Clinical trials: A-PRF, open to volunteers
Partial Edentulism, Dental Implant Placement
Effect of Advanced PRF and Hyaluronic Acid on Dental Implant Healing
This randomized parallel-group clinical trial aimed to evaluate the clinical efficacy of advanced platelet-rich fibrin (A-PRF) combined with hyaluronic acid (HA) in enhancing peri-implant bone formation in patients undergoing…
- Trial name
- NCT07792720
- Testing
- Delayed Dental Implant Placement, Advanced Platelet-Rich Fibrin (A-PRF), Hyaluronic Acid 1.5%
- Where
- Yemen
- Volunteers
- 30 people
- Sponsor
- Samar Ali Abdu Salamah
Pudendal Neuralgia
Conventional Versus High-Voltage Long-Duration Pulsed Radiofrequency of the Pudendal Nerve
This study is a single-center, prospective, randomized controlled trial evaluating two types of pulsed radiofrequency (PRF) treatment for patients with pudendal neuralgia.
- Trial name
- NCT07356102
- Testing
- Intervention Type * Select the type of intervention. Procedure / Surgery Intervention Name * Enter a brief, descriptive name for the intervention. Use a non-proprietary (generic) name, if available, High-Voltage Long-Duration Pulsed Radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Ankara City Hospital Bilkent
Distal Hypospadias, Hypospadias
Fibrin-Enhanced TIP Versus Grafted TIP Urethroplasty in Distal Hypospadias
Hypospadias is a common congenital condition in boys in which the opening of the urethra is located on the underside of the penis.
- Trial name
- FTIP-RCT (NCT07319780)
- Testing
- Fibrin-Enhanced TIP Urethroplasty, Grafted TIP Urethroplasty
- Where
- 2 sites in Indonesia, Uzbekistan
- Volunteers
- 100 people
- Sponsor
- National Children's Medical Center, Uzbekistan
Hypospadias
Efficacy of PRF in Hypospadias Repair
Hypospadias is an anomaly characterized by an ectopic ventral urethral meatus, and an incomplete or hooded prepuce. Its incidence is estimated at 1 in 200-300 live male births, with variations across populations and severity…
- Trial name
- NCT07757828
- Testing
- Tubularized Incised Plate urethroplasty with intraoperative placement of autologous PRF onto the urethral plate., standard Tubularized Incised Plate urethroplasty
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Chronic Skin Ulcer
PRF With Topical Antibiotics or Antiseptics in Chronical Wounds Version 1.4
Platelet rich fibrin (PRF) is a new therapy option for chronic wounds with yet unproven therapeutic efficacy. This randomised controlled trial aims to provide evidence of the efficacy of PRF as monotherapy as well as a growth…
- Trial name
- PRF-TAT (NCT02652169)
- Testing
- PRF mixed with amikacin and teicoplanin, PRF mixed with PHMB plus Macrogolol, PRF plus normal saline
- Where
- Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Vienna
Peri-implant Mucosa Thickness
Hyaluronic Acid vs I-PRF With Microneedling in Enhancing Peri-implant Soft Tissue
This study aims to compare the use of microneedling alone versus with hyaluronic acid or i-PRF in conjunction with microneedling in peri-implant mucosa in the esthetic zone to test the superior increase in gingival thickness.
- Trial name
- NCT07750756
- Testing
- Hyaluronic Acid (HA), Platelet rich fibrin
- Volunteers
- 42 people
- Sponsor
- Ain Shams University
Thin Peri-implant Mucosal Phenotype
Peri-implant Soft Tissue Augmentation Using Microneedling With i-PRF vs. Connective Tissue Graft
This randomized controlled clinical trial aims to evaluate a minimally invasive technique for peri-implant soft tissue augmentation using microneedling combined with injectable platelet-rich fibrin (i-PRF) compared with the…
- Trial name
- NCT07667855
- Testing
- Connective Tissue Graft (CTG), Microneedling with Injectable Platelet-Rich Fibrin (MN+i-PRF)
- Where
- Lebanon
- Volunteers
- 24 people
- Sponsor
- Beirut Arab University
Tympanic Membrane Perforation, Chronic Otitis Media
Platelet-Rich Fibrin in Revision Cartilage Tympanoplasty
The aim of this study is to evaluate the success rate of revision surgery using a conchal cartilage graft supported with autologous platelet-rich fibrin (PRF), performed under local anesthesia, in patients who previously…
- Trial name
- NCT07893418
- Testing
- PRF-supported conchal cartilage tympanoplasty under local anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Osteonecrosis of the Jaw
Leukocyte- and Platelet-Rich Fibrin in the Surgical Treatment of Medication-related Osteonecrosis of the Jaw
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious side-effect of antiresorptive therapies used in the management of bone diseases, such as osteoporosis or bone metastases.
- Trial name
- PeRFOrMand (NCT06419010)
- Testing
- Surgery with the use of L-PRF, Standard surgery
- Where
- 7 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Toulouse
Gingival Recession
Evaluation of the Modified VISTA Technique Using ALB-PRF vs CTG in the Treatment of Multiple Miller Class III Recessions
treatment of miller class III RT2 gingival recession using modified vista technique using connective tissue graft vs albumin PRF
- Trial name
- NCT06643507
- Testing
- Connective tissue graft, ALB-PRF
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
PRF, Hypospadias
A Multicenter Randomized Controlled Trial Comparing Platelet-Rich Fibrin and Ventral Dartos Flap as Intermediate Layers in Tabularized Incised Plate (TIP) Urethroplasty for Distal Hypospadias With Mild Penile Curvature
Distal hypospadias is the most common form of hypospadias. The Tubularized Incised Plate (TIP) repair is the standard surgical technique for this condition; however, complications such as fistula formation and meatal stenosis…
- Conditions
- PRF, Hypospadias, Distal Hypospadias, Hypospadias Repair
- Trial name
- PRF (NCT07045545)
- Testing
- - Group A: Platelet-rich fibrin membrane prepared intraoperatively and applied over neourethra, Group B: Ventral dartos flap rotated over neourethra
- Where
- Uzbekistan
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- National Children's Medical Center, Uzbekistan
Maxillary Sinus Floor Augmentation, Alveolar Bone Loss
PRF vs. Graftless Sinus Lift With Implant Placement
The goal of this clinical trial is to evaluate the effectiveness of sinus floor elevation using platelet-rich fibrin (PRF) compared to a graftless approach in adult patients with atrophic posterior maxilla (residual bone height…
- Conditions
- Maxillary Sinus Floor Augmentation, Alveolar Bone Loss, Atrophy, Platelet-rich Fibrin
- Trial name
- NCT07090694
- Testing
- Graftless Transcrestal Sinus Floor Elevation with Immediate Implant Placement, Platelet-Rich Fibrin (PRF)-Assisted Transcrestal Sinus Floor Elevation with Immediate Implant Placement
- Where
- Saudi Arabia
- Volunteers
- 8 people
- Sponsor
- Dar Al Uloom University
TMJ Disc Displacement With Reduction
Ultrasound-guided Versus Arthroscopic Guided PRF Injection for TMJ Disc Displacement.
To compare the clinical effectiveness of ultrasound-guided versus arthroscopic guided platelet rich fibrin injection in the management of anterior disc displacement with reduction of the temporomandibular joint, in terms of pain…
- Trial name
- NCT07535073
- Testing
- ultrasound guided platelet rich fibrin injection, Arthroscopic guided platelet rich Fibrin injection
- Volunteers
- 18 people
- Sponsor
- Cairo University
Melasma, Facial Melasma
Injectable Platelet-Rich Fibrin Versus Intradermal Tranexamic Acid for Melasma
Melasma is a chronic acquired hyperpigmentation disorder that commonly affects the face and has a significant impact on quality of life.
- Trial name
- NCT07540702
- Testing
- Injectable Platelet-Rich Fibrin, Tranexamic acid 100 mg/mL (Kapron)
- Where
- Egypt
- Volunteers
- 21 people
- Sponsor
- Kasr El Aini Hospital
Gingival Recession, Gingival Recession, Localized
Coronally Advanced Tunnel Combined With Xenogenic Dermal Matrix and L-PRF
Gingival recession is the exposure of the root surface due to the gum margin moving away from the crown of the tooth. It's common in adults and becomes more prevalent and severe with age.
- Conditions
- Gingival Recession, Gingival Recession, Localized, Mucogingival Defects
- Trial name
- CAF+XADM (NCT06634043)
- Testing
- Coronally Advanced Tunel + ADM (Novomatrix®), Coronally Advanced Tunel + ADM (Novomatrix®) + L-PRF
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Andres Matteo Pascual La Rocca
Periodontitis, Periodontal Inflammation
PRF as Adjunct to Subgingival Instrumentation in Step 2 Periodontal Therapy
Periodontitis is characterized by a chronic, multifactorial inflammatory process driven by dysbiotic plaque biofilms. It is recognized as the most common chronic inflammatory non-communicable disease in humans.
- Conditions
- Periodontitis, Periodontal Inflammation, Periodontal Attachment Loss
- Trial name
- PRFSTEP2 (NCT07013682)
- Testing
- PRF as adjunct to non-surgical mechanical debridement, Control, non-surgical mechanical debridement alone
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Bern
Sinus Floor Augmentation, Maxillary Sinus Floor Elevation
Evaluation of Lateral Sinus Floor Elevation Using Xenograft Versus L-PRF Block Combined With Xenograft
Rehabilitation of the posterior maxilla with dental implants is frequently complicated by insufficient residual bone height resulting from alveolar ridge resorption and maxillary sinus pneumatization.
- Conditions
- Sinus Floor Augmentation, Maxillary Sinus Floor Elevation, Sinus Lift, Xenograft
- Trial name
- NCT07677007
- Testing
- Lateral sinus lift with Xenograft Alone, Lateral sinus lift using L-PRF Block + Xenograft
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Gingival Recession
Changes of Soft Tissue Grafting: A Randomized Study
To correct gum recession, patient's own tissue from the roof of the mouth is harvested and placed where there is root exposed. This is considered gold standard of treatment.
- Trial name
- NCT05633511
- Testing
- Split Mouth Design
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Tufts University
Papillary Reconstruction
Papillary Reconstruction Using Three Different Modalities
papillary reconstruction will be done by three techniques : injection of hyaluronic acid in the base of the papilla and booster doses can be required , injection of ALB-PRF which resorbs slowly and so longer effect the last…
- Trial name
- NCT07159802
- Testing
- Papillary reconstruction
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Periodontitis, Intrabony Periodontal Defect
Treatment of Intrabony Defects With Injectable Platelet-Rich Fibrin and Xenogenic Grafts
The use of injectable platelet-rich fibrin (i-PRF) in both surgical and non-surgical dental treatments has become increasingly widespread.
- Conditions
- Periodontitis, Intrabony Periodontal Defect, Periodontal Diseases, Periodontal Defect
- Trial name
- NCT07146776
- Testing
- open flap debridement with I-prf and xenogeneic graft, open flap debridement with saline and xenogenic graft
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi