Clinical trials: 28 Day Mortality
Sepsis, Critical Illness
Peripheral Perfusion Index Trajectory to Predict 28-Day Mortality in Patients With Sepsis in the Intensive Care Unit
Sepsis is a life-threatening condition caused by the body's overwhelming response to infection, and it remains a leading cause of death in intensive care units.
- Trial name
- PERFUSE-ICU (NCT07740304)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Trakya University
Critical Illness, Vitamin D Deficiency
The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients
In the VITdAL-ICU trial using a large oral dose of vitamin D3 in 480 adult critically ill patients, there was no benefit regarding the primary endpoint hospital length of stay.
- Conditions
- Critical Illness, Vitamin D Deficiency, Covid19
- Trial name
- VITDALIZE (NCT03188796)
- Testing
- Cholecalciferol
- Where
- 18 sites in Austria, Belgium and 2 more
- Volunteers
- 2,400 people
- Sponsor
- Medical University of Graz
Critical Illness
Functional ICUS in Uganda and Their Survival Outcomes
Aim of the study is to describe the functional characteristics of Icus in Uganda and their @8-day patient characteristics it is a prospective cohort study .All Icus in Uganda will be included and their admitted patients followed…
- Trial name
- NCT03511742
- Where
- Uganda
- Volunteers
- 367 people
- Sponsor
- Makerere University
Sepsis, Thrombocytopenia
The Effect of REcombinant Human Thrombopoietin (rhTPO) on Sepsis Patients With aCUte Severe thrombocytopEnia
The purpose of this study is to determine whether recombinant human thrombopoietin(rhTPO) can rapidly increase the platelets counts, shorten the time of the platelet returned to normal, reduce platelet transfusion and bleeding…
- Trial name
- RESCUE (NCT02707497)
- Testing
- rhTPO
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Ruilan Wang
Mortality Prediction
28-day Mortality Prediction for Critically Ill Patients in the Intensive Care Unit: Physician-nurse vs. Score
There are several scores for predicting mortality within 28 days in the intensive care unit, including APACHE 2, MPM 2 and MODS.
- Trial name
- NCT06665529
- Testing
- 28-day mortality prediction by ICU staff and mortality scores
- Where
- Israel
- Sponsor
- Meir Medical Center
Septic, Acute Respiratory Distress Syndrome
Lessening Organ Dysfunction With VITamin C in Septic ARDS
The primary objective of the study aims to compare the effect of high-dose intravenous vitamin C vs. placebo on a composite of death or persistent organ dysfunction - defined as continued dependency on mechanical ventilation, new…
- Trial name
- LOVIT ARDS (NCT04404387)
- Testing
- Administration of vitamin C
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid19, SARS-CoV2 Infection
Atorvastatin for Reduction of 28-day Mortality in COVID-19: RCT
This randomized placebo-controlled double-blinded clinical trial aims to test the efficacy of administering atorvastatin 40 mg to hospitalized COVID-19 patients for 28 days on the all-cause 28-day mortality.
- Conditions
- Covid19, SARS-CoV2 Infection, COVID-19 Pneumonia
- Trial name
- COVID-STAT (NCT04952350)
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Mansoura University
Sepsis, Sepsis and Coagulopathy
Sepsis-associated Thrombocytopenia and Platelet Transfusion （STAPT）
Currently, there are no multicenter studies on platelet transfusion for SAT patients, and the benefits and risks of platelet transfusion still require further validation based on large-sample data.
- Trial name
- NCT07230067
- Testing
- SAT patients
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Crush Syndrome, Rhabdomyolysis
Inflammation Indıces and Mortality in Adult Crush Syndrome
This single-center, retrospective observational cohort study evaluated the prognostic value of complete blood count-derived inflammatory indices - the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR)…
- Conditions
- Crush Syndrome, Rhabdomyolysis, Systemic Inflammatory Response, Critical Illness
- Trial name
- NCT07433127
- Where
- Turkey (Türkiye)
- Volunteers
- 325 people
- Sponsor
- Ataturk University
The Number of Ventilator-free Days in the 28 Days Following LT
Veno-arterial ExtraCorporeal Membrane Oxygenation to Reduce Morbidity and Mortality Following Lung TransPlant
In patients undergoing lung transplantation (LT), the investigators hypothesize that a "systematic" intraoperative ECMO strategy would reduce the need for invasive mechanical ventilation in the first 28 days without increasing…
- Trial name
- ECMOToP (NCT05664204)
- Testing
- Veno-arterial extracorporeal membrane oxygenation
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Nutritional Risk
Analysis of Risk Factors and Prognostic Predictive Value in Sepsis Patients With Nutritional Risk
Sepsis is a common critical illness in intensive care units, characterized by systemic inflammatory response, immune dysfunction, microcirculatory issues, and multi-organ failure.
- Trial name
- NCT07278167
- Testing
- Retrospective data analysis, no intervention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- The Affiliated Hospital of Inner Mongolia Medical University
Hypomagnesemia
Dynamic Magnesium Replacement Strategies and 28-Day Mortality in Non-Cardiac Critically Ill Patients With Hypomagnesemia: A Target Trial Emulation
This study looks at how different ways of giving magnesium (a nutrient) affect the risk of death within 28 days for adults with low magnesium levels who are in the intensive care unit (ICU) for non-heart-related reasons.
- Trial name
- NCT07380542
- Where
- China
- Volunteers
- 12,887 people
- Sponsor
- Fujian Provincial Hospital
Sarcopenia ICU Ultrasound
Assessment of the Prognostic Value of the Thickness of the Quadriceps and Abdominal Muscles Measured by Ultrasound for 28-day Mortality in Postoperative ICU Patients
Ultrasound measurement of muscle thickness, particularly of the quadriceps, can be used to highlight a reduction in lean mass. Sarcopenia is annvoluntary loss of lean mass, and it is a frequent and major problem in the intensive…
- Trial name
- SARCOPENIE (NCT05276921)
- Testing
- ultrasound
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
28-day Mortality, Sepsis
Predictive Value of Dynamic Combination of BNP and NGAL for the Prognosis of Patients With Sepsis
Objective: to clarify the predictive value of brain natriuretic peptide (BNP) in combination with neutrophil gelatinase associated lipocalin (NGAL) for the prognosis of patients with sepsis.
- Trial name
- NCT02871544
- Testing
- BNP and NGAL
- Volunteers
- 124 people
- Sponsor
- Southeast University, China