Clinical trials: ALLOGRAFT
Heart Transplantation
Induction of Donor Specific Tolerance in Recipients of Cardiac Allografts by Donor Stem Cell Infusion
The goal of this research study is to establish chimerism and avoid graft-versus-host disease in patients who need a heart transplant.
- Trial name
- NCT00497757
- Testing
- enriched hematopoetic stem cell infusion
- Volunteers
- 62 people
- Sponsor
- Suzanne T. Ildstad
Heart Transplantation
Donor Derived Cell Free DNA (Dd-cfDNA) as a Biomarker for Allograft Rejection in Heart Transplant Recipients
Following heart transplantation (HTx), lifelong immunosuppressive treatment is required to prevent the immune system from attacking, damaging, and rejecting the donor hear (allograft).
- Trial name
- TRANSCEND (NCT07886489)
- Testing
- Donor-derived cell free DNA
- Where
- 3 sites in Denmark, Norway
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Acute Myeloid Leukemia
Feasibility and Efficiency Study of Leukemic Cell Mobilization With Plerixafor Injection
The study will be conducted as a single center Phase I/II study to evaluate the safety of administering Plerixafor administered as part of a myeloablative preparative regimen (Institutional Protocol:Fludarabine 50mg/m2/da x 4…
- Trial name
- NCT01141543
- Testing
- Plerixafor (mozobil)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Pulmonary Complications
Pulmonary Complications of Allografts
This is a prognostic study of the late lung complications arising at the patient's having received an allograft of hematopoetic stem cells.
- Trial name
- ALLOPULM (NCT01219972)
- Where
- France
- Volunteers
- 245 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Meniscus Tear, Meniscus Disorder
Clinical Outcomes, Graft Longevity, and Chondral Protection Following Primary or Revision Meniscal Allograft Transplantation Surgery
The MERCuRE (MEniscus, REstoration, Conservation, and Repair) group is embarking on a 20-year follow-up study to evaluate the clinical outcomes, graft longevity, and chondral protection following primary or revision Meniscal…
- Conditions
- Meniscus Tear, Meniscus Disorder, Patient Satisfaction
- Trial name
- NCT06749431
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Joint Restoration Foundation, Inc.
Cardiac Allograft Vasculopathy
Physiologic Assessment of Microvascular Function in Heart Transplant Patients
The aim of the study is to evaluate the impact of early microvascular disease assessed by coronary physiologic indices such as fractional flow reserve (FFR), coronary flow reserve (CFR), index of microvascular resistance (IMR) on…
- Trial name
- NCT02798731
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Primary Renal Allograft Candidate, Kidney Transplantation
Open-Label Phase 2 Trial of a Steroid-Free, CNI-Free, Belatacept-Based Immunosuppressive Regimen
The primary objective is to evaluate a NULOJIX® (belatacept) based regimens as a means of improving long-term graft function without increasing the risks of immunologic graft injury by avoiding both calcineurin inhibitors (CNIs)…
- Trial name
- NCT01856257
- Testing
- Anti-thymocyte Globulin (Rabbit), belatacept, methylprednisolone
- Where
- 3 sites in United States
- Volunteers
- 71 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Deficiency of Anterior Cruciate Ligament, Displacement of Bone Allograft
MRI Study of Ballooning and Ligamentisation Short Transplants ACL Hamstring According to Technical DT4
MRI study of ballooning and ligamentisation short transplants of anterior cruciate ligament (ACL) according to DT4 technique in 60 patients with more than one year of follow up.
- Trial name
- MRI-DT4 (NCT02626975)
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Lille
Acute Myeloid Leukemia, Relapsed, Adult, Acute Myeloid Leukemia Refractory
Intensity Modulated Total Marrow Irradiation in Fully Human Leukocyte Antigen (HLA)-Matched and Partially-HLA Mismatched Allogeneic Transplantation Patients With High-Risk Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML), and Myelodysplastic Syndrome (MDS)
The study is a Phase II clinical trial. Patients will receive intensity-modulated total marrow irradiation (TMI) at a dose of 9 Gray (Gy) with standard myeloablative fludarabine intravenous (IV) and targeted busulfan (FluBu4)…
- Conditions
- Acute Myeloid Leukemia, Relapsed, Adult, Acute Myeloid Leukemia Refractory, Chronic Myeloid Leukemia - Accelerated Phase, Myelodysplastic Syndromes
- Trial name
- BMT-13 (NCT06802315)
- Testing
- Intensity modulated total marrow irradiation, Cyclophosphamide (CTX), Fludarabine (Fludara)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Illinois Chicago
Chronic Allograft Nephropathy
Validity of Strain Elastography for the Evaluation of Chronic Allograft Nephropathy
Chronic allograft nephropathy is one of dreaded complication of kidney transplant. It is one of the major determinants of long term graft survival.
- Trial name
- NCT05682313
- Testing
- Elastography arm
- Where
- Egypt
- Volunteers
- 188 people
- Sponsor
- Kasr El Aini Hospital
Leukemia, Lymphoma
Bortezomib-based GVHD Prophylaxis After Allogeneic Transplant for Patients Without Matched Related Donors
A common problem after stem cell transplant is graft-versus-host-disease (GVHD). GVHD is a complication of transplantation where the donor graft attacks and damages some of your tissues.
- Conditions
- Leukemia, Lymphoma, Myelodysplastic Syndrome
- Trial name
- NCT01323920
- Testing
- Bortezomib, Tacrolimus, Methotrexate
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Dana-Farber Cancer Institute
Outcomes of Allograft
Long Term Outcomes of Osteochondral Allografts for Osteochondral Defects of the Knee
The purpose of this study is to evaluate the functional and clinical outcomes of patients receiving femoral condyle osteochondral allografts, to evaluate potential predisposing factors to failure of such grafts, and to compare…
- Trial name
- LongTermOC (NCT02308358)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Tooth Loss
Comparison of Dimensional Changes After Tooth Extractions Between Xenograft and Allograft
To compare dimensional changes in extraction socket of single rooted teeth, 6 months post extraction, when grafted with xenograft versus allograft.
- Trial name
- PilotXenAllo (NCT04550689)
- Testing
- Bone graft
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- UConn Health
Acute Myelogenous Leukemia AML, Myelodysplastic Syndrome MDS
Vidaza and Valproic Acid Post Allogeneic Transplant for High Risk AML and MDS
Phase II trial combining azacitidine with valproic acid as maintenance therapy post allogeneic stem cell transplantation in patients with high-risk MDS/AML.
- Trial name
- NCT02124174
- Testing
- Vidaza and Valproic Acid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Patrick Stiff
Non-Hodgkin's Lymphoma, Hodgkins Disease
Autologous and Allogeneic Transplant for Relapsed Lymphoma
The sequential combination of myeloablative therapy and autologous stem cell transplantation (APBSCT) followed by a reduced intensity allogeneic stem cell transplant (Allo SCT) and post SCT adoptive cellular immunotherapy will be…
- Trial name
- NCT00802113
- Testing
- Fludarabine, Busulfan, Anti-Thymocyte Globulin
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Columbia University
Kidney Transplantation
Development and Validation of a Multidimensional Score to Predict Long-term Kidney Transplant Outcomes
To further develop personalized medicine in kidney transplantation and improve transplant patient outcomes, attention has been given to define early surrogate endpoints that might aid therapeutic interventions, clinical trials…
- Trial name
- iBOX (NCT03474003)
- Testing
- No intervention
- Where
- 10 sites in United States, Belgium and 1 more
- Volunteers
- 7,557 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Graft Rejection, Kidney Transplant
Study Evaluating A Planned Transition From Tacrolimus To Sirolimus In Kidney Transplant Recipients
This study will look at the effect on long-term kidney function using tacrolimus right after a transplant and then switching to sirolimus at 3 to 5 months after the transplant.
- Conditions
- Graft Rejection, Kidney Transplant, Renal Allograft Recipients, Renal Transplant
- Trial name
- NCT00895583
- Testing
- Tacrolimus, Sirolimus
- Where
- 44 sites in United States, Argentina and 5 more
- Volunteers
- 254 people
- Sponsor
- Pfizer
Allograft, Cold Temperature
Immunological Reaction of the Recipient After Cold-stored Saphenous Venous Allograft (Bioprotec)
The study investigators propose to perform a blood test before and after allograft placement in all patients receiving a cold-stored venous allografts at the University Hospital of Nîmes to study the occurrence of FVFA-related…
- Conditions
- Allograft, Cold Temperature, Saphenous Vein
- Trial name
- REACIMALLOGV (NCT05096351)
- Testing
- Blood test
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Rotator Cuff Syndrome, Rotator Cuff Injury
Allograft Reconstruction of Massive Rotator Cuff Tears vs Partial Repair Alone
The investigators hypothesize that the use of an allograft adjuvant to partial repair will lead to improved shoulder outcome measure scores compared to partial repair alone in massive rotator cuff tears.
- Conditions
- Rotator Cuff Syndrome, Rotator Cuff Injury, Disorder of Rotator Cuff, Full Thickness Rotator Cuff Tear
- Trial name
- NCT01987973
- Testing
- Partial Rotator Cuff Repair, Partial Rotator Cuff Repair with Allograft Augmentation
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Ivan Wong
Leukemia, Lymphoma
Prevention of Graft-Versus-Host Disease in Patients With Advanced Leukemia or Lymphoma Who Are Eligible for Peripheral Stem Cell Transplantation
RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill tumor cells.
- Conditions
- Leukemia, Lymphoma, Graft Versus Host Disease
- Trial name
- NCT00003056
- Testing
- cyclosporine, cyclosporine and methotrexate
- Where
- 13 sites in United States, Australia
- Volunteers
- 105 people
- Sponsor
- Baxalta now part of Shire
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.