Clinical trials: sponsored by Merck Sharp & Dohme LLC
HIV Infections
Raltegravir Treatment in Patients Failing Highly Active Antiretroviral Therapy (HAART) in Denmark
Raltegravir is the first integrase inhibitor approved for treatment of HIV infected patients harboring multiresistant viruses. The drug has been proved effective in both trials and clinical settings, but the long-term efficacy is…
- Trial name
- NCT01061957
- Where
- Denmark
- Volunteers
- 96 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Asthma
Comparison of Combination Therapy: Montelukast and Inhaled Steroid on Exercise Induced Bronchoconstriction
The purpose of this study is to compare the effects of 2 weeks therapy of montelukast, budesonide, their combination on exercise induced bronchoconstriction (EIB) and airway inflammation in children and young adults, not on…
- Trial name
- NCT00462592
- Testing
- budesonide, montelukast
- Where
- 2 sites in Canada
- Volunteers
- 18 people
- Sponsor
- Hamilton Health Sciences Corporation
HIV Infection, HIV Infections
Preparing for Adolescent HIV Vaccine Trials in South Africa:
This study will use the licensed HPV vaccine, Gardasil, as a surrogate for an HIV vaccine, in order to explore some of the ethico-legal,psycho-social and logistical challenges involved in running an HIV vaccine trial in…
- Trial name
- CATSA (NCT00944879)
- Where
- South Africa
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Desmond Tutu HIV Centre
Asthma
Analysis of Exhaled Breath by Biosensors in Adults With Asthma
The aim of this study is to investigate the pattern of organic volatile compounds (VOCs) in the exhaled breath detected by biosensors in adults with persistent mild asthma.
- Trial name
- NCT00819676
- Testing
- analysis of exhaled breath by biosensors, measurement of exhaled nitric oxide
- Where
- Italy
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Lung Disease, Obstructive, Signs and Symptoms, Respiratory
The Effect of Montelukast Treatment in Wheezy Infants
The study is designed to evaluate the efficacy of montelukast on symptom-free days in unselected group of very young children with wheeze and recurrent asthma like symptoms.
- Trial name
- Montelukast (NCT00934713)
- Testing
- montelukast
- Where
- Finland
- Volunteers
- 112 people
- Sponsor
- University of Helsinki
Myocardial Ischemia
Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation
PCI (optimal catheter-based coronary revascularization) + intensive medical therapy is superior to intensive medical therapy alone using the combined endpoint of all-cause mortality or nonfatal MI.
- Trial name
- NCT00007657
- Testing
- Intensive medical therapy, Percutaneous Coronary Intervention (PCI) plus intensive medical therapy
- Where
- 48 sites in United States, Canada
- Volunteers
- 3,260 people
- Sponsor
- US Department of Veterans Affairs
Gastroenteritis, Rotavirus Vaccines
Cost-Effectiveness Analysis of Rotavirus Vaccination for Children in Korea
The primary objective of the proposed project is to estimate the economic impact of a national rotavirus immunization program in preventing rotavirus diarrhea among Korean children.
- Conditions
- Gastroenteritis, Rotavirus Vaccines, Cost-Effectiveness
- Trial name
- NCT00669929
- Where
- 3 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Type 1 Diabetes
Renin Angiotensin System Study (RASS/B-RASS)
To determine if renin angiotensin medications can prevent or delay the onset of diabetic kidney disease.
- Trial name
- NCT00143949
- Testing
- enalapril, losartan
- Where
- 3 sites in Canada
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Michael Mauer, MD
Asthma
Effects of Montelukast in Children With Asthma
Leukotriene receptor antagonists (LTRAs) reduce fractional exhaled nitric oxide (FENO) concentrations in children with asthma, but the effect of LTRA withdrawal on FENO and lung function is unknown.
- Trial name
- NCT00675285
- Testing
- montelukast sodium
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Catholic University of the Sacred Heart
Invasive Fungal Infection, Aspergillosis
Evaluate Three Methods for Diagnosis of Invasive Fungal Infection in Chinese Patients After HSCT
The purpose of this study is to assess the cut-off value of GM/G test in Chinese patients after hematopoietic stem cell transplantation, and evaluate GM/G test and real-time PCR for diagnosis of IFI in Chinese patients.
- Conditions
- Invasive Fungal Infection, Aspergillosis, Fungemia, Hematopoietic Stem Cell Transplantation
- Trial name
- NCT00460330
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University
Enterobacteriaceae Infections, Bacteremia
Infections Caused by ESbL-Producing Enterobacteriaceae in Italy
To assess the molecular epidemiology, clinical impact, treatment outcome and risk factors for infections caused by Enterobacteriaceae producing ESBLs in Italy in a large multicenter observational survey. SPECIFIC OBJECTIVES 1.
- Conditions
- Enterobacteriaceae Infections, Bacteremia, Pneumonia, Skin Diseases
- Trial name
- NCT00404625
- Testing
- Risk factors for infections due to ESBL+ Enterobacteriaceae, Risk factors for inadequate initial antimicrobial therapy, Overall and 30-day mortality in bad first antibiotic therapy
- Where
- 6 sites in Italy
- Volunteers
- 813 people
- Sponsor
- University of Siena
Otitis Media, Pneumococcal Infections
Efficacy Trial of Two Pneumococcal Conjugate Vaccines (PncCRM and PncOMPC) for Prevention of Acute Otitis Media Due to Vaccine Serotypes
This was a randomized, double-blinded multicenter cohort study of Finnish children aged 2 to 24 months. The study was designed to evaluate the efficacy of two 7-valent pneumococcal conjugate vaccines (PncCRM and PncOMPC)…
- Trial name
- NCT00378417
- Testing
- 7-valent pneumococcal-CRM197 conjugate vaccine, 7-valent pneumococcal-OMPC conjugate vaccine
- Where
- 5 sites in Finland
- Volunteers
- 3,075 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
HIV Infections
A Multicenter, Open-Label, Randomized, 24-Week Study to Compare the Safety and Activity of Indinavir Sulfate, 800 Mg q 8 h Versus 1,200 Mg q 12 h in Combination With Zidovudine and 3TC
To demonstrate that the antiviral activity and safety/tolerability of a test regimen of indinavir is equivalent to that of a control regimen of indinavir when each is coadministered with zidovudine (ZDV) (or stavudine, d4T) and…
- Trial name
- NCT00002208
- Testing
- Indinavir sulfate, Lamivudine, Stavudine
- Where
- 15 sites in United States
- Volunteers
- 400 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
Indinavir Plus Efavirenz Plus Adefovir Dipivoxil in HIV-Infected Patients Who Have Not Had Success With Nelfinavir
The purpose of this study is to compare the effectiveness of giving indinavir plus efavirenz plus adefovir dipivoxil to patients who have failed treatment with nelfinavir and patients who have never taken a protease inhibitor…
- Trial name
- NCT00002220
- Testing
- Indinavir sulfate, Efavirenz, Levocarnitine
- Where
- 11 sites in United States
- Volunteers
- 120 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
A Study on the Safety and Effectiveness of Twice-Daily Nelfinavir Plus Twice-Daily Indinavir Plus Efavirenz in HIV-Positive Patients Who Have Never Taken Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) or Protease Inhibitors
Indinavir is usually taken three times a day. The purpose of this study is to see if it is safe and effective to take indinavir only twice a day plus nelfinavir (also taken twice a day) and efavirenz (taken once a day).
- Trial name
- NCT00002235
- Testing
- Indinavir sulfate, Nelfinavir mesylate, Efavirenz
- Where
- 5 sites in United States
- Volunteers
- 6 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
Safety and Effectiveness of an Anti-HIV Drug Combination Taken Twice Daily
The purpose of this study is to see whether taking indinavir (IDV) plus ritonavir (RTV) plus stavudine (d4T) plus lamivudine (3TC) 2 times each day is safe and can lower the level of HIV in the blood.
- Trial name
- NCT00002241
- Testing
- Indinavir sulfate, Ritonavir, Lamivudine
- Where
- 18 sites in United States
- Volunteers
- 80 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
A Study of L-735,524 in HIV-Positive Children and Adolescents
To evaluate the safety, tolerability, and plasma concentration profiles of indinavir sulfate ( MK-639; Crixivan ) in HIV-seropositive older children and adolescents.
- Trial name
- NCT00002351
- Testing
- Indinavir sulfate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections, Hemophilia A
Effect of Indinavir Plus Two Other Anti-HIV Drugs on Blood Clotting in HIV-Positive Males With Hemophilia
The purpose of this study is to see if indinavir plus two other anti-HIV drugs affect blood clotting in HIV-positive patients with hemophilia.
- Trial name
- NCT00002386
- Testing
- Indinavir sulfate, Lamivudine, Stavudine
- Where
- 8 sites in United States, Canada
- Volunteers
- 55 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
A Comparison of Two Dose Levels of Indinavir Combined With Two Nucleoside Analogue Reverse Transcriptase Inhibitors (NRTIs) in HIV-Infected Patients
The purpose of this study is to determine if two dose levels of indinavir combined with two nucleoside analogue reverse transcriptase inhibitors (NRTIs) have the same effect on plasma viral load (level of HIV in the blood).
- Trial name
- NCT00002406
- Testing
- Indinavir sulfate
- Where
- 29 sites in United States
- Volunteers
- 350 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations
The purpose of this study is to compare two different anti-HIV drug combinations, one that contains nelfinavir (NFV) and one that does not. The best dosing schedule for indinavir (IDV) also will be studied.
- Trial name
- NCT00002430
- Testing
- Indinavir sulfate, Nelfinavir mesylate, Lamivudine
- Where
- 46 sites in United States
- Volunteers
- 220 people
- Sponsor
- Merck Sharp & Dohme LLC