Clinical trials: Phase 4
Meningococcal Disease; Meningococcal Meningitis
Single-center, Open-label Study: Immunogenicity and Safety Observation After Vaccination With ACYW135 Meningococcal Polysaccharide Vaccine in Junior High School Students Aged 13-15 Years
The sample size of this study is 200 participants, aiming to evaluate the protective effect after vaccination with quadrivalent meningococcal polysaccharide vaccine in the 13-15 age group, and to provide scientific evidence and…
- Trial name
- NCT07885371
- Testing
- MPSV-ACYW
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhejiang Provincial Center for Disease Control and Prevention
Malaria Infection
Humanitarian Evaluation of Spatial Emanators for Malaria Control
The overall aim of this study is to evaluate the feasibility, implementation, public health effectiveness, durability, acceptability and cost of delivering long-lasting spatial emanators at scale through United Nations High…
- Trial name
- NCT07886281
- Testing
- Guardian™ long-lasting spatial emanators
- Where
- South Sudan
- Volunteers
- 32,584 people, healthy volunteers welcome
- Sponsor
- The Mentor Initiative
Multiple Myeloma in Relapse
Self-administered Subcutaneous Daratumumab in Patients With Multiple Myeloma
The main goal in this open label, phase four, prospective, non-randomized, sponsor-initiated multicenter feasibility study is to evaluate the feasibility and safety of self-administration of subcutaneously (SC) daratumumab in the…
- Trial name
- SCILLA (NCT07191379)
- Testing
- The study intervention is self-administration of SC daratumumab by the patient, thereby changing the administration from an outpatient setting to a home setting.
- Volunteers
- 50 people
- Sponsor
- Odense University Hospital
Acute Otitis Media (AOM)
Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Otitis Media)
This study is being conducted at multiple hospitals and clinics to better understand whether antibiotics truly help children feel better when they have an ear infection (acute otitis media).
- Trial name
- MEASURE (NCT07730814)
- Testing
- Amoxicillin, Amoxicillin-Clavulanate
- Where
- 5 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- Nader Shaikh
Crohn Disease
Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease
Crohn's disease (CD) is a condition that causes inflammation (swelling, redness) of the lining and wall of the small intestine, large intestine, or both.
- Trial name
- CAMEO (NCT05781152)
- Testing
- Anti-TNF therapy
- Where
- 26 sites in United States, Canada
- Volunteers
- 1,270 people
- Sponsor
- Connecticut Children's Medical Center
Leukemia-Lymphoma
Pain Control in Pediatric Oncology: Utility of EMLA Cream vs Lidocaine Injection in Lumbar Punctures
A common procedure in children with cancer is the spinal tap, or lumbar puncture (LP), in which a needle is inserted into the spinal canal.
- Trial name
- NCT04003012
- Testing
- EMLA, Lidocaine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- CAMC Health System
Obesity, Childhood
GLP-1 Plus Lifestyle for Overall Wellness: Find Your Way Forward
The rapid emergence of new and highly effective obesity medications has turned the field of pediatric weight management on its head.
- Trial name
- GLOW (NCT06977438)
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 1,020 people
- Sponsor
- University of Minnesota
ACUTE SINUSITIS, Sinusitis
Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Sinusitis)
This study is being conducted at multiple hospitals and clinics to better understand whether antibiotics truly help children feel better when they have a sinus infection (acute sinusitis).
- Trial name
- MEASURE (NCT07732699)
- Testing
- Amoxicillin, Amoxi Clavulanate
- Where
- 5 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- Nader Shaikh
Surgery, Pain, Post Operative
Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial
This trial is being completed to compare two commonly used options to treat pain after discharge from surgery. Participants that undergo tonsil removal, gallbladder removal, and knee scope will be eligible to enroll.
- Trial name
- CARES for Kids (NCT06671002)
- Testing
- NSAID, Opioid, Acetaminophen
- Where
- 9 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Scoliosis Idiopathic Adolescent
The Effect of Dexamethasone Administration Route and Local Anesthetic Concentration on Pain, Inflammatory Response, and Neuromonitoring in Children Undergoing Scoliosis Correction
Scoliosis correction surgery in children is a complex procedure with significant risks, including postoperative pain, inflammatory response, and potential neurological complications.
