Clinical trials: ACTH
Kidney Diseases
Idiopathic Focal Segmental Glomerulosclerosis (FSGS) and Treatment With ACTH
FSGS is an immunologic disorder wherein circulating immune proteins cause damage to the kidneys and progressive injury and scarring.
- Trial name
- NCT01155141
- Testing
- H.P. Acthar Gel
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Dermatomyositis, Juvenile Dermatomyositis
Efficacy and Safety of H.P. Acthar Gel for the Treatment of Refractory Cutaneous Manifestations of Dermatomyositis
This study will assess the safety and efficacy of H.P. Acthar gel for treating the cutaneous manifestations in patients with refractory classic dermatomyositis, juvenile dermatomyositis, and amyopathic dermatomyositis.
- Trial name
- NCT02245841
- Testing
- H.P. Acthar Gel
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- The Cleveland Clinic
Sarcoidosis, Pulmonary
Acthar Gel in Participants With Pulmonary Sarcoidosis
The purpose of this study is to find out if Acthar Gel is safe and effective to treat pulmonary sarcoidosis. Participants will be randomly assigned (like flipping a coin) to receive a shot under their skin of Acthar Gel or a…
- Trial name
- PULSAR (NCT03320070)
- Testing
- Acthar Gel
- Where
- 29 sites in United States
- Volunteers
- 55 people
- Sponsor
- Mallinckrodt
Adrenal Incidentaloma, Cortisol Overproduction
Morbidity and Mortality in Autonomous Cortisol Secretion
Benign enlargements of the adrenal glands (adrenal adenomas) are frequent in adults. In the general population these adenomas are rare in subjects below 40 years of age but at the age of 60 and 80 years the prevalence is 6 and…
- Trial name
- NCT03919734
- Where
- Sweden
- Volunteers
- 4,596 people
- Sponsor
- Region Skane
Preterm Birth Complication, Stress Related Disorder
Effect of Maternal Odor and Kangaroo Care on Serum Cortisol and Comfort Levels in Preterm Infants: a Randomised Trial
Aims and objectives: Studies on stress are generally aimed at young children and infants. However, in the neonatal period, "especially in preterm babies", this issue was not given enough attention and was almost completely…
- Conditions
- Preterm Birth Complication, Stress Related Disorder, Cortisol Overproduction
- Trial name
- NCT05607706
- Testing
- Exposure to maternal odor
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Istanbul Nisantasi University
Cushing's Disease, Hypercortisolism
Osilodrostat Therapy and 11C-methionine PET to Improve Corticotroph Adenoma Detection
Cushing's disease is a rare condition where the body produces too much of a hormone called cortisol. Cortisol helps with metabolism, the immune system, and managing stress.
- Conditions
- Cushing's Disease, Hypercortisolism, Pituitary Adenoma, Pituitary ACTH Secreting Adenoma
- Trial name
- OPTIMAL (NCT06701838)
- Testing
- 11C-Methionine PET/CT
- Volunteers
- 15 people
- Sponsor
- Imperial College London
Dry Eye Disease
Clinical Efficacy of H.P. Acthar Gel 80 U/ml to Improve the Signs and Symptoms in Subjects With Dry Eye Disease
Study Title: A Phase 4 Study to Assess the Clinical Efficacy of H.P. Acthar Gel 80 U/ml to Improve the Signs and Symptoms in Subjects with Dry Eye Disease
- Trial name
- NCT03287635
- Testing
- Corticotropin 80Unit/Ml Repository Injection
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Toyos Clinic
Idiopathic Focal Segmental Glomerulosclerosis
Acthar for Treatment-Resistant or Treatment-Intolerant Proteinuria
Focal segmental glomerulosclerosis (FSGS) is a condition that harms the kidney "filters" that remove waste from the blood. Proteins are supposed to stay in the blood. Damaged "filters" let protein get into the kidney.
- Trial name
- PODOCYTE (NCT02633046)
- Testing
- Acthar Gel
- Where
- 47 sites in United States, Argentina and 5 more
- Volunteers
- 63 people
- Sponsor
- Mallinckrodt ARD LLC
Breast Cancer, Fatigue
Role of Beta-Endorphin in Cancer Therapy Fatigue
The investigators aim to test whether beta-endorphin, a substance our bodies make in response to painful and stressful stimuli, plays a causative role in radiation-induced fatigue that cancer patients receiving radiation therapy…
- Trial name
- NCT01113905
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Massachusetts General Hospital
Exercise Immunology, Exercise Physiology
Effects of Whole-Body HIIT and Moderate Continuous Exercise on Immune Function
This randomized controlled trial aimed to investigate the effects of a 12-week Whole-Body High-Intensity Interval Training (WB-HIIT) program compared with Moderate-Intensity Continuous Training (MICT) on immune function in…
- Trial name
- WBHIIT-IMM (NCT07618455)
- Testing
- Whole-Body High-Intensity Interval Training (WB-HIIT), Moderate-Intensity Continuous Training (MICT)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bitlis Eren University
Sarcoidosis, Pulmonary Sarcoidosis
Acthar Gel for Chronic Pulmonary Sarcoidosis (ACPS)
An randomized trial of two maintenance doses of Acthar Gel for patients with chronic pulmonary sarcoidosis. Patients will be observed for 24 weeks of treatment.
- Trial name
- ACPS (NCT02188017)
- Testing
- Acthar gel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Cushing's Disease, Corticotrophin Adenoma
Targeted Therapy With Gefitinib in Patients With USP8-mutated Cushing's Disease
The USP8 gene and its downstream target, epidermal growth factor receptor (EGFR), is a potential therapeutic target of Cushing disease.
- Trial name
- NCT02484755
- Testing
- Gefitinib
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Huashan Hospital
Pain, Beta-endorphin
Double-blind, Randomized Controlled Study to Assess the Analgesic Effect of 2 g of Magnesium Dipyrone (Metamizol) and Changes in Plasma Beta-endorphin Immunoreactivity Values in Patients Undergoing Elective Inguinal Herniorrhaphy Under Epidural Anesthesia.
A double-blind, randomized controlled study is designed to assess the analgesic effect of a single intravenous dose of 2 g of magnesium dipyrone (metamizol) and whether the administration of the active drug will be associated…
- Conditions
- Pain, Beta-endorphin, Dipyrone, Hernia Surgery
- Trial name
- NCT04595877
- Testing
- Dipyrone administration, Pain assessment, beta-endorphin immunoreactivity
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Antonio Martín Duce
Scleritis
A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis
ATLAS study is a clinical trial to evaluate the potential role of subcutaneous adrenocorticotropic hormone (ACTH) gel in the management of non-infectious scleritis.
- Trial name
- ATLAS (NCT03465111)
- Testing
- ACTH (adrenocorticotropic hormone) gel
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Metropolitan Eye Research & Surgery Institute
Dermatomyositis, Polymyositis
Dermatomyositis and Polymyositis Registry
By creating a registry, physicians will have the opportunity to understand the clinical outcomes of Myositis patients treated with Acthar.
- Trial name
- ADAPT (NCT01637064)
- Testing
- Acthar
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Phoenix Neurological Associates, LTD
Multiple Sclerosis
Evaluation of the Response to Acthar Gel Therapy in Patients Who Failed Intravenous Methylprednisolone (IVMP) for MS Relapses
Although ACTHAR gel is approved for the treatment of acute relapses, it is currently not widely used. Thus, we propose to conduct a small open-label proof-of-concept trial to evaluate the response to ACTHAR gel therapy in…
- Trial name
- NCT01900093
- Testing
- Acthar Gel
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Aaron Miller
Menopause
Cortisol Levels on Menopausal Symptoms - Ancillary (Addendum) Study to Protocol 16997
This is an ancillary study to Protocol 16997 to examine the stress hormone level in women with menopausal symptoms. This ancillary project will collect additional data from the 45 subjects enrolled in Protocol 16997 (no subjects…
- Trial name
- NCT00950781
- Testing
- ACTH
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Postural Tachycardia Syndrome
Adrenocorticotropic Hormone Stimulation in Postural Orthostatic Tachycardia Syndrome (POTS)
This study is to determine different chemical levels in the blood during a low salt diet. This study will compare normal volunteers to those with Postural Tachycardia Syndrome (POTS)
- Trial name
- NCT01764711
- Testing
- Cosyntropin administration
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Systemic Lupus Erythematosus (SLE)
Acthar for the Treatment of Systemic Lupus Erythematosus (SLE) in Patients With a History of Persistently Active Disease
This Phase 4 study is being performed to examine the effects of Acthar for the indicated use of treatment of SLE. This study will enroll patients with steroid-dependent, persistently active SLE with arthritic and/or cutaneous…
- Trial name
- NCT01753401
- Testing
- Acthar, Steroid Drug
- Where
- 22 sites in United States
- Volunteers
- 38 people
- Sponsor
- Mallinckrodt
Multiple Sclerosis
Comprehensive Analysis of Relapse in Multiple Sclerosis
This study will determine changes in: 1) the immune activity, characterized as the "immunorepertoire;" 2) 7 Tesla MRI brain images; 3) clinical outcomes; and 4) patient reported quality of life outcomes in subjects with…
- Trial name
- NCT01906684
- Testing
- Acthar Gel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tanner Foundation for Multiple Sclerosis