Clinical trials: AD - Alzheimer's Disease
Alzheimer's Disease
A Multicenter, Double Blind, Placebo-Controlled, Safety and Tolerability Study of BMS-708163 in Patients With Prodromal Alzheimer's Disease
The purpose of this study is to determine the safety and tolerability of BMS-708163 in patients with Prodromal Alzheimer's disease over a treatment period of a minimum of 104-weeks.
- Trial name
- NCT00890890
- Testing
- Avagacestat
- Where
- 64 sites in United States, Canada and 4 more
- Volunteers
- 263 people
- Sponsor
- Bristol-Myers Squibb
Mild Cognitive Impairment (MCI), Mild Alzheimer's Disease
Sensory-cognitive and Physical Fitness Training in Mild Cognitive Impairment
Age-related cognitive decline is unavoidable. However, recent results of neuroplasticity-based research show that neuroplasticity-based training and physical activity might have the potential to decelerate or even reverse effects…
- Trial name
- NCT01061489
- Testing
- auditory discrimination training, physical movement training
- Where
- 2 sites in Germany
- Volunteers
- 65 people
- Sponsor
- University of Konstanz
Alzheimer's Disease
Memantine and Comprehensive, Individualized Management of Alzheimer's Disease and Caregiver Training
The purpose of this study is to determine whether a comprehensive, individualized management approach with caregiver training and medication with memantine will alleviate symptoms in community dwelling patients with moderate to…
- Trial name
- NCT00120874
- Testing
- Individualized management of AD including caregiver training, Memantine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Alzheimer Disease
Alzheimer's Disease Stem Cells Multiple Infusions
The purpose of this research study is to test the safety, possible side effects, and possible effectiveness of mesenchymal stem cell infusions when given to people with a diagnosis of mild to moderate Alzheimer's disease.
- Trial name
- NCT04040348
- Testing
- Approximately 100 million cells allogeneic hMSC
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Bernard (Barry) Baumel
Dementia, Alzheimer Disease
Assessing Acceptability, Cost, and Efficacy of STELLA-Support Via Technology
STELLA (Support via Technology Living and Learning with Advancing Alzheimer's disease and related dementias) is a multicomponent video-conference based intervention that aims to help family members caring for persons of dementia…
- Conditions
- Dementia, Alzheimer Disease, Caregiver Burnout, Family Members
- Trial name
- STELLA (NCT04335110)
- Testing
- STELLA (Support via TEchnology: Living and Learning with Advancing Alzheimer's disease and related dementias)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Oregon Health and Science University
Alzheimer Disease
P75NTR, Diagnostic Biomarker for Alzheimer's Disease: Quantification Study in Cerebrospinal Fluid
This research will be achieved by the assessment of p75NTR-ECD expression (total and linked to different species of Aβ (Aβ1-40 and Aβ-1-42)) within the cerebrospinal fluid (CSF) of patients with AD dementia, mild cognitive…
- Trial name
- P75NTR-MND (NCT02946710)
- Testing
- cerebrospinal fluid
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Toulouse
Alzheimer Disease, Parkinson Disease
An Exploratory Study to Confirm Efficacy of Modified Deep Cervical Lymphovenous Anastomosis (LVA) in Alzheimer's Disease/ Parkinson's Disease
Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by pathological protein accumulation in the brain-Aβ/tau in AD and α-synuclein in PD.
- Trial name
- SOLVEN (NCT06852352)
- Testing
- Modified deep cervical Lymphatic-Venous Anastomosis
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Zhejiang Provincial People's Hospital
Alzheimer Disease
At Home Gamma tACS in Alzheimer's Disease (tACS@Home)
Brain oscillations are ubiquitous in the human brain and have been implicated in cognitive and behavioral states defined in precisely tuned neural networks.
- Trial name
- tACS@Home (NCT05643326)
- Testing
- 40 Hz transcranial alternating current stimulation
- Where
- Italy
- Volunteers
- 53 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Alzheimer Disease, Subjective Cognitive Decline
Early Diagnosis of SCD Based on Radiogenomics
The incidence of AD dementia is increasing due to the aging population, putting a heavy burden on our society and economics. Exploring the mechanisms underlying SCD due to preclinical AD has scientific and clinical significance.
- Conditions
- Alzheimer Disease, Subjective Cognitive Decline, Neuroimaging, Gene
- Trial name
- NCT04696315
- Testing
- Multiple features extraction
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Ying Han
Alzheimer Disease, Mild Cognitive Impairment
TPSAlz - Transcranial Pulse Stimulation in Alzheimer's Disease
The goal of this study is to evaluate the effects of transcranial pulse stimulation (TPS) in modulating cognitive functions as well as structural and functional connectivity in individuals with mild cognitive impairment and early…
- Trial name
- TPSAlz (NCT07883148)
- Testing
- Transcranial pulse stimulation (TPS)
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- IRCCS San Raffaele Roma
Alzheimer Disease, Cognitive Decline Due to Alzheimer Disease
Randomized Trial of Low-dose Naproxen in Cognitively Intact Persons at Risk of Alzheimer's Dementia
Two-year double-masked trial of over-the-counter dosage of naproxen sodium vs placebo in 200 cognitively normal participants with a parental or multiplex first-degree family history Alzheimer's disease (AD) dementia.
- Conditions
- Alzheimer Disease, Cognitive Decline Due to Alzheimer Disease, Mild Cognitive Impairment Due to Alzheimer Disease
- Trial name
- NCT02702817
- Testing
- Naproxen
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Alzheimer Disease
Repetitive TMS of the Posterior DMN in AD
The primary aim of this project is to investigate the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) on cognition in patients with mild to moderate Alzheimer's disease.
- Trial name
- NCT05454540
- Testing
- REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Alzheimer Disease, Healthy Subjects
Home Test for Measuring Plasma P-tau217 in Alzheimer's Disease
The goal of this is to develop an easy at home test that can be used to assist in diagnosing Alzheimer's disease (AD). The test will use an FDA approved device for at home blood sample collection.
- Trial name
- NCT06622135
- Testing
- Tasso Lancet Device
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Insight Research Institute
Alzheimer's Disease
" The Eyes Have it " : Ocular Saccade Abnormalities in Prodromal Alzheimer's Disease
Alzheimer's disease (AD) has a prolonged prodromal phase before the stage of dementia. Subtle executive cognitive function deficits can be detected at this early pre-dementia phase, more than 10 years before dementia.
- Trial name
- LYLO (NCT01630525)
- Testing
- Neuropsychological assessment, ophthalmologic checkup, Automated non-invasive oculometry
- Where
- 3 sites in France
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Alzheimer's Disease
Double-blind, Placebo-controlled Study of Oral Dimebon in Subjects With Mild to Moderate Alzheimer's Disease
This study will evaluate the safety and potential benefit of Dimebon as compared to placebo in patients with mild to moderate Alzheimer's Disease.
- Trial name
- NCT00377715
- Testing
- Dimebon
- Where
- Russia
- Volunteers
- 183 people
- Sponsor
- Medivation, Inc.
Alzheimer Disease
A Phase 2 Study to Evaluate Efficacy and Safety of AL002 in Participants With Early Alzheimer's Disease
A phase 2 randomized, double blind, placebo controlled study evaluating the efficacy and safety of AL002 in participants with Early Alzheimer's Disease.
- Trial name
- INVOKE-2 (NCT04592874)
- Testing
- AL002
- Where
- 87 sites in United States, Argentina and 10 more
- Volunteers
- 356 people
- Sponsor
- Alector Inc.
APOE 4
Network-Level Mechanisms for Preclinical Alzheimer's Disease Development
The purpose of this project is to test the hypothesis that AGB101 low dose levetiracetam extended release formulation can reduce abnormal hyperfunctional activity in the hippocampus in normal, healthy adults.
- Trial name
- NCT03461861
- Testing
- AGB101 220 mg
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Alzheimer's Disease
Effect of LY2062430 on the Progression of Alzheimer's Disease
Alzheimer's disease (AD) is an age-related degenerative disorder of the brain, characterized by progressive decline in cognitive function and ability to perform activities of daily living, and ultimately can lead to death due to…
- Trial name
- EXPEDITION2 (NCT00904683)
- Testing
- LY2062430
- Where
- 95 sites in United States, Australia and 11 more
- Volunteers
- 1,040 people
- Sponsor
- Eli Lilly and Company
Alzheimer's Disease
A Multiple Ascending Dose Study of BPN14770 in Healthy Young and Elderly Male or Female Subjects
This is a randomized, double-blind (Investigator and subject-blinded) placebo-controlled, multiple, ascending-dose study to evaluate the safety, tolerability, and pharmacokinetic profile of BPN14770 in healthy young and elderly…
- Trial name
- NCT02840279
- Testing
- BPN14770
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Tetra Discovery Partners
Alzheimer's Disease
[18F]Florbetazine ([18F]92) for Beta Amyloid PET Imaging in Alzheimer's Disease
[18F]Florbetazine ([18F]92) is a molecularly targeted imaging agent for Aβ protein with a novel diaryl-azine scaffold. It has shown specific binding affinity to Aβ aggregates in postmortem human AD brains and excellent brain…
- Trial name
- NCT06141356
- Testing
- [18F]Florbetazine ([18F]92), [11C]PIB
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
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