Clinical trials: A
Leukemia, Myeloid, Acute
A Study of AC220 Given After Transplant in Subjects With Acute Myeloid Leukemia (AML)
The purpose of this study is to define a safe dose of AC220 when given as maintenance therapy after treatment with an allogeneic stem cell transplant.
- Trial name
- NCT01468467
- Testing
- AC220
- Where
- 5 sites in United States
- Volunteers
- 13 people
- Sponsor
- Daiichi Sankyo
Nociceptive Pain
Cervical Neuromodulation and Nociceptive Processing
Several studies have demonstrated that direct currents delivered through the skin at the level of the lumbar spinal cord can influence spinal cord function.
- Trial name
- MICROVOLT (NCT05127200)
- Testing
- Starstim (Neuroelectrics)
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Depressive Disorder, Depressive Disorder, Treatment-Resistant
Effect of Psilocybin on the Positive Valence System in Treatment-resistant Depression
The study hypothesis is that the antidepressant effect of psilocybin is mediated by a normalization of the functioning of the positive valence system.
- Conditions
- Depressive Disorder, Depressive Disorder, Treatment-Resistant, Hallucinogens, Reinforcement, Psychology
- Trial name
- PSILODAC (NCT06650800)
- Testing
- Psilocybin, MRI
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Breast Cancer, Metastasis
Abemaciclib in Combination With Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
This is an open label multicenter, Phase IB/II Study of Abemaciclib in Combination with Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer
- Trial name
- NCT05095207
- Testing
- Abemaciclib, Bicalutamide
- Where
- 3 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cognition, Inflammation
Effects of Peanut Intake on Cognitive Functions
The study will test the effects of Peanuts on task-related brain activation and cognitive functions in older adults with memory complaints.
- Trial name
- NCT05532007
- Testing
- Peanuts, Habitual Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Breast Cancer
Molecular Signature for Breast Cancer
The main objective of this study is to evaluate and compare the diagnostic performance of a diagnostic assistance tool for analysis of 5 prognostic and predictive markers of breast cancer (HER2, Ki67 Index, Mitoses, Estrogen…
- Trial name
- MoSi4BCa (NCT05724407)
- Testing
- Diagnostic assistance tool
- Volunteers
- 220 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critically Ill, Intubation Complication
Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients
The aim of this retrospective cohort study is to compare the safety and efficacy of induction agents for tracheal intubation in critically ill adult patients.
- Conditions
- Critically Ill, Intubation Complication, Oxygenation, Airway Management
- Trial name
- NCT07222007
- Testing
- induction type for intubation in ICU
- Where
- United States
- Volunteers
- 806 people
- Sponsor
- Zeliha Alicikus
Hypoxic-ischemic Encephalopathy
Neonatal Erythropoietin in Asphyxiated Term Newborns
The purpose of this study is to determine the safety and pharmacokinetics of moderate to high doses of erythropoietin in newborn infants with birth asphyxia.
- Trial name
- NEAT (NCT00719407)
- Testing
- erythropoietin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Schistosomiasis Mansoni, Circulating Cathodic Antigen Urine Based Dipstick
Evaluation of the Use of a Urin Test Strip to Determine the Spread of Schistosoma Infections in Areas Where Schistosomiasis Infections Are Low in Kenya
The purpose of this study is to evaluate the use of a urine test strip in diagnose schistosoma mansoni in areas of Kenya where the rate of infections are low.
- Trial name
- NCT00463307
- Where
- Kenya
- Volunteers
- 1,100 people
- Sponsor
- DBL -Institute for Health Research and Development
Arthritis, Rheumatoid
A Phase 3 Study Comparing 2 Doses of CP-690,550 vs. Placebo for Treatment of Rheumatoid Arthritis
This Phase 3 study is intended to provide evidence of the efficacy and safety of CP 690,550 when dosed 5 mg and 10 mg twice a day as monotherapy in adult patients with moderate to severe Rheumatoid Arthritis.
- Trial name
- NCT00814307
- Testing
- CP-690,550
- Where
- 95 sites in United States, Brazil and 14 more
- Volunteers
- 611 people
- Sponsor
- Pfizer
Healthy Volunteers
A Study Comparing Two Ways of Taking Olomorasib (LY3537982) in Healthy Participants
The main purpose of this study is to compare how much and how quickly olomorasib gets into the bloodstream when it is taken in 2 different ways, and to check for any side effects.
- Trial name
- NCT07794592
- Testing
- Olomorasib test, Olomorasib reference
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Overeating, Overweight
Testing a Brief Mindful Eating Program
This project evaluated the effects of a brief manualized mindful eating intervention as a treatment for overeating with individuals with overweight and obesity.
- Conditions
- Overeating, Overweight, Obesity
- Trial name
- NCT04531436
- Testing
- Brief mindful eating intervention
- Where
- Canada
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- McGill University
Acute Myeloid Leukemia
Biology and Treatment Strategy of AML in Its Subgroups: Multicenter Randomized Trial by the German Acute Myeloid Leukemia Cooperative Group (AMLCG)
The study in patients with primary and secondary AML and high-risk MDS uses a risk-stratified, randomized design to evaluate the role of high-dose araC in induction, of G-CSF priming, and of autologous stem cell transplantation.
- Trial name
- NCT00266136
- Testing
- Cytarabine, Thioguanine, Daunorubicin
- Where
- Germany
- Volunteers
- 3,500 people
- Sponsor
- University Hospital Muenster
Chronic Lymphocytic Leukemia
Study of Immune Responses to Influenza Vaccination With or Without Imiquimod Application in Untreated CLL Patients
The purpose of the study is to determine whether it is possible to improve the immune response rate to 'flu vaccination in patients with chronic lymphocytic leukaemia (CLL).
- Trial name
- CLLIFVAC (NCT00596336)
- Testing
- Imiquimod cream, influenza vaccine
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The Royal Bournemouth Hospital
Metastatic Breast Cancer, Metastatic Colon/Rectum Cancer
Efficacy Study of [F-18]RGD-K5 Positron Emission Tomography (PET) as a Tool to Monitor Response to an Anti-angiogenic Drug
A Pilot Phase II Study The primary objective for this study is: To explore the usefulness of [F-18]RGD-K5 PET/CT to predict efficacy or early response to Avastin® (the anti-angiogenesis drug) plus chemotherapy treatment before…
- Conditions
- Metastatic Breast Cancer, Metastatic Colon/Rectum Cancer, Non-squamous Non-small Cell Lung Cancer
- Trial name
- K5-101 (NCT00988936)
- Testing
- [F-18]RGD-K5
- Where
- 8 sites in United States
- Volunteers
- 35 people
- Sponsor
- Siemens Molecular Imaging
Atrial Fibrillation
Multi-electrode PulmonarY Vein Isolation Versus Single Tip Wide Area Catheter Ablation for Paroxysmal Atrial Fibrillation (PAF)
The MYSTIC_PAF trial investigates the differences between treatment with a single-tip catheter against a multielectrode catheter in cardiac ablation procedures in patients with paroxysmal atrial fibrillation.
- Trial name
- MYSTIC-PAF (NCT01696136)
- Testing
- Cardiac ablation for Atrial Fibrillation
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- L.V.A. Boersma
Multiple Sclerosis, Nurse's Role
The Effect of Nurse Practitioner (NP-led) Care Upon Mood in People With Multiple Sclerosis
MS is the leading cause of non-traumatic disability in young adults. Canada and Alberta, have the highest prevalence of people with multiple sclerosis (PwMS) in the world.
- Trial name
- NCT04388592
- Testing
- Nurse Practitioner (NP) Led Care Arm
- Where
- Canada
- Volunteers
- 248 people
- Sponsor
- University of Alberta
Gestational Diabetes Mellitus as Antepartum Condition
Glycemic Impact of Myo-inositol in Pregnancy
Myo-inositol has been shown to decrease the rate of diabetes in pregnancy in European studies. It is not known exactly how this occurs or what it does to the sugar when the supplement is taken.
- Trial name
- NCT02149992
- Testing
- myo-inositol, Continuous glucose monitoring surveillance, Glucose monitoring
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Measles, Mumps
Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Children in Their Second Year of Life
The purpose of this study is to evaluate end of shelf-life potency in terms of the immunogenicity and safety of GSK Biologicals' trivalent MMR vaccine, by comparing it to Merck \& Co., Inc.'s MMR vaccine, which is approved for…
- Conditions
- Measles, Mumps, Rubella, Measles-Mumps-Rubella Vaccine
- Trial name
- NCT01681992
- Testing
- Priorix, M-M-R II, Varivax
- Where
- 81 sites in United States, Czechia and 5 more
- Volunteers
- 4,538 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bradycardia, Tachycardia
Randomized Study of the Use of Warfarin During Pacemaker or ICD Implantation in Patients Requiring Long Term Anticoagulation
Patients requiring long term anticoagulation often undergo transition of their warfarin to heparin in anticipation of invasive surgical procedures such as pacemaker or ICD implantation.
- Conditions
- Bradycardia, Tachycardia, Atrial Fibrillation, Valvular Heart Disease
- Trial name
- NCT00721136
- Testing
- continue warfarin through the procedure, Hold warfarin, Warfarin held with heparin transition.
- Where
- 2 sites in United States
- Volunteers
- 104 people
- Sponsor
- Johns Hopkins University
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