Clinical trials: A
High-Grade Glioma
Concurrent XRD-0394 With Radiation Therapy for High Grade Gliomas
This is an open-label, dose-finding study of XRD-0394 in subjects with newly diagnosed and recurrent high grade gliomas receiving radiation therapy, with and without concurrent temozolomide based on O6-Methylguanine-DNA…
- Trial name
- NCT06829173
- Testing
- XRD-0394, Radiation Therapy, Surgical Resection
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- NYU Langone Health
Depression
OxSYPan: Oxford Study With Young People on Antidepressants
Fluoxetine is commonly used to treat adolescent depression, but the neural mechanisms underlying antidepressant drugs in the young brain are still poorly understood.
- Trial name
- OxSYPan (NCT03436173)
- Testing
- Fluoxetine, Peppermint syrup
- Volunteers
- 32 people
- Sponsor
- University of Oxford
Glaucoma, Ocular Hypertension
Assessing the Efficacy of DuoTrav as a Replacement Therapy in Glaucoma Patients in Russia
The purpose of this study is to evaluate the efficacy of changing to DuoTrav® (Travoprost 0.004%/Timolol 0.5%) from prior prostaglandin analogue or beta-blocker monotherapy in Russian glaucoma patients with open-angle glaucoma or…
- Trial name
- NCT01696383
- Testing
- Travoprost 0.004%/Timolol 0.5% Fixed Combination (DuoTrav)
- Sponsor
- Alcon Research
Wounds, Wound of Skin
A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.
The goal of this clinical trial is to follow the progress of wounds in those with venous leg ulcers and diabetic foot ulcers while using an absorbent dressing called Mepilex Up.
- Conditions
- Wounds, Wound of Skin, Wound Leg, Wound; Foot
- Trial name
- NCT05588583
- Testing
- Mepilex Up
- Where
- 4 sites in United States
- Volunteers
- 68 people
- Sponsor
- Molnlycke Health Care AB
Stroke
Stroke Upper Limb Rehabilitation With Robot Operators: a Synergistic Approach for Human-Robot Interaction and Rehabilitative Trials.
In clinical scenario, clinical scales and kinematic analysis are usually used for the evaluation of patients. However, these methods are limited, since they may suffer from the lack of objectivity and sensitivity.
- Trial name
- SULLRO (NCT07768683)
- Testing
- Upper Limb robotic training
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Villa Beretta Rehabilitation Center
Encephalitis, Tick-Borne
Study of the Safety, Tolerability and Immune Response of TBE Vaccines Administered to Healthy Children
The purpose of this study is to evaluate the safety, immunogenicity and tolerability of TBE vaccines administered to children.
- Trial name
- NCT00311441
- Testing
- Tick-Borne Encephalitis vaccine
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Novartis
Colonic Diseases, Functional
Combination Herbal Therapy (CHT) Versus Placebo in Patients With Irritable Bowel Syndrome (IBS)
This is an 8-week double-blind, placebo-controlled, randomized, parallel-group study with an additional two week baseline observation period to evaluate the safety of combination herbal therapy (CHT) versus placebo and short and…
- Trial name
- NCT00130741
- Testing
- CHT - herbal therapy
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Atrial Fibrillation, Atrial Flutter
Suture Closure AFtEr VEIN Access for Cardiac Procedures (SAFE-VEIN) Trial
Primary objective: To compare the safety and efficacy of closure strategies post venous access procedures. Hypothesis: We anticipate that the use of a venous closure device will decrease the time to hemostasis (TTH), time to…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Heart Block, Pulmonary Embolism and Thrombosis
- Trial name
- SAFE-VEIN (NCT04632641)
- Testing
- Perclose ProGlide Suture-Mediated Closure System (SMC) - LARGE-BORE PROCEDURES, Figure 8 Suture - LARGE-BORE PROCEDURES
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Wake Forest University Health Sciences
Peripheral Arterial Disease
Momentum-enabled Treadling Methodology to Improve Gait and Enhance Mobility
This is a pilot study of a new exercise device (TREDLR) designed to facilitate repetitive ankle flexion/extension movements (i.e., "treadling") through a momentum-driven internal flywheel while seated.
- Trial name
- NCT03891641
- Testing
- Treadwell Tredlr
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of North Carolina, Chapel Hill
Depression Symptoms, Anxiety Symptoms
Internet-based Cognitive Behavioral Therapy: a Factorial Randomized Controlled Trial About Treatment Content and Support
The purpose of this study is to investigate the differences in treatment outcomes between individually tailored and transdiagnostic internet-based cognitive behavioral therapy (ICBT), as well as the differences between weekly…
- Trial name
- NCT06209541
- Testing
- Internet-based cognitive behavioral therapy (ICBT)
- Where
- 2 sites in Sweden
- Volunteers
- 176 people
- Sponsor
- Linkoeping University
Non-small Cell Lung Cancer
Afatinib In Combination With Cisplatin Or Carboplatin + Pemetrexed In Patients With EGFR-Mutant Lung Cancers Undergoing Definitive Chemoradiation
The purpose of this Phase I study is to test the safety of combining afatinib with standard chemotherapy and radiation. The drug afatinib will be given before the chemotherapy and radiation therapy to shrink the tumor and…
- Trial name
- NCT01836341
- Testing
- Afatinib, Cisplatin, Carboplatin
- Sponsor
- Memorial Sloan Kettering Cancer Center
Bioavailability and AUC
The Objective of This Study Was to Compare and Quantify the Bioavailability of Citrulline Byproducts in Blood Samples and in Urine Samples After a Single Dose of the Assigned Dietary Supplement. The Treatment Arms Containing the Following Molecules: Citrulline HCL and L-Citrulline,
Citrulline dietary supplements are of interest for improving cardiovascular and exercise performance. The health benefits of citrulline are attributable to its ability to increase arginine levels in the body through the…
- Trial name
- NCT06977854
- Testing
- Removal from study. In case of adverse event, subject treated for the AE., removal from study
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vireo Systems, Inc.
