Clinical trials: A-PRF
Pulpitis - Irreversible
A-prf,Nanochitosan Combined With A-prf Compared to Chitosan for Symptomatic Irreversible Pulpitis of Mature Teeth
Clinical and radiographic assessment of A-prf,A-prf combined with nanochitosan compared to chitosan for symptomatic irreversible pulpits in lower permanent first molar
- Trial name
- NCT06438523
- Testing
- PULPOTOMY OF MATURE PERMENANT TEETH
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Dental Pulp Necroses
Efficacy of Regenerative Endodontic Treatment With PRF as a Secondary Treatment of Mature Necrotic Incisors in Adolescents
Evalaution of clinical success of secondary treatment for total 40 permanent incisors with failed root canal treatment with apical radiolucency.
- Trial name
- PRF (NCT05517187)
- Testing
- no intervention, Platelet rich fibrin
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nahda University
Sinus Floor Augmentation, Maxillary Sinus Floor Elevation
Evaluation of Lateral Sinus Floor Elevation Using Xenograft Versus L-PRF Block Combined With Xenograft
Rehabilitation of the posterior maxilla with dental implants is frequently complicated by insufficient residual bone height resulting from alveolar ridge resorption and maxillary sinus pneumatization.
- Conditions
- Sinus Floor Augmentation, Maxillary Sinus Floor Elevation, Sinus Lift, Xenograft
- Trial name
- NCT07677007
- Testing
- Lateral sinus lift with Xenograft Alone, Lateral sinus lift using L-PRF Block + Xenograft
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
A-PRF, ALLOGRAFT
Sticky Bone Compared to A-PRF(Platlet Rich Fibrin) Effect on Alveolar Ridge Preservation
In this research investigators are going to detect the effect of using different type of materials(sticky bone\platlet rich fibrin ) compared to normal healing on the dimensional changes of alveolar crest after single rooted…
- Trial name
- NCT05536492
- Testing
- A-PRF, ALLOGRAFT
- Where
- Palestinian Territories
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Arab American University (Palestine)
Pain, Edema
Leukocyte- and Platelet Rich Fibrin (L-PRF) Application in Impacted Mandibular Third Molar Removal Surgery
The purpose of this study was to evaluate the influence of leukocyte- and platelet-rich fibrin (L-PRF) on impacted mandibular third molar (IMTM) extraction wound healing, patient postoperative discomfort, and incidence of…
- Conditions
- Pain, Edema, Wound Heal
- Trial name
- NCT03357484
- Testing
- Leukocyte- and platelet rich fibrin, Blood clot
- Where
- Lithuania
- Volunteers
- 30 people
- Sponsor
- Lithuanian University of Health Sciences
Peri-Implantitis, Bone Resorption
Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF)
Platelet-rich fibrin (PRF) is a second-generation platelet concentrate used for tissue and bone regeneration. PRF releases growth factors such as TGF-β, PDGF, VEGF, IGF, and FGF, which are known to promote wound healing and bone…
- Conditions
- Peri-Implantitis, Bone Resorption, Platelet-Rich Fibrin
- Trial name
- PRF (NCT06679283)
- Testing
- Open flap debridement with a chemo-electric device + PRF, Open flap debridement with a chemo-electric device alone (control)
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bern
Necrotic Immature Permanent Teeth, Regenerative Endodontic Treatment
Application of Advanced Platelet-Rich Fibrin Plus (A-PRF+) in Revascularisation of Necrotic Immature Permanent Teeth
The goal of this clinical trial is to evaluate the effectiveness of an advanced platelet-rich fibrin plus (A-PRF+) revascularization procedure to promote healing and root development in necrotic immature permanent single-rooted…
- Conditions
- Necrotic Immature Permanent Teeth, Regenerative Endodontic Treatment, Pulp Regeneration, Root Maturation
- Trial name
- A-PRF+ (NCT07092488)
- Testing
- Advanced Platelet-Rich Fibrin Plus (A-PRF+) Revascularization Procedure
- Where
- Croatia
- Volunteers
- 28 people
- Sponsor
- University of Zagreb
Gingival Recession
Clinical Evaluation of Two Different Surgical Techniques With PRF in the Treatment of Multiple Gingival Recessions
This prospective clinical study aims to evaluate and compare the effectiveness of coronally advanced flap (CAF) and tunnel techniques, both combined with platelet-rich fibrin (PRF), in the treatment of multiple Miller Class I-II…
- Trial name
- NCT06986525
- Testing
- CAF with PRF, Tunnel with PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Gingival Recession, Gingival Recession, Localized
Coronally Advanced Tunnel Combined With Xenogenic Dermal Matrix and L-PRF
Gingival recession is the exposure of the root surface due to the gum margin moving away from the crown of the tooth. It's common in adults and becomes more prevalent and severe with age.
- Conditions
- Gingival Recession, Gingival Recession, Localized, Mucogingival Defects
- Trial name
- CAF+XADM (NCT06634043)
- Testing
- Coronally Advanced Tunel + ADM (Novomatrix®), Coronally Advanced Tunel + ADM (Novomatrix®) + L-PRF
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Andres Matteo Pascual La Rocca
Periodontitis
L-PRF Plus Non Surgical Periodontal Treatment
Abstract: Background: Leucocyte and Platelet-Rich Fibrin (L-PRF) has shown to promote regenerative processes, even reporting antibacterial effect.
