Clinical trials: ACL Tear
Anterior Cruciate Ligament Rupture
Liposomal Bupivacaine for Pain Control Following Anterior Cruciate Ligament Reconstruction
This study will consist of 80 patients ages 18 to 50 at the Emory Orthopaedic and Spine Center who are undergoing Anterior Cruciate Ligament (ACL) reconstruction with a quadriceps tendon autograft or bone patellar tendon bone…
- Trial name
- NCT02189317
- Testing
- Exparel
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Anterior Cruciate Ligament (ACL) Tear
Sciatic Technique Comparison of Nerve Blockade for Pain Control Following Hamstring Autograft Harvest in Adolescents
The purpose of this research is to compare the effect of single-injection sciatic PNB to continuous sciatic PNB on 1) postoperative pain control as measured by self-reported pain scores, pain medication use, and unplanned…
- Trial name
- NCT02947633
- Testing
- Single-injection sciatic PNB, Continuous sciatic PNB
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Reliability and Validity of Inline Dynamometry Study for Measuring Knee Extensor Torque
This study will investigate the reliability and validity of an inline 'pull-type' dynamometer for measuring peak knee extensor torque.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT05109871
- Testing
- KForce Link
- Where
- United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Knee Injuries
Clinical Trial Comparing Three Anterior Cruciate Ligament Reconstructive Procedures
The objective of this prospective study is to assess the clinical, functional and radiological outcomes of three different ACL reconstruction procedures: Bone Patella Bone graft, Single bundle hamstring graft and anatomical…
- Trial name
- NCT00418964
- Testing
- Single bundle hamstring, Double bundle hamstring, Bone patellar tendon bone
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Chinese University of Hong Kong
Anterior Cruciate Ligament Tear
Bridge-Enhanced ACL Repair vs ACL Reconstruction
The goal of this trial is to compare the efficacy of the Bridge-Enhanced Anterior Cruciate Ligament Repair (BEAR™) technique with the current method of treatment for anterior cruciate ligament (ACL) injuries, ACL reconstruction.
- Trial name
- NCT02664545
- Testing
- BEAR Scaffold, Tendon Graft
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Miach Orthopaedics
Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture
Effects of Platelet Rich Plasma Injections on Biomarkers After Anterior Cruciate Ligament Tears
A potential long-term consequence of anterior cruciate ligament injuries is the development of post-traumatic osteoarthritis in the years following injury.
- Trial name
- NCT04088227
- Testing
- Experimental Group, Control Group
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Andrews Research & Education Foundation
ACL Tear
Effects of Blood Flow Restriction Rehabilitation After Anterior Cruciate Ligament Reconstruction
The study is a prospective randomized control trial consisting of subjects requiring ACL reconstruction with BTB autograft. Subjects were randomly divided into two groups following their inclusion in the study.
- Trial name
- NCT04484961
- Testing
- Blood flow restriction (BFR)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Anterior Cruciate Ligament Tear
IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions
Injury to the knee during sports participation often involves partial or full detachment of the anterior cruciate ligament (abbreviated as ACL). ACL tears cause pain, swelling and inflammation.
- Trial name
- EASI ACL (NCT02930122)
- Testing
- anakinra (150mg), Saline intraarticularly
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cale Jacobs, PhD
Anterior Cruciate Ligament Tear, Knee Meniscus Tear
Adductor Canal Block Versus Femoral Block on Pain and Quadriceps Strength
The purpose of this study is to compare the effects of a femoral nerve block vs. an adductor canal block on pain and quadriceps muscle strength for knee arthroscopy surgery.
- Trial name
- NCT05190120
- Testing
- Femoral Nerve Block, Adductor Canal Nerve Block, preoperative Femoral Nerve Block using 20ml of 0.5% ropivacaine
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of California, San Francisco
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
The PreOperative Management of Patients Awaiting Anterior Cruciate Ligament Reconstruction
Patient experiences of the NHS ACL treatment pathway are unknown. This study aims to explore patient experiences of anterior cruciate ligament ruptures at three different time points on the patient pathway: (1) 12 participants up…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Rehabilitation
- Trial name
- POP-ACLR (NCT05529511)
- Testing
- Phase 1 - semi-structured interviews, Phase 2 - consensus meeting
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Anterior Cruciate Ligament Tear
Personalized Blood Flow Restriction for Anterior Cruciate Ligament Rehabilitation
This is a cross-sectional study on the use of personalized blood flow restriction during rehabilitation exercises and its effects on biomechanics on people who have had an anterior cruciate ligament reconstruction and healthy…
- Trial name
- NCT04635579
- Testing
- Blood flow restriction
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Washington
Anterior Cruciate Ligament Tear
Moderated Blood Flow Restriction After Anterior Cruciate Ligament Reconstruction
The aim of this study is to determine if there is a difference in post operative rehabilitation after anterior cruciate ligament (ACL) reconstruction surgery while using moderated blood flow therapy vs. standard physical therapy.
- Trial name
- Delfi (NCT02911909)
- Testing
- Delfi, Standard rehabilitation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Missouri-Columbia
Rupture of Anterior Cruciate Ligament
Evaluation of rGH Therapy to Prevent Muscle Atrophy in Patients With ACL Tears
Anterior cruciate ligament (ACL) tears are among the most frequent traumatic knee injuries that occur in physically active individuals.
- Trial name
- NCT02420353
- Testing
- Somatropin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Anterior Cruciate Ligament Tear
IPACK Versus Popliteal Sciatic Nerve Block in ACL Reconstruction
This is a prospective study comparing femoral nerve block plus sciatic nerve block to femoral nerve block plus infiltration of the posterior knee capsule (IPACK) in patients undergoing arthroscopic anterior cruciate ligament…
- Trial name
- NCT03983941
- Testing
- Ropivacaine injection
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Sujana Dontukurthy
Anterior Cruciate Ligament Rupture, Deficiency of Anterior Cruciate Ligament
Comparison of Three Methods for Anterior Cruciate Ligament Reconstruction
The purpose of this randomized clinical trial is to determine the difference in quality of life outcome at two years, in patients undergoing an Anterior Cruciate Ligament (ACL) reconstruction procedure with either a patellar…
- Conditions
- Anterior Cruciate Ligament Rupture, Deficiency of Anterior Cruciate Ligament, Chronic Instability of Knee, Anterior Cruciate Ligament Injury
- Trial name
- NCT00529958
- Testing
- Patellar Tendon, Hamstring Tendon, Double-Bundle
- Where
- Canada
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Anterior Cruciate Ligament Rupture
Initial Graft Tension and ACL Surgery
The anterior cruciate ligament (ACL) is one of four strong ligaments connecting the bones of the knee joint. If overstretched, the ACL can tear. Reconstruction of a torn ACL is now a common surgical procedure.
- Trial name
- NCT00434837
- Testing
- Initial graft tension during ACL reconstruction surgery
- Where
- 2 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Rupture of Anterior Cruciate Ligament, Tear of Anterior Cruciate Ligament
Trial Evaluating Postop Pain and Muscle Strength Among Regional Anesthesia Techniques for Ambulatory ACL Reconstruction
Despite the apparent multifaceted benefit in differentiating blockade sites and duration of nerve blockade, the efficacy of continuous adductor canal blockade utilized specifically in ACL reconstruction has not been extensively…
- Trial name
- NCT02584452
- Testing
- Mepivacaine, adductor canal continuous nerve catheter, Normal Saline as bolus followed by bupivacaine
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Vanderbilt University Medical Center
Blood Flow Restriction, ACL Tear
Blood Flow Restriction Training (BFR) in an Adolescent Population
While there are a number studies that have reported on the use of BFR in the adult population, there is limited information about the use of BFR in the adolescent population.
- Conditions
- Blood Flow Restriction, ACL Tear, ACL Injury
- Trial name
- NCT04285879
- Testing
- Blood Flow Restriction using Delfi Personalized Tourniquet System
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Connecticut Children's Medical Center
Anterior Cruciate Ligament (ACL) Tears
Early Treatment for Acute ACL Tear
This research study is the first of its kind and will allow health care professionals and researchers to answer many questions about the reasons why anterior cruciate ligament (ACL) injury leads to knee pain and disability and…
- Trial name
- AAA (NCT01692756)
- Testing
- Kenalog
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Cale Jacobs
Tibial Meniscus Injuries, Tibial Meniscus Tears
Success of Long-acting Anti-inflammatories After Anterior Cruciate Ligament and Meniscal Injury
The purpose of this study is to determine if extended-release triamcinolone acetonide treatment alters the progressive changes in bone shape previously demonstrated after anterior cruciate ligament (ACL) reconstruction with…
- Conditions
- Tibial Meniscus Injuries, Tibial Meniscus Tears, Tibial Meniscus, Torn, Anterior Cruciate Ligament Tear
- Trial name
- SLAM (NCT04331002)
- Testing
- Zilretta
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Austin V Stone