Clinical trials: AIS, open to volunteers
Adolescent Idiopathic Scoliosis
Interest of Adapted Physical Activity by Tele-rehabilitation in Chronic Pathology - Idiopathic Scoliosis in Adolescents
This study is a randomised controlled trial designed to compare two adapted physical activity treatments for adolescent idiopathic scoliosis (AIS).
- Trial name
- NCT06262269
- Testing
- Home-based adapted physical activity program supervised by an APA teacher via individual video conference., First period of the home-based adapted physical activity program with an exercise booklet., Second period of the home-based adapted physical activity program with an exercise booklet.
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Association des Paralysees de France (APF)
Scoliosis
Prospective Multicenter Evaluation of a New Predictive Model for the Progression of Adolescent Idiopathic Scoliosis
Scoliosis is a three-dimensional deformity affecting the orientation and position of the spine. Locally, the shape of the vertebra is also affected.
- Trial name
- NCT02434003
- Where
- 9 sites in United States, Canada and 4 more
- Volunteers
- 1,200 people
- Sponsor
- St. Justine's Hospital
Metastatic Castration-resistant Prostate Cancer (CRPC), Metastatic Castration-resistant Prostate Carcinoma
Novel ACK1 Inhibitor (R)-9b in Patients With Prostate Cancer
TITLE: Phase 1 First in Human Trial to Assess Safety and Tolerability of the Novel ACK1 Inhibitor (R)-9bMS in Patients with Prostate Cancer (PHAROS) STUDY DESCRIPTION: Prostate cancer (PC) patients receive androgen deprivation…
- Trial name
- PHAROS (NCT06705686)
- Testing
- (R)-9bMS
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- TechnoGenesys, Inc.
Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Saruparib in Combination With Physician's Choice of ARPI in Patients With mHSPC Previously Treated With Docetaxel or 177Lu-PSMA Therapy Without Disease Progression and PSA ≥ 0.2 ng/mL (EvoPAR-PR05)
The primary objective of this study is to measure efficacy of saruparib + physician's choice of ARPI compared with placebo + ARPI in men with metastatic hormone-sensitive prostate cancer (mHSPC) who have previously received…
- Trial name
- EvoPAR-PR05 (NCT07711002)
- Testing
- Saruparib, Enzalutamide, Darolutamide
- Where
- 210 sites in United States, Austria and 19 more
- Volunteers
- 1,330 people
- Sponsor
- AstraZeneca
Prostate Cancer (Adenocarcinoma), mCRPC (Metastatic Castration-resistant Prostate Cancer)
A Study of Talazoparib With or Without Enzalutamide in People With Prostate Cancer Who Have Previously Received Abiraterone Acetate or Darolutamide
The purpose of this study is to find out whether talazoparib in combination with enzalutamide or talazoparib alone delays cancer progression in people with metastatic castration-resistant prostate cancer (mCRPC) who have…
- Trial name
- TALENT (NCT06844383)
- Testing
- Talazoparib with enzalutamide, Talazoparib
- Where
- 8 sites in United States
- Volunteers
- 126 people
- Sponsor
- Prostate Cancer Clinical Trials Consortium
Adolescent Idiopathic Scoliosis
Minimally Invasive Surgery vs Standard Posterior Approach in the Treatment of Developmental Idiopathic Scoliosis
This is a randomized trial with 1:1 allocation. The aim of the study is to evaluate clinical and radiographic outcomes in patients with developmental age idiopathic scoliosis treated with mini invasive scoliosis surgery (MIS)…
- Trial name
- NCT05860673
- Testing
- mini invasive scoliosis surgery, posterior spinal fusion technique
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- Istituto Ortopedico Rizzoli
Prostate Cancer (Diagnosis), Prostate Cancer Stage IV
High Cardiovascular Risk Intervention With Cardio-Oncology Consultation for Prostate Cancer Following Androgen Receptor Pathway Inhibitor (ARPI) Therapy (Heart-Safe)
In patients with prostate cancer (PC), cardiovascular disease (CVD) causes significant morbidity and is the second leading cause of death.
- Conditions
- Prostate Cancer (Diagnosis), Prostate Cancer Stage IV, CV Risk
- Trial name
- NCT07223385
- Testing
- Cardio-Oncology Referral, Notification to PCP/General Cardiologist
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Cedars-Sinai Medical Center
Adolescence Idiopathic Scoliosis
Machine Learning Prediction of Disease Progression in Adolescent Idiopathic Scoliosis
Background and Problem Overview Adolescent Idiopathic Scoliosis (AIS) is a progressive musculoskeletal disorder characterized by a three-dimensional deformation of the spine occurring during adolescence.
- Trial name
- NCT07556042
- Testing
- Core Stabilization Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University
Shoulder Pain
Pneumoperitoneum Management With SurgiQuest AirSeal® at Low vs. Higher Pressure
A prospective, randomized, controlled single-center clinical Study designed to evaluate Physician Preference related to the use of the SurgiQuest AirSeal® Insufflation System (AIS) at low vs.
- Trial name
- PRESSURE (NCT02837601)
- Testing
- AirSeal® Insufflation System (AIS)
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Akron Children's Hospital
Fertility Disorders
TRAP Study: Testosterone for Androgen Receptor Polymorphism
To determine whether pretreatment with transdermal testosterone increases the number of cumulus-oocyte complexes (COCs) obtained after ovarian stimulation by more than 1.5 in patients with low ovarian reserve and androgen…
- Trial name
- TRAP (NCT06195163)
- Testing
- Transdermal Gel in Sachet Dosage Form, No pretreatment
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
Adolescent Idiopathic Scoliosis (AIS)
Intravenous Dexamethasone for ESP Block Analgesia in Children Undergoing Idiopathic Scoliosis Surgery
This randomized, double-blind, placebo-controlled study will evaluate the effect of intravenous dexamethasone on postoperative analgesia in children and adolescents undergoing surgery for idiopathic scoliosis with bilateral…
- Trial name
- NCT07890220
- Testing
- Dexamethasone (0.1 mg/kg), Dexamethasone (0.2 mg/kg)
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Poznan University of Medical Sciences
Scoliosis Idiopathic Adolescent
BSPTS and Core Stabilization Exercises in Adolescents With Idiopathic Scoliosis
This study aims to investigate the short-term effects of adding core stabilization exercises to Barcelona Scoliosis Physical Therapy School (BSPTS) exercises in adolescents with idiopathic scoliosis.
- Trial name
- NCT07761260
- Testing
- BSPTS Plus Core Stabilization Exercise, BSPTS Exercise
- Volunteers
- 36 people
- Sponsor
- Istinye University
Prostate Cancer
Phase I/II Trial of Pembrolizumab and Androgen-receptor Inhibitor With or Without 225Ac-J591 for Progressive Metastatic Castration Resistant Prostate Cancer
This is a phase I/II study investigating the combination of 225Ac-J591 (a drug that can deliver radiation to prostate cancer cells) with pembrolizumab (immunotherapy, a drug that increases the immune system's ability to destroy…
- Trial name
- NCT04946370
- Testing
- 225Ac-J591, Pembrolizumab, Androgen receptor inhibitor
- Where
- 4 sites in United States
- Volunteers
- 52 people
- Sponsor
- Weill Medical College of Cornell University
Adolescent Idiopathic Scoliosis (AIS)
Hypnosis for Pain and Nausea Reduction in Scoliosis Surgery: An Interventional Study
This study evaluates whether preoperative hypnosis can reduce postoperative pain, nausea, and opioid use in adolescents undergoing scoliosis surgery. Participants aged 12-18 years will receive hypnosis training before surgery.
- Trial name
- HYP-SCOL (NCT07854951)
- Testing
- Hypnosis
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Scoliosis Idiopathic Adolescent, Scoliosis Define Themselves
Reliability and Validity of the Adolescent Idiopathic Scoliosis - Truncal Anterior Asymmetry Scoliosis Questionnaire (TAASQ)
The survey examines how individuals with scoliosis define themselves and their physical appearance. Our aim in this study was to translate this survey into Turkish and demonstrate its reliability and validity.
- Conditions
- Scoliosis Idiopathic Adolescent, Scoliosis Define Themselves, Physical Perception of Their Bodies
- Trial name
- NCT07276165
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Hasan Kalyoncu University
Lung Adenocarcinoma, Frozen Section
Sublobar Resection for Adenocarcinoma in Situ/Minimally Invasive Adenocarcinoma Diagnosed by Intraoperative Frozen Section (ECTOP-1019)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1019. The goal of this clinical trial is to confirm the therapeutic effect of sublobar resection for AIS/MIA diagnosed by…
- Conditions
- Lung Adenocarcinoma, Frozen Section, Sublobar Resection
- Trial name
- NCT06031181
- Testing
- Sublobar Resection
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Fudan University
Scoliosis, Respiratory Function
The Effect of Curve Type Determined According to the Rigo Classification on Respiratory Muscle Strength, Quality of Life, and Functional Status in Individuals Diagnosed With Adolescent Idiopathic Scoliosis.
Adolescent Idiopathic Scoliosis (AIS) is a disorder that occurs between the ages of 10 and 18, with an unknown etiology, and is characterized by a three-dimensional deformity of the spine.
- Conditions
- Scoliosis, Respiratory Function, Rigo Classification, MIP
- Trial name
- NCT07863492
- Volunteers
- 120 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Thrombosis, Acute Ischemic Stroke (AIS)
Intravenous Thrombolytic Therapy for Acute Ischemic Stroke Patients with Low NIHSS and Non-disabling Deficits
Minor stroke is considered an acute ischemic stroke (AIS) that has a National Institute of Health Stroke Scale (NIHSS) score ≤ 5 points.
- Trial name
- ALLOW (NCT06115070)
- Testing
- Intravenous thrombolysis (alteplase and other guideline-recommended thrombolytic agents)
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Adolescent Idiopathic Scoliosis
Brace Monitoring for Adolescent Idiopathic Scoliosis (AIS)
The overall aim of the study is to utilize a novel device and smartphone application in order to improve measurement of patient compliance with at-home bracing for scoliosis as well as create a more accurate assessment of brace…
- Trial name
- NCT03292601
- Testing
- NYRC Brace Scoliosis Monitor
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Columbia University
Acute Ischemic Stroke
Safety and Preliminary Efficacy of Hibernation-Like Therapy (Chlorpromazine and Promethazine) in Patients With Acute Ischemic Stroke (AIS) Eligible for Reperfusion Therapy.
This is a single-center, dose-escalation and dose-expansion Phase I study designed to evaluate the safety of hibernation-like therapy (Chlorpromazine and Promethazine, C+P) and observe improvements in infarct volume in patients…
- Trial name
- CHILL-S (NCT07364344)
- Testing
- Hibernation-like Therapy (Chlorpromazine and Promethazine, C+P)
- Volunteers
- 57 people
- Sponsor
- Ji Xunming,MD,PhD