Clinical trials: A
Non Hodgkin's Lymphoma
Allogenic CD19-targeting CAR-γδT Cell Therapy in R/R NHL
This is a single center, prospective, open-label, single-arm, phase 1/2 study for patients with r/r B-cell NHL to evaluate the safety and efficacy of gene edited allogenic CD19 CAR-γδT cells.
- Trial name
- NCT05554939
- Testing
- Allogenic CD19 CAR-γδT cell, Fludarabine, Cyclophosphamide
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Migraine
Ascending Single Doses of Erenumab (AMG 334) in Healthy Adults and Migraine Patients
The primary purpose of this study is to determine whether erenumab is safe and well tolerated in healthy adults and migraine patients.
- Trial name
- NCT01688739
- Testing
- Erenumab
- Where
- Belgium
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Amgen
Head and Neck Squamous Cell Carcinoma
A Clinical Study of SI-B001 in Combination With Paclitaxel/Docetaxel in the Treatment of Recurrent and Metastatic HNSCC
This Phase IIa study is a clinical trial to evaluate the safety and efficacy of SI-B001 in combination with paclitaxel or docetaxel in patients with recurrent or metastatic head and neck squamous cell carcinoma…
- Trial name
- NCT05054439
- Testing
- SI-B001, Paclitaxel, docetaxel
- Where
- 7 sites in China
- Volunteers
- 45 people
- Sponsor
- Sichuan Baili Pharmaceutical Co., Ltd.
Obesity
Psychological Symptoms Among Adolescents Enrolled in a Bariatric Surgery Program
This study will examine the interaction of psychological factors and serious overweight to determine if particular patterns of psychological symptoms are helpful in predicting outcomes of weight loss surgery.
- Trial name
- NCT01079377
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- New York State Psychiatric Institute
Acute Pain
Paravertebral Catheters for Pancreatic Surgery
Design: Level I randomized prospective outcomes study comparing two groups of patients. One group will receive bupivacaine and dilaudid thoracic epidural analgesia (PCA) post-operatively.
- Trial name
- NCT02363777
- Testing
- Epidural, Paravertebral catheters
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Ischemic Stroke, Acute
Molecular Characteristics of Phlegm-heat Syndrome in Ischemic Stroke
The molecular characteristics of ischemic stroke with phlegm-heat syndrome and candidate biomarkers were identified based on multi-omics data.
- Trial name
- NCT06470477
- Testing
- Guideline-based treatment
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Dongzhimen Hospital, Beijing
Pectus Excavatum
Post Operative Pain Control Using Ropivacaine and the ON-Q System in the Adult Pectus Excavatum Patient
Pectus excavatum (PE) is a common chest wall deformity where the sternum is displaced posteriorly. In severe cases, surgery is performed to correct the defect.
- Trial name
- NCT01816477
- Testing
- ON-Q soaker catheter system, Epidural (ropivicaine 0.25%)
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Mayo Clinic
Pain, Postoperative, Pain Sensitivity, Postoperative
Effect of Mobilization on Acute Postoperative Pain and Nociceptive Function
Aim of the present study is twofold. First we want to evaluate the effect of mobilization on acute postoperative pain Second to test weather chances in pain sensitivity are occurring following surgery and mobilization after total…
- Trial name
- NCT01018277
- Testing
- Mobilization (walking)
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Hvidovre University Hospital
Advanced Solid Tumord
Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TJ107 in Chinese Patients With Advanced Solid Tumors
This is a two-part study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of TJ107 in Chinese patients with advanced solid tumors.
- Trial name
- NCT04001075
- Testing
- TJ107
- Where
- 4 sites in China
- Volunteers
- 32 people
- Sponsor
- TJ Biopharma Co., Ltd.
Auditory Processing Disorder
An 'Off-the-shelf' Assistive Listening Device: Normal-hearing Children.
The cochlea, the sensory organ of hearing, is a structure of the temporal bone on the skull. In everyday life sounds are heard via air conduction.
- Trial name
- NCT03695575
- Testing
- Bone-conduction headset
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Children's Hearing Evaluation and Amplification Resource, Ltd.
Spinal Cord Injuries
FES-assisted Gait Intervention in People with Spinal Cord Injury - Pilot Study
A spinal cord injury (SCI) disrupts the communication within the nervous system, leading to limitations in sensorimotor activities such as walking.