- Trial name
- NCT04520438
- Testing
- Leukocyte and platelet rich fibrin, Non-Surgical Periodontal treatment
- Where
- Chile
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Intrauterine Adhesions
Clinical Study of i-PRF Intrauterine Perfusion for Endometrial Regeneration and Repair in Moderate to Severe Intrauterine Adhesions
Intrauterine adhesions (IUA) caused by endometrial basal layer injury can lead to reduced menstrual flow, infertility, recurrent pregnancy loss, and poor reproductive outcomes.
- Trial name
- IPRF-IUA (NCT07536971)
- Testing
- Injectable Platelet-Rich Fibrin, Sodium Hyaluronate
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Bone Regeneration
Guided Bone Regeneration With L-PRF in the Atrophic Maxilla - The GLAM Technique
16 patients with severe resorbed maxillae referred to Implantology Institute® will be submitted to full arch surgery, with simultaneous implant placement and regeneration in the aesthetic zone, with the GLAM technique.
- Trial name
- NCT03391258
- Testing
- Bone Regeneration with GLAM technique
- Where
- Portugal
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Implantology Institute
PRF
The Efficacy of A-PRF+ on Postoperative Outcomes Following Surgical Removal of Impacted Mandibular Third Molars (A-PRF+: Advanced Platelet Rich Fibrin)
Objectives: This study aims to evaluate the effects of A-PRF+ on postoperative pain, swelling, and trismus after surgical removal of impacted mandibular third molars.
- Trial name
- A-PRF+ (NCT05824793)
- Testing
- A-PRF+
- Where
- Vietnam
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Gingival Recession
Comparison of Using Collagen Membrane and A-PRF Using VISTA Technique in Gingival Recession Treatment
To assess the efficacy of minimally invasive Vestibular Incision Subperiosteal Tunnel Access (VISTA) with collagen membrane and Advanced Platelet-rich Fibrin (A-PRF) in the treatment of multiple buccal gingival recession type…
- Trial name
- NCT06357351
- Testing
- vestibular incision sub periosteal tunnel access ( VISTA) technique.
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Melasma, Facial Melasma
Injectable Platelet-Rich Fibrin Versus Intradermal Tranexamic Acid for Melasma
Melasma is a chronic acquired hyperpigmentation disorder that commonly affects the face and has a significant impact on quality of life.
- Trial name
- NCT07540702
- Testing
- Injectable Platelet-Rich Fibrin, Tranexamic acid 100 mg/mL (Kapron)
- Where
- Egypt
- Volunteers
- 21 people
- Sponsor
- Kasr El Aini Hospital
Extraction, Tooth, Tooth Fracture
Platelet-Rich Fibrin (PRF) vs Bone Graft With Membrane for Ridge Preservation After Tooth Extraction
This study uses a natural material called Platelet-Rich Fibrin (PRF) to help improve healing after tooth removal. PRF is made from your own blood.
- Conditions
- Extraction, Tooth, Tooth Fracture, Tooth Crown Fracture, Root; Fracture
- Trial name
- NCT07595198
- Testing
- Platelet-rich fibrin (PRF), Freeze-dried bone allograft, Collagen barrier membrane
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Alveolar Ridge Resorption
Different Approaches for Alveolar Ridge Preservation
Following tooth extraction, physiologic remodeling of the alveolar ridge results in significant horizontal and vertical bone resorption, often accompanied by soft tissue collapse.
- Trial name
- NCT07818447
- Testing
- Bone Allograft + Autologous Platelet-Rich Fibrin (PRF) Membrane, Control group, Bone Allograft + Resorbable Guided Bone Regeneration Membrane
- Where
- Greece
- Volunteers
- 51 people
- Sponsor
- Danae A. Apatzidou
Periodontal Diseases
Application of L-PRF in Periodontal Surgery
The study will compare the clinical outcomes of the two procedures, open flap debridement (OFD) compared to open flap debridement with leukocyte and platelet-rich fibrin (L-PFR) as well as differences in patient postoperative…
- Trial name
- NCT06296498
- Testing
- Leukocyte Platelet-rich fibrin, Standard of care OFD
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Gingival Recession
Connective Tissue Graft From Tuberosity Area and L-PRF Associated With Coronally Advanced Flap for Root Coverage
The aim of the present randomized controlled clinical study is to compare the efficacy of subepithelial connective tissue graft harvested from the maxillary retromolar tubeosity area and L-PRF membranes in the treatment of RT1…
- Trial name
- NCT05783258
- Testing
- Periodontal surgery with CAF+tSCTG, Periodontal surgery with CAF+L-PRF
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- G. d'Annunzio University
Dental Caries, Pulp Caping
Clinical and Radiographic Evaluation of Indirect Pulp Capping Using Platelet Rich Fibrin Versus Mineral Trioxide Aggregate in Deep Carious Molars: a Randomized Controlled Trial
The aim of this study is the clinical and radiographic evaluation of (Platelet-Rich Fibrin (PRF) versus Mineral Trioxide Aggregate (MTA) in indirect pulp capping when used with deep carious molars over 1 year follow up.
- Conditions
- Dental Caries, Pulp Caping, Indirect Pulp Treatment, Indirect Pulp Cap
- Trial name
- NCT06889363
- Testing
- MTA, PRF
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University