HER2-positive Breast Cancer, Stage III Ovarian Epithelial Cancer
Vaccine Therapy With Sargramostim (GM-CSF) in Treating Patients With Her-2 Positive Stage III-IV Breast Cancer or Ovarian Cancer
RATIONALE: Vaccines may help the body build an effective immune response to kill tumor cells. Colony-stimulating factors, such as GM-CSF, may increase the number of immune cells found in bone marrow or peripheral blood.
- Conditions
- HER2-positive Breast Cancer, Stage III Ovarian Epithelial Cancer, Stage III Ovarian Germ Cell Tumor, Stage IIIA Breast Cancer
- Trial name
- NCT00436254
- Testing
- pNGVL3-hICD vaccine, sargramostim, flow cytometry
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Washington
Alcohol Drinking, Alcohol Use Disorder
Effect of Theta Burst Stimulation on Alcohol Cue Reactivity
Alcohol Use Disorder (AUD) is prevalent, devastating, and difficult to treat. The intransigence of AUD is readily apparent in the Trauma Unit of Wake Forest University Baptist Hospital, wherein 23% of trauma related admissions…
- Conditions
- Alcohol Drinking, Alcohol Use Disorder, Trauma Injury, Alcohol Dependence
- Trial name
- NCT04223154
- Testing
- Real iTBS to the dlPFC
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University Health Sciences
HIV, Sexual Behavior
Development of a Methamphetamine Early Intervention
Methamphetamine abuse has a strong and consistent epidemiologic association with high-risk sexual behavior and both prevalent and incident HIV in men who have sex with men (MSM), and some authorities have advocated…
- Conditions
- HIV, Sexual Behavior, Methamphetamine, Behavioral Research
- Trial name
- NCT01174654
- Testing
- Contingency management
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- University of Washington
Schizophrenia
52-week Open Label Safety-Tolerability Study
Phase 3, open label, multicenter study designed to assess the long term safety and tolerability of LB-102 for the treatment of adult patients with stable schizophrenia
- Trial name
- NOVA3 (NCT07369154)
- Testing
- LB-102
- Where
- 23 sites in United States
- Volunteers
- 900 people
- Sponsor
- LB Pharmaceuticals Inc.
Ketogenic Dieting, Weight Loss
Weight Loss for a Healthier You Programme
In view of the research gap in the safety of traditional ketogenic diet, there is a need for a healthy alternative to the ketogenic diet that reduces the individual's propensity to adverse diet choices.
- Conditions
- Ketogenic Dieting, Weight Loss, Obesity, Metabolic Syndrome
- Trial name
- NCT05049954
- Testing
- Calorie-Restricted Healthy Ketogenic Diet, Calorie-Restricted Low Fat Diet
- Where
- Singapore
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Benign Thyroid Nodules, Ablation
Microwave vs. Radiofrequency Ablation for Benign Thyroid Nodules: A Multicenter Randomized Controlled Trial Study
Compared with traditional treatment methods, ultrasound-guided thermal ablation is more targeted, less invasive and more reliable.
- Trial name
- NCT04046354
- Testing
- Ultrasound-guided Percutaneous Microwave Ablation, Ultrasound-guided Percutaneous Radiofrequency Ablation
- Where
- China
- Volunteers
- 149 people
- Sponsor
- Chinese PLA General Hospital
Pulmonary Arterial Hypertension
Iloprost Power Disc-15 in Pulmonary Arterial Hypertension
A Phase IIIb, Multicenter, Open-Label Study of Patients With Pulmonary Arterial Hypertension Treated With Iloprost(Inhalation)Evaluating Safety and Inhalation Times When Converting From Power Disc-6 to Power Disc-15 With the…
- Trial name
- INHALE-15 (NCT00723554)
- Testing
- Iloprost PD-6, Iloprost PD-15
- Where
- 36 sites in United States
- Volunteers
- 63 people
- Sponsor
- Actelion
Fruquintinib, S-1
Fruquintinib Plus S-1 and Raltitrexed (RSF) for MCRC
Based on the FRECO-2 study, Fruquintinib has become one of the standard third-line treatments for advanced colorectal cancer; however, its objective response rate (ORR) remains low.
- Conditions
- Fruquintinib, S-1, Raltitrexed
- Trial name
- NCT06427005
- Testing
- Fruquintinib, S-1, raltitrexed
- Where
- 2 sites in China
- Volunteers
- 66 people
- Sponsor
- Meng Qiu
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