Find a clinical trial
Decayed Primary Molars
Pain Perception With Cordless Electronic Local Anesthetic Delivery System
22 children with two primary molars that need extraction or pulpotomy will be selected to compare pain perception between conventional dental syringe and cordless electronic local anesthetic delivery system.
- Trial name
- NCT07915531
- Testing
- Cordless Electronic local anesthetic delivery system, Conventional dental syringe
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
IgE-Mediated Cow Milk Allergy
Evaluation of the Tolerance of a New Formula Based on Hydrolyzed Rice Proteins in Children With Cow's Milk Allergy
The goal of this clinical trial is to see if a new formula based on hydrolysed rice proteins (Rice formula) is well tolerated by infants and young children with cow's milk allergy.
- Trial name
- NCT07197814
- Testing
- Rice formula (New formula based on hydrolysed rice proteins)
- Where
- Italy
- Volunteers
- 29 people
- Sponsor
- Health and Happiness Research Limited
Depressive Symptoms
Improving Mood for Adolescents Through Teaming With End-Users in Routine Care (The iMATTER Project)
This pilot randomized controlled trial will examine the feasibility, acceptability and preliminary efficacy of an adolescent depression prevention program, Brief Interpersonal Psychotherapy-Adolescent Skills Training (B-IPT-AST)…
- Trial name
- NCT07020572
- Testing
- Brief Interpersonal Psychotherapy - Adolescent Skills Training (B-IPT-AST), Services as usual (SAU)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Children's Hospital of Philadelphia
Asthma
A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/Albuterol Sulfate is Effective in Preventing Asthma Exacerbations
The primary objective of the study is to assess the efficacy of high dose fluticasone propionate (Fp)/albuterol sulfate (ABS) integrated electronic module multidose dry powder inhaler (eMDPI) compared to ABS eMDPI in decreasing…
- Trial name
- NCT06052267
- Testing
- TEV-56248, Albuterol sulfate
- Where
- 391 sites in United States, Argentina and 20 more
- Volunteers
- 2,769 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D LLC
Transfusion-dependent Beta-Thalassemia
Safety and Efficacy of the Lentiviral Vector in Gene Therapy of Beta-thalassemia Patients
This is a non-randomized, open-label, single-dose study. The aim of this study is to evaluate the safety and efficacy of the treatment with lentiviral vector encoding βA-T87Q-globin gene transduced autologous hematopoietic stem…
- Trial name
- NCT06219239
- Testing
- KL003 cell injection Drug Product
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Otoferlin Gene-mediated Hearing Loss
Long Term Follow-up Study of AAVAnc80-hOTOF Gene Therapy
This multi-center, observational, post-intervention long term follow-up (LTFU) study will monitor for safety and efficacy of AAVAnc80-hOTOF in individuals with sensorineural hearing loss due to otoferlin gene mutations who have…
- Trial name
- NCT06696456
- Where
- 5 sites in United States, Spain and 1 more
- Volunteers
- 30 people
- Sponsor
- Eli Lilly and Company
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)
The main purpose of this study is to evaluate the efficacy and safety of lebrikizumab in participants with chronic rhinosinusitis and nasal polyps treated with intranasal corticosteroids. The study will last about 18 months.
- Trial name
- NCT06338995
- Testing
- LY3650150, Standard therapy for INCS
- Where
- 202 sites in United States, Argentina and 18 more
- Volunteers
- 510 people
- Sponsor
- Eli Lilly and Company
Oral Hygiene
Game-based Oral Health Promotion
Parents and caregivers play a key role in shaping children's oral health-related behaviours. However, traditional oral health education (OHE) is not engaging for young children.
- Trial name
- NCT07916896
- Testing
- OHE for children, OHE for parents, OHE interactive game kits
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Anxiety Disorder of Adolescence, Avoidant / Restrictive Food Intake Disorder
Parent-Based Intervention for Childhood Avoidant/Restrictive Food Intake Disorder (ARFID)
This study aims to test the efficacy of a parent-based approach to treating Avoidant/Restrictive Food Intake Disorder (ARFID) in children, SPACE-ARFID (Supportive Parenting for Anxious Childhood Emotions, adapted for ARFID), by…
- Trial name
- NCT07916974
- Testing
- Supportive Parenting for Anxious Childhood Emotions (SPACE), Nutritional Support (NS)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Yale University
Duchenne Muscular Dystrophy
Safety and Efficacy of KER-065 in Participants With Duchenne Muscular Dystrophy
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and efficacy of KER-065 administered to adult and pediatric ambulatory and nonambulatory male participants with…
- Trial name
- NCT07704099
- Testing
- KER-065
- Where
- 4 sites in Georgia, New Zealand
- Volunteers
- 36 people
- Sponsor
- Keros Therapeutics, Inc.
