Clinical trials: AKI - Acute Kidney Injury
Acute Kidney Injury, Continuous Renal Replacement Therapy (CRRT)
Ultrasound-Guided Microbubble Removal and Filter Lifespan During CRRT: A Pilot Crossover Study
What is this study about? This study is designed to evaluate whether ultrasound-guided removal of microbubbles during circuit priming in Continuous Renal Replacement Therapy (CRRT) can extend the filter lifespan for critically…
- Conditions
- Acute Kidney Injury, Continuous Renal Replacement Therapy (CRRT), Filter Clotting, Microbubbles
- Trial name
- NCT07005531
- Testing
- Ultrasound-Guided Microbubble Clearance During Circuit Priming
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Doppler-Based Renal Ultrasound, Urinary Oxygen Tension
The Predictive Value of Doppler Based Renal Ultrasound and Urinary Oxygen Tension for Prediction of Acute Kidney Injury After Open Heart Surgery
This study aims to investigate the predictive value of Doppler-based renal ultrasound and urinary oxygen tension in the development of acute kidney injury after cardiac surgery.
- Conditions
- Doppler-Based Renal Ultrasound, Urinary Oxygen Tension, Acute Kidney Injury, Open Heart Surgery
- Trial name
- NCT07037485
- Testing
- Renal resistive index, Renal Artery Pulsatility Index, Urinary oxygen tension (PUO2)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Acute Kidney Injury
Lithium Clearance in Patients With High Risk of Acute Kidney Injury
Renal lithium clearance is hypothesized to be a useful indicator of renal tubular function. In this study lithium clearance will be monitored in patients with sepsis associated acute kidney injury and in healthy controls.
- Trial name
- NCT05648435
- Testing
- Lithium measures
- Where
- Norway
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Acute Kidney Injury, Critical Illness
Preventing Acute Kidney Injury and Improving Outcome in Critically Ill Patients Utilising Risk Prediction Score
An interventional controlled trial to test the feasibility of applying risk score based prevention for critically ill patient at high risk to develop acute kidney injury (AKI)
- Trial name
- PRAIOC-RISKS (NCT03178435)
- Testing
- Measures to prevent AKI among critically ill patients
- Where
- Egypt
- Volunteers
- 198 people
- Sponsor
- Kasr El Aini Hospital
Contrast-associated Acute Kidney Injury
An Observational Study of Percutaneous Glomerular Filtration Rate (TGFR) in the Early Warning of Contrast-induced Acute Kidney Injury During the Peri-examination Period of Emergency Enhanced CT
This is a single-center, prospective observational study. We aim to evaluate the performance of transdermal glomerular filtration rate (TGFR) compared with baseline estimated glomerular filtration rate (eGFR) for early prediction…
- Trial name
- NCT07850947
- Testing
- Transdermal glomerular filtration rate (TGFR) monitoring
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Kidney Injury After Adult Cardiac Surgery
The Effect of High Single Dose of Dexamethasone in Prevention of Post-operative Acute Kidney Injury in Cardiac Surgeries Requiring Cardiopulmonary Bypass
The aim of the current study is to assess the effect of intra operative single high dose dexamethasone (1 mg/kg) in decreasing the incidence of post-operative acute kidney injury after cardiac surgeries with cardiopulmonary bypass
- Trial name
- NCT06783634
- Testing
- Dexamethasone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Acute Kidney Injury
Study of the Incidence and Prognosis of Intrahospital Acute Kidney Injury
The goal of this observational study is to investigate the epidemiology of acute kidney injury in hospitalized patients. The main question it aims to answer is: how frequent is the development of acute kidney injury in patients…
- Trial name
- SIPARIO-1 (NCT06697730)
- Where
- Italy
- Volunteers
- 43,000 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Acute Kidney Injury KDIGO 3, Continuous Renal Replacement Therapy Initiated by the Clinician in Charge Without Emergency
Is Myocardial Stunning Induced by Continuous Renal Replacement Therapy a Reality in Critically Ill Patients?
Myocardial stunning during chronic intermittent hemodialysis is a well-described phenomenon. Little case series of patients presenting myocardial stunning during renal replacement therapy for acute kidney injury in critically ill…
- Conditions
- Acute Kidney Injury KDIGO 3, Continuous Renal Replacement Therapy Initiated by the Clinician in Charge Without Emergency, Myocardial Stunning
- Trial name
- MS-CRRT (NCT05209230)
- Testing
- Continuous renal replacement therapy, Control group
- Where
- 3 sites in France
- Volunteers
- 42 people
- Sponsor
- Hospices Civils de Lyon
Critical Illness
Bedside Renal Ultrasound Assessment in Patients With Acute Kidney Injury
Exploring the predictive and evaluative value of various indicators of bedside critical renal ultrasound in critically ill patients with acute kidney injury (AKI)
- Trial name
- NCT06156098
- Testing
- No Intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qin Zhang
Acute Lung Injury, Acute Kidney Injury
Safety and Efficacy Evaluation of CO2 Removal in Combination With Continuous Veno-Venous Hemodialysis/Hemodiafiltration Therapy
Objective of the study is to assess the safety and efficacy of CO2 removal by the multiECCO2R (CO2 Removal System) on the multiFiltrate/multiFiltrate Pro in veno-venous extracorporeal circulation during continuous renal…
- Conditions
- Acute Lung Injury, Acute Kidney Injury, Hypercapnia, Covid19
- Trial name
- multiECCO2R (NCT04871893)
- Testing
- multiECCO2R blood-gas exchanger
- Where
- 6 sites in Germany
- Volunteers
- 28 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Acute Kidney Injury, Hemodialysis
Comparison of Slow Efficiency Daily Dialysis (SLEDD) With Unfractionated Heparin Versus Citrasate in Critically Ill Patients.
The purpose of this study is to compare the feasibility, safety and efficacy of hemodialysis with unfractionated heparin compared to hemodialysis with Citrasate in Critically Ill Patients.
- Trial name
- NCT01228292
- Testing
- Unfractionated heparin, Citrasate
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- University Hospital, Antwerp
Acute Kidney Injury
Cell Cycle Arrest Proteins for Early Diagnosis of Acute Kidney Injury After Solid Organ Transplant
Renal failure is a common complication of lung transplant (LUTX) and orthotopic liver transplantation (OLTX). Early diagnosis of acute kidney injury (AKI) in this cohort is of utmost importance, since AKI after solid organ…
- Trial name
- LUTX/OLTX_AKI (NCT05907434)
- Testing
- Nephrocheck (AKI score)
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Policlinico Hospital
Acute Kidney Injury, Chronic Kidney Disease
Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults
Sepsis is the most common cause of childhood death worldwide. Millions of children survive, but are left with impaired health. Sepsis-related Acute Kidney Injury (sAKI) is increasingly recognized as a significant factor…
- Conditions
- Acute Kidney Injury, Chronic Kidney Disease, Hypertension
- Trial name
- IMPRESS-YA (NCT02599844)
- Testing
- Iodohippurate, 24 hour ambulatory Blood Pressure, Peripheral Arterial Tonometry
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Healthy
The Effect of Lower Intraabdominal Pressure on Syndecan-1, sVEGF-R2, Occludin, KIM-1, and IL-6 on Living Donor Laparoscopic Nephrectomy
This study aimed to evaluate the increase of intraabdominal pressure 12- 14 mmHg caused by pneumoperitoneum resulted from carbon dioxide (CO2) insufflation induce glycocalyx endothelial injury that cause kidney tubular injury on…
- Trial name
- NCT03219398
- Testing
- Pneumoperitoneum pressure
- Where
- Indonesia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Acute Renal Injury
Dialyzing Wisely - Improving the Delivery of Acute Renal Replacement Therapy to Albertans
Implementation of an evidence-based and best practices acute RRT pathway aiming to decrease acute RRT program and healthcare systems costs while improving important patient-reported outcomes.
- Trial name
- NCT05186636
- Testing
- KPI reports, Prescriber reports
- Where
- 15 sites in Canada
- Volunteers
- 9,348 people
- Sponsor
- University of Alberta
Acute Kidney Injury
Acute KIDnEy Injury in CoviD-19
This is a prospective observational parallel group cohort study that will aim to recruit 220 participants who were admitted to the hospital with COVID-19 between 1st March 2020 and 30th June 2020 (Group A - 110 participants who…
- Trial name
- AIDED (NCT04583293)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 320 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
AKI - Acute Kidney Injury, Delirium, Postoperative
Metabolomics Analysis of Acute Kidney Injury and Delirium After Cardiac Surgery
Clinical evidence suggests that renal injury leads to changes in the structure of the cerebral cortex in patients, suggesting the existence of the renal brain axis.
- Trial name
- NCT06508593
- Testing
- Serum metabolic profile
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
COVID-19
A Randomized, Double-Blind, Placebo-Controlled Phase 2/3 Study to Determine the Safety and Effectiveness of Azeliragon in the Treatment of Patients Hospitalized for Coronavirus Disease 2019 (COVID-19) or Pneumonia
A new drug called azeliragon could be used to treat patients with COVID-19 or other pneumonia infections but the researchers don't know.
- Trial name
- NCT05815485
- Testing
- Azeliragon
- Where
- 3 sites in United States
- Volunteers
- 144 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Heart Failure, Acute Kidney Injury
Evaluation of VEXUS Score of Patients With Heart Failure in the Intensive Care Unit.
Heart failure is a syndrome that progresses with symptoms and signs caused by cardiac dysfunction and results in a shortened life expectancy (1).
- Trial name
- NCT06389708
- Volunteers
- 100 people
- Sponsor
- Inonu University
Acute Kidney Injury
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor
The purpose of this study is to determine whether perioperative intravenous administration of pantoprazole will improve kidney function parameters following cardiac surgery with cardiopulmonary bypass compared to famotidine and…
- Trial name
- NCT06154226
- Testing
- Pantoprazole, Famotidine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston
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