Clinical trials: AIDS
HIV Infection
SNAP: Switching Nucleoside Analogues Protocol - Lipoatrophy and Mitochondrial Function
HIV infected subjects receiving antiretroviral treatment for greater than 6 years with be evaluated for clinical lipoatrophy and mitochondrial function after switching nucleoside analogues from stavudine (d4T) to tenofovir…
- Trial name
- NCT00225082
- Testing
- Nucleoside analogue switch
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Northwestern University
HIV Infections
Combination Latency Reversal With High Dose Disulfiram Plus Vorinostat in HIV-infected Individuals on ART
Antiretroviral therapy (ART) dramatically reduces Human Immunodeficiency Virus (HIV) replication leading to restoration of immune function and a near normal life expectancy, but treatment is lifelong and there is no cure.
- Trial name
- NCT03198559
- Testing
- Disulfiram, (National Drug Code) NDC 0378-4141-01, Vorinostat, NDC 00006-0568-40
- Where
- Australia
- Volunteers
- 5 people
- Sponsor
- University of Melbourne
Clinician Attitudes About PrEP
Clinician Attitudes and Behaviors Regarding Use of Pre-Exposure Prophylaxis (PrEP) for Primary HIV Prevention
This is a three phase study designed to examine clinician behaviors with regard to recommending and prescribing pre-exposure prophylaxis (PrEP) as a primary Human Immunodeficiency Virus (HIV) prevention strategy, and to identify…
- Trial name
- NCT01751659
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infection
TMC125-C227: A Phase II Randomized, Active-Controlled, Open Label Trial to Investigate the Efficacy and Tolerability of TMC125 in HIV-1 Infected Subjects, Who Are PI-Naive and With Documented Genotypic Evidence of NNRTI Resistance From Previous NNRTI Use
The purpose of this study is to determinate the effectiveness, safety and tolerability (how well the body accepts the drug) of an investigational Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) called TMC125.
- Trial name
- NCT00225303
- Testing
- TMC125
- Volunteers
- 116 people
- Sponsor
- Tibotec Pharmaceuticals, Ireland
HIV, Tobacco Use
Optimizing Treatment of Co-occurring Smoking and Unhealthy Alcohol Use Among PWH in Nairobi, Kenya
People with HIV (PWH) smoke tobacco cigarettes and drink alcohol at higher rates than the general population, both in the US and internationally, including low- and middle-income countries.
- Conditions
- HIV, Tobacco Use, Alcohol Use Disorder
- Trial name
- NCT06790342
- Testing
- Cystine, Positively Smoke Free, Standard of Care
- Where
- 2 sites in Kenya
- Volunteers
- 300 people
- Sponsor
- University of Chicago
HIV
Effects of the Anti-HIV Pill Truvada on Gene Transcription in the Gastrointestinal Tract of HIV-uninfected Individuals
As explained in detail in a recently published hypothesis article (Hladik F. A new hypothesis on HIV cure. F1000Research, 4:77 (2015)), the investigators hypothesize that NRTI drugs may reduce the likelihood of HIV eradication by…
- Trial name
- NCT02621242
- Testing
- Upper endoscopy, Anoscopy, Truvada
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Washington
AIDS-Related Primary Effusion Lymphoma
Clinical and Genomic Factors for Prognosis of AIDS Primary Effusion Lymphoma
This research trial studies clinical factors and gene expression analysis for prognosis in tissue samples from patients with acquired immune deficiency syndrome (AIDS)-related primary effusion lymphoma.
- Trial name
- NCT02823327
- Testing
- Laboratory Biomarker Analysis, Medical Chart Review
- Where
- 6 sites in United States
- Volunteers
- 25 people
- Sponsor
- AIDS Malignancy Consortium
HIV-1-infection
Etravirine Plus 2 Analogs in HIV-infected Patients
The purpose of this study is to evaluate the virological and clinical efficacy of etravirine plus 2 active nucleos(t)ide reverse-transcriptase inhibitors (NRTIs) in HIV-infected patients.
- Trial name
- NCT01437241
- Where
- 11 sites in Spain
- Volunteers
- 175 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Cardiac Steatosis, Hepatic Steatosis
Cardiometabolic Effects of Eplerenone in HIV Infection
Background: People with human immunodeficiency virus (HIV) are at a high risk of getting visceral or deep belly fat. Visceral fat can cause health problems like heart or liver disease.
- Trial name
- NCT02629094
- Testing
- Inspra /Eplerenone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Meningitis, Cryptococcal, HIV Infections
A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients With AIDS
To compare the safety and effectiveness of fluconazole with that of placebo as maintenance treatment for preventing the relapse of cryptococcal meningitis in patients with AIDS.
- Trial name
- NCT00002294
- Testing
- Fluconazole
- Where
- 5 sites in United States
- Sponsor
- Pfizer
HIV Infections
Influence of Atorvastatin on Viral Replication During Antiretroviral Treatment Interruption
To determine the influence of atorvastatin on plasma viral replication when the latter is given before and during highly active anti-retroviral therapy (HAART) in patients with HIV infection and viral suppression.
- Trial name
- NCT00355251
- Testing
- Atorvastatin 40 mg/Atorvastatin 80 mg
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- Germans Trias i Pujol Hospital
HIV Infection, Human Papillomavirus-Related Cervical Carcinoma
Enhancing Cervical Cancer Screening and Treatment in Women Living With HIV in Kenya, the ENHANCE LINKAge Trial
Background In sub-Saharan Africa (SSA), human papillomavirus (HPV) and HIV create a dual burden of disease that causes significant morbidity and mortality in the form of cervical cancer (CC).
- Conditions
- HIV Infection, Human Papillomavirus-Related Cervical Carcinoma, Screening Strategy
- Trial name
- NCT06708351
- Testing
- Best Practice, Health Promotion and Education, HPV Self-Collection
- Where
- Kenya
- Volunteers
- 2,280 people, healthy volunteers welcome
- Sponsor
- Emory University
HIV Infections
HIV Prevention Counseling for Men Who Have Sex With Men
The purpose of this study is to see if a behavioral intervention, a special kind of counseling, can reduce the risk of HIV infection in men who have sex with men.
- Trial name
- NCT00000931
- Testing
- Behavioral intervention, Risk-reduction counseling
- Where
- 6 sites in United States
- Volunteers
- 4,350 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cryptococcal Meningitis, HIV Infections
High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals
Cryptococcal meningitis (CM) is an infection of the membranes covering the brain and spinal cord, caused by the fungus Cryptococcus neoformans.
- Trial name
- NCT00885703
- Testing
- Fluconazole, Amphotericin B
- Where
- 10 sites in United States, India and 6 more
- Volunteers
- 168 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infection
Safety and Immunogenicity Study of tgAAC09, a Gag-PR-RT AAV HIV Vaccine
The purpose of this study is to determine safety and immunogenicity (ability to induce an immune response) of a novel HIV vaccine based on adeno-associated virus (AAV)
- Trial name
- A001 (NCT00482027)
- Testing
- tgAAC09
- Where
- 5 sites in Belgium, Germany and 1 more
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Lymphoma
Chemotherapy and Radiation Therapy in Treating Patients With HIV-Related Primary Central Nervous System Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with chemotherapy may kill more tumor cells.
- Trial name
- NCT00003261
- Testing
- methotrexate, zidovudine, neoadjuvant therapy
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
HIV Infections
Efficacy and Tolerability of an Antiretroviral Bi-Therapy in HIV Infected Patients With Multidrug Resistance
This study investigated whether a calibrated reduction in antiretroviral drug pressures could stabilize the evolution and the pathogenic potential of resistant HIV viruses.
- Trial name
- NCT00120783
- Testing
- Indinavir, Lamivudine, Ritonavir
- Where
- France
- Volunteers
- 40 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Hearing Loss
A Simplified Patient-Centered Educational Tool for Improved Hearing-Aid Outcomes
Hearing loss is the second most prevalent service-connected disability among Veterans. Hearing aids are the most common technological intervention for hearing loss.
- Trial name
- NCT01940705
- Testing
- Hearing-Aid Informational Guide, Hearing-Aid DVD, Teach-back Technique
- Where
- United States
- Volunteers
- 269 people
- Sponsor
- VA Office of Research and Development
HIV Infections
Assessing the Safety of Dapivirine Gel and Film Formulations
This is a study to determine the safety of dapivirine gel and dapvirine film for healthy, HIV-uninfected women aged 18-45 years using the product for 7 daily doses.
- Trial name
- NCT01548560
- Testing
- Dapivirine Vaginal Film, Dapivirine Vaginal Gel
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- International Partnership for Microbicides, Inc.
Tobacco Smoking
Computer Delivered and Community Health Worker Supported Smoking Cessation Intervention
The prevalence of tobacco smoking is high among persons with HIV (PWH). The investigators are piloting a two session computer-delivered intervention (CBI) with linkage to a community health worker (CHW) among hospitalized PWH…
- Trial name
- NCT04566159
- Testing
- CBI-CHW, Standard Care
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Johns Hopkins University