Clinical trials: AKI - Acute Kidney Injury
Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension
Intraoperative Hypotension and Acute Kidney Injury After Off-pump Coronary Artery Bypass Grafting Surgery
Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. Hypotension is an important risk factor for the development of AKI after noncardiac surgery.
- Conditions
- Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension, Acute Kidney Injury
- Trial name
- NCT03889730
- Where
- China
- Volunteers
- 821 people
- Sponsor
- Peking University First Hospital
Coronary Artery Bypass Grafting, Postoperative Acute Kidney Injury
Trajectory-Based Phenotyping After Coronary Artery Bypass Surgery
Coronary artery bypass grafting is a commonly performed heart surgery, but patients may have different risks for postoperative complications even when their preoperative risk scores are similar.
- Conditions
- Coronary Artery Bypass Grafting, Postoperative Acute Kidney Injury, Postoperative Complications, Risk Stratification
- Trial name
- NCT07598682
- Testing
- Early Postoperative Phenotype Classification
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Acute Kidney Injury
Improving Patient Assessment After Acute Kidney Injury (AKI)
The goal of this clinical trial is to improve patient care after acute kidney injury (AKI). It has three related parts. The main questions it aims to answer are: 1.
- Trial name
- IMPACT-AKI (NCT07569588)
- Testing
- Iohexol renal clearance measurement, Cystatin C, Creatinine
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Nottingham
Anesthesia, Spinal Aneshtesia
Renal Functions in Preeclamptic Pregnant Women Using Neutrophil Gelatinase-associated Lipocalin (NGAL) and Standard Renal Function Tests
Acute kidney injury (AKI) is a significant postoperative complication. Risk factors for AKI include impaired renal perfusion, decreased functional renal reserve, as well as advanced age, peripheral arterial disease, diabetes…
- Conditions
- Anesthesia, Spinal Aneshtesia, Acute Kidney Failure, Spinal Anesthesia Induced Hypotension
- Trial name
- NCT07015359
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Nihan Aydin Guzey
Nephrectomy, Nephroureterectomy
Goal-directed Hemodynamic Management and Kidney Injury After Radical Nephrectomy or Nephroureterectomy
Radical nephrectomy and nephroureterectomy are common operations for the treatment of renal cell carcinoma and upper tract urothelial carcinoma, respectively. However, acute kidney injury frequently occurs after surgery.
- Conditions
- Nephrectomy, Nephroureterectomy, Hemodynamic Management, Acute Kidney Injury
- Trial name
- NCT05149196
- Testing
- Targeted hemodynamic management, Routine care
- Where
- China
- Volunteers
- 1,724 people
- Sponsor
- Peking University First Hospital
Acute Kidney Injury
Association Between Postoperative Administration of L-Arginine and CSA-AKI
To investigate the association between the the early administration of L-Arginine after CPB-assisted cardiac surgery and the incidence of CS-AKI in adult patients. To test if it can reduce the incidence of post-operative AKI.
- Trial name
- NCT06248359
- Testing
- L-Arginine hydrochloride
- Where
- China
- Volunteers
- 5,135 people
- Sponsor
- Xijing Hospital
Kidney Injury, Renal Failure, Acute
Prevalence of Hypotension Associated With Preload Dependence During Continuous Renal Replacement Therapy
Per-dialytic hypotension is common in Intensive Care Unit patients under continuous renal replacement therapy, and occurs in nearly 50% of the patients.
- Trial name
- PRELOAD-CRRT (NCT03139123)
- Testing
- Hemodynamic monitoring during passive leg raising
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Hospices Civils de Lyon
Renal Replacement Therapy, Acute Kidney Injury
PrEvalence of Acute and Chronic Kidney Disease Treated by Renal Replacement Therapy
A prospective international, multi-centre, prevalence study on the epidemiology of the use of renal replacement therapy for ICU patients who have acute kidney injury and chronic end stage kidney disease.
- Conditions
- Renal Replacement Therapy, Acute Kidney Injury, Chronic End Stage Kidney Disease
- Trial name
- PEACE (NCT02341885)
- Where
- Belgium
- Volunteers
- 2,000 people
- Sponsor
- European Society of Intensive Care Medicine
Acute Kidney Injury (Nontraumatic), Dialysis; Complications
WISDOM UK: Low Dose-intensity Versus Standard Dose-intensity CRRT in Critically Ill Patients
Acute kidney injury is a potentially life threatening condition which affects 1 in 2 patients in the Intensive Care Unit (ICU). Patients often need dialysis treatment, also called renal replacement therapy.
- Trial name
- WISDOM UK (NCT07447791)
- Testing
- low intensity of CRRT, usual intensity of CRRT
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Covid19, Thrombotic Microangiopathies
Ravulizumab and COVID-19
Ultomiris (Ravulizumab), is a monoclonal antibody that specifically targets terminal complement products and is proposed for the treatment of COVID-19 induced microvasculature injury and endothelial damage leading to thrombotic…
- Conditions
- Covid19, Thrombotic Microangiopathies, Acute Kidney Injury
- Trial name
- NCT04570397
- Testing
- Ravulizumab
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Brigham and Women's Hospital
Anemia Renal
Erythropoietin Role in Acute Kidney Injury
The use of erythropoietin to treat anemia in acute kidney injury (AKI) is controversial. No previous clinical trial has assessed the possible reduction of transfusions when erythropoietin is started very early in a setting of…
- Trial name
- EAKI (NCT03401710)
- Testing
- Erythropoietin
- Where
- Lebanon
- Volunteers
- 134 people
- Sponsor
- Saint-Joseph University
Liver Cirrhosis, Acute Kidney Injury
To Study Efficacy of Albumin in Cirrhosis With Spontaneous Bacterial Peritonitis at Low Risk for AKI Development
The role of Albumin in prevention and Treatment of Acute Kidney Injury (AKI) in patients with Spontaneous Bacterial Peritonitis (SBP) who are at high risk of AKI development has been clearly defined , which decreases the…
- Trial name
- NCT04437810
- Testing
- Albumin, Standard Medical Treatment
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute Renal Failure
Low Dose Thymoglobin in Renal Transplant Patients
This is a planned single center prospective randomized study evaluating the safety and efficacy of low dose thymoglobulin as induction agent in renal transplant recipients.
- Trial name
- NCT01280617
- Testing
- Thymoglobulin, Thymoglobulin 0.75mg/kg dose
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Lahey Clinic
Liver Cancer, Adult
Risk Stratification and Proactive Nursing Intervention for Acute Kidney Injury Following Interventional Therapy in Patients With Liver Cancer
This study focuses on the early identification and precision prevention of acute kidney injury (AKI) following interventional therapy in patients with liver cancer.
- Trial name
- NCT07681817
- Testing
- Risk-stratified active nursing intervention group, Standard care (usual post-interventional nursing care)
- Volunteers
- 200 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Acute Kidney Injury
Relation Between Acute Kidney Injury and Mineral Bone Disease
Relation between acute kidney injury and mineral bone disease
- Trial name
- NCT05548725
- Testing
- Reguired field
- Volunteers
- 100 people
- Sponsor
- Assiut University
Contrast-induced Acute Kidney Injury (CI-AKI)
Hemodynamic Effects Of Impella On Renal Circulation And Risk Of CA-AKI Among Patients Undergoing Protected PCI
Patients undergoing Percutaneous Coronary Intervention (PCI) are exposed to the risk of suffering from a damage to the kidneys which goes under the name of Contrast-Associated Acute Kidney Injury (CA-AKI), which is more common if…
- Trial name
- NCT04928118
- Testing
- Evaluate the blood flow and pressure into kidneys
- Sponsor
- Virginia Commonwealth University
Acute Kidney Injury, Liver Disease
Continuous Renal Replacement Therapy in the Setting of Orthotopic Liver Transplant
To evaluate the efficacy of continuous renal replacement therapy (CRRT) during orthotopic liver transplantation (OLT) in clearing excess solutes and improving acid-base parameters.
- Conditions
- Acute Kidney Injury, Liver Disease, Chronic Kidney Disease, End Stage Kidney Disease
- Trial name
- NCT01619449
- Testing
- Renal replacement therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
Kidney Transplantation, Acute Kidney Injury
Molecular Markers of Acute Kidney Injury in Elderly Deceased Donors
Scoring systems that combine donor clinical and morphological parameters to predict outcome of kidney transplantation lack enough specificity to be generally accepted.
- Trial name
- MoliDon (NCT06171438)
- Testing
- Urine Biomarkers, Gene expression profiling of donor kidneys by microarray, Gene expression profiling of recipient kidneys by microarray
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Kidney Injury
Prevention of Acute Kidney Injury in Cardiac Surgery Patients
Acute kidney injury (AKI) has no uniform criteria, but is commonly defined as an increase in serum creatinine concentration by at least 25% from baseline.
- Trial name
- NCT00921518
- Testing
- Sodium Bicarbonate
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Community Medical Center, Scranton, PA
Stable Angina, Unstable Angina
Efficacy of Vitamin E in Preventing Contrast-Induced Acute Kidney Injury Following Coronary Angiography
The purpose of this study is to evaluate the effect of vitamin E on preventing from incidence of contrast induced acute kidney injury (CI-AKI) in the patients who undergone coronary angiography.
- Conditions
- Stable Angina, Unstable Angina, Non ST Segment Elevation Myocardial Infarction, Post MI
- Trial name
- NCT02070679
- Testing
- Vitamin E
- Where
- 2 sites in Iran
- Volunteers
- 284 people
- Sponsor
- Urmia University of Medical Sciences
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