Clinical trials: γδ T Cells
Sepsis, Antigen-presenting Function
Study on Antigen-presenting Function of Gamma Delta T Cells in Sepsis and Its Molecular Mechanisms
Study on antigen-presenting function of gamma delta T cells in sepsis and its molecular mechanisms
- Conditions
- Sepsis, Antigen-presenting Function, γδ T Cells
- Trial name
- NCT03379896
- Testing
- Collect peripheral blood sample
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Prostate Cancer Metastatic
A Phase 1/2 Trial of ADI-212 in mCRPC
This is a Phase 1/2 multicenter, open-label, dose finding and dose expansion study of ADI-212 in participants with metastatic castration-resistant prostate cancer (mCRPC)
- Trial name
- NCT07793435
- Testing
- ADI-212, Fludarabine, Cyclophosphamide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Adicet Therapeutics
Acute Myeloid Leukemia
Gamma Delta T-cell Infusion for AML at High Risk of Relapse After Allo HCT
The purposes of the study are to determine the maximum tolerated dose (MTD) and effectiveness of Artificial Antigen Presenting Cell (AAPC)-expanded donor T-cells administered as a single infusion after an allogeneic hematopoietic…
- Trial name
- NCT05015426
- Testing
- Gamma Delta T-Cell Infusion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Acute Myeloid Leukemia
Ex-vivo Expanded γδ T-lymphocytes (OmnImmune®) in Patients With Acute Myeloid Leukaemia (AML)
This study investigates the potential curative properties of gamma delta T-cells obtained from a blood-related donor of an AML patient.
- Trial name
- NCT03790072
- Testing
- OmnImmune®
- Where
- Czechia
- Volunteers
- 10 people
- Sponsor
- TC Biopharm
Malignant Solid Tumours
Allogeneic γδ T Cell Therapy for the Treatment of Solid Tumors
The study is to determine the safety, feasibility and efficacy of allogeneic γδ T cell therapy in patients with solid tumors.
- Trial name
- NCT04765462
- Testing
- Allogeneic γδ T cells
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Breast Cancer
Safety and Efficiency of γδ T Cell Against Breast Cancer(Her-, er-, and pr-)
In this study, effects of γδT cells on human breast cancer (her2-, er-,pr-) in combination with tumor reducing surgery, for example cryosurgery going to be investigated.
- Trial name
- NCT02418481
- Testing
- DC-CIK, γδ T Cell, Combination
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Neuroblastoma
Pilot Study of Zoledronic Acid and Interleukin-2 for Refractory Pediatric Neuroblastoma
Neuroblastoma (NB) is the most common extracranial solid tumor in children, with an annual incidence of 10.5 per million children less than 15 years of age. NB accounts for 15% of childhood cancer deaths.
- Trial name
- NCT01404702
- Testing
- Zoledronic Acid, Aldesleukin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Malignant Meningioma
γδ T-PD-1 Ab Cells in the Treatment of Malignant Meningioma
This study intends to combine the advantages of γδ T cells and PD-1 monoclonal antibody to conduct an exploratory clinical study on the safety and efficacy of PD-1 antibody armored γδ T cells (γδ T-PD-1 Ab cells) in the treatment…
- Trial name
- NCT07172178
- Testing
- γδ T-PD-1 Ab cells
- Volunteers
- 12 people
- Sponsor
- Nanjing Medical University
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Safety and Efficiency of γδ T Cell Against Hematological Malignancies After Allo-HSCT
This study investigates the infusion safety and potential curative properties of ex-vivo expanded γδ T cells obtained from the same donor for patients who have hematological malignancies and have accepted allogeneic hematopoietic…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, Lymphoma
- Trial name
- NCT04764513
- Testing
- Ex-vivo expanded γδ T cell infusion
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese PLA General Hospital
Acute Myeloid Leukemia
Ex-vivo Expanded γδ T Lymphocytes in Patients With Refractory/Relapsed Acute Myeloid Leukaemia
This study investigates the potential curative properties of ex-vivo expanded gamma delta T-cells obtained from a blood-related donor for patients with relapsed or refractory acute myeloid leukemia.
- Trial name
- NCT04008381
- Testing
- Ex-vivo Expanded γδ T Lymphocytes
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Membranous Nephropathy, Lupus Nephritis (LN)
Efficacy and Safety of CD19 CAR-γδ T Cells in the Treatment of Relapsed/Refractory Autoimmune Nephropathy
This study is a single-arm, single-center, open-label, dose-escalation exploratory clinical study designed to evaluate the safety, tolerability, and preliminary efficacy of CD19 CAR-γδ T cells.
- Conditions
- Membranous Nephropathy, Lupus Nephritis (LN), IgA Nephropathy (IgAN)
- Trial name
- NCT07535138
- Testing
- CD19 CAR-γδ T cell
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Air Force Military Medical University, China
Pancreatic Cancer
Safety and Efficiency of IRE Plus γδ T Cell Against Locally Advanced Pancreatic Cancer
In this study, effects of γδT cells on human Pancreatic Cancer in combination with tumor reducing surgery, for example IRE going to be investigated.
- Trial name
- NCT03180437
- Testing
- IRE surgery, IRE plus γδ T cells
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Advanced Solid Tumor
γδ T-PD-1 Ab Cells in the Treatment of Advanced Solid Tumors
This study intends to combine the advantages of γδ T cells and PD-1 monoclonal antibody to conduct an exploratory clinical study on the safety and efficacy of PD-1 antibody armored γδ T cells (γδ T-PD-1 Ab cells) in the treatment…
- Trial name
- NCT06404281
- Testing
- γδ T-PD-1 Ab cells
- Where
- China
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Changzhou No.2 People's Hospital
Liver Cancer
Safety and Efficiency of γδ T Cell Against Hepatocellular Liver Cancer
In this study, effects of γδT cells on human hepatocellular liver cancer in combination with tumor reducing surgery, for example cryosurgery going to be investigated.
- Trial name
- NCT02425735
- Testing
- DC-CIK cells, γδ T cells, γδ T/DC-CIK cells
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Lung Cancer
Safety and Efficiency of γδ T Cell Against Non Small Lung Cancer ( Without EGFR Mutation)
In this study, effects of γδT cells on human non small lung cancer ( without EGFR mutation) in combination with tumor reducing surgery, for example cryosurgery going to be investigated.
- Trial name
- NCT02425748
- Testing
- DC-CIK, γδ T Cell, γδ T/DC-CIK cells
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fuda Cancer Hospital, Guangzhou