Clinical trials: 2019-nCoV Disease
Acute Hypoxemic Respiratory Failure, COVID-19
Dexamethasone and Oxygen Support Strategies in ICU Patients With Covid-19 Pneumonia
The main manifestation of COVID-19 is acute hypoxemic respiratory failure (AHRF). In patients with AHRF, the need for invasive mechanical ventilation is associated with high mortality. Two hypotheses will be tested in this study.
- Trial name
- COVIDICUS (NCT04344730)
- Testing
- Dexamethasone injection, conventional oxygen, CPAP
- Where
- France
- Volunteers
- 550 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
the Use of Modern Technology Applications in Home Isolation
The Validity of Modern Mobile Applications in Management of COVID-19 Home Isolation Patients: a Survey for Health Care Professionals
In late 2019, a novel coronavirus, SARS-CoV-2, was identified as the causative agent of a cluster of pneumonia cases (COVID-19) in Wuhan, China. Clinical symptoms of COVID-19 may be mild or severe.
- Trial name
- NCT04548492
- Testing
- Survey
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anosmia
Clinical Assessment of Insulin Fast Dissolving Film in Treatment of Post Infection Anosmia
The study aimed to investigate the efficacy of insulin in a new dosage form ( fast dissolving film) in treatment of anosmia in patients post infested with Covid-19. The study implication based in two methods evaluations 1.
- Trial name
- NCT04657809
- Testing
- Insulin film, Fast dissolving film
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Soad Ali
Severe Acute Respiratory Syndrome Coronavirus 2, Coronavirus Infection
Fluvoxamine for Adults With Mild to Moderate COVID-19
This clinical trial aims to determine if fluvoxamine, a selective serotonin reuptake inhibitor with high affinity for the sigma-1 receptor, can be used in mild to moderate COVID-19 to prevent the progression to severe COVID-19.
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2, Coronavirus Infection, Mild to Moderate COVID-19
- Trial name
- NCT04711863
- Testing
- Fluvoxamine
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Asan Medical Center
Posttraumatic Stress Disorder, Prolonged Grief Disorder
Tele-based Psychological Emotional Support for Informal CARegivers of COVID-19 Patients in Intensive Care
The experience of a loved one's stay in a COVID-19 intensive care unit (ICU), either intubated or on respiratory support, forces family caregivers (hereafter 'caregivers') to face core existential fears, such as uncertainty and…
- Conditions
- Posttraumatic Stress Disorder, Prolonged Grief Disorder, COVID
- Trial name
- CO-CarES (NCT04409821)
- Testing
- Tele-delivered psychological intervention
- Where
- 6 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Eating Behavior, COVID-19
Dietary and Lifestyle Habits During the Pandemic of COVID-19 in Greece
The aim of this study was to examine potential changes in children' and adolescents' dietary and lifestyle (physical activity, sedentary behaviour and sleep) habits during the quarantine that was implemented in Greece due to…
- Trial name
- COV-EAT (NCT04437121)
- Testing
- Online Survey about Dietary and Lifestyle Habits
- Where
- Greece
- Volunteers
- 397 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
COVID-19, Musculoskeletal Pain
Noninvasive Neuromodulation in the Management of Post-COVID Musculoskeletal Pain
Brief Summary: The post-Covid syndrome is a problem that affects a significant number of people in the world. Among the most common symptoms is pain, and although there is no specific data on neuropathic pain and Covid, due to…
- Trial name
- NCT06723821
- Testing
- Neuromodulation group
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Alcala
Corona Virus Infection, COVID-19
Inhaled NO for the Treatment of COVID-19 Caused by SARS-CoV-2 (US Trial)
The purpose of this open label, randomized, study is to obtain information on the safety and efficacy of 80 ppm Nitric Oxide given in addition to the standard of care of patients with COVID-19 caused by SARS-CoV-2.
- Conditions
- Corona Virus Infection, COVID-19, SARS-CoV 2, Nitric Oxide
- Trial name
- NCT04397692
- Testing
- Nitric Oxide delivered via LungFit™ system
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Beyond Air Inc.
Covid19
Anti-COVID19 AKS-452 Fusion Protein Vaccine - ACT Study
Combinatorial phase I/II safety, tolerability and immunogenicity single center open-label clinical study of AKS-452 COVID-19 vaccination study
- Trial name
- ACT (NCT04681092)
- Testing
- AKS-452
- Where
- Netherlands
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Coronavirus Infection, Pneumonia, Viral
HFNC Treatment in COVID-19 Pneumonia
coronavirus disease 2019 related pneumonia is causing acute respiratory failure and this is the most common reason for ICU admission. We have several different way for respiratory support.
- Conditions
- Coronavirus Infection, Pneumonia, Viral, Acute Respiratory Failure
- Trial name
- NCT04424836
- Testing
- high flow nasal cannula device
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
COVID-19, SARS-CoV-2 Infection
The Safety and Immunogenicity of SCTV01C in Healthy Population Aged ≥18 Years Previously Vaccinated With mRNA COVID-19 Vaccine.
The objective of this study is to evaluate the safety, tolerability and immunogenicity of SCTV01C in healthy population aged ≥18 years previously vaccinated with mRNA COVID-19 vaccine.
- Trial name
- NCT05043311
- Testing
- SCTV01C
- Where
- United Arab Emirates
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sinocelltech Ltd.
Influenza, Human, SARS Virus
Influence of Prior Infection With COVID-19 on Occurrence of Influenza-like Illness or Acute Respiratory Infection
Background: Each Belgian winter season is characterized by a wave of influenza like and respiratory symptoms. Especially, the elderly people are more vulnerable to be infected by influenza, but also RSV.
- Conditions
- Influenza, Human, SARS Virus, COVID-19, Espiratory Tract Infections
- Trial name
- PICOV (NCT04527614)
- Testing
- qRT-PCR and serology
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sciensano
Coronavirus Disease 2019 (COVID-19), Respiratory Illness
BCG Vaccination to Protect Healthcare Workers Against COVID-19
Phase III, two-group multicentre, randomised controlled trial in up to 10 078 healthcare workers to determine if BCG vaccination reduces the incidence and severity of COVID-19 during the 2020 pandemic.
- Conditions
- Coronavirus Disease 2019 (COVID-19), Respiratory Illness, Corona Virus Infection, COVID-19
- Trial name
- BRACE (NCT04327206)
- Testing
- BCG Vaccine, 0.9%NaCl
- Where
- 36 sites in Australia, Brazil and 3 more
- Volunteers
- 6,828 people, healthy volunteers welcome
- Sponsor
- Murdoch Childrens Research Institute
Covid19, Myocardial Infarction
Outcomes of Patients Who Survived Treatment on an Intensive Care Unit for COVID-19 in England and Wales
This retrospective cohort study aims to characterise outcomes for patients treated on an intensive care unit (ICU) with COVID-19 in England and Wales, one year after discharge from hospital.
- Conditions
- Covid19, Myocardial Infarction, Stroke, Critical Illness
- Trial name
- OPTIC-19 (NCT04838106)
- Testing
- Not applicable as observational study
- Where
- United Kingdom
- Volunteers
- 319,600 people
- Sponsor
- University of Oxford
Depression, Anxiety
Description of the Lived Experiences of Family Caregivers for People With Mental Health Comorbidities
Mental health problems such as depression, trauma and anxiety are common in low-resource contexts, such as Zambia. Comorbidity, or having multiple mental health problems, is the norm.
- Conditions
- Depression, Anxiety, Trauma
- Trial name
- MCE (NCT07760701)
- Where
- Zambia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Critically Illness, Sedation
Inhaled Sedation in COVID-19-related Acute Respiratory Distress Syndrome (ISCA): an International Research Data Study in the Recent Context of Widespread Disease Resulting From the 2019 (SARS-CoV2) Coronavirus Pandemics (COVID-19)
The authors hypothesized that inhaled sedation, either with isoflurane or sevoflurane, might be associated with improved clinical outcomes in patients with COVID-19-related ARDS, compared to intravenous sedation.
- Conditions
- Critically Illness, Sedation, Invasive Mechanical Ventilation, Acute Respiratory Distress Syndrome
- Trial name
- ISCA (NCT04383730)
- Testing
- Intravenous sedation, Inhaled sedation
- Where
- 12 sites in United States, France and 3 more
- Volunteers
- 203 people
- Sponsor
- University Hospital, Clermont-Ferrand
COVID-19, Post COVID-19 Syndrome
Different Treatment Options Used for Post Covid-19 Syndrome
This study aimed to assess functioning during the recovery phase post-COVID-19 and to evaluate symptoms prolonging after COVID-19 infection and how to manage these symptoms.
- Conditions
- COVID-19, Post COVID-19 Syndrome, Ginkgo Biloba, Piracetam
- Trial name
- NCT07722000
- Testing
- Ginkgo biloba, Piracetam, Ginkgo biloba and Piracetam
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Beni-Suef University
COVID-19, Influenza
Equity Evaluation of Fact Boxes on Informed COVID-19 and Influenza Vaccination Decisions - Study Protocol
The study aims to evaluate whether evidence-based fact boxes on COVID-19 and influenza vaccination contribute to the decision making of laypeople from different social backgrounds in different educational settings (e.g.
- Trial name
- NCT06076421
- Testing
- Fact box
- Where
- Germany
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Harding Center for Risk Literacy
Covid19, ARDS, Human
Exhaled Breath Particles as a Clinical Indicator for Lung Injury and Acute Respiratory Distress Syndrome (ARDS)
Acute Respiratory Distress Syndrome (ARDS) reflects the hallmark of the critical course of coronavirus (COVID19). The investigators have recently shown that Exhaled Breath Particles (EBP) measured as particle flow rate (PFR) from…
- Conditions
- Covid19, ARDS, Human, ALI
- Trial name
- NCT04503057
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Lund University Hospital
Covid19
TOcilizumab and Covid-19 : Risk of Severe INfection
SARS-CoV2 is responsible for a pandemic that has been evolving for approximately 18 months. The virus' capacity for dissemination and its virulence are responsible for significant morbidity and mortality.
- Trial name
- TOCSIN (NCT05017441)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Fondation Hôpital Saint-Joseph
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