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Transfusion-dependent Alpha-Thalassemia, Transfusion-dependent Beta-Thalassemia
A Study to Investigate the Efficacy, Pharmacokinetics, and Safety of Mitapivat in Pediatric Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT)
The primary objective of this study is to compare the effect of mitapivat versus placebo on transfusion burden in pediatric participants with α- or β-transfusion-dependent thalassemia.
- Trial name
- ENERGIZEKids-T (NCT07506863)
- Testing
- Mitapivat
- Where
- 4 sites in United States
- Volunteers
- 54 people
- Sponsor
- Agios Pharmaceuticals, Inc.
Chronic Granulomatous Disease
Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995
This study is a longitudinal and cross-sectional evaluation of patients with Chronic Granulomatous Disease (CGD) who received or are receiving hematopoietic cell transplantation (HCT) for their disease under a variety of…
- Trial name
- NCT02116764
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Attention-Deficit/ Hyperactivity Disorder (ADHD)
Pharmacogenomics of Stimulant Treatment Response
The "Pharmacogenomics of Stimulant Treatment Response" (PGx-STaR) study aims to identify genetic profiles related to methylphenidate treatment outcomes in children and adolescents aged 6-24 with Attention deficit/hyperactivity…
- Trial name
- PGx-STaR (NCT06221358)
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- University of Calgary
Parkinson Disease, Mild Cognitive Impairment
Non-invasive Brain Stimulation for the Treatment of Mild Cognitive Impairment in Parkinson's Disease
This cross-over pilot study aims to study the acceptability of two methods of non-invasive brain stimulation for the treatment of Parkinson's disease mild cognitive impairment (PD-MCI) - repetitive transcranial magnetic…
- Trial name
- NESCIO-PD (NCT06399731)
- Testing
- High-frequency (10Hz) rTMS, Anodal tDCS
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC
Endocrine Disease, Infertility
Hormonal Regulation of Puberty and Fertility
Background: The body produces gonadotropin-releasing hormone (GnRH) about every 2 hours. GnRH travels through the bloodstream to the pituitary gland, where it stimulates the gland to produce hormones called gonadotropins.
- Conditions
- Endocrine Disease, Infertility, Hypogonadism, Amenorrhea
- Trial name
- NCT01511588
- Where
- 2 sites in United States
- Volunteers
- 111 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Relapsing Multiple Sclerosis
Study to Assess Effects of Ublituximab in Pediatric Participants With Relapsing Forms of Multiple Sclerosis
The primary purpose of this study is to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) of ublituximab in participants ages 10 to less than (<)18 years and body weight greater than or equal to (≥)25 kilograms (kg) to…
- Trial name
- NCT07220252
- Testing
- Ublituximab, Fingolimod
- Where
- 6 sites in United States, Poland and 1 more
- Volunteers
- 240 people
- Sponsor
- TG Therapeutics, Inc.
Blood Disease
Alpha/Beta T-cell Depleted Blood-forming Stem Cell Transplant From Related or Unrelated Donors for Blood Diseases in Children and Young Adults
This study is being done to see if the investigators can take peripheral blood stem cells from either an adult family member or a closely matched unrelated donor, and run them through a special lab instrument to remove alpha/beta…
- Trial name
- NCT04806347
- Testing
- TCRαβ+/CD19+ depleted Hematopoietic stem cell (HSC) graft, CliniMACS® System
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Wisconsin, Madison
Glycogen Storage Disease Type IA, Glycogen Storage Disease Type I
Accuracy of Home Lactate Meter and Accu-chek Glucometer in Patients With Glycogen Storage Disease
The goal of this study is to determine if the Lactate Plus meter is accurate compared to lab lactate levels, and to determine if the Accu chek guide glucometer is accurate compared to lab serum glucose levels in patients with…
- Conditions
- Glycogen Storage Disease Type IA, Glycogen Storage Disease Type I, Glycogen Storage Disease Type IB, Glycogen Storage Disease Xi
- Trial name
- NCT07459582
- Testing
- Lactate Meter, Accu Chek
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Connecticut Children's Medical Center
Stress and Performance, Pilot Stress
The Investigators Want to See if There is a Correlation Between Stress and the Microbiome for Pilots and Astronauts and if There is a Way to Optimize This Balance for Pilots so That They Can Maximize Aerodynamic Decision Making on the Flight Deck.