Oneida Nation Members
The AHA Oneida Study
The purpose of this clinical trial is to learn whether a cultural nutritional program can change stroke risk factors, cognitive decline, and learn how school education programs about nutrition can improve health in the Oneida…
- Trial name
- NCT07139132
- Testing
- Health Wellness Coaching, Carotid ultrasound, School-age nutritional education program
- Where
- 2 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cerebral Palsy, Early Assessment
Early Detection of Cerebral Palsy Subtype
Early identification of cerebral palsy (CP) has improved with the combined use of the General Movements Assessment (GMA), the Hammersmith Infant Neurological Examination (HINE) and magnetic resonance imaging (MRI).
- Conditions
- Cerebral Palsy, Early Assessment, Early Rehabilitation Intervention
- Trial name
- MILPCI2024 (NCT07916519)
- Testing
- Neurofunctional assessment for early identification of cerebral palsy motor subtypes and functional prognosis
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Transfusion-dependent Beta-Thalassemia, Gene Therapy
Growth and Development-related Outcomes in Children With Transfusion-dependent Beta-thalassemia After Gene Therapy
The investigate will conduct a cohort study to compare the growth and development, metabolism, lifestyle behavior, and health-related quality of life among three groups: children with transfusion-dependent β-thalassemia (TDT) who…
- Trial name
- NCT05991336
- Testing
- Gene therapy
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Ventricular Tachyarrhythmia
Lead EvaluAtion for Defibrillation and Reliability (LEADR) / Lead Evaluation for Defibrillation and Reliability in Left Bundle Branch Area Pacing (LEADR LBBAP)
The LEADR study is designed to assess the safety and efficacy of the Next Generation ICD lead. The LEADR LBBAP study is being conducted under the existing US FDA Investigational Device Exemption (IDE) for the Next Generation ICD…
- Trial name
- NCT04863664
- Testing
- Defibrillation (RV Implant), Defibrillation (LBBAP Implant)
- Where
- 55 sites in United States, Australia and 18 more
- Volunteers
- 1,007 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
T-cell Acute Lymphoblastic Lymphoma, T-non-Hodgkin Lymphoma
Autologous T-Cells Expressing a Second Generation CAR for Treatment of T-Cell Malignancies Expressing CD5 Antigen
Patients eligible for this study have a type of blood cancer called T-cell leukemia or lymphoma (lymph gland cancer). The body has different ways of fighting infection and disease. No one way seems perfect for fighting cancers.
- Conditions
- T-cell Acute Lymphoblastic Lymphoma, T-non-Hodgkin Lymphoma, T-cell Acute Lymphoblastic Leukemia
- Trial name
- MAGENTA (NCT03081910)
- Testing
- Autologous CD5.CAR/28zeta CAR T cells, Allogeneic CD5.CAR/28zeta CAR T cells
- Where
- 2 sites in United States
- Volunteers
- 104 people
- Sponsor
- Baylor College of Medicine
Friedreich Ataxia
Characterisation of the Cognitive Profile of Patients Suffering From Friedreich's Ataxia
Friedreich's Ataxia (FA) Friedreich's Ataxia is a neurodegenerative disease caused by a homozygous expansion of the GAA triplet repeats of the frataxin gene (FXN). FA usually begins in childhood or adolescence.
- Trial name
- CPCAF (NCT05874388)
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Preterm Birth Infants
Effect of Antenatal Dexamethasone on Postnatal Adrenal Hormones in Preterm Neonates
This study is designed to evaluate the effect of antenatal dexamethasone administration on postnatal adrenal hormone levels in preterm neonates.
- Trial name
- NCT07916142
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Cerebral Palsy, Spastic
Nervus Vagus Stimulation and Cerebral Palsy
This study investigated the acute effects of transcutaneous auricular vagus nerve stimulation (taVNS) on autonomic nervous system regulation and spasticity in children with spastic cerebral palsy.
- Trial name
- NCT06880887
- Testing
- nervus vagus stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul Medipol University Hospital
CKD (Chronic Kidney Disease) Stage 5D
Impact of Propionic Acid on Regulatory T Cell Function in Children With CKD
Pro-Kids is a multi-center, double-blind, randomized and placebo-controlled intervention study in children with chronic kidney disease.
- Trial name
- Pro-Kids (NCT05858437)
- Testing
- Sodium propionate
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Charite University, Berlin, Germany
Refractive Errors
Correcting Myopia Among Secondary School Children to Increase Academic High School Attendance Rates in Rural Communities
Chinese children are some of the most short-sighted in the world, but only one in five children in poor areas who needs glasses has them.
- Trial name
- SWISH (NCT04077086)
- Testing
- Spectacles
- Where
- 3 sites in China, United Kingdom
- Volunteers
- 10,000 people
- Sponsor
- Queen's University, Belfast
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.