Clinical trials: A
Lichen Planopilaris, Cicatricial Alopecia
The Effectiveness of Hydroxychloroquine Versus Methotrexate in the Treatment of Lichen Planopilaris in Routine Clinical Care: a Patient Preference Trial
Rationale Lichen planopilaris (LPP) is a prevalent form of cicatricial alopecia, predominantly affecting women and causing irreversible hair loss.
- Trial name
- HEMLET (NCT06512753)
- Testing
- Hydroxychloroquine, Methotrexate
- Where
- Netherlands
- Volunteers
- 56 people
- Sponsor
- Erasmus Medical Center
Hip Osteoarthritis
Intravenous Dexmedetomidine as a Perioperative Autonomic-Immune Neuromodulator
Surgical trauma induces activation of the sympathetic nervous system and triggers a systemic inflammatory response that may adversely affect postoperative recovery.
- Trial name
- NCT07743853
- Testing
- Dexmedetomidine
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Poznan University of Medical Sciences
Epidural Anesthesia, Percutaneous Nephrolithotomy (PCNL)
Predictors of Epidural Depth in Percutaneous Nephrolithotomy and Model Development
Accurate estimation of epidural depth is critical for safe epidural anesthesia during percutaneous nephrolithotomy (PCNL). Although various imaging modalities can predict epidural depth, they increase healthcare burden and are…
- Trial name
- NCT07697053
- Where
- China
- Volunteers
- 3,278 people
- Sponsor
- Tongji Hospital
Venous Leg Ulcers
Clinical Trial Evaluating an Amnion Membrane Allograft Intended for Use in the Management of Non- Healing Venous Leg Ulcers Versus Standard Of Care Alone
The main purpose of this research study is to compare the proportion of wound closure in subjects that receive E-GRAFT™ with SOC versus FIBRACOL™ with SOC.
- Trial name
- NCT06764953
- Testing
- E-GRAFT ™, FIBRACOL™
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Skye Biologics Holdings, LLC
Survival, Prosthesis, Peri-Implantitis
Maxillary Sinus Floor Augmentation With Different Grafting Materials
Implant placement in the posterior maxilla is compromised due to atrophy of the alveolar process and maxillary sinus pneumatisation. Bone augmentation is frequently necessary before or in conjunction with implant placement.
- Conditions
- Survival, Prosthesis, Peri-Implantitis, Patient Satisfaction
- Trial name
- NCT04749953
- Testing
- Maxillary sinus floor augmentation
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Knee Osteoarthritis
A Comparison of Manual Physical Therapy and Corticosteroid Injections for Knee Osteoarthritis
The purpose of this study is to compare an orthopaedic manual physical therapy (OMPT) approach to a corticosteroid injection approach for the management of knee osteoarthritis.
- Trial name
- SMART (NCT01427153)
- Testing
- Orthopaedic manual physical therapy, Corticosteroid Injection
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- Madigan Army Medical Center
Infection
Teicoplanin in Treating Septicemia in Patients Who Are Receiving Chemotherapy Through a Central Venous Catheter
RATIONALE: Giving the antibiotic teicoplanin by infusion and allowing bacteria to be exposed to the antibiotic for a longer period of time may be effective in preventing or controlling septicemia.
- Trial name
- NCT00024453
- Testing
- teicoplanin
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 1,360 people
- Sponsor
- Children's Cancer and Leukaemia Group
Hip Arthroscopy
Effect of Post-operative Brace on Pain and Patient Outcomes Following Hip Arthroscopy for FAIS
The routine application of hip brace following hip arthroscopy for femoroacetabular impingement syndrome (FAIS) has no proven clinical benefits.
- Trial name
- NCT05592353
- Testing
- Brace
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Alexander Weber
Advanced Cancer
An Investigational Immunotherapy Study of BMS-986299 Alone and in Combination With Nivolumab and Ipilimumab in Participants With Solid Cancers That Have Spread or Cannot be Removed
The purpose of this study is to determine whether BMS-986299 both by itself and in combination with Nivolumab and Ipilimumab is safe and tolerable in the treatment of advanced solid tumors.
- Trial name
- NCT03444753
- Testing
- BMS-986299, Nivolumab, Ipilimumab
- Where
- 9 sites in United States
- Volunteers
- 82 people
- Sponsor
- Bristol-Myers Squibb
Major Depressive Disorder
Psychostimulant Augmentation of Repetitive TMS for the Treatment of Major Depressive Disorder
This study analyzes the affects or Adderall extended-release (XR) in Subjects receiving brain stimulation therapy for the treatment of Major Depressive Disorder. Subjects will be assigned by chance to active or placebo group.
- Trial name
- Stimulant-rTMS (NCT04509102)
- Testing
- Adderall-XR
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Pneumonia, Pneumocystis Carinii, HIV Infections
A Randomized, Double-Blind, Placebo Controlled Study of l-Leucovorin in Combination With Trimethoprim / Sulfamethoxazole in the Therapy of Pneumocystis Carinii Pneumonia in Patients With the Acquired Immunodeficiency Syndrome
The primary objective of the study is to evaluate the effectiveness of l-leucovorin in preventing toxicity from high dose trimethoprim / sulfamethoxazole (TMP / SMX) used as a therapy for Pneumocystis carinii pneumonia (PCP) in…
- Trial name
- NCT00002002
- Testing
- Trimethoprim, Sulfamethoxazole, Leucovorin calcium
- Where
- United States
- Sponsor
- Lederle Laboratories
Pulmonary Arterial Hypertension
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess Safety and Efficacy of Ambrisentan in Subjects With Pulmonary Arterial Hypertension.
A phase 3, randomized, double-blind, placebo-controlled study to assess safety and efficacy of ambrisentan in subjects with pulmonary arterial hypertension.
- Trial name
- NCT00423202
- Testing
- ambrisentan
- Volunteers
- 186 people
- Sponsor
- Gilead Sciences
Paroxysmal Nocturnal Hemoglobinuria (PNH)
SLN12140 in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) in China
The goal of this clinical trial is to learn if drug SLN12140 works to treat Complement Inhibitor-Naïve Subjects with Paroxysmal Nocturnal Hemoglobinuria in adults.
- Trial name
- NCT07387302
- Testing
- SLN12140
- Volunteers
- 10 people
- Sponsor
- Linno Pharmaceuticals, Inc.
Cross-linked Hyaluronic Acid
Treatment of Buccal Ginvigal Recessions With the Tunnel Technique in Conjunction With Cross-linked Hyaluronic Acid and Subepithelial Connective Tissue Graft. A Randomized Clinical Trial
To evaluate the outcomes of buccal gengival recession type 1 (RT1) treated with the tunnel technique in conjunction with a cross-linked hyaluronic acid and subepithelial palatal connective tissue grafts.
- Trial name
- NCT05436002
- Testing
- With Cross-linked Hyaluronic Acid
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Lisbon
Alzheimer Disease
Study to Compare the Pharmacokinetics of Daily Administration of Tricaprilin on Ketone Body Production
This is a Phase I, single center, open label, multiple dose, pharmacokinetic (PK) study recruiting healthy older subjects.
- Trial name
- NCT04268953
- Testing
- Tricaprilin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cerecin
Healthy Adult Participants
A Phase 1 Study of KHN707 Tablets in Healthy Participants
This is a single-center, randomized, double-blind, placebo-controlled study . The objective is to evaluate the safety , tolerability and PK profile of KHN707 tablets in Chinese healthy participants.
- Trial name
- NCT07557537
- Testing
- KHN707 tablet
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Chengdu Kanghong Pharmaceutical Group Co., Ltd.
Acute Mountain Sickness, Blood Oxygen Saturation, Headache
Ibuprofen vs Acetaminophen for AMS Prevention
AMS (acute mountain sickness) affects those who ascend too high (>2000m) too fast. Acetazolamide is an effective drug for the prevention of AMS where proper acclimatization with gradual ascent may not be an option.
- Trial name
- NCT02244437
- Testing
- Ibuprofen, Acetaminophen
- Where
- Nepal
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Mountain Medicine Society of Nepal
Healthy
Evaluation of the Angle of Head and Neck Flexion Forward During Mobile Phone Use
The aim of this study is to investigate the effect of smartphone use on head and neck flexion angle during sitting and standing positions.
- Trial name
- NCT07190937
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Atrial Fibrillation
Safety and Effectiveness of Low Dose Edoxaban in Patients With NVAF
The efficacy and safety of edoxaban has not been adequately studied in Asians versus non-Asians, who are quite different physiologically from each other.
- Trial name
- LEDIOS (NCT03554837)
- Where
- South Korea
- Volunteers
- 2,562 people
- Sponsor
- Samsung Medical Center
Covid19
A Study to Evaluate the Safety and Efficacy of GX-I7 in Elderly Patients With Asymptomatic or Mild Symptoms of COVID-19
This is a Phase 2 prospective, randomized, placebo-controlled, double-blinded, parallel group, single administration, multi-center study to assess the safety and efficacy of efineptakin alfa single treatment compared to placebo…
- Trial name
- NCT04810637
- Testing
- GX-I7
- Where
- 2 sites in Indonesia
- Volunteers
- 210 people
- Sponsor
- PT Kalbe Genexine Biologics
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