Clinical trials: sponsored by Yonsei University
Dyslipidemias, Atherosclerotic Cardiovascular Disease
Effects of Pitavastatin or Combination of Pitavastatin and Ezetimibe on Glucose Metabolism Compared to AtoRvastatin in atheroscLerotic Cardiovascular Disease Patients With Metabolic Syndrome: The EZ-PEARL Randomized Trial
The purpose of this study was to investigate the effect of pitavastatin or pitavastatin and ezetimibe combination therapy on glucose metabolism compared to atorvastatin in patients with atherosclerotic cardiovascular disease with…
- Trial name
- NCT05705804
- Testing
- Pitavastatin, Pitavastatin plus Ezetemibe, Atorvastatin
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Ischemic Heart Disease (IHD)
Gangwon PCI Prospective Registry
This prospective, multicenter registry will consecutively enroll patients of all ages undergoing percutaneous coronary intervention (PCI) at four university hospitals in Gangwon Province, Republic of Korea.
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease (IHD), Unstable Angina (UA), Non-ST Elevated Myocardial Infarction
- Trial name
- GWPCI (NCT02038127)
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- 4 sites in South Korea
- Volunteers
- 10,000 people
- Sponsor
- Yonsei University
Leukemia, Lymphoid
Efficacy of Risk-Stratified Treatment in Newly Diagnosed Infant Leukemia
This clinical trial is an open-label, multicenter, prospective phase 2 clinical trial targeting pediatric leukemia patients of infant age.
- Trial name
- NCT06516679
- Testing
- Consolidation #4(without daunorubicin), Consolidation #4(with daunorubicin), Allogeneic hematopoietic stem cell transplantation after Consolidation #4(with daunorubicin)
- Where
- 10 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Neoplasms of Bone and Articular Cartilage With Unspecified Anatomical Site
EVERolimus and LenvAtinib Versus Everolimus for Bone Sarcoma
Those studies demonstrate strong rationale to combine a multikinase inhibitor targeting VEGFR, PDGFR with mTOR inhibitor. Moreover, another multi-targeted TKI, lenvatinib monotherapy showed promising activity in osteosarcoma.
- Trial name
- NCT07619950
- Testing
- Everolimus and Lenvatinib, Everolimus
- Volunteers
- 94 people
- Sponsor
- Yonsei University
Vascular Malformations, Arteriovenous Malformations
A Study to Evaluate the Efficacy and Safety of Everolimus in Patients With Teratment-refractory Vascular Anomalies
Background and Objectives Vascular anomalies are a heterogeneous group of disorders classified into vascular tumors and vascular malformations according to the ISSVA classification.
- Conditions
- Vascular Malformations, Arteriovenous Malformations, Venous Malformation, Lymphangioma
- Trial name
- NCT07477548
- Testing
- Everolimus
- Volunteers
- 67 people
- Sponsor
- Yonsei University
Fabry Disease
Effect of Agalsidase Alfa on Cardiac Inflammation in Patients With Fabry Disease: A [18F]-FDG PET-CMR Study
This is a prospective observational study. All patients will initiate and maintain treatment with agalsidase alfa during the study period.
- Trial name
- NCT07235709
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Yonsei University
Gait Disorders, Neurologic, Cerebral Palsy
Home-based Gait Rehabilitation Service Using the Insole-type Gait Analysis Device for Children With Cerebral Palsy
Walking is a crucial daily activity that requires complex coordination of muscular systems. It is essential for bone and muscle health, cardiovascular fitness, and activities of daily living, making it an important indicator of…
- Trial name
- NCT06461923
- Testing
- Insole wearing
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Yonsei University
Breast Cancer, Radiation Therapy
Effect of Bra Use During Radiotherapy for Breast Cancer Radiotherapy
This prospective randomized study investigated the reproducibility of breast shape, radiation dose irradiated to the lungs, heart, dose distribution, patient satisfaction, and treatment toxicity when wearing and not wearing a bra…
- Trial name
- NCT06178861
- Testing
- Group wearing a radiotherapy bra
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Yonsei University
Normal Pressure Hydrocephalus
Identifying Gait Changes From a CSF Tap Test Using a Smart Insole in iNPH
The goal of this clinical trial is to to evaluate various gait parameters by a sensor-embedded smart insole before and after the cerebrospinal fluid (CSF) tap test in idiopathic normal pressure hydrocephalus (iNPH) patients.
- Trial name
- NCT06722768
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Bone Marrow Examination, Urologic Surgical Procedures
Comparison of the Clinical Performance and Safety of the Ambu®AuraGainTM Laryngeal Mask in Children Undergoing Surgery in the Supine and Prone Position - A Prospective, Noninferiority Clinical Trial
The Ambu Auragain is a 2nd generation laryngeal mask airway that is widely used in adult and pedicatric patients. While its use is generally recommended in patients undergoing surgery in the supine position, depending on patient…
- Conditions
- Bone Marrow Examination, Urologic Surgical Procedures, Orthopedic Surgery
- Trial name
- NCT05286021
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Yonsei University
Scoliosis
Effect of Intraoperative Paravertebral Block on Postoperative Pain and Recovery in Patients Undergoing Mechanical Correction for Scoliosis
Pain management after scoliosis surgery is challenging for the anesthesiologists. This surgery causes severe postoperative pain and patients undergoing these operations are children or adolescents who are increased pain sensation…
- Trial name
- NCT04773509
- Testing
- Paravertebral block
- Where
- South Korea
- Volunteers
- 32 people
- Sponsor
- Yonsei University
Health Status(Death, Stroke Etc)
Artificial Intelligence-enabled Large-scale Electrocardiogram Feature Extraction and Exploring Association Between the Extracted Features and Mortality, Stroke or Various Health Outcome of Interest
In this study, large-scale ECG data (Electrocardiogram data of all patients stored in the MUSE system by measuring standard 12-guided ECG at Severance Health Checkup at Severance Hospital from November 1, 2005 to October 31…
- Trial name
- NCT06179849
- Where
- South Korea
- Volunteers
- 3,000,000 people
- Sponsor
- Yonsei University
Patients With Cryptorchism Who Are Planning to Undergo Orchiopexy
Does Low Dose of Dexamethasone Enhance Analgesic Quality of Caudal Analgesia in Children Undergoing Orchiopexy?
Caudal block is one of the most effective modalities to reduce pain both during and after the surgery involving areas under the umbilicus.
- Trial name
- NCT04841018
- Testing
- High dose dexamethasone, Low dose dexamethasone
- Where
- South Korea
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Emergency Patient Transported by Ambulance
Evaluation of Effectiveness for Connected Network for EMS Comprehensive Technical-support Using Artificial Intelligence (CONNECT-AI) System by Community Intervention
This study aims to verify the effectiveness of the connected network for EMS comprehensive technical-support using artificial intelligence (CONNECT-AI) system through demonstration in the local community.
- Trial name
- NCT04829279
- Testing
- CONNECT AI system group
- Where
- South Korea
- Volunteers
- 15,392 people
- Sponsor
- Yonsei University
Atrial Fibrillation
Artificial Intelligence Guided Patient Selection for Atrial Fibrillation Catheter Ablation: Randomized Clinical Trial (AI-PAFA Trial)
Atrial fibrillation (AF) is a major cardiovascular disease with a prevalence of 1.7% of the total population in Korea, associated with 25% of ischemic stroke and 30% of heart failure, and is a major cardiovascular disease that…
- Trial name
- NCT04997824
- Testing
- Artificial Intelligence-based atrial fibrillation catheter ablation, Medical Therapy
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Yonsei University
Vesico-Ureteral Reflux, Filum Terminale Lipoma
Effects of Parental Holding on Pain Response in Young Children During Cystometry
Cystometry is essential for diagnosis and treatment plans by identifying the causes of lower urinary tract symptoms and objectively evaluating bladder functions in diseases such as neurogenic bladder, voiding dysfunction, and…
- Trial name
- NCT05864131
- Testing
- Lying, Holding
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Yonsei University
Children Aged 6 Months to 10 Years Old Under General Anesthesia
Biobank of Lung Ultrasonography in Children Undergoing General Anesthesia
For children aged 6 months to 10 years old under general anesthesia, intraoperative lung ultrasound pictures are acquired, grades are evaluated for each pictures and machine learning is used to learn and apply it.
- Trial name
- NCT05069337
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Pediatric Patients Undergoing Hypospadias Surgery
Does the Single Use of Intravenous Dexamethasone Enhance Analgesic Quality of Pudendal Analgesia in Children Undergoing Hypospadias Surgery?
Hypospadias is a congenital malformation that occurs in an embryological process, and occurs with an incidence of about 1/300 in male children.
- Trial name
- NCT04836962
- Testing
- normal saline, dexamethasone
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Yonsei University
Pediatric Germ Cell Tumor
Paclitaxel/Ifosfamide/Cisplatin Chemotherapy for High Risk Pediatric Germ Cell Tumor
Germ cell tumor has generally good prognosis, but high risk germ cell tumor has still very poor prognosis. There remains the need of further improvement with other chemotherapy strategy.
- Trial name
- NCT05455918
- Testing
- TIP treatment (paclitaxel/ifosfamide/cisplatin)
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Yonsei University
Infants Aged 0 Days to 13 Months Scheduled for Elective Surgery
Effect of Pressure Support Ventilation During Anesthetic Emergence on Postoperative Atelectasis in Infant
Atelectasis occurs in patients of all ages who receive mechanical ventilation under general anesthesia, and although fatal cases are rare, it is known as a cause of postoperative hypoxia or fever.
- Trial name
- NCT05373589
- Testing
- conventional ventilation, group C, pressure support, group PS
- Where
- South Korea
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Yonsei University