Clinical trials: ACL Tears
Rupture of Anterior Cruciate Ligament, Osteoarthritis
Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): Onsite Follow-up
In this study we will examine patients who have undergone unilateral ACL reconstruction surgery to determine which structural and functional characteristics of the knee two and ten years post reconstruction surgery, aspects of…
- Trial name
- MOON-Onsite (NCT00478894)
- Where
- 4 sites in United States
- Volunteers
- 432 people
- Sponsor
- Vanderbilt University
ACL Tear
Quadriceps Strengthening ACL Reconstruction
The purpose of this study is to characterize quadriceps function and squat biomechanics during the early strengthening phase in adolescent patients undergoing a standardized combined neuromuscular electrical stimulation (NMES)…
- Trial name
- ACL (NCT07015541)
- Testing
- NMES and BFR, Standard physical therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Exploring Prolonged AMR in ACL Reconstructed Patients
The goal of this observational study is to explore the significance of subject-reported outcomes and clinical parameters in relation to the occurence of prolonged presence of arthrogenic muscle responses (AMR) in anterior…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, ACL
- Trial name
- NCT06430775
- Where
- Belgium
- Volunteers
- 190 people
- Sponsor
- University Ghent
Knee Injuries
Clinical Trial Comparing Three Anterior Cruciate Ligament Reconstructive Procedures
The objective of this prospective study is to assess the clinical, functional and radiological outcomes of three different ACL reconstruction procedures: Bone Patella Bone graft, Single bundle hamstring graft and anatomical…
- Trial name
- NCT00418964
- Testing
- Single bundle hamstring, Double bundle hamstring, Bone patellar tendon bone
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Chinese University of Hong Kong
Anterior Cruciate Ligament Injuries, Quadriceps Muscle Atrophy
Vitamin D to Improve Quadricep Muscle Strength
Quadriceps muscle strength is one of the key determinants for patients to fulfill the Return-to-Play (RTP) criteria after an anterior cruciate ligament reconstruction (ACLR), in which the muscle size is directly linked to muscle…
- Conditions
- Anterior Cruciate Ligament Injuries, Quadriceps Muscle Atrophy, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT05174611
- Testing
- Vitamin D3
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
ACL Tear
Psychological Factors Influencing the Patient-reported and Functional Outcome of ACL Reconstruction and Their Sex-specific Differences
Psychological parameters among patients undergoing ACL reconstruction and their impact on the patient-reported and functional outcome of reconstruction will be prospectively evaluated
- Trial name
- NCT06156501
- Testing
- ACL Reconstruction
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
ACL Injury, ACL Tear
The Pediatric ALL Evaluation and Trial
The overall aim of this multicenter RCT is to determine whether concomitant ALL reconstruction in children undergoing and ACL reconstruction will longitudinally result in a lower rate of graft failure than ACL reconstruction…
- Trial name
- PALLET (NCT04825587)
- Testing
- Patients will be randomized into one of two study arms: (1) concomitant ACL and ALL reconstruction or (2) ACL reconstruction alone.
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Anterior Cruciate Ligament Rupture, Rehabilitation
Evaluation of the Effects of Home-based Functional Exercise on Patients With ACL
This study will evaluate the effect of home-based functional exercise on patients with anterior cruciate ligament rupture reconstruction based on the health belief model.
- Trial name
- NCT03890848
- Testing
- Wechat application reminder intervention, routine guidance during discharge
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Peking University Third Hospital
Rupture of Anterior Cruciate Ligament
Multicenter ACL Revision Study (MARS)
The purpose of this study is to determine the effects of modifiable risk factors on patient-reported quality of life, physical activity levels, and risk of early osteoarthritis following revision anterior cruciate ligament (ACL)…
- Trial name
- MARS (NCT00625885)
- Where
- 49 sites in United States, Canada
- Volunteers
- 1,234 people
- Sponsor
- Vanderbilt University Medical Center
Anterior Cruciate Ligament Rupture, Femoral Nerve Block
FNB in ACL Recon Under GA
The investigators will compare the results of sono-guided femoral nerve block in arthroscopic surgery for anterior cruciate ligament reconstruction under general anesthesia.
- Trial name
- NCT06048848
- Testing
- Sono-guided injection, Ropivacaine injection, Saline injection
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Chuncheon Sacred Heart Hospital
ACL Injury, ACL Tears
Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction
This is a prospective, multi-center, randomized, double-blind, placebo-controlled trial evaluating the efficacy of oral tranexamic acid (TXA) in improving postoperative outcomes following anterior cruciate ligament reconstruction…
- Conditions
- ACL Injury, ACL Tears, ACL Surgery
- Trial name
- NCT07115056
- Testing
- Tranexamic Acid (TXA)
- Where
- 6 sites in United States
- Sponsor
- Campbell Clinic
Anterior Cruciate Ligament Rupture
Allogeneic Bone-patellar Tendon-bone Transplantation
Objective To investigate the mid-term clinical effect of bone-patellar tendon-bone (BPTB) graft double-bundle reconstruction of the anterior cruciate ligament (ACL) of the knee joint under arthroscope.
- Trial name
- NCT04951531
- Testing
- BPTB double-bundle allograft, BPTB single-bundle allograft group, BPTB single-bundle autograft group
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Peking University Third Hospital
Anterior Cruciate Ligament Rupture
Arthroscopic ACL Reconstruction: Quadriceps Tendon vs Hamstring Tendon Autograft - A Prospective RCT
A prospective randomized controlled trial comparing functional outcomes of arthroscopic anterior cruciate ligament reconstruction using quadriceps tendon autograft versus hamstring tendon autograft at SMS Medical College, Jaipur.
- Trial name
- NCT07470944
- Testing
- Arthroscopic ACL Reconstruction
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Sawai Mansingh Medical College
ACL - Anterior Cruciate Ligament Deficiency
Comparison of Surgical Repair Versus Functional Treatment in Patients With Proximal ACL Tear
Isolated ruptures of the anterior cruciate ligament (ACL) can be proximal, distal or occur in the middle of the ACL. Treatment of patients with proximal lesions should be graded.
- Trial name
- SUTUFONC (NCT06178484)
- Where
- France
- Volunteers
- 144 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Reconstruction of the Anterior Cruciate Ligament of the Knee Joint, by the Method of Stabilization of the Screw With a Bioabsorbable Method, With or Without the Use of Autogenous Spongiform Bone Grafts.
Clinical and comparative evaluation of the results of autograft healing of the tendon of the semitendinus muscle in the tibial canal, after reconstruction of the anterior cruciate ligament of the knee joint, by the method of…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Knee Injuries
- Trial name
- NCT05328544
- Testing
- ACL reconstruction of the knee joint by arthroscopic technique, with the tibial fixation method using a bioabsorbable screw (Arthrex) with the use of autogenous cancellous bone grafts, ACL reconstruction of the knee joint by arthroscopic technique, with the tibial fixation method using a bioabsorbable screw (Arthrex) without the use of autogenous cancellous bone grafts
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- eMKa MED Medical Center
Anterior Cruciate Ligament Rupture
Tolerance, Efficacy, revAlidation, Myostim
Evaluation of efficacy and tolerance of a food supplement (MYOSTIM®) versus a placebo in postoperative revalidation of patients after reconstructive surgery of anterior cruciate ligament.
- Trial name
- NCT04684771
- Testing
- MYOSTIM®
- Where
- 2 sites in Belgium
- Volunteers
- 35 people
- Sponsor
- Alternativa International S.A
Anterior Cruciate Ligament Rupture
The Clinical Outcome of Anterior Cruciate Ligament Reconstruction
Retrospective cohort study. The investigators evaluated the early, middle and long term effects of different surgical methods of anterior cruciate ligament reconstruction on knee function.
- Trial name
- RCACLR (NCT03984474)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Anterior Cruciate Ligament Rupture
BFRT in Adolescents After ACL Reconstruction
This is an interventional study that will examine effects of blood flow restriction training (BFRT) in adolescents aged 12-18 after anterior cruciate ligament reconstruction surgery (ACLR).
- Trial name
- NCT04390035
- Testing
- Blood Flow Restriction using Delfi Personalized Tourniquet System
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Healthcare of Atlanta
Anterior Cruciate Ligament Rupture
Absorbable Interface Screw Clinical Trial
Validation of the safety and efficacy of absorbable interface screws for clinical use
- Trial name
- NCT05431790
- Testing
- Absorbable interface screws manufactured by Natong Biotechnology, Absorbable interface screws manufactured by INION.
- Volunteers
- 86 people
- Sponsor
- Peking University Third Hospital
Anterior Cruciate Ligament Rupture, Electroencephalography
Functional Connectivity After Anterior Cruciate Ligament Reconstruction
Background: Despite surgical reconstruction and rehabilitation, individuals after a primary anterior cruciate ligament injury have a significantly increased risk of relapse.
- Conditions
- Anterior Cruciate Ligament Rupture, Electroencephalography, Injuries
- Trial name
- FCACLR (NCT05487768)
- Testing
- EEG measurement
- Where
- Belgium
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent