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Obesity, Overweight
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
The main purpose of this study, performed under Master Protocol J4M-MC-PWMP (NCT06672549), is to evaluate the efficacy, safety, and pharmacokinetics of orforglipron once daily oral versus Placebo in adolescent participants with…
- Trial name
- NCT06672939
- Testing
- Orforglipron
- Where
- 34 sites in United States, Israel and 4 more
- Volunteers
- 150 people
- Sponsor
- Eli Lilly and Company
Non Bleeding Patients With Thrombocytopenia
Platelet Transfusion Thresholds in Non-Bleeding Patients
This is a study of platelet transfusion thresholds in patients with thrombocytopenia without bleeding and benifits of transfusion in those critically ill patients to prevent bleeding
- Trial name
- NCT07915284
- Testing
- Platlet transfusion
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Vaping, Vaping Cessation
Social Media Support Groups for Adolescent Vaping Cessation
The purpose of this study is to pilot test feasibility and acceptability of the Quit the Hit Toolkit, a social media-based nicotine vaping cessation program for adolescents and young adults, adapted for use in community settings.
- Conditions
- Vaping, Vaping Cessation, Nicotine Dependence
- Trial name
- NCT07540780
- Testing
- Social Media Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Aplastic Anemia, TPO Receptor Agonists
Standard Immunosuppressive Therapy Combined With Romiplostim N01 as First-line Treatment for Severe Aplastic Anemia
This prospective, single center, single-arm study aims to evaluate the efficacy and safety of anti-human T lymphocyte porcine immunoglobulin (p-ALG) in combination with cyclosporine and Romiplostim in treating severe aplastic…
- Trial name
- NCT06613880
- Testing
- standard IST combined with Romiplostim N01
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Effects of Animation Based Video Education and Brochure Based Education Before the Echocardiography Procedure
Animation-Based Video and Brochure-Based Education
This study was designed as a three-arm, parallel-group, randomized controlled trial to evaluate the effects of animation-based training versus brochure-based training before echocardiography on children's anxiety, fear, and…
- Trial name
- PREP-ECHO (NCT07737041)
- Testing
- Animated based video education, Brochure based education
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Merve Koyun
Hematopoietic and Lymphoid Cell Neoplasm, Immune System Disorder
Collection of Research Data and Samples From Patients Treated With Immunotherapy to Study Its Side Effects
This study collects research data and samples from patients who experience immunotherapy side effects to store for use in future research studies.
- Conditions
- Hematopoietic and Lymphoid Cell Neoplasm, Immune System Disorder, Malignant Solid Neoplasm
- Trial name
- NCT04242095
- Testing
- Biospecimen Collection, Medical Chart Review
- Where
- 630 sites in United States
- Volunteers
- 2,240 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Haemophilia A, Haemophilia B
Safety of Intraosseous Anaesthesia in Children With Haemophilia
Effective local anaesthesia is essential for safe and comfortable dental treatment in children with haemophilia. However, conventional nerve block techniques, particularly inferior alveolar nerve block, carry an increased risk of…
- Conditions
- Haemophilia A, Haemophilia B, Dental Caries
- Trial name
- NCT07916467
- Testing
- Intraosseous Anaesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ankara Yildirim Beyazıt University
Neuroblastoma, Diffuse Intrinsic Pontine Glioma
PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy
A Phase I open-label, multicenter study, to evaluate the safety, feasibility, and maximum tolerated dose (MTD) of treating children with newly diagnosed DIPG or recurrent neuroblastoma with molecular targeted therapy in…
- Trial name
- PEACH (NCT04837547)
- Testing
- Tumor-specific ex vivo expanded autologous lymphocyte transfer (TTRNA-xALT)
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Childhood Obesity
National Childhood Obesity Prevention Programme BE FIT 24
The project is a national, prospective, multicenter, interventional pilot project of early detection of childhood overweight and the prevention of obesity in the Czech Republic.
- Trial name
- BE FIT 24 (NCT07057453)
- Testing
- Motivation Engagement for Movement and Interactive Nutrition Development
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic
First Episode Psychosis (FEP)
California Collaborative Network to Promote Data Driven Care and Improve Outcomes in Early Psychosis
The proposed project seeks to create a California early psychosis network using a core assessment battery of valid, low burden measures and mHealth technology platform to collect client-level data, visualize data via clinician…
- Trial name
- EPI-CAL (NCT04007510)
- Testing
- EPI-CAL data network, Community DUP Assessment Tool
- Where
- United States
- Volunteers
- 736 people
- Sponsor
- University of California, Davis
Cranioplasty, Postoperative Complications
Risk Factors for Complications After Cranioplasty
Cranial defects often result from brain injuries, hemorrhages, strokes, or brain tumors. These conditions can increase pressure inside the skull, and if left untreated, may lead to dangerous complications like brain herniation.
