Clinical trials: ALLOGRAFT
Graft Vs Host Disease
Post-transplantation Cyclophosphamide in Haploidentical Stem Cell Allografts Dose Reduction: 50 mg/kg vs 25 mg/kg
Allogeneic hematopoietic cell transplantation (HSCT) is a worldwide recognized therapy for several hematologic malignancies; a modality extensively used around the world due to its effectivity; however, an HLA-matched sibling or…
- Trial name
- NCT05780554
- Testing
- Cyclophosphamide
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- Centro de Hematología y Medicina Interna
Knee Injury
Evaluation of a Composite Cancellous and Demineralized Bone Plug (CR-Plug) for Repair of Knee Osteochondral Defects
The objective of this study is to determine how effective a plug made out of human bone (called "CR-Plug") will be in the treatment of smaller, focal defects (like the injury the patient has to their knee).
- Trial name
- NCT00984594
- Testing
- Primary injury site, Backfill site
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- RTI Surgical
Multiple Myeloma
ECT-001 (UM171) Expanded Cord Blood Transplant to Treat High-risk Multiple Myeloma
Multiple Myeloma (MM) is a morbid disease associated with a poor outcome and while current therapies with new drugs have improved survival, MM still remains incurable in most patients.
- Trial name
- NCT03441958
- Testing
- ECT-001 (UM171) expanded cord blood
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Spinal Stenosis
The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation in the Elderly With Spinal Stenosis Due to Degenerative Spondylolisthesis
The average life expectancy in Denmark is increasing resulting in an increasing part of the population having age-related disease, ex lumbar spinal stenosis (LSS).
- Trial name
- IVANOS (NCT01618435)
- Testing
- i-FACTOR
- Where
- 2 sites in Denmark
- Volunteers
- 108 people
- Sponsor
- Sygehus Lillebaelt
Tennis Elbow, Lateral Epicondylitis \(Tennis Elbow\)
Efficacy of CTM for Tennis ELbow
In this study, the objective is to evaluate the effectiveness of a single application of human Connective Tissue Allograft (CTA) as a treatment of LET.
- Conditions
- Tennis Elbow, Lateral Epicondylitis \(Tennis Elbow\), Lateral Elbow Tendinopathy
- Trial name
- NCT06171555
- Testing
- CTM, Celestone
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Indiana Hand to Shoulder Center
ACL Deficient Knee
ACLR: Isolated Autograft vs Allograft With Lateral Extra-articular Tenodesis
This study seeks to evaluate the utility of non-irradiated allograft tissue with lateral extra-articular tenodesis (LET) in the setting of anterior cruciate ligament reconstruction (ACLR).
- Trial name
- NCT06668155
- Testing
- Autograft Group, Allograft with LET Group
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Transplantation, Heart-Lung, Chronic Lung Allograft Dysfunction
Evaluation of Electrical Impedance Tomography for the Diagnosis of Chronic Rejection in Lung Transplants Recipients
Electrical impedance tomography (EