Clinical trials: A
Esophageal Cancer, Chemoradiotherapy
Consolidation of Toripalimab and Capecitabine After Chemoradiotherapy in ESCC
Definitive chemoradiotherapy (CRT) is the standard treatment for locally advanced unresectable esophageal cancer, but its efficacy remains unsatisfactory.
- Trial name
- EC-CRT-008 (NCT07177794)
- Testing
- toripalimab, capecitabine
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Sun Yat-sen University
Congenital Adrenal Hyperplasia
Comparison of Chronocort Versus Standard Hydrocortisone Replacement Therapy in Participants Aged 16 Years and Over With Congenital Adrenal Hyperplasia
This study is a randomized, double-blind, active-controlled, phase III study of Chronocort® compared with immediate-release hydrocortisone replacement therapy in participants aged 16 years and over with Congenital Adrenal…
- Trial name
- CONnECT (NCT05063994)
- Testing
- Chronocort, Cortef
- Where
- 21 sites in United States, France and 1 more
- Volunteers
- 55 people
- Sponsor
- Neurocrine UK Limited
Allogenic Bone Marrow Transplantation
Rehab Study for alloBMT Patients
The goals of this phase III clinical trial is to determine effectiveness in the setting where it will be implemented as well as to gain an understanding of the context for implementation.
- Trial name
- CaRE-4-alloBMT (NCT07457866)
- Testing
- CaRE-4-alloBMT
- Where
- Canada
- Volunteers
- 208 people
- Sponsor
- Jennifer Jones
Melatonin Bioavailability
Kinetic of Compounds of a Melatonin-based Formulation in Healthy Subjects
This study is conducted to clinically document the melatonin and zinc bioavailability of a dietary supplement containing delayed release melatonin, zinc and lemon balm
- Trial name
- NCT05419466
- Testing
- dietary supplement, 1 tablet containing delayed release melatonin, zinc and lemon balm
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Larena SAS
Adult Solid Neoplasm
Tivantinib and Temsirolimus in Treating Patients With Solid Tumors That is Metastatic or Cannot be Removed by Surgery
This phase I trial studies the side effects and best dose of tivantinib when given in combination with temsirolimus in treating patients with solid tumors that have spread to other parts of the body or cannot be removed by…
- Trial name
- NCT01625156
- Testing
- Laboratory Biomarker Analysis, Pharmacological Study, Temsirolimus
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Poly Cystic Ovary Treatment for Infertility
Surgical and Non Surgical Treatment Option in Poly Cystic Ovary Cases
The study will focus on treatment of Poly Cystic Ovary Syndrome patients with infertility The aim is to to find the best treatment by comparison of surgical and non surgical intervention
- Trial name
- NCT05699356
- Testing
- Non Surgical treatment, laparoscopic drilling, Treatment of Poly cystic ovary for infertility by Life style modification
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
Gastroesophageal Reflux Disease (GERD)
A Study to Determine the Effectiveness of Endoscopic Full-Thickness Plication for the Treatment of GERD
The aim of this study was to determine the effectiveness of endoscopic full-thickness plication (Plicator; NDO Surgical, Inc., Mansfield, MA) for the treatment of GERD in comparison to a sham procedure.
- Trial name
- NCT00575822
- Testing
- NDO Full-thickness Plicator
- Where
- 15 sites in United States, Belgium and 1 more
- Volunteers
- 159 people
- Sponsor
- NDO Surgical, Inc.
Hematologic Malignancies
Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies and High-Risk Newly Diagnosed AML
SLS009 (formerly GFH009) is a potent and highly selective CDK9 inhibitor. In this study the safety, tolerability, and antitumor activity of single agent SLS009 are assessed in two dose escalation groups (Group 1 in patients with…
- Trial name
- NCT04588922
- Testing
- SLS009, venetoclax, azacitidine
- Where
- 32 sites in United States, China
- Volunteers
- 160 people
- Sponsor
- Sellas Life Sciences Group
Asthma
Bronchodilator Properties and Safety in Asthma
Recent large clinical studies have demonstrated the interest of LAMA therapy in the management of asthma, when compared to LABA.
- Trial name
- NCT01951222
- Testing
- V0162
- Where
- Germany
- Volunteers
- 59 people
- Sponsor
- Pierre Fabre Medicament
Homeless Services, Human Services Training
Implementation, Fidelity, and Outcomes Following Novel and Usual Critical Time Intervention Training
Clinical social workers and other staff providing direct care to individuals experiencing homelessness face multiple challenges in obtaining training and implementing evidence-based practices in diverse community settings.
- Trial name
- NCT02427022
- Testing
- CTI
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Center for Social Innovation, Massachusetts
Abscess, Cellulitis
Aquacel Versus Iodoform Gauze for Filling Abscess Cavity Following Incision and Drainage
This study compares Aquacel against routine Iodoform packing for packing abscess cavities after incision and drainage. It is hypothesized that Aquacel will produce speedier healing of the abscess.
- Trial name
- NCT00984022
- Testing
- Type of dressing - Iodoform, Type of dressing - Aquacel
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Valleywise Health
Endometrial Cancer, Cancer Screening
DNA CDO1 and CELF4 Methylation for Endometrial Cancer Screening
Based on the previous study of NCT04651738, we performed this trial to further confirm the accuracy of host DNA CDO1 and CELF4 methylation for endometrial cancer screening.
- Conditions
- Endometrial Cancer, Cancer Screening, DNA Methylation, Testing Accuracy
- Trial name
- NCT05290922
- Testing
- DNA methylation testing
- Where
- China
- Volunteers
- 7,150 people
- Sponsor
- Lei Li
Self Harm
Multicenter Study to Evaluate the Clinical and Cost-effectiveness of a Culturally Adapted Therapy (C-MAP)
To evaluate the clinical and cost-effectiveness of a culturally adapted therapy (C-MAP) in patients with a history of self-harm
- Trial name
- C-MAP (NCT02742922)
- Testing
- Culturally adapted therapy (C-MAP)
- Where
- 7 sites in Pakistan
- Volunteers
- 901 people
- Sponsor
- Pakistan Institute of Living and Learning
Lung Neoplasms
Safety and Feasibility of Pulmonary Surgery Marker System in the Intraoperative Localization of Small Pulmonary Nodules
As the detection of small pulmonary nodules continuously grows, the intraoperative localization of small pulmonary nodules is in great demand.
- Trial name
- NCT04211051
- Testing
- LungBrella marker implantation and VATS partial lobe resection
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Ruijin Hospital
Clinical Decision Support Systems, Diagnostic Reasoning
Effects of Agent-assisted, LLM-assisted and Traditional Workflows on Diagnosis and Management Planning at Admission
The goal of this clinical trial is to evaluate whether AI-assisted workflows improve physicians' admission diagnosis and management planning performance on standardized simulated inpatient cases, among practicing internal…
- Conditions
- Clinical Decision Support Systems, Diagnostic Reasoning, Artificial Intelligence (AI)
- Trial name
- NCT07760051
- Testing
- Agent-assisted workflow, LLM-assisted workflow, Traditional Workflow
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke
The Fall Monty Activity Programme Feasibility Study
Between 45-73% of people who have had a stroke fall over in the months and years following their stroke. Falls not only lead to injuries such as broken hips, but they may also lead to fear of falling.
- Trial name
- FallMAP (NCT03484351)
- Testing
- Fall Monty Activity Programme (FallMAP)
- Where
- Australia
- Volunteers
- 5 people
- Sponsor
- Curtin University
Healthy
The Effects of Exercise Timing and Intensity on Motor Learning in Healthy Adults.
The purpose of this study is to compare of the effects of a single session of aerobic exercise with different intensity and timing on motor learning processes in healthy young adults.
- Trial name
- NCT06166251
- Testing
- low ıntensity aerobic exercise, moderate ıntensity aerobic exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Trakya University
Endometrial Hyperplasia, Endometrial Cancer
Preliminary Study of Endometrial Hyperplasia Groundwork for a Study to Define Precursors of Endometrial Cancer
This study, conducted jointly by the National Cancer Institute and the Kaiser Permanente Center for Health Research Northwest (KPCHRN) in Portland, Oregon, will lay the groundwork for a future study to identify precursors of…
- Conditions
- Endometrial Hyperplasia, Endometrial Cancer, Postmenopausal Bleeding, Vaginal Bleeding
- Trial name
- NCT00339651
- Where
- United States
- Volunteers
- 745 people
- Sponsor
- National Cancer Institute (NCI)
Alpha1-antitrypsin Deficiency, Healthy Volunteers
GLASSIA Infusion Rate Study
The purpose of this study was to generate sufficient safety and tolerability information in support of an increase in the infusion rate of intravenous GLASSIA in the prescribing information from 0.04 to 0.2 mL/kg/min.
- Trial name
- NCT01651351
- Testing
- Alpha1-proteinase inhibitor
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Baxalta now part of Shire
Urinary Tract Infection
A Study to Assess the Safety, Tolerability and Efficacy of Ertapenem Sodium in the Treatment of Complicated Urinary Tract Infections (0826-048)
The purpose of this study is to evaluate the safety, tolerability and efficacy of ertapenem sodium as initial therapy for the treatment of complicated urinary tract infections, including pyelonephritis in indian adults.
- Trial name
- NCT00379951
- Testing
- ertapenem sodium
- Volunteers
- 107 people
- Sponsor
- Merck Sharp & Dohme LLC
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