Clinical trials: sponsored by Tata Memorial Centre
Oral Mucositis, Total Body Irradiation
Chlorophyllin for Reducing Oral Mucositis in Total Body Irradiation Prior to Transplant
The goal of this phase II, single-arm interventional clinical trial is to evaluate whether oral sodium copper chlorophyllin (CHL) can reduce the frequency and severity of oral mucositis in patients aged 12-65 years undergoing…
- Conditions
- Oral Mucositis, Total Body Irradiation, Hematological Malignancies, Hematopoietic Stem Cell Transplantation (HSCT)
- Trial name
- ChROMME-TBI (NCT07709195)
- Testing
- Sodium Copper Chlorophyllin
- Where
- India
- Volunteers
- 17 people
- Sponsor
- Tata Memorial Centre
Hematological Malignancy, GVHD - Graft-Versus-Host Disease
Study of Standardized Withaferin-A for the Treatment of Steroid Refractory Acute Graft Versus Host Disease.
Study Design Prospective, single center, single arm, Phase II study. Research aims and objectives Aim: To evaluate the efficacy and safety of standardized Withaferin A in steroid refractory acute GvHD in patients post allogeneic…
- Conditions
- Hematological Malignancy, GVHD - Graft-Versus-Host Disease, Steriod Refractory
- Trial name
- Withaferin_A (NCT07708987)
- Testing
- Standardized Withaferin A (SWA)
- Where
- India
- Volunteers
- 34 people
- Sponsor
- Tata Memorial Centre
CNS Tumor, Artificial Intelligence (AI)
Self-administered Remote Neurological Examination Using Mobile Application in Patients With Brain Tumors
The goal of this observational study is to evaluate the feasibility and accuracy of a self-administered remote neurological examination using the "Iskhaa" mobile application in patients with brain tumors aged above 5 years who…
- Conditions
- CNS Tumor, Artificial Intelligence (AI), Glioma, Digital Health
- Trial name
- NEMO (NCT07236840)
- Testing
- Neurological assessment
- Where
- India
- Volunteers
- 600 people
- Sponsor
- Tata Memorial Centre
Brain Tumor, Pediatric
Intensity Modulated PrOton Therapy in Pediatric BRain Tumors (IMPORT)
Children diagnosed with benign or low-grade brain tumors often require radiation therapy to control their disease. While radiation can be effective, traditional techniques using X-rays (photon-based radiotherapy) expose healthy…
- Trial name
- IMPORT (NCT07338526)
- Testing
- Intensity-modulated proton therapy (IMPT), Photon-based intensity-modulated radiation therapy (IMRT).
- Where
- India
- Volunteers
- 94 people
- Sponsor
- Tata Memorial Centre
Musculoskeletal Disease Other, GVHD, Chronic
Leflunomide for Musculoskeletal GVHD After Allogeneic Stem Cell Transplant
Graft versus host disease (GVHD) is a well-known complication of allogeneic transplant. In GVHD, the cells of the donor attack the patient's tissues and cause damage. It can affect any organ or system of the body.
- Trial name
- NCT04932564
- Testing
- Leflunomide tablet
- Where
- India
- Volunteers
- 1 people
- Sponsor
- Tata Memorial Centre
Brain Tumors, Medulloblastoma
Systemic Biomarkers to Predict Radiation-Induced Neurocognitive Decline
Radiation constitutes an integral component in the management of primary brain tumors in pediatric and young adults like medulloblastoma, ependymoma, low-grade glioma, pituitary tumors, etc.
- Conditions
- Brain Tumors, Medulloblastoma, Glioma, Ependymoma
- Trial name
- BIO-RIN (NCT06779487)
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Tata Memorial Centre
DIPG
A Study of Low Dose Bevacizumab With Conventional Radiotherapy Alone in Diffuse Intrinsic Pontine Glioma
In this study, the investigators are testing improvement in survival outcomes in DIPG patients when stratified with MR perfusion score and treated with the said protocol.
- Trial name
- LoBULarDIPG (NCT04250064)
- Testing
- Bevacizumab Injection, Ultra-low-dose RT
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Tata Memorial Centre
Brain Tumor, Oncology
Tracing Brain Tumors Through Deep Time
Brain tumors involve different age groups with a wide range of tumor types involving different anatomical compartments of the brain.
- Trial name
- TRACE (NCT06381531)
- Testing
- Imaging with CT and MRI
- Where
- India
- Volunteers
- 10,000 people
- Sponsor
- Tata Memorial Centre
Neurocognitive Dysfunction
Evaluation of Memantine in the Preservation of Memory and Neurocognition Following CSI
The goal of this clinical trial is to evaluate the role of memantine in preservation of memory and neurocognition in patients undergoing craniospinal irradiation.
- Trial name
- MEMENTO (NCT06275035)
- Testing
- Memantine Oral Tablet
- Where
- India
- Volunteers
- 101 people
- Sponsor
- Tata Memorial Centre
CNS Tumor
Artificial Intelligence in CNS Radiation Oncology
Radiotherapy involves the use of high-energy X-rays, which can be used to stop the growth of tumor cells. Radiotherapy constitutes an essential avenue in the treatment of brain tumors.
- Trial name
- AI-RAD (NCT06036394)
- Testing
- The images (CT, MRI, PET) used for RT planning, mid-treatment imaging as part of IGRT or disease evaluation, and response assessment/ surveillance post-RT
- Where
- India
- Volunteers
- 6,000 people
- Sponsor
- Tata Memorial Centre
Medulloblastoma, WNT-activated
Focal Radiotherapy Plus Low Dose Craniospinal Irradiation Followed by Adjuvant Chemotherapy in WNT Medulloblastoma.
This clinical study is going to be done on a type of brain tumor in children called Medulloblastoma. The WNT pathway type of medulloblastoma is considered to be low risk and have the best outcomes in terms of survival.
- Trial name
- FOR-WNT2 (NCT04474964)
- Testing
- Low dose Craniospinal Irradiation plus Focal Radiotherapy
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Tata Memorial Centre
Glioma
Spatial and Temporal Characterization of Gliomas Using Radiomic Analysis
Glioma are type of primary brain tumors arising within the substance of brain. Different type of gliomas are seen which are classified depending upon pathological examination and advanced molecular techniques, which help to…
- Trial name
- GLIO-RAD (NCT06036381)
- Testing
- Radiomic analysis of imaging - MRI, PET, CT
- Where
- India
- Volunteers
- 1,000 people
- Sponsor
- Tata Memorial Centre
Prostate Cancer
Randomized Trial of Prostate Only or Pelvic RT in High Risk Prostate Cancer
Evidence to justify the use of the pelvic field is lacking for men with high risk localized prostate cancer. An additional randomized study is needed in men with a potential risk of nodal involvement to test the hypothesis that…
- Trial name
- POP-RT (NCT02302105)
- Testing
- IGRT
- Where
- India
- Volunteers
- 224 people
- Sponsor
- Tata Memorial Centre
Glioma
Craniospinal Irradiation in Histone AlteRed Midline Glioma
Paediatric H3K27/H3G34 mutant diffuse midline gliomas are high grade gliomas that arise in midline structures/cerebral hemispheres and are known to have dismal outcomes.
- Trial name
- CHARM (NCT06720727)
- Testing
- craniospinal irradiation
- Where
- India
- Volunteers
- 32 people
- Sponsor
- Tata Memorial Centre
Cervical Cancer, Cervical Precancerous Lesions
Trial of Two Versus Three Doses of Human Papillomavirus (HPV) Vaccine in India
The primary study hypothesis wasthat a two-dose human papillomavirus (HPV) vaccine regimen would offer similar immunogenicity and protection as that of a three-dose regimen to girls against persistent HPV infection and cervical…
- Trial name
- NCT00923702
- Testing
- Prophylactic quadrivalent HPV vaccine Merck (Gardasil®)
- Where
- 8 sites in India
- Volunteers
- 22,729 people, healthy volunteers welcome
- Sponsor
- Partha Basu
Non-Invasive Bladder Urothelial Carcinoma
Intravesical BCG: is the Urinary Bladder Ready to Receive it
Prospective cohort and Prospective observational study which aims To define the healing time-frame of the resected area of the bladder after TURBT.
- Trial name
- NCT05335512
- Volunteers
- 100 people
- Sponsor
- Tata Memorial Centre
Cervical Cancer
An International Study on Magnetic Resonance Imaging (MRI)-Guided Brachytherapy in Locally Advanced Cervical Cancer
Background: The standard treatment of locally advanced cervical cancer is radio-chemotherapy including external beam radiotherapy (EBRT), brachytherapy (BT) and concomitant chemotherapy with weekly Cisplatin.
- Trial name
- EMBRACE (NCT00920920)
- Testing
- 3D MRI-guided Brachytherapy
- Where
- Austria
- Volunteers
- 1,416 people
- Sponsor
- Medical University of Vienna