- Conditions
- Cranioplasty, Postoperative Complications, Risk Assessment
- Trial name
- NCT06740773
- Where
- 3 sites in China
- Volunteers
- 1,368 people
- Sponsor
- Qilu Hospital of Shandong University
Depressive Symptoms
School Adolescent Mood Project: Efficacy of IPT-AST in Schools
This school-based randomized controlled trial will: a) examine the effects of telehealth-administered Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), an evidence-based depression prevention program, as compared…
- Trial name
- SAM (NCT04109716)
- Testing
- Interpersonal Psychotherapy - Adolescent Skills Training, Services as usual
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- Children's Hospital of Philadelphia
Trauma Centers/Statistics & Numerical Data, Trauma Blunt
Medical,Nursing Record,PE, Blood Test and Radiological Examination ,Morality and Mobility of Multiple Trauma Patient
This study aims to analyze statistical data on physiological examination values, blood test results, and radiological findings in patients admitted to the emergency department for severe trauma.
- Conditions
- Trauma Centers/Statistics & Numerical Data, Trauma Blunt, Trauma (Including Fractures), Trauma Abdomen
- Trial name
- trauma (NCT07903727)
- Testing
- Collect results of trauma patients
- Volunteers
- 700 people
- Sponsor
- St. Martin De Porress Hospital
Congenital Malformations
Contribution of Optical Genome Mapping (OGM) in the Diagnosis of Multiple Congenital Malformations With or Without Intellectual Disability Without Genetic Abnormality
Congenital malformations result from an embryonic or foetal developmental disorder (DD) affecting one or more systems (cardiac, skeletal, nervous, etc.). These are referred to as multiple congenital anomalies (MCAs).
- Trial name
- CARTOGEN-N (NCT07370792)
- Testing
- blood sample
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Céline PEBREL-RICHARD
Suicidal Ideas, Suicidal Ideation
A Pre-post Study of a Lethal Means Safety Planning Intervention for Youth at Elevated Suicide Risk in the Emergency Department.
The purpose of this study is to test whether a lethal means safety planning intervention, TEEN LENS ED, is acceptable to teens at elevated suicide risk and their caregivers in the Emergency Department.
- Conditions
- Suicidal Ideas, Suicidal Ideation, Suicidal Thoughts, Firearm Safety
- Trial name
- TEEN LENS ED (NCT07916792)
- Testing
- TEEN LENS, Usual Care
- Volunteers
- 200 people
- Sponsor
- University of Colorado, Denver
Conductive Hearing Loss, Mixed Hearing Loss
Post-Market Registry Study for Vibrant Hearing Solutions
This observational registry collects retrospective and prospective, data from children and adults who use CE-marked MED-EL implantable (PMEI, BCI, or AMEI) or non-implantable (BCD) hearing solutions as part of routine care.
- Conditions
- Conductive Hearing Loss, Mixed Hearing Loss, Sensorineural Hearing Loss, Single Sided Deafness
- Trial name
- NCT07906314
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
PARKINSON DISEASE (Disorder)
Early COMT Inhibition in PD
This prospective, randomized, assessor-blinded, parallel-group clinical trial aims to compare the effectiveness of early add-on opicapone versus levodopa dose escalation in patients with Parkinson's disease experiencing emerging…
- Trial name
- OPITECH (NCT07917546)
- Testing
- Opicapone 50 mg, L-DOPA/DDCI
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Neuromed IRCCS
LAMA2-MD (Merosin Deficient Congenital Muscular Dystrophy, MDC1A)
Preclinical Assessment of an Engineered HMGB1 Protein as a Novel Companion Therapy for Muscular Dystrophies
This is a monocentric, no-profit, retrospective and prospective observational cohort study conducted at IRCCS Ospedale San Raffaele. The study does not entail any additional procedures or interventions for participants.
- Trial name
- HEAL-MD (NCT07745218)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS San Raffaele
Neuroblastoma
GD2 Specific CAR and Interleukin-15 Expressing Autologous NKT Cells to Treat Children With Neuroblastoma
This research study combines two different ways of fighting cancer: antibodies and Natural Killer T cells (NKT). Antibodies are types of proteins that protect the body from infectious diseases and possibly cancer.
- Trial name
- GINAKIT2 (NCT03294954)
- Testing
- GINAKIT Cells, GINAKIT cells + Etanercept
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Baylor College of Medicine
Retinoschisis, Retinal Disease
Safety and Efficacy Study of IVB102 Injection in Subjects With X-linked Retinoschisis
The goal of this clinical trial is to evaluate the safety and efficacy of IVB102 injection in subjects with XLRS.
- Conditions
- Retinoschisis, Retinal Disease, Retinal Degeneration, Eye Diseases
- Trial name
- NCT06289452
- Testing
- IVB102 Injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- InnoVec Biotherapeutics Inc.
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