Clinical trials: sponsored by University of Cincinnati
Sickle Cell Disease, Pain
Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0
The proposed research is to determine the clinical efficacy and neurobiological mechanisms of acupuncture analgesia in patients with sickle cell disease.
- Conditions
- Sickle Cell Disease, Pain, Acupuncture, Quantitative Sensory Testing
- Trial name
- NCT06725550
- Testing
- needling acupuncture, laser acupuncture
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Obesity & Overweight
Healthy Eating for My Infant: A Community- Informed Infant Obesity Prevention Program Addressing the Impact of Maternal Mental Health on Eating and Feeding
Infants from low-income families are at increased risk for obesity, but obesity prevention programs tailored specifically to the needs of these infants are lacking.
- Trial name
- NCT07284108
- Testing
- Healthy Eating for My Infant (HEMI)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Developmental Language Disorder
Neuroimaging Reveals Treatment-related Changes in DLD
Children with developmental language disorders (DLD, aka specific language impairment), a prevalent pediatric disorder, experience hallmark grammar deficits with life-long impacts on educational and occupational outcomes.
- Trial name
- NCT05268341
- Testing
- My Sentence Builder
- Where
- 6 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Mild Depression
Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth
The primary goal is to investigate to what extent changes in glutamate and glutathione modulation and functional integration between brain networks associated with emotion and attention regulation are associated with treatment…
- Trial name
- NAC+MIND (NCT07464886)
- Testing
- N-acetylcysteine, Mindfulness-based cognitive therapy
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Cincinnati
Prostate Cancer
3-Tesla MRI in Finding Tumors in Patients With Known or Suspected Prostate Cancer
In standard clinical care, the prostate is imaged by magnetic resonance imaging (MRI) which is a procedure to take pictures of body structures by using a strong magnetic field and radio waves.
- Trial name
- NCT01653093
- Testing
- 3-Tesla magnetic resonance imaging (3T MRI), diffusion-weighted magnetic resonance imaging, dynamic contrast-enhanced magnetic resonance imaging
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- University of Cincinnati
Bipolar Disorder, Weight Gain
Topiramate vs. Placebo in Preventing Weight Gain in Bipolar Disorder Treated With Olanzapine
The primary objective of this study is to examine the efficacy of topiramate in combination with olanzapine for the prevention of weight gain in youth with bipolar disorder.
- Trial name
- NCT00394095
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Cincinnati
Pediatric Obesity
Healthy Eating for My Infant (HEMI)
Infants from underserved and minority backgrounds are at increased risk for obesity and poor feeding and nutrition outcomes, but obesity prevention programs tailored specifically to the needs of these infants are lacking.
- Trial name
- NCT04977947
- Testing
- Healthy Eating for My Infant
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Anxiety Disorders
Trial With the Treatment of Sertraline in Youth With Generalized, Separation and/or Social Anxiety Disorders.
A Multicenter, acute, randomized, double-blind, placebo-controlled, flexible-dose trial with the treatment of sertraline.
- Trial name
- EV-SoPRANO (NCT04221997)
- Testing
- sertraline
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Cancer, Renal Failure
Fernald Community Cohort -18 Year Observational Study
The Fernald Community Cohort consists of the 9782 persons who were enrolled in the Fernald Medical Monitoring Program (FMMP) (1990-2008).
- Conditions
- Cancer, Renal Failure, Diabetes, Cardiovascular Disease
- Trial name
- FCC (NCT02295085)
- Where
- United States
- Volunteers
- 9,782 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Anxiety
Pharmacogenetically-guided Escitalopram Treatment for Pediatric Anxiety: Aiming to Improve Safety and Efficacy (PrEcISE)
This double-blind, 12-week study will consist include132 anxious youth who are randomized (1:1) to standard or pharmacogenetically-guided escitalopram dosing.
- Trial name
- PrEcISE (NCT04623099)
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Anxiety, Depressive Symptoms
Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety (AtLAS-A)
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by open-label naturalistic follow-up.
- Trial name
- AtLAS-A (NCT04245436)
- Testing
- Duloxetine, Escitalopram
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Cincinnati
Speech Sound Disorder
Simplified Ultrasound Feedback for Speech Remediation
Recent research in motor control shows that people learn new movements best when they receive feedback external to the body. Traditional ultrasound speech therapy works well for many children, but involves teaching children to…
- Trial name
- SUFSR (NCT06366256)
- Testing
- Traditional ultrasound biofeedback, Simplified ultrasound biofeedback
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Cincinnati
Depression, Anxiety
Mechanism of Antidepressant-Related Dysfunctional Arousal in High-Risk Youth
A 16-week double blind, placebo-controlled investigation of escitalopram in adolescents with depression and/or anxiety with a family history of Bipolar Disorder.
- Conditions
- Depression, Anxiety, Bipolar Disorder
- Trial name
- NCT02553161
- Testing
- Escitalopram, Cognitive behavioral Psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Hypertension
A Nutrition Intervention to Lower Blood Pressure in Adolescents
The purpose of this study is to evaluate the efficacy of a 12-week, clinic-based, behavioral nutrition intervention emphasizing fruits, vegetables, and low fat dairy compared to routine nutrition care on changing diet quality and…
- Trial name
- NCT00431288
- Testing
- diet high in fruits, vegetables, and dairy, Routine nutrition care
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Cincinnati
Attention Deficit Hyperactivity Disorder
Neuroimaging Study of Risk Factors for Adolescent Bipolar Disorder
The main purpose of this study is to see the affects of the study medication called mixed amphetamine salts-extended release (MAS-XR) on brain function by taking brain pictures.
- Trial name
- NERF (NCT02478788)
- Testing
- mixed amphetamine salts-extended release (MAS-XR)
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Recurrent Diffuse Intrinsic Pontine Glioma
Hypofractionated Radiotherapy for Recurrent DIPG
This study evaluates the feasibility of hypofractionated radiotherapy (RT) in the palliative treatment of recurrent diffuse intrinsic pontine glioma (DIPG).
- Trial name
- NCT03841435
- Testing
- Hypofractionated Radiotherapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Cincinnati
Weight, Body, Diet Habit
Healthy Start to Feeding Intervention
The current study will test the impact of a 3-session obesity prevention program targeting healthy introduction of solid foods in infancy on growth trajectories, appetite regulation, and diet.
- Trial name
- NCT03597061
- Testing
- Healthy Start to Feeding
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Bipolar Youth Treated With Second-generation Antipsychotics
SGA-induced Metabolic Syndrome in Bipolar Youth
The investigators tested the hypothesis that long-chain omega-3 (LCn-3) fatty acid supplementation will attenuate the adverse cardiometabolic effects of second-generation antipsychotics exposure in first-episode adolescent manic…
- Trial name
- NCT01858948
- Testing
- Omega, Quetiapine fumarate
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Cincinnati
Hypertension, Pre-Hypertension
Modifying Dietary Behavior in Adolescents With Elevated Blood Pressure
The purpose of this study is to examine the long term effects of a 24-week clinically-based behavioral nutrition intervention emphasizing the DASH diet compared to routine nutrition care on changing diet quality, blood pressure…
- Trial name
- DASH-4-Teens (NCT00585832)
- Testing
- DASH-4-Teens, Routine Care
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- University of Cincinnati
Attention Deficit Disorder
Effect of Omega-3 Fatty Acid on Cortical Function in ADHD
The study hypothesis is that DHA is more effective than placebo in increasing brain activation and reducing symptoms in psychostimulant-free children with ADHD.
- Trial name
- NCT01883817
- Testing
- DHA Omega-3
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati