Clinical trials: AKI - Acute Kidney Injury
Shock
Renin-guided Hemodynamic Management in Patients With Shock
Shock is a major risk factor for mortality among patients admitted to intensive care units (ICUs). Since various hemodynamic strategies uniformly delivered to patients with shock have failed to improve clinically relevant…
- Trial name
- RENIN (NCT05898126)
- Testing
- Renin-guided hemodynamic management, Usual care
- Where
- 3 sites in Croatia, Italy
- Volunteers
- 800 people
- Sponsor
- Università Vita-Salute San Raffaele
Cardiac Surgery
Intravenous Amino Acid Therapy for Kidney Protection in Cardiac Surgery.
To date, no pharmacological agents are proven efficacious in treating perioperative AKI. There is a strong biological rationale for the administration of amino acid in the management of patients at risk of AKI with increases in…
- Trial name
- PROTection (NCT03709264)
- Testing
- Amino Acids
- Where
- 22 sites in Croatia, Italy and 1 more
- Volunteers
- 3,511 people
- Sponsor
- Università Vita-Salute San Raffaele
Acute Kidney Injury
Acute Kidney Injury in Newborns With Perinatal Asphyxia
The aim of the study is to investigate the role of serum cystatin C (sCysC) as an early predictor for both diagnosis and short term outcome evaluation of acute kidney injury (AKI) in neonates with perinatal asphyxia admitted to…
- Trial name
- NCT03617055
- Testing
- serum cystatin c
- Volunteers
- 50 people
- Sponsor
- Assiut University
Critical Illness, Acute Kidney Injury
Saline Against Lactated Ringers or Plasmalyte in the Emergency Department
This study will be a cluster-randomized, single-center trial comparing 0.9% saline (normal saline) vs physiologically-balanced crystalloid fluids (Lactated Ringers or Plasmalyte A) for intravenous fluid administration in the…
- Trial name
- SaLt-ED (NCT02614040)
- Testing
- 0.9% Saline, Physiologically-balanced isotonic crystalloid
- Where
- United States
- Volunteers
- 14,000 people
- Sponsor
- Vanderbilt University
Acute Kidney Injury
Urine Sample Processing Study
The objective of the study is to collect and process urine samples from Intensive Care Unit (ICU) subjects with moderate to severe (Stage 2 or 3) acute kidney injury (AKI) for use in assessing the effects of urine sample freezing…
- Trial name
- NCT05483088
- Testing
- Urine collection for NEPHROCLEAR CCL14 Test
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Astute Medical, Inc.
Acute Kidney Injury, Post-Operative Delirium
Short-term Atorvastatin's Effect on Acute Kidney Injury Following Cardiac Surgery
Aim1a: Statin naive patient's scheduled for cardiac surgery will be randomized to 80mg atorvastatin or placebo on the day prior to surgery and then 40mg daily thereafter until hospital discharge to test the hypothesis that…
- Conditions
- Acute Kidney Injury, Post-Operative Delirium, Icu Delirium, Acute Renal Failure
- Trial name
- NCT00791648
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 653 people
- Sponsor
- Vanderbilt University Medical Center
Septic Shock, Acute Renal Failure
Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock
The objective of this study is to determine the feasibility of conducting a large scale randomized controlled trial comparing standard and renally adjusted dosage of antibiotics in the septic shock patients with acute renal…
- Trial name
- NCT00816790
- Testing
- Piperacillin/Tazobactam
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Fraser Health
Congenital Heart Disease, Acute Kidney Injury
Nitric Oxide During CPB to Reduce AKI in Neonates
This is a prospective, randomized, double-blind, placebo-controlled pilot study to investigate whether supplemental Nitric Oxide (NO) gas delivered during cardiac surgery with cardiopulmonary bypass (CPB) reduces the incidence…
- Trial name
- NCT03946462
- Testing
- NO gas delivered during cardiac surgery
- Where
- United States
- Sponsor
- Fabio Savorgnan
Acute Kidney Injury, Sepsis
Pirfenidone Effect on the Recovery of Renal Function in Septic Acute Kidney Injury
Patients with Septic AKI will be randomized in three arms, group PFD 1,200 will receive PDF 600mg every 12 hrs per mouth, group PDF 600 will receive PFD 600mg in the morning and placebo equivalent at night and Group Placebo will…
- Trial name
- AKI (NCT02530359)
- Testing
- Pirfenidone extended release
- Volunteers
- 90 people
- Sponsor
- Hospital Civil de Guadalajara
Acute Kidney Injury, Acute Kidney Disease
The Effect of Preoperative Biological Age on Hemodynamics and Renal Function
Background The aim of this study is to explore the potential value of preoperative biological age as a predictor of intraoperative hemodynamic changes and postoperative renal function injury.
- Conditions
- Acute Kidney Injury, Acute Kidney Disease, Intraoperative Hypotension, Post-induction Hypotension
- Trial name
- NCT07080086
- Volunteers
- 268,833 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Acute Kidney Injury
Neutrophil Gelatinase-associated Lipocalin in Major Abdominal Surgery
Acute kidney injury (AKI) after major surgery is a well-known complication. The incidence of AKI after major surgery ranges from 13% to 50%.
- Trial name
- NCT05721638
- Testing
- Neutrophil gelatinase-associated lipocalin
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Antalya Training and Research Hospital
Acute Kidney Injury, Cardiac Disease
Evaluation of AKI by Measuring the NephroCheck Test After Pediatric Cardiac Surgery
Blood and urine samples of over 200 pediatric subjects (over 28 days to 3 years) undergoing complex cardiac surgery with cardiopulmonary bypass (CPB) will be collected at several time points to measure corresponding biomarkers…
- Conditions
- Acute Kidney Injury, Cardiac Disease, Surgery
- Trial name
- NCT03963284
- Testing
- cardiac surgery, NephroCheck test
- Volunteers
- 350 people
- Sponsor
- Shanghai Children's Medical Center
COVID-19 Pandemic
Elevated Liver Enzymes as a Predictor of Acute Kidney Injury in Hospitalized Patients With COVID-19
In critically ill patients, AKI is a common complication of COVID-19 infection, occurring in 23% to 43% of cases, and was correlated with poor clinical outcomes.
- Trial name
- COVID-19 (NCT05157152)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Acute Kidney Injury, Biomarkers
Combining Biomarkers and Electronic Risk Scores to Predict AKI in Hospitalized Patients
The study's objective is to evaluate the additive value of renal biomarkers (from blood and urine) for identifying individuals at high risk for severe acute kidney injury (AKI) above that of a novel natural language processing…
- Trial name
- NCT05988658
- Testing
- ESTOP - AKI 2.0
- Where
- 2 sites in United States
- Volunteers
- 800 people
- Sponsor
- University of Chicago
Acute Kidney Injury, Renal Failure
Retrospective Data Analysis of CKRT (Continuous Kidney Replacement Therapy) Treatments in Adult Mode With multiFiltratePRO
The multiFiltratePRO is a device for extracorporeal blood purification treatments. In this retrospective analysis, the treatments of patients who received at least one treatment with the investigational device as mentioned…
- Trial name
- CKRT-AKI (NCT06236984)
- Testing
- multiFiltratePRO with all CKRT treatment modes
- Where
- 3 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Machine Learning, Acute Kidney Injury
Machine Learning Predict Renal Replacement Therapy After Cardiac Surgery
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a major complication which may result in adverse impact on short- and long-term mortality.
- Conditions
- Machine Learning, Acute Kidney Injury, Renal Replacement Therapy, Prediction Models
- Trial name
- NCT04977687
- Where
- China
- Volunteers
- 2,108 people
- Sponsor
- Chinese PLA General Hospital
Acute Kidney Injury
Safety and Efficiency Study of Loading Dose Atorvastatin in Cardiac Surgery
Statins were reported to have pleiotropic effects including antiinflammatory, anti-oxidative stress effects and stabilise plaque in some conditions.
- Trial name
- NCT01547455
- Testing
- Atorvastatin(Lipitor)
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Peking Union Medical College
Acute Kidney Injury
Acute Kidney Injury After Cardiac Surgery Based on KDIGO Criteria
The aim of this study was to apply the acute kidney injury criteria based on KDIGO classification in a population of patients undergoing cardiac surgery [coronary artery bypass grafting (CABG) or cardiac valve surgery (CVS)] and…
- Trial name
- NCT00777465
- Where
- Brazil
- Volunteers
- 2,804 people
- Sponsor
- Hospital de Base
Sickle Cell Disease, Kidney Injury
Acute Kidney Injury in Patients With Sickle Cell Disease
Patients with sickle cell disease may be at risk for acute kidney injury (AKI)during sickle cell crisis (pain or acute chest syndrome).
- Conditions
- Sickle Cell Disease, Kidney Injury, Kidney Diseases, Kidney Disease, Chronic
- Trial name
- NCT03105271
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Acute Kidney Injury
Aortix Therapy for Perioperative Reduction of Kidney Injury
The study is a prospective, non-randomized feasibility study to evaluate the safety and performance of providing support with the Aortix System to patients at heightened risk of acute kidney injury (AKI) undergoing cardiovascular…
- Trial name
- A Priori (NCT04999163)
- Testing
- Aortix System
- Where
- 5 sites in Australia
- Volunteers
- 20 people
- Sponsor
- Procyrion
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