Clinical trials: ACL Reconstruction, open to volunteers
Anterior Cruciate Ligament Reconstruction Rehabilitation
Effects of tDCS on Motor Cortex During ACL Recovery
Anterior Cruciate Ligament (ACL) is a prevalent injury, particularly among young and physically active individuals. The efficacy of transcranial direct current stimulation (tDCS) and exercise-based rehabilitation on neuromuscular…
- Trial name
- NCT06818201
- Testing
- NIBS, Rehabilitation
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
ACL - Anterior Cruciate Ligament Rupture
Soft-tissue Quadriceps Autograft ACL-reconstruction in the Skeletally-immature vs. Hamstrings
To date, the use of the quadriceps tendon as an autograft option in primary paediatric Anterior Cruciate Ligament (ACL) reconstruction has not been well studied.
- Trial name
- SQuASH (NCT03896464)
- Testing
- Soft tissue hamstring autograft, Quadriceps tendon autograft
- Where
- 6 sites in Canada, Japan
- Volunteers
- 352 people
- Sponsor
- McMaster University
Knee Injuries
Full Vs Partial Weightbearing During the First Six Weeks of Rehab. After Fibular Collateral Ligament Reconstruction
This is a prospective randomized controlled trial with the purpose to determine if patients undergoing fibular collateral ligament (FCL) reconstruction alone or combined FCL and anterior cruciate ligament (ACL) reconstructions…
- Trial name
- NCT05073263
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Twin Cities Orthopedics
Anterior Cruciate Ligament Injuries, Knee Injuries
Effects of Early Rehabilitation Using Blood Flow Restriction and/or Surface Electromyography Biofeedback on Quadriceps Activation and Strength After Anterior Cruciate Ligament Reconstruction: A Multicenter Randomized Controlled Trial
Many patients experience quadriceps inhibition after anterior cruciate ligament (ACL) reconstruction, delaying strength recovery, hindering return to sport, and potentially increasing the risk of re-injury.
- Conditions
- Anterior Cruciate Ligament Injuries, Knee Injuries, Muscle Weakness
- Trial name
- NCT07145606
- Testing
- Standard Rehabilitation, Blood Flow Restriction (BFR) Training, sEMG Biofeedback
- Where
- 4 sites in France, Switzerland
- Volunteers
- 200 people
- Sponsor
- Haute Ecole ARC Sante
ACL
Interventions to Enhance Quadriceps Output After ACLR
The investigators are interested in determining what treatments are effective in reducing inhibition after anterior cruciate ligament (ACL) surgery and helping people increase quadriceps strength.
- Trial name
- NCT07674784
- Testing
- NMES, Vibration
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Wisconsin, Madison
Anterior Cruciate Ligament
Robot-Assisted Versus Conventional Arthroscopic ACL Reconstruction: A Prospective Comparative Study
This study aims to evaluate the clinical efficacy and biomechanical accuracy of a newly developed robot-assisted system for anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT07086417
- Testing
- Robot-Assisted Arthroscopic ACL Reconstruction, Conventional Arthroscopic ACL Reconstruction
- Volunteers
- 120 people
- Sponsor
- Chunyan Jiang
ACL, Anterior Cruciate Ligament
Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction
The goal of this study is to gather pilot data to help inform a future clinical trial. As such, the investigators will employ a randomized clinical trial design, but data will only be collected on 9 total subjects.
- Conditions
- ACL, Anterior Cruciate Ligament, ACL Injury
- Trial name
- Mi-SPA (NCT06529692)
- Testing
- Split-Belt Training
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Michigan
Anterior Cruciate Ligament Reconstruction
Operation ACL: Rehabilitation After Anterior Cruciate Ligament Reconstruction
Scientific Research Question Overall Purpose: Regarding rehabilitation after anterior cruciate ligament reconstruction (ACLR), there is a knowledge gap - a lack of evidence.
- Trial name
- NCT06318039
- Testing
- Novel program, Traditional program
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Linnaeus University
ACL Reconstruction
Protein Supplementation After ACL Surgery
The purpose of the study is to assess the longitudinal post-operative care effects of protein supplementation on muscle atrophy in the post-operative period following ACL reconstruction.
- Trial name
- NCT06311058
- Testing
- Whey protein isolate, Protein + BAA
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- The Methodist Hospital Research Institute
Anterior Cruciate Ligament Rupture
BFRT in Adolescents After ACL Reconstruction
This is an interventional study that will examine effects of blood flow restriction training (BFRT) in adolescents aged 12-18 after anterior cruciate ligament reconstruction surgery (ACLR).
