Clinical trials: ACS
Acute Coronary Syndrome, Myocardial Infarction
Biomarkers in Acute Cardiac Care
The primary aim of the study is to investigate new cardiac biomarkers and algorithms to diagnose acute coronary syndrome in patients with suspected acute myocardial infarction.
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Chest Pain
- Trial name
- BACC (NCT02355457)
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Acute Coronary Syndrome, Coronary Stent Implantation
A Study of Low and Standard-dose Ticagrelor After Intervention for ACS Patients
This study is to evaluate the safety and efficacy of 60mg ticagrelor plus 100mg Aspirin to prevent major adverse cardiovascular and cerebrovascular events in one years after drug-eluting stents implantation for Chinese ACS…
- Trial name
- TIGER (NCT04255602)
- Testing
- Ticagrelor 60mg, Ticagrelor 90mg
- Where
- 8 sites in China
- Volunteers
- 2,120 people
- Sponsor
- Shanghai Tong Ren Hospital
Cardiac Rehabilitation, Acute Coronary Syndrome
Mobile Tele-Monitoring Guided Cardiac Rehabilitation in Post-Acute Coronary Syndrome Patients
Cardiac rehabilitation (CR) programmes are effective measures to reduce recurrent ischemic events in post-acute coronary syndrome (ACS) patients.
- Trial name
- REHAB+ (NCT05207072)
- Where
- 4 sites in Netherlands, Spain
- Volunteers
- 900 people
- Sponsor
- Maastricht University
Sickle Cell Disease (SCD), Acute Chest Syndrome (ACS)
CPAP for Hypoxemic Acute Chest Syndrome in Sickle Cell Disease
Sickle cell disease (SCD) is a severe hemoglobinopathy, considered the first monogenic disease in the world. Acute chest syndrome (ACS), one of the most frequent and serious complications of SCD, is defined by the association of…
- Trial name
- SIPAP (NCT07703566)
- Testing
- O2+CPAP group
- Volunteers
- 140 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Smoking, Acute Coronary Syndrome
Smoking Cessation for Patients With Acute Coronary Syndrome (ACS)
The aim of the present study is to assess if a personal care program of smokers hospitalised for acute coronary syndrome can change the smoking habits as compared with similar patients in conventional care program at 6 months.
- Trial name
- PATPAC (NCT00987597)
- Testing
- Technique of in-vivo exposure (cigarette) and mental image exposure (craving), conventional follow-up
- Where
- France
- Volunteers
- 144 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Cardiac Syndrome, Stent Thrombosis
REsponsiveness to CLOpidogrel and Stent-related Events in Acute Coronary Syndromes (RECLOSE 2 - ACS)
The main objective of the project is to assess the long-term prognostic impact of residual platelet reactivity after optimal antiplatelet therapy in a large cohort of patients with acute coronary syndrome undergoing invasive…
- Conditions
- Acute Cardiac Syndrome, Stent Thrombosis, Platelet Function, Antiplatelet Therapy
- Trial name
- RECLOSE2-ACS (NCT01231035)
- Where
- Italy
- Volunteers
- 1,789 people
- Sponsor
- Careggi Hospital
Acute Coronary Syndromes (ACS)
Sirolimus-Coated vs Paclitaxel-Coated DCBs in ACS Treatment
This study aims to investigate and compare the local inflammatory responses and plaque healing characteristics between sirolimus-coated and paclitaxel-coated coronary drug-coated balloons in patients with acute coronary syndrome.
- Trial name
- NCT07514988
- Testing
- Sirolimus-coated DCB, Paclitaxel-coated DCB
- Where
- China
- Volunteers
- 60 people
- Sponsor
- China National Center for Cardiovascular Diseases
Medication Adherence, Acute Coronary Syndrome
Improving Medication Adherence in Post-ACS Patients
Many post Acute Coronary Syndrome(ACS) patients do not take their medications (including aspirin) as prescribed, leading to an increase in mortality. Patients enrolled in this study will be enrolled into one of two groups.
- Trial name
- NCT00576160
- Testing
- PST therapy
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Columbia University
Pain, Sickle Cell Disease
Choosing Opioid Management for Pain and Analyzing Acute Chest Syndrome (ACS) Rates Equally
The pathophysiology of sickle cell disease (SCD) manifestations, are complex with interactions of intracellular hemoglobin, membrane and endothelial activation but the hallmark remains recurrent and painful vaso-occlusive…
- Trial name
- COMPARE (NCT01380197)
- Testing
- Morphine, Nubain
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Healthcare of Atlanta
Coronary Arterial Disease (CAD), Plaque
Intracoronary Cryotherapy Effect on Stabilization of Vulnerable Plaque in Patients With Stable Angina or ACS - A Traditional Feasibility Study
ICECAP is a multi-centre, prospective, single-arm, interventional, traditional feasibility clinical investigation to evaluate the efficacy and safety of intra-coronary cryotherapy on vulnerable or high-risk plaque (HRP), using…
- Conditions
- Coronary Arterial Disease (CAD), Plaque, Vulnerable Plaque, Cryotherapy
- Trial name
- ICECAP (NCT06939374)
- Testing
- Intracoronary Cryotherapy
- Where
- 3 sites in Belgium, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cryotherapeutics SA
Acute Coronary Syndrome (ACS), Myocardial Infarction
VITROS Immunodiagnostic Products hs Troponin I
The purpose of this clinical study is to collect data to substantiate the use of the VITROS hs Troponin I test as an aid in the diagnosis of myocardial infarction (MI).
- Trial name
- NCT03581578
- Where
- 24 sites in United States
- Volunteers
- 1,630 people
- Sponsor
- Ortho-Clinical Diagnostics, Inc.
Non-ST Elevation Myocardial Infarction, Acute Coronary Syndrome
Cardiac MRI Prior to Invasive Coronary Angiography in Patients With Suspected Non-ST-Elevation Myocardial Infarction
Patients with a suspected myocardial infarction are subdivided into ST-elevation and non-ST-elevation myocardial infarctions (STEMI and NSTEMI, respectively) using ECG.
- Trial name
- KaPSICA-CMR (NCT06566625)
- Testing
- Cardiac MRI (CMR) examination
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm
Acute Coronary Syndrome
Study of a Quality Improvement Toolkit in Kerala, India, Among Hospitals Treating Acute Coronary Syndrome Patients
The trial assesses the effect on 30-day major adverse cardiovascular event (MACE) rate of using a quality improvement toolkit among hospitals in Kerala, India.
- Trial name
- ACS QUIK (NCT02256657)
- Testing
- Quality Improvement Toolkit
- Where
- 63 sites in India
- Volunteers
- 21,374 people
- Sponsor
- Northwestern University
Vascular Diseases, Surgery
Monocentric Retrospective Observational Study; Analysis of Gore Excluder ACS Device Using Numerical Simulation
andated when the risk of rupture is low and interventional treatment is offered to patients at high risk of rupture. Rupture risk is driven by aneurysm diameter and growth rate.
- Trial name
- ACSSim (NCT06428877)
- Testing
- analyzed on the post-operative scanner
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Acute Coronary Syndromes, Secondary Prevention
triPle Oral thERapy With Bempedoic Acid vs uSual Care in Early Lipid Management of Patients With acUte coronAry synDromE
Early and intensive LDL-cholesterol (LDL-c) reduction is associated with improved short-term and long-term outcomes. Bempedoic acid is an oral ATP citrate lyase inhibitor that lowers LDL-c upstream of HMG-CoA reductase.
- Conditions
- Acute Coronary Syndromes, Secondary Prevention, Lipids
- Trial name
- PERSUADE (NCT07440381)
- Testing
- Triple oral lipid lowering treatment
- Where
- 35 sites in Italy
- Volunteers
- 600 people
- Sponsor
- Heart Care Foundation
ACS - Acute Coronary Syndrome
Telemedicine Follow-up for Post-ACS Patients
The aim is to compare the safety of using telemedicine and office visit follow-up in post-acute coronary syndrome patients
- Trial name
- NCT04485754
- Testing
- Telemedicine FU, Office FU
- Where
- Russia
- Volunteers
- 88 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Acute Coronary Syndrome (ACS)
Maintenance of Platelet Inhibition With Cangrelor
The purpose of this study is to demonstrate that patients receiving cangrelor infusion before coronary artery bypass grafting have an acceptable safety profile and can undergo surgery without excessive bleeding peri-operatively.
- Trial name
- Bridge (NCT00767507)
- Testing
- cangrelor
- Where
- United States
- Volunteers
- 221 people
- Sponsor
- The Medicines Company
Acute Coronary Syndrome
Cardiology-Emergency Medicine Cardiac Biomarker Research Initiative
This is an OBSERVATIONAL Specimen procurement and data collections trial for acute coronary syndrome that will be conducted in the Emergency Department at Henry Ford Hospital.
- Trial name
- ED~Cards (NCT01984853)
- Testing
- OBSERVATIONAL REGISTRY
- Where
- United States
- Volunteers
- 575 people
- Sponsor
- Henry Ford Health System
Diabetes Mellitus, Acute Coronary Syndrome
The POST-ACS Study
Individuals with T2DM have a two-fold excess risk of cardiovascular (CV) events compared with their non-diabetic counterparts. Although it is the primary cause of death in T2DM, there is no significant evidence that intensive…
- Conditions
- Diabetes Mellitus, Acute Coronary Syndrome, Coronary Artery Disease
- Trial name
- NCT05322200
- Testing
- A computerized tomography (CT) coronary angiogram, Vicorder (Skidmore medical, UK), Blood tests for inflammation and oxidative stress markers
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Swansea Bay University Health Board
Acute Coronary Syndrome
The Effectivity of the Mobile App "HARKIT I-Care" in Secondary Prevention in Post-ACS Patients
HARKIT I-Care is a mobile application developed by the National Cardiovascular Center Harapan Kita (NCCHK) to leverage patients in achieving their targets for the secondary prevention of cardiovascular diseases.
- Trial name
- NCT05622292
- Testing
- HARKIT I-Care Application
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia