Find a clinical trial
Hypoxic-ischemic Encephalopathy (HIE)
The PROTECT-HIE Pilot Trial
Some babies experience a lack of oxygen and blood flow around the time of birth. This can lead to a serious condition called hypoxic-ischemic encephalopathy (HIE), which can injure the brain and other organs, including the heart.
- Trial name
- PROTECT-HIE (NCT07406477)
- Testing
- Dobutamine, TnECHO
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Psychiatric Disorders, Anxiety Disorders
Gaze-Contingent Music Therapy Augmentation of CBT for Pediatric Anxiety
Background: Anxiety disorders are becoming more common among children and teenagers. Anxiety can lead to long-term physical and mental problems, such as depression.
- Trial name
- NCT06595953
- Testing
- Gaze-Contingent Music Reward Therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Mental Health (NIMH)
Gross Motor
The Hidden Burden of Cerebral Palsy: Exploring the Relationship Between Gross Motor Function of Children, Maternal Low Back Pain, and Quality of Life
Caregiving for cerebral palsy children covers a very wide range of activities such as heavy lifting and turning, bathing, helping the child to use the toilet, getting the child to sleep, dressing and assisting the transfer causes…
- Trial name
- cerebral palsy (NCT07919002)
- Testing
- gross motor group
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- October 6 University
Familial Hypercholesterolaemia
Early Detection of Familial Hypercholesterolaemia in Pre-school Children ( CzeCH-IT)
The project is a national, prospective, multicenter, non-interventional project of screening for the disease Familial hypercholesterolaemia (FH) in pre-school children in the Czech Republic.
- Trial name
- NCT07912281
- Where
- 62 sites in Czechia
- Volunteers
- 6,276 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Reproductive Physiological Processes, Pediatrics
Reproductive Axis Maturation in the Early Post-Menarchal Years
Background: Most adult women with irregular periods of unknown cause report symptoms dating back to early adolescence. This study aims to learn how girls' periods change in the 2 years after their first period.
- Conditions
- Reproductive Physiological Processes, Pediatrics, Adolescent Health, Adolescent Development
- Trial name
- NCT03986021
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Healthy Volunteers
Sample Collection From Healthy Volunteers for Assay Optimization
Background: The Laboratory of Immune System Biology (LISB) works with other labs at the National Institutes of Health. They study how parts of living things come together to make a whole.
- Trial name
- NCT03538600
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dermatitis Atopic
Pharmacokinetics, Immunogenicity and Safety of Subcutaneous Dupilumab and Berahyaluronidase Alfa (ALT-B4) Coformulation
This is a Phase 3, open label, randomized, parallel-group, 2-arm study. The purpose of this study is to measure PK, immunogenicity, safety and, tolerability of dupilumab hyaluronidase coformulation compared with dupilumab…
- Trial name
- EXTENSA (NCT07919899)
- Testing
- Dupilumab coformulated with berahyaluronidase alfa, Dupilumab
- Volunteers
- 150 people
- Sponsor
- Sanofi
Major Depression Disorder, ANXIETY DISORDERS (or Anxiety and Phobic Neuroses)
Digital Interventions for Relapse Prevention in Adolescence
Some adolescents experience periods of anxiety and/or depression, and some find that these periods return over time. The purpose of this study is to examine whether digital interventions-where individuals work systematically with…
- Trial name
- DigiTIFF (NCT07346911)
- Testing
- Transdiagnostic app intervention, Transdiagnostic mastery course
- Where
- Norway
- Volunteers
- 495 people
- Sponsor
- University of Oslo
Eating Disorders, Hypoestrogenemia
The Role of Estrogen in the Neurobiology of Eating Disorders
This is a randomized, double blind, placebo-controlled study of the effects of transdermal estradiol versus placebo on cognitive flexibility, reward processing, and eating disorder pathology in hypoestrogenemic female adolescents…
- Trial name
- REACT (NCT03740204)
- Testing
- 17-β estradiol transdermal patches, Micronized progesterone 200 MG
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Massachusetts General Hospital
Lactium, Premedication
Lactium Premedication to Prevent Emergence Agitation
This biased coin sequential allocation, dose finding study will be conducted to determine the effective dose of oral lactium in 90% of children (ED90) for prevention of emergence agitation during recovery from adenotonsillectomy.
- Conditions
- Lactium, Premedication, Emergence Agitation, Adenotonsillectomy
- Trial name
- NCT07894484
- Testing
- Lactium
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Primary T-cell Immunodeficiency Disorders, Common Variable Immunodeficiency
Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies
Background: Allogeneic blood or marrow transplant is when stem cells are taken from one person s blood or bone marrow and given to another person. Researchers think this may help people with immune system problems.
- Conditions
- Primary T-cell Immunodeficiency Disorders, Common Variable Immunodeficiency, Immune System Diseases, Autoimmune Lymphoproliferative
- Trial name
- NCT02579967
- Testing
- Immunosuppression Only Conditioning -Closed with amendment L, Reduced Intensity Conditioning, Myeloablative Conditioning-Closed with amendment L
- Where
- 2 sites in United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Prematurity, Feeding Behaviors
Effects of Environmental Comfort and Oral Motor Stimulation on Comfort and Oral Feeding Readiness in Preterm Infants
This study aims to evaluate the effects of short-term environmental comfort interventions and oral motor stimulation on comfort and oral feeding readiness in preterm infants.
- Trial name
- NCT07917871
- Testing
- Massage, White Noise, Oral Motor Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Marmara University
Acne
Safety, Tolerability, and Clinical Effectiveness of Adapalene/Clindamycin Phosphate Gel (Klenzit®-C) in Vietnamese Patients With Mild to Moderate Acne Vulgaris
The CLEAN ACNE Study is a prospective, observational, Phase IV, open-label, multicenter, single-arm study at 3-5 sites in Vietnam.
- Trial name
- Clean Acne (NCT07918001)
- Testing
- Klenzit®-C (Adapalene/Clindamycin Phosphate Gel)
- Where
- 3 sites in Vietnam
- Volunteers
- 225 people
- Sponsor
- IR INNOVATE RESEARCH PRIVATE LIMITED
Congenital Adrenal Hyperplasia (CAH), Familial Male-Limited Precocious Puberty (FMPP)
Natural History Study of Patients With Excess Androgen
This study will evaluate and gather information in patients with genetic causes of too much androgen (male-like hormone) in order to better understand the effects of too much androgen and describe problems associated with it.
- Trial name
- NCT00250159
- Where
- 2 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Peripheral Blood Stem Cell Transplantation, Hematopoietic Stem Cell Transplantation
The Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination With Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis After Reduced Intensity Conditioning and Peripheral Blood Stem Cell Transplantation
Background: Blood cancers (such as leukemias or lymphomas) often do not respond to standard treatments. A transplant of blood stem cells from a healthy donor can help people with these cancers.
- Trial name
- NCT05436418
- Testing
- Melphalan, Sirolimus, Total Body Irradiation (TBI)
- Where
- 2 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Li-Fraumeni Syndrome, Neoplasms
Clinical and Genetic Studies of Li-Fraumeni Syndrome
Background: Li-Fraumeni syndrome (LFS) is a genetic condition that increases the risk for some types of cancer. LFS may lead to cancer of the bone or connective tissue, breast, and brain.
- Conditions
- Li-Fraumeni Syndrome, Neoplasms, Tp53 Mutations
- Trial name
- NCT01443468
- Where
- 2 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Moderately to Severely Active Ulcerative Colitis
A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative Colitis
This Phase III, randomized, double-blind, multicenter, induction and maintenance study will evaluate the safety and efficacy of Afimkibart (RO7790121) in pediatric participants with moderate to severe active ulcerative colitis…
- Trial name
- AMETRINE-PEDS (NCT07158242)
- Testing
- Afimkibart
- Where
- 29 sites in United States, Australia and 7 more
- Volunteers
- 100 people
- Sponsor
- Hoffmann-La Roche
HIV Infections
Long-term Follow-up of Long-acting Cabotegravir (CAB LA) for PrEP (Pre-exposure Prophylaxis) in Participants at Risk of Acquiring HIV (Human Immunodeficiency Virus)
The purpose of this study is long-term evaluation of long-acting injectable cabotegravir (CAB LA) for HIV pre-exposure prophylaxis (PrEP) in eligible participants who have completed DAIDS (Division of AIDS) sponsored studies HPTN…
- Trial name
- PALISADE (NCT06134362)
- Testing
- CAB LA
- Where
- 33 sites in Argentina, Botswana and 10 more
- Volunteers
- 2,998 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Asthma, COPD (Chronic Obstructive Pulmonary Disease)
Reducing Exposure With Air Cleaners and Technology
Fine particulate matter (PM2.5) is a type of air pollution made up of extremely tiny particles that can harm our health. Because PM2.5 particles are so small, they can travel deep into the lungs when inhaled.
- Trial name
- REACT (NCT07914010)
- Testing
- Air Cleaner, PM2.5 Monitor with Visual Air Quality Indicator, Educational Materials
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of California, Berkeley
Leukocyte Disorders, Respiratory Tract Diseases
Collection of Lung Fluid and Tissue Samples for Research
This study will collect fluid and tissue specimens from the lungs and nose of healthy people and people with a history of lung infections.
- Conditions
- Leukocyte Disorders, Respiratory Tract Diseases, Bronchoscopy
- Trial name
- NCT00471250
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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