Clinical trials: 65 Years Older
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Open-label Phase 3 BTK Inhibitor Ibrutinib vs Chlorambucil Patients 65 Years or Older With Treatment-naive CLL or SLL
A Randomized, Multicenter, Open-label, Phase 3 Study of the Bruton's Tyrosine Kinase Inhibitor PCI-32765 versus Chlorambucil in Patients 65 Years or Older with Treatment-naive Chronic Lymphocytic Leukemia or Small Lymphocytic…
- Trial name
- NCT01722487
- Testing
- Ibrutinib, Chlorambucil
- Where
- 108 sites in United States, Australia and 14 more
- Volunteers
- 269 people
- Sponsor
- Pharmacyclics LLC.
Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia
Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatumomab in Treating Older Patients With Acute Lymphoblastic Leukemia
This phase II trial studies the side effects and how well blinatumomab and combination chemotherapy or dasatinib, prednisone, and blinatumomab work in treating older patients with acute lymphoblastic leukemia.
- Conditions
- Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1, Recurrent Acute Lymphoblastic Leukemia
- Trial name
- NCT02143414
- Testing
- Biopsy Procedure, Biospecimen Collection, Blinatumomab
- Where
- 195 sites in United States
- Volunteers
- 53 people
- Sponsor
- National Cancer Institute (NCI)
Chronic Pain
Mindfulness on Physical and Mental Condition in Older Adults With Chronic Pain
This research corresponds to an experimental study, a randomized controlled clinical trial in people over 65 years of age, distributed into two groups: the experimental group will receive a program that will consist of an…
- Trial name
- NCT06213181
- Testing
- Mindfulness intervention
- Where
- Spain
- Volunteers
- 86 people
- Sponsor
- University of Jaén
Fatigue, Older Adults (65 Years and Older)
Exploring the Effect of the Hypershell Hip Exoskeleton on Fatiguing, Everyday Activities in Older Adults
The goal of this clinical trial is to learn how wearing the Hypershell lower-limb exoskeleton affects perceived fatigue during everyday mobility activities in adults aged 65 years and older.
- Conditions
- Fatigue, Older Adults (65 Years and Older), Exoskeleton Device
- Trial name
- Hypershell (NCT07840872)
- Testing
- Performance test, Hypershell assistance (EXO-ON Actuation)
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Pneumococcal Infections
Study Evaluating Safety and Immunogenicity of 13-Valent Pneumococcal Conjugate Vaccine With Influenza Vaccine in Adults
The 13-valent pneumococcal conjugate vaccine (13vPnC) is being developed for adults to prevent pneumococcal diseases such as meningitis (inflammation of the brain lining), septicemia (blood poisoning), and pneumonia (inflammation…
- Trial name
- NCT00492557
- Testing
- 13-valent pneumococcal conjugate vaccine, 13vPnC + TIV
- Volunteers
- 1,185 people, healthy volunteers welcome
- Sponsor
- Pfizer
Functional Status, Postoperative Complications
Association Between Preoperative Health and Functional Status and Postoperative Complications in Elderly Patients
Using prospectively collected clinical data from the Chinese Perioperative Database of Elderly Patients, this study retrospectively analyzed patients aged ≥65 years who underwent elective non-cardiac, non-neurosurgical procedures…
- Conditions
- Functional Status, Postoperative Complications, Older Adults (65 Years and Older)
- Trial name
- NCT07259837
- Where
- China
- Volunteers
- 8,751 people
- Sponsor
- Chinese PLA General Hospital
Obesity & Overweight, Aged 65 Years or Older
COMPASS 65+ - Community-based Physical Activity Snacks for Healthy Aging in Overweight and Obese Aged Adults
This study will explore a new way for older adults to become more physically active. As people get older, it's common to gain weight and lose muscle strength.
- Trial name
- COMPASS65+ (NCT07289529)
- Testing
- Group-based "Snack Exercise" Training and Prescription, Brief educational counseling session
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- University of Coimbra
Diabetes, Hypertension
A Spanish Pillbox App for Elderly Patients Taking Multiple Medications
Background: Non-adherence and medication errors are common among patients with complex drug regimens. Applications for smartphones and tablets are known to be effective for improving adherence but they have not been tested in…
- Trial name
- ALICE (NCT02071498)
- Testing
- Pillbox app named ALICE, oral and written information
- Where
- Spain
- Volunteers
- 99 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Influenza, Human
A Study on the Efficacy of a Vaccine Against Influenza in Adults ≥65 Years of Age
This study will compare an investigational mRNA flu vaccine with a licensed flu vaccine in adults 65 years of age and older. Participants will receive one injection and will be followed during the flu season.
- Trial name
- NCT07805707
- Testing
- mRNA Seasonal Flu vaccine, Licensed Influenza Vaccine
- Where
- 163 sites in United States
- Volunteers
- 54,000 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Older Adults (65 Years and Older), Postoperative Care
The Perioperative Pathway for Older Adults
More than 1.5 million people undergo surgery in Sweden each year, and over 770,000 of them are aged 65 years or older. Older adults often have more complex health needs and may require additional support throughout the surgical…
- Conditions
- Older Adults (65 Years and Older), Postoperative Care, Preoperative Care, Intraoperative Care
- Trial name
- POP (NCT07764289)
- Testing
- No intervention
- Volunteers
- 1,000,000 people
- Sponsor
- Örebro University, Sweden
Older Adults (65 Years and Older), Healthy Older Adults
Effects of Assessment and Verbal Feedback on Physical Function and Exercise Adherence in Healthy Older Adults
The goal of this pilot Randomized Controlled Trial (RCT) was to investigate whether the provision of periodic assessment and verbal feedback during an exercise program has an effect on adherence, physical function and…
- Conditions
- Older Adults (65 Years and Older), Healthy Older Adults, Community Dwelling Older Adults
- Trial name
- NCT07437521
- Testing
- Periodic assessment and individualized verbal feedback
- Where
- Greece
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of West Attica
Fraility, Anxiety, Preoperative
The Relationship Between Preoperative Anxiety Level and Frailty Score in Elderly Patients Scheduled for Elective Hip Arthroplasty: A Prospective Observational Study
Frailty is a state of vulnerability resulting from decreased physiological reserve across multiple organ systems, impairing an individual's ability to withstand stressors.
- Conditions
- Fraility, Anxiety, Preoperative, Hip Arthroplasty
- Trial name
- NCT07633483
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Acute Myeloid Leukemia
A Randomized Study of Post-Remission Therapy in Elderly Patients With Acute Myelogenous Leukemia.
In this ALFA-9803 trial in AML patients aged 65 years or more, we randomly compared idarubicin or daunorubicin throughout the study (first randomization) and two different post-remission strategies (second randomization): one…
- Trial name
- NCT00363025
- Testing
- Two post-remission strategies, Idarubicin versus daunorubicin
- Where
- 13 sites in France
- Volunteers
- 465 people
- Sponsor
- Acute Leukemia French Association
Pneumococcal Vaccines, Pneumococcal Conjugate Vaccine
A Phase 3 Trial Evaluating the Safety, Tolerability, and Immunogenicity of a 13-valent Pneumococcal Conjugate Vaccine in Japanese Elderly Adults Aged 65 Years Old and Older
The purpose of this study is to evaluate the safety, tolerability and immunogenicity of a single dose of 13-valent pneumococcal conjugate vaccine compared to a single dose of 23-valent pneumococcal polysaccharide vaccine in…
- Trial name
- NCT01646398
- Testing
- 13-valent pneumococcal conjugate vaccine, 23-valent pneumococcal polysaccharide vaccine
- Where
- 8 sites in Japan
- Volunteers
- 764 people, healthy volunteers welcome
- Sponsor
- Pfizer
Dietary Habits, Accidental Falls
Workshop for Primary Prevention of Falls. CHANGING TO NEVER FALL. CTNF
The purpose of this study is to determine whether a primary prevention workshop is effective decreasing at least 13% the annual incidence of falls in elderly compared to the habitual counseling.
- Conditions
- Dietary Habits, Accidental Falls, Unspecified Fall, Occurrence at Home, Physical Activity
- Trial name
- CTNF (NCT02645006)
- Testing
- 3 session workshop, 1 session workshop
- Where
- Spain
- Volunteers
- 316 people
- Sponsor
- Sociedad Madrileña de Medicina de Familia y Comunitaria
Influenza (Healthy Volunteers)
Study to Assess the Immune Response and the Safety Profile of a High-Dose Quadrivalent Influenza Vaccine (QIV-HD) Compared to a Standard-Dose Quadrivalent Influenza Vaccine (QIV-SD) in Taiwanese Adults 65 Years of Age and Older
Primary Objective: Immunogenicity: To describe the immune response induced by high-dose quadrivalent influenza vaccine (QIV-HD) and AdimFlu-S (QIS) by hemagglutinin inhibition (HAI) measurement method in all participants.
- Trial name
- NCT04537234
- Testing
- High-Dose Quadrivalent Influenza Vaccine, Standard-Dose Quadrivalent Influenza Vaccine
- Where
- 4 sites in Taiwan
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Insulin Dependent Diabetes, Diabetes (DM)
Integrating New Skills Into Diabetes Education With CGM
This study is designed to test the preliminary efficacy of a three-stage continuous glucose monitor (CGM) integration program for older adults who are taking insulin.
- Conditions
- Insulin Dependent Diabetes, Diabetes (DM), Diabetes (Insulin-requiring, Type 1 or Type 2), Diabetes Education
- Trial name
- INSIDE-CGM (NCT07463209)
- Testing
- Three-stage CGM integration program, One-time clinic-based CGM training, Self-directed CGM training
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of North Carolina, Chapel Hill
Older Adults (65 Years and Older)
Technology-based Hand Rehabilitation in Older People
Because hand and cognitive functions decline in the elderly, intervention programs addressing these problems are necessary. In recent years, creating rehabilitation programs using technology has gained popularity.
- Trial name
- NCT07507279
- Testing
- Technological hand rehabilitation exercises, Home exercises, Dual task with technological hand exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Acute Myeloid Leukemia
A Study of Azacitidine and Venetoclax Versus a Stem Cell Transplant in People 65 Years and Older With Acute Myeloid Leukemia
The researchers are doing this study to find out if an allogeneic hematopoietic stem cell transplant (HSCT) or maintenance therapy with azacitidine and venetoclax is more effective at keeping AML from coming back (relapsing).
- Trial name
- NCT06903702
- Testing
- Azacitidine (AZA), Venetoclax, Allogeneic hematopoietic stem cell transplantation
- Sponsor
- Memorial Sloan Kettering Cancer Center
Tetanus
Antitetanus Vaccination for People Older Than 65 Years.
In the last ten years, more than one hundred generalized tetanus cases were declared in France. Most of them were affecting people older than 70 years with an important mortality (around 28%).
- Trial name
- VAT65 (NCT03266211)
- Testing
- Questionnaire Patients, Questionnaire General practitioner
- Where
- France
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon