Clinical trials: ACS
Coronary Artery Disease
ST Monitoring to Detect Acute Coronary Syndrome Events in Implantable Cardioverter Defibrillator Patients
This is a prospective, non-randomized, multicenter, pivotal Investigational Device Exemption (IDE) study. The intent of this study is to demonstrate the safety and effectiveness of the ST Monitoring Feature in St Jude Medical ICD…
- Trial name
- AnalyzeST (NCT01424722)
- Testing
- Fortify® ST, Fortify Assura® ST, Ellipse® ST family of devices
- Where
- 97 sites in United States
- Volunteers
- 2,258 people
- Sponsor
- Abbott Medical Devices
Acute Coronary Syndromes (ACS), Pneumonia
Analysis of Growth Differentiation Factor 15 (GDF-15), Mid Regional proAdrenomedullin (MR proADM), and Persepsin Levels in Patient in Acute Coronary Syndrome Patients With Pneumonia, With or Without Influenza Vaccination
The goal of this observational study is to analyze the relationship between various biomarkers (GDF-15, MR proADM, and Presepsin) in patients with Acute Coronary Syndrome (ACS) who also have Pneumonia and Chronic Obstructive…
- Conditions
- Acute Coronary Syndromes (ACS), Pneumonia, COPD (Chronic Obstructive Pulmonary Disease)
- Trial name
- NCT07604103
- Testing
- Vaxigrip, antibiotic treatments, percutaneus coronary intervention
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- University of Brawijaya
Non-ST-elevation Acute Coronary Syndromes
Exploring Efficacy of Intensive Rosuvastatin Treatment Peri-PCI in Chinese Patients With Non ST-segment Elevated Acute Coronary Syndrome(NSTE-ACS)
This is a 30-day, randomized, open-label, 3-arm, parallel-group, multicenter study exploring efficacy of intensive rosuvastatin treatment peri-PCI in Chinese patients with NSTE-ACS.
- Trial name
- NCT02284503
- Testing
- Rosuvastatin
- Where
- China
- Volunteers
- 1,350 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Coronary Syndrome
Randomized Trial of Prehospital Tropin Levels in Acute Coronary Syndrome (ACS)
This study randomizes patients seen by Redmond Medic One into a control arm and a study arm when they present with acute coronary syndrome and have non-contributory ECG's (i.e.non-STEMI).
- Trial name
- NCT00764205
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Redmond Fire Department Medic One
Acute Coronary Syndrome, Gender
Prospective Multicenter Registry of Gender, Diversity and Inclusion (GEDI) of Women With Acute Coronary Syndrome
Create a multicenter prospective registry that collects information from women affected by acute coronary syndrome (ACS). This registry aims to understand the diversity in the presentation of women with ACS.
- Conditions
- Acute Coronary Syndrome, Gender, Genetic Predisposition
- Trial name
- ACS GEDI (NCT06441942)
- Where
- 4 sites in Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Type 2 Diabetes Mellitus, Coronary Heart Disease
Glycemic Variability, Gut Microbiota, and Prognosis in T2DM With ACS
Patients with type 2 diabetes mellitus (T2DM) diagnosed with acute coronary syndrome (ACS) by coronary angiography in the Second Affiliated Hospital of Nanchang University were consecutively included in a prospective cohort…
- Trial name
- NCT06573060
- Testing
- Continuous glucose monitoring
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Acute Coronary Syndromes (ACS)
Early Intensive Lipid-Lowering With Inclisiran for Plaque Stabilization in Acute Coronary Syndrome
This multicenter, randomized, open-label clinical trial will evaluate whether an early intensive lipid-lowering strategy can improve coronary plaque stabilization in patients hospitalized with acute coronary syndrome.
- Trial name
- SEsiR-ACS (NCT07799779)
- Testing
- Inclisiran, Atorvastatin or Rosuvastatin, Ezetimibe
- Where
- South Korea
- Volunteers
- 294 people
- Sponsor
- Seoul National University Bundang Hospital
Acute Coronary Syndrome
Rapid Assessment of Cardiac Markers for the Evaluation of Acute Coronary Syndrome (RACE-ACS)
This clinical trial is being conducted to 1) evaluate the possible usefulness of a panel of cardiac markers in assessing emergency department patients with possible acute coronary syndrome, 2) evaluate the usefulness of BNP in…
- Trial name
- NCT00206817
- Testing
- Triage CardioProfilER (Troponin I, Myoglobin, CK-MB, BNP)
- Where
- 6 sites in United States
- Sponsor
- Abbott RDx Cardiometabolic
Acute Coronary Syndrome
Atorvastatin Versus Rosuvastatin on Contrast Induced Acute Kidney Injury (PRATO-ACS 2)
The aim of the project is to compare the nephro-protective effects of high-dose atorvastatin and high-dose rosuvastatin on the incidence of Contrast Induced-Acute Kidney Injury in patients with non-ST-elevation acute coronary…
- Trial name
- PRATO-ACS-2 (NCT01870804)
- Testing
- Rosuvastatin, Atorvastatin
- Where
- Italy
- Volunteers
- 760 people
- Sponsor
- Centro Cardiopatici Toscani
Myocardial Ischemia
Multimodality Investigation of Intermediate Culprit Lesion With Negative FFR in NSTE-ACS
Ten-fifteen percent of acute coronary syndromes without ST-segment elevation (NSTE-ACS) are caused by intermediate lesions without signs of unstable plaque.
- Trial name
- SHERLOCK (NCT03205514)
- Testing
- NSTE-ACS with intermediate stenosis and negative FFR
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University Hospital of Ferrara
Acute Coronary Syndrome/ Myocardial Infarction, Coronary Artery Disease
Enabling Patient-Reported Outcomes Through Innovative Care - ACS (EPIC-ACS)
This study evaluates the effectiveness of an innovative care approach that integrates face-to-face education, motivational counseling, and mobile health (mHealth) support delivered via the LINE application among Thai older adults…
- Trial name
- NCT07390006
- Testing
- Innovative Care Approach, Usual Post-Acute Coronary Syndrome Care
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Acute Coronary Syndrome
Statin Contrast Induced Nephropathy Prevention
This open-label study, prospective, randomized trial evaluating the acute (in-hospital) pleiotropic and clinical effects of a hydrophilic statin (rosuvastatin) in patients with acute coronary syndrome
- Trial name
- PRATO-ACS (NCT01185938)
- Testing
- Rosuvastatin
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Centro Cardiopatici Toscani
Acute ST Segment Elevation Myocardial Infarction, Acute Coronary Syndrome
Comparing Ticagrelor and Clopidogrel Pharmacodynamics After Thrombolysis
This study involves doing platelet function testing in patients who have undergone fibrinolysis. Fibrinolysis (Use of clot busting medicine in heart attack) is the standard of care to restore blood flow in blocked arteries as…
- Trial name
- TACAT (NCT02048085)
- Testing
- Ticagrelor, Clopidogrel
- Where
- United States
- Sponsor
- Medical Center of South Arkansas
Acute Coronary Syndrome
Study to Validate Simple Acute Coronary Syndrome Score
The Simple Acute Coronary Syndrome (SACS) Score was developed as a Risk Stratification Tool for Acute Coronary Syndrome (ACS). It is a tool which rates a patient's: SYMPTOMS, EKG FINDINGS, RISK FACTOR PROFILE, and CARDIAC MARKERS…
- Trial name
- SACS Score (NCT00947804)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital, Florida
Angina, Unstable
Diagnosis and Treatment of ACS in the ED: The Impact of Rapid Bedside cTnI Testing on Outcomes
In a randomized, controlled clinical trial, point-of care testing at the bedside using the cardiac biomarker troponin I in ED patients with possible ACS will be compared to traditional testing of this assay for myocardial…
- Trial name
- Dispo-ACS (NCT00222352)
- Testing
- Point of Care cTnL testing
- Where
- 4 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- University of Cincinnati
Autonomous Cortisol Secretion (ACS), ACTH-Independent Cushing Syndrome
SPI-62 as a Treatment for Hypercortisolism Related to a Benign Adrenal Tumor
This is study with SPI-62 to evaluate the efficacy, safety, and pharmacological effect of SPI-62 in subjects with hypercortisolism related to a benign adrenal tumor. Each subject will receive 2mg of SPI-62 daily.
- Conditions
- Autonomous Cortisol Secretion (ACS), ACTH-Independent Cushing Syndrome, ACTH-Independent Adrenal Cushing Syndrome, Somatic
- Trial name
- ACSPIRE (NCT05436639)
- Testing
- SPI-62 dose
- Where
- 5 sites in United States, Romania and 1 more
- Volunteers
- 30 people
- Sponsor
- Sparrow Pharmaceuticals
Heart Attack, Stroke
ACS Registry - A Non-interventional Study to Estimate the Rates of Outcomes in ACS Patients in Moscow
Cardiovascular diseases (CVD) are currently the leading cause of death in industrialized countries and are expected to become the leading cause of death in emerging countries by 20201.
- Conditions
- Heart Attack, Stroke, Cardiovascular Death
- Trial name
- NCT03654157
- Where
- 27 sites in Russia
- Volunteers
- 1,576 people
- Sponsor
- AstraZeneca
Acute Coronary Syndrome (ACS)
Assessment of Endothelial Vasomotricity After Treatment by Nicotinic Acid in Acute Coronary Syndrome
The investigators' work proposes to evaluate the effectiveness of the Acid Nicotinique (Niaspan®), only molecule currently marketed, ready to raise the plasmatic levels of HDL-c.
- Trial name
- EVANACS (NCT00855257)
- Testing
- Acid Nicotinique
- Where
- France
- Volunteers
- 93 people
- Sponsor
- French Cardiology Society
Acute Coronary Syndromes (ACS), Adherence
Adherence to Secondary Prevention Drugs and Influencing Factors After Acute Coronary Syndrome in Patients at a Tertiary Center in Nepal
This study aimed to assess adherence to secondary prevention medications among patients in Nepal following an Acute Coronary Syndrome (ACS) event and to identify factors affecting adherence.
- Trial name
- NCT07288502
- Testing
- My Experience of Taking Medicines (MYMEDS) questionnaire
- Where
- Nepal
- Volunteers
- 109 people
- Sponsor
- Institute of medicine, Maharagjung medical campus
Depression
Treatment of Depression in Acute Coronary Syndrome (ACS) Patients
Emotional states of depression in association with ischemic heart diseases, such as myocardial infarction or unstable angina, are risk factors for subsequent cardiac events and mortality.
- Trial name
- TREATED-ACS (NCT00998400)
- Testing
- CBT in combination with WBT and life style modification
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Bologna