gastrointestinal endoscopy and Doppler ultrasound
- Where
- 2 sites in Canada
- Volunteers
- 102 people
- Sponsor
- University Health Network, Toronto
Patient Safety
Medical Safety Huddles - a Multi-site QI Project
This quality improvement project will implement and evaluate the impact of physician-specific huddles, termed "medical safety huddles" on patient safety within four programs/sites at Sinai Health Systems, St.
- Trial name
- NCT05365516
- Testing
- Implementing medical safety huddles
- Where
- 4 sites in Canada
- Volunteers
- 4 people
- Sponsor
- University Health Network, Toronto
Nasopharyngeal Carcinoma
Positron Emission Tomography Scanning and Epstein-Barr Virus DNA Levels in the Staging and Follow-up of Nasopharyngeal Carcinoma.
The standard treatment for nasopharyngeal cancer involves either radiation alone or radiation plus chemotherapy. Before the start of treatment,patients require an imaging scan to assess the extent of disease.
- Trial name
- NCT00188253
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Prostate Cancer
Preference-Based Exercise RCT for Men With PC on ADT
Prostate cancer affects 1 in 7 men. Half of these men are treated with androgen deprivation therapy (ADT). ADT slows disease progression and prolongs survival, but it also leads to worse quality of life (QOL), fatigue, loss of…
- Trial name
- PBExRCT (NCT03335631)
- Testing
- Exercise
- Where
- 3 sites in Canada
- Volunteers
- 56 people
- Sponsor
- University Health Network, Toronto
Hypertension
Use of a Hypertension Tool to Manage Blood Pressure in Hemodialysis
The objective of this project is to develop, validate, and implement a tool to help manager hypertension in patients on hemodialysis.
- Trial name
- NCT03089385
- Testing
- Hypertension tool
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Flap Necrosis
Near Infrared Imaging and Flap Necrosis
Skin flaps following mastectomy breast surgery that do not have enough oxygen are at risk for necrosis which can increase wound healing problems, postoperative recovery time and be costly to the hospital systems and affect the…
- Trial name
- NCT03476499
- Testing
- Near Infrared Imaging (NIR) device
- Where
- 2 sites in Canada
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Prostate Cancer
ADT Exercise Trial and Economic Analysis
Prostate Cancer (PC) affects 1 in 7 men. Nearly half of those diagnosed with PC will receive androgen deprivation therapy (ADT) as part of their treatment. ADT is good at managing PC but has many side effects.
- Trial name
- ADTExRCT (NCT02834416)
- Testing
- Supervised Group Exercise, Home Based Exercise
- Where
- 4 sites in Canada
- Volunteers
- 38 people
- Sponsor
- University Health Network, Toronto