- Trial name
- NCT06789029
- Testing
- perineural Dexamethasone, intravenous Dexamethasone
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Atopic Dermatitis
Dupilumab De-escalation in Pediatric Atopic Dermatitis
This is a pilot investigator-blinded, randomized clinical trial to assess the feasibility of dupilumab treatment discontinuation or dose-reduction in children aged 1-17 years who have achieved sustained atopic dermatitis (AD)…
- Trial name
- NCT06116526
- Testing
- Dupilumab - Discontinuation, Dupilumab - Dose Reduction, Dupilumab - Standard Dose
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Primary Myelofibrosis, Polycythemia Vera
CINC424A2X01B Rollover Protocol
This is a long term safety study for patients that have been treated with either ruxolitinib or a combination of ruxolitinib with panobinostat, on a Novartis or Incyte sponsored study, who have been judged by the study…
- Conditions
- Primary Myelofibrosis, Polycythemia Vera, Graft Versus Host Disease, Acute Myeloid Leukemia
- Trial name
- NCT02386800
- Testing
- ruxolitinib, panobinostat
- Where
- 97 sites in Australia, Belgium and 23 more
- Volunteers
- 279 people
- Sponsor
- Novartis Pharmaceuticals
Bloodstream Infection, Bacteremia Sepsis
Oral Switch in Pediatric Bloodstream Infections
This nationwide, multicenter, randomized, non-inferiority trial of children and adolescents with uncomplicated bloodstream infections aims to investigate if early-oral antibiotic switch (experimental arm) is non-inferior to…
- Trial name
- Oral_Switch (NCT07791914)
- Testing
- Oral antibiotic therapy, Standard IV antibiotic therapy
- Where
- 18 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- Ulrikka Nygaard
Acne Vulgaris
Clascoterone Versus Clindamycin Added to Adapalene/Benzoyl Peroxide for Moderate Facial Acne
This randomised trial compares two treatments added to the same standard acne gel in people with moderate facial acne. All participants will use adapalene 0.1%/benzoyl peroxide 2.5% gel at night.
- Trial name
- CLASCO-ACNE (NCT07881315)
- Testing
- Clascoterone 1% cream, Clindamycin 1% lotion, Adapalene 0.1%/benzoyl peroxide 2.5% gel
- Where
- Pakistan
- Volunteers
- 118 people
- Sponsor
- Allied Hospital Faisalabad
Juvenile Idiopathic Arthritis
Optimizing Treatment for Patients With Juvenile Idiopathic Arthritis in Sustained Remission: The MOVE-JIA Trial
The goal of this clinical trial is to compare three different maintenance and step-down treatment strategies in children and adolescents with juvenile idiopathic arthritis in sustained remission.
- Trial name
- MOVE-JIA (NCT06653634)
- Testing
- Methotrexate, TNF Inhibitor
- Where
- 7 sites in Norway
- Volunteers
- 150 people
- Sponsor
- Oslo University Hospital
HIV-1-infection
A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments
The goal of this clinical study is to provide continued access to the study drug(s) to children and adolescents with human immunodeficiency virus type 1 (HIV-1) who completed their participation in an applicable parent study and…
- Trial name
- NCT06337032
- Testing
- F/TAF (High Dose Tablet), F/TAF (Low Dose Tablet), F/TAF (Lowest Dose Tablet)
- Where
- 15 sites in Argentina, Panama and 4 more
- Volunteers
- 350 people
- Sponsor
- Gilead Sciences
Gonorrhea, Chlamydia
Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections
The goal of this open-label, randomized trial is to assess the efficacy of doxycycline prophylaxis in reducing incidences of bacterial sexually transmitted infections (STIs) among adolescent and young adult females while also…
- Conditions
- Gonorrhea, Chlamydia, Syphilis, Sexually Transmitted Infections (STIs)
- Trial name
- NCT06738407
- Testing
- Doxycycline hyclate delayed released 200 mg, Doxycycline hyclate delayed released 200 mg weekly, Per standard of care with quarterly STI testing/treatment and sexual health counseling
- Where
- 13 sites in United States
- Volunteers
- 760 people
- Sponsor
- Westat
Vital Pulp Therapies, Indirect Pulp Cap
Vital Pulp Treatment in Primary Teeth
In primary teeth, decay that is near the pulp (tooth nerve)is treated with either a pulpotomy or indirect pulp treatment if the tooth is not going to be extracted A pulpotomy involves removing the top 1/2 of the pulp, placing a…
- Conditions
- Vital Pulp Therapies, Indirect Pulp Cap, Pulpotomy
- Trial name
- NCT02298504
- Testing
- Mineral Trioxide Aggregate, Biodentin, Vitrebond
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Fibrinogen, Spine Deformity
Effect of Prophylactic Fibrinogen Concentrate In Scoliosis Surgery
EFISS is a prospective, randomized, placebo-controlled trial testing the feasibility, safety and efficacy of prophylactic administration of fibrinogen in paediatric spinal surgery.
- Conditions
- Fibrinogen, Spine Deformity, Coagulopathy, Consumption, Bleeding
- Trial name
- EFISS (NCT05391412)
- Testing
- Fibrinogen Concentrate Human
- Where
- Czechia
- Volunteers
- 32 people
- Sponsor
- Brno University Hospital
Acute Otitis Media, AOM - Acute Otitis Media
Amoxicillin-clavulanate Versus Amoxicillin Versus Placebo in Acute Otitis Media in Children
The goal of this trial is to compare amoxicillin to amoxicillin-clavulanate and to placebo in the treatment of acute middle ear infections in small children.
- Trial name
- SAVOtitis (NCT07878910)
- Testing
- Amoxicillin, Amoxicillin + Clavulanate
- Where
- 3 sites in Finland
- Volunteers
- 219 people
- Sponsor
- Kuopio University Hospital