The investigators are going to test the bacteria growing in your intestine to see if it influences your ability to manage stress while flying an airplane.
- Trial name
- NCT07829159
- Testing
- Flight simulator
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Child Development, Motor Skills
Classroom Exercise Snacks for Creativity, Motor Skills, and Academic Engagement in Elementary School Children
The purpose of this study is to evaluate whether brief, classroom-based exercise snacks (short bursts of physical activity performed during class time) can improve creativity, motor skills, and academic engagement in elementary…
- Conditions
- Child Development, Motor Skills, Executive Function
- Trial name
- ES-Kids (NCT07899242)
- Testing
- Classroom-Based Exercise Snacks
- Where
- Iran
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Abadan Branch
Congenital Heart Disease in Children
Evaluation of Preoperative Preparation in Children Undergoing Cardiac Surgery or Catheterization
Children undergoing cardiac surgery or cardiac catheterization often experience significant stress and anxiety during the preoperative period.
- Trial name
- GETREADY (NCT07414251)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Autism Spectrum Disorder, Social Stories
Effect of Social Stories on Anesthesia Compliance in Children With Autism
Children with Autism Spectrum Disorder (ASD) frequently experience heightened anxiety and reduced cooperation during the perioperative period, which can complicate anesthesia induction and negatively affect procedural safety and…
- Trial name
- NCT07356895
- Testing
- Social Stories Group, Routine Preoperative Preparation Group
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Occupational Accidents, Incubation Period, Infectious Disese
Admission and Management of Occupational or Other Exposures to Biodefense/Bioterrorism Agents or to Epidemic/Emerging Infectious Diseases
Background: Increased clinical attention has been paid to the evaluation and management of bioterrorism-related illness (such as anthrax infection) and emerging infectious diseases (such as Severe Acute Respiratory Syndrome…
- Trial name
- NCT01200953
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Guideline Implementation, Physiotherapy
Physiotherapy Practice in Flemish Nursing Homes
The goal of this observational study is to evaluate the extent to which physiotherapy sessions in Flemish nursing homes adhere to the IAGG-GARN guidelines and to explore factors influencing clinical practice among…
- Conditions
- Guideline Implementation, Physiotherapy, Nursing Homes, Focus Group
- Trial name
- NCT07576751
- Testing
- Mapping therapy sessions
- Where
- 4 sites in Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Pulmonary Arterial Hypertension
Investigational Trial to Evaluate Safety and Tolerability of Treprostinil in Children Diagnosed With PAH
The goal of this clinical trial is to evaluate safety and tolerability of preservative-free parenteral treprostinil in paediatric patients with PAH (PH Group 1) who are below 18 years of age.
- Trial name
- NCT06350032
- Testing
- preservative-free parenteral treprostinil
- Where
- 5 sites in Austria, France and 3 more
- Volunteers
- 20 people
- Sponsor
- AOP Orphan Pharmaceuticals AG
Congenital Disorders of Glycosylation
Clinical and Basic Investigations Into Known and Suspected Congenital Disorders of Glycosylation
Background: Proteins, fats, and other molecules are the body s building blocks. Many of these molecules must have sugars, or chains of sugars, attached to work properly.
- Trial name
- NCT02089789
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
AI-CBT Intervention Group, Waitlist Control Group
AI-Based CBT Chatbot for Adolescent Social Anxiety
The goal of this clinical trial is to learn if a CBT-based AI chatbot works to reduce social anxiety in teenagers. It will also look at how the chatbot works, including changes in thinking patterns, emotion management, and safety…
- Trial name
- NCT07897084
- Testing
- AI-CBT intervention group
- Volunteers
- 120 people
- Sponsor
- Central China Normal University
Mycobacterium Infections, Tuberculosis, Multidrug-Resistant
Training Protocol on the Natural History of Tuberculosis
Background: Tuberculosis (TB) is an infectious disease that affects numerous people worldwide. Researchers are interested in actively recruiting individuals with TB for research and treatment studies.
- Conditions
- Mycobacterium Infections, Tuberculosis, Multidrug-Resistant, Latent Tuberculosis, Tuberculosis
- Trial name
- NCT01212003
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Kidney Disease, Nephrotic Syndrome
Immune System Related Kidney Disease
Kidney diseases related to the immune system include, nephrotic syndrome, glomerulonephritis, membranous nephropathy, lupus nephritis, and nephritis associated with connective tissue disorders.
- Trial name
- NCT00001979
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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