- Trial name
- NCT04390035
- Testing
- Blood Flow Restriction using Delfi Personalized Tourniquet System
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Healthcare of Atlanta
ACL Reconstruction
Kinesiophobia vs. Task-Specific Fear: Defining Movement-Related Fear in ACL Reconstruction Patients
Kinesiophobia, defined as an excessive and irrational fear of physical movement due to perceived vulnerability to injury, has gained significant attention in clinical and scientific communities.
- Trial name
- Ki-TASK-ACLR (NCT07190456)
- Testing
- Exposure to neutral images visualization, Exposure to nocive images visualisation, Exposure to anticipated realisation of a feared movement
- Where
- 2 sites in Portugal
- Volunteers
- 21 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Anterior Cruciate Ligament Injuries
Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction
To evaluate the effect of graded exposure and mindfulness meditation after ACLR, the investigators will determine the effect of graded exposure and mindfulness meditation to 1) decrease self-reported injury-related fear and…
- Trial name
- NCT05949177
- Testing
- Graded Exposure and Mindfulness Meditation, Waitlist Control
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of North Carolina, Chapel Hill
ACL Surgery, Quadriceps Strength
KEA vs Towel for Early Quad Activation Post Anterior Cruciate Ligament Reconstruction
The goal of this clinical trial is to learn if a novel Knee Extensors Activation (KEA) device can improve quadriceps muscle activation in adults after anterior cruciate ligament (ACL) reconstruction surgery.
- Trial name
- NCT07040384
- Testing
- Knee Extensors Activation (KEA) Device, Conventional Towel-Based Exercise
- Volunteers
- 40 people
- Sponsor
- Jouf University
Anterior Cruciate Ligament Reconstruction Rehabilitation, Quadriceps Muscle Function
Determining the Effects of Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After ACL Reconstruction
After knee surgery for a torn ACL, many women struggle with weak thigh muscles for years, partly due to reduced brain signals to these muscles.
- Trial name
- NCT07128602
- Testing
- active transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Arcadia University
Anterior Cruciate Ligament Injuries, Post-Traumatic Osteoarthritis of Knee
Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction
The goal of this pilot randomized clinical trial is to look into the efficacy of concentrated bone marrow aspirate (cBMA) in improving post traumatic osteoarthritis (PTOA) symptoms in patients undergoing revision anterior…
- Conditions
- Anterior Cruciate Ligament Injuries, Post-Traumatic Osteoarthritis of Knee, Bone Marrow Aspirate Concentrate, ACL Injury
- Trial name
- NCT06311513
- Testing
- Concentrated Bone Marrow Aspirate Injection, Revision Anterior Cruciate Ligament Reconstruction
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis (OA) of the Knee, ACL Reconstruction
Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction
Osteoarthritis (OA) is a condition that causes pain and stiffness in the joints, often due to injuries like torn ligaments. Even after surgery, these injuries can lead to long-term joint problems.
- Trial name
- PROTO-WP4 (NCT06596824)
- Testing
- Training intervention
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
ACL Injury, Meniscal Injuries
Intraoperative Energy Expenditure During ACL Reconstruction Surgery
This prospective observational study evaluates the intraoperative energy expenditure of the surgeon during anterior cruciate ligament reconstruction procedures.
- Trial name
- NCT07683247
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- ASL Lecce
ACL, LET
Long-term Clinical and Radiographic Results of Revision Anterior Cruciate Ligament Reconstruction Using a Single-bundle Technique and External Tenodesis With Achilles Tendon Allograft.
Several techniques for revision of anterior cruciate ligament (ACL) reconstruction and different types of grafts have been used over the years.
- Trial name
- ACL_REVISION (NCT06868147)
- Where
- Italy
- Volunteers
- 59 people
- Sponsor
- Stefano Zaffagnini
Anterior Cruciate Ligament Injury, Tunneling Technique
Evaluation of the Correlation Between Bone Tunnel Projection Placement and Clinical Outcomes in Anterior Cruciate Ligament Reconstruction Surgery
Anterior cruciate ligament (ACL) rupture is a common and clinically significant injury, particularly among young, active, and athletic adults, and may lead to knee instability and functional impairment.
- Conditions
- Anterior Cruciate Ligament Injury, Tunneling Technique, Tendon Graft; Complication, Mechanical
- Trial name
- NCT07876635
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sakarya University
Anterior Cruciate Ligament Reconstruction (ACLR), Anterior Cruciate Ligament Injury
Stair Biomechanics and Vibration Study After ACLR
This study examines how people who have had anterior cruciate ligament reconstruction (ACLR) move their legs during walking and stair negotiation, and whether a single session of vibration changes how they ascend and descend…
- Trial name
- NCT07922785
- Testing
- Whole-body Vibration, Local Muscle Vibraton, Control condition
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill