Clinical trials: completed, sponsored by University of Florida
Duchenne Muscular Dystrophy
Tadalafil as Adjuvant Therapy for DMD
This project will assess the vascular responsiveness in leg muscles of boys with Duchenne muscular dystrophy (DMD) to one single dose of tadalafil, a common vasodilator drug, using non-invasive techniques (MRI or Doppler…
- Trial name
- NCT05195775
- Testing
- Tadalafil
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Florida
Medulloblastoma, Neuroectodermal Tumor
Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor
Immunotherapy is a specific approach to treating cancer that has shown promise in adult patients for the treatment of melanoma, malignant brain tumors, and other cancers.
- Trial name
- Re-MATCH (NCT01326104)
- Testing
- TTRNA-xALT, TTRNA-DCs
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- University of Florida
HPV
Text and Talk: A Multi-level Intervention to Increase Provider HPV Vaccine Recommendation Effectiveness
This study will test the effectiveness of two interventions (parent-targeted text messages and a brief clinician-targeted training) at increasing HPV vaccination among 11- to 12-year-olds living in Florida.
- Trial name
- Text&Talk (NCT05006833)
- Testing
- Brief Provider Training - Bundled Approach, Brief Provider Training - Benefits Approach, Parent Interactive Text Message - Bundled Approach
- Where
- United States
- Volunteers
- 8,043 people, healthy volunteers welcome
- Sponsor
- University of Florida
Weight Gain Prevention, Physical Inactivity
Family Fit Iterative App Development
The overall aim of this study is to test the acceptability and usability of a mobile application (app) for family-based physical activity and weight gain prevention among parent/guardian and child (ages 9-12 years) dyads.
- Trial name
- NCT06148246
- Testing
- Family Fit Condition
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Educational Problems
The Efficacy of Biplane Versus Single Plane Ultrasound in Facilitating Caudal Epidural Anesthesia in Pediatric Patients.
Ultrasound guidance plays a pivotal role in caudal epidural block in pediatric patients. In comparison to conventional single-plane ultrasound, biplane ultrasound offers the advantage of providing simultaneous transverse and…
- Trial name
- NCT06319989
- Testing
- Biplane Ultrasound, Single plane ultrasound
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Florida
Type 1 Diabetes (T1D)
Lactobacillus Johnsonii in Children and Adolescents With T1D
While genetics demonstrated a major risk factor for the development of type 1 diabetes (T1D), microbiota dysbiosis has been suggested as an elicitor in immunological tolerance and of beta cell autoimmunity.
- Trial name
- NCT03961854
- Testing
- L. johnsonii Probiotic
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Asthma
AIM2ACT: A Mobile Health Tool to Help Adolescents Self-Manage Asthma
The aim is to test the efficacy of AIM2ACT and long-term maintenance of treatment effects in a fully-powered randomized controlled trial with 160 early adolescents with poorly controlled persistent asthma, ages 12-15 years, and a…
- Trial name
- AIM2ACT (NCT04448002)
- Testing
- AIM2ACT, mHealth Attention Control Condition
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- University of Florida
Duchenne Muscular Dystrophy (DMD)
Twice Weekly Steroids and Exercise as Therapy for DMD
The study team will determine the potential of low dose twice weekly prednisone and whether exercise training can synergize to delay disease progression and improve muscle strength/physical function in boys with Duchenne muscular…
- Trial name
- NCT04322357
- Testing
- Prednisone, Exercise Training on standard steroid regimen, Exercise training on twice-weekly steroids
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Florida
Dementia With Lewy Bodies
The PACE-DLB Study
The PACE-DLB Study is for people with at least moderate dementia with Lewy bodies (DLB) and their primary caregiver. The study's goals are to learn more about the experiences of people with DLB and their caregivers as DLB…
- Trial name
- NCT04829656
- Where
- 5 sites in United States
- Volunteers
- 378 people
- Sponsor
- University of Florida
Pediatric ALL, Acute Disease
Improving Nighttime Access to Care and Treatment; Part 2- Ghana
Globally, leading causes of death among children one month to 5 years old are pneumonia, diarrheal disease and malaria which are treatable early in the disease-course with low-cost medications.
- Trial name
- INACT2-G (NCT05506683)
- Testing
- MotoMeds pediatric telemedicine and medication delivery service (TMDS)
- Where
- Ghana
- Volunteers
- 1,239 people
- Sponsor
- University of Florida
Autism Spectrum Disorder
Sensory Intervention for Children With Autism
Greater than 80% of children with autism spectrum disorder (ASD) experience sensory differences that make it difficult for them to fully participate in meaningful everyday activities.
- Trial name
- NCT06246487
- Testing
- Occupational Therapy Intervention
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Florida
Tuberculosis, Human Immunodeficiency Virus
Contributing Factors for Poor HIV Treatment Response in Children With TB/HIV Coinfection
Efavirenz (EFV)-based antiretroviral therapy (ART) remains the preferred regimen in human immunodeficiency virus (HIV)-infected children aged 3 years or older on rifampin-containing antituberculosis (anti-TB) therapy.
- Conditions
- Tuberculosis, Human Immunodeficiency Virus, Coinfection
- Trial name
- NCT03800407
- Testing
- Observational study
- Where
- Ghana
- Volunteers
- 213 people
- Sponsor
- University of Florida
Acute Kidney Injury
Long Term Cognitive Impact of Pediatric Acute Renal Injury
The research study will investigate the longitudinal cognitive outcomes in subjects admitted as children diagnosed with sepsis who may have had acute kidney injury.
- Trial name
- NCT02372734
- Testing
- Pediatric Quality of Life (Peds QL) Survey
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of Florida
Asthma in Children
Early Administration of Steroids in the Ambulance Setting
Asthma is the most common chronic disease of childhood and is a leading cause of emergency medical treatment. For children experiencing an asthma exacerbation, emergency department (ED) guidelines recommend early systemic…
- Trial name
- EASI-AS-ODT (NCT03962894)
- Testing
- Prednisolone
- Where
- 7 sites in United States
- Volunteers
- 834 people
- Sponsor
- University of Florida
Individual, Category, and No-label Conditions
Infant and Parent Shared Book Reading
This work is guided by two specific aims and is expected to result in a better understanding of the effectiveness of shared book reading as a tool for supporting parent-infant interactions and infant learning across the first…
- Trial name
- NCT04337372
- Testing
- Effects of shared book reading: Labels
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Florida
Infection
Optimal Feeding Tube Dwell Time in VLBW Infants to Reduce Feeding Tube Contamination
The study team will determine whether a decreased feeding tube dwell time will reduce feeding tube contamination
- Trial name
- NCT03728608
- Testing
- Feeding tube dwell time of 48 hours, Feeding tube dwell time of 7 day
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- University of Florida
Tuberculosis, Human Immunodeficiency Virus
Adequacy of the New Pediatric Isoniazid/Rifampin/Pyrazinamide (HRZ) Tablet
Lack of quality-assured pediatric formulations of the first-line antituberculosis (anti-TB) drugs is barrier to optimized tuberculosis (TB) treatment outcome in children.
- Conditions
- Tuberculosis, Human Immunodeficiency Virus, Coinfection
- Trial name
- NCT03800381
- Testing
- Observational PK study
- Where
- Ghana
- Volunteers
- 92 people
- Sponsor
- University of Florida
Spinal Cord Injury (SCI)
Restoring Walking in Non-ambulatory Children With Severe Chronic Spinal Cord Injury (SCI) (Kids STEP Study)
The Kids STEP Study aims to 1. Determine if walking can be restored in children with incomplete SCI and little to no leg movement 2. Identify the neural pathways that permit recovery of walking
- Trial name
- NCT00488280
- Testing
- Locomotor Training
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Florida
Tobacco Use Behavior
Smoking Prevention Through Social Connections Among Adolescents - ASPIRE
The central hypothesis of this study is that the addition of social influence strategies to a web-based program called ASPIRE will boost its success in lowering intention to use tobacco among adolescents and experiencing stronger…
- Trial name
- NCT02703597
- Testing
- Surveys, ASPIRE, GSA-ASPIRE-Network
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- University of Florida
Methicillin-Resistant Staphylococcus Aureus
Analysis of CA-MRSA Transmission: An ED Population Sampling Strategy
Given that the Emergency Department (ED) has become the entry way for large populations of patients into the health care system, a strategy of sampling MRSA isolates in ED populations and merging this information with…
- Trial name
- NCT02363166
- Testing
- Acute Abscess Group
- Where
- United States
- Volunteers
- 575 people
- Sponsor
- University of Florida