- Trial name
- NCT05908175
- Testing
- FES-assisted gait training
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Stichting Reade
Parkinson Disease
LRRK2 Mutation and Parkinson's Disease
The Leucine-Rich Repeat Kinase 2 (LRRK2) is implicated in autosomal dominant Parkinson's disease (PKD). An inhibitor for the leucine-rich repeat kinase 2 (LRRK2) is in pre-clinical development for potential use in treating…
- Trial name
- NCT01424475
- Testing
- Healthy, PKD Patients
- Where
- United Kingdom
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Locally Advanced Non-small Cell Lung Cancer, Efficacy and Safety
Evaluating Efficacy and Safety of Anlotinib Combined With Concurrent Chemoradiotherapy Followed by Consolidation Immunotherapy for Locally Advanced Non-small Cell Lung Cancer
This is a prospective, randomized, controlled phase II clinical study for evaluating anlotinib combined with concurrent chemoradiotherapy followed by consolidation immunotherapy versus concurrent chemoradiotherapy followed by…
- Trial name
- NCT05481775
- Testing
- Anlotinib, Chemotherapy, Radiotherapy
- Where
- China
- Sponsor
- Sun Yat-sen University
Tobacco Use Cessation
Emergency Department Smoking Cessation Study
Tobacco smoke claims approximately 6000 lives annually in BC. In this study, the investigators will determine whether referring smoking patients from the Vancouver General Hospital Emergency Department to the investigators…
- Trial name
- NCT01454375
- Testing
- Referral to QuitNow Services
- Where
- Canada
- Volunteers
- 1,301 people
- Sponsor
- University of British Columbia
Visual Impairment, Macular Edema
A Clinical Study in Current Medical Practice of the Efficacy and Safety of Ranibizumab 0.5mg in Diabetic Patients Presenting a Visual Impairment Due to Macular Edema
The purpose of this study is to evaluate the proportion of patients with a 10 letters gain on Best Corrected Visual Acuity (BCVA) at 6 months in current medical practice.
- Trial name
- LUDIC (NCT01315275)
- Testing
- Ranibizumab
- Where
- 43 sites in France
- Volunteers
- 394 people
- Sponsor
- Novartis Pharmaceuticals
Obesity & Overweight
Comparative Effectiveness of Western Pharmacotherapy Versus Integrative Western and Traditional Chinese Medicine for Weight Management in Central Taiwan: A Real-World Cohort Study
Obesity is a major public health issue. While modern Western pharmacotherapies (e.g., GLP-1 receptor agonists) and Traditional Chinese Medicine (TCM) are utilized for weight management, the comparative effectiveness of their…
- Trial name
- NCT07646457
- Where
- Taiwan
- Volunteers
- 296 people
- Sponsor
- National Yang Ming Chiao Tung University
Locally Advanced Papillary Renal Cell Carcinoma, Metastatic Papillary Renal Cell Carcinoma
Testing Cabozantinib, Crizotinib, Savolitinib and Sunitinib in Kidney Cancer Which Has Progressed
This phase II trial studies how well cabozantinib s-malate, crizotinib, savolitinib, or sunitinib malate work in treating patients with kidney cancer that has spread from where it started to nearby tissue or lymph nodes or to…
- Conditions
- Locally Advanced Papillary Renal Cell Carcinoma, Metastatic Papillary Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v7, Stage IV Renal Cell Cancer AJCC v7
- Trial name
- NCT02761057
- Testing
- Biospecimen Collection, Bone Scan, Cabozantinib S-malate
- Where
- 595 sites in United States, Canada
- Volunteers
- 152 people
- Sponsor
- National Cancer Institute (NCI)
Anesthesia
Wound Infiltration With Ketorolac Versus Lidocaine for Postoperative Analgesia After Total Abdominal Hysterectomy
The main goal of this study is to compare wound infiltration with ketorolac versus lidocaine for postoperative analgesia in total abdominal hystrectomy (TAH) operation.
- Trial name
- NCT03394001
- Testing
- Wound infiltration, Lidocaine Hydrochloride, Ketorolac tromethamine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Schizophrenia Spectrum and Other Psychotic Disorders
A Randomized Controlled Trial With Rituximab for Psychotic Disorder in Adults
Immunological factors are assumed to be determinants for some psychiatric disorders, thus anti-inflammatory drugs may be helpful. However, studies on such treatments are scarce.
- Trial name
- RCT-RITS (NCT05622201)
- Testing
- Rituximab
- Where
- Sweden
- Volunteers
- 123 people
- Sponsor
- Region Örebro County
Asthma
Study of MAP0010 in Asthmatic Children and Adolescents
The objectives of this study are to evaluate the efficacy, tolerability and pharmacokinetics of 2 doses of MAP0010 (Unit Dose Budesonide) in asthmatic children/adolescents.
- Trial name
- NCT00697801
- Testing
- MAP0010 low dose, MAP0010 high dose
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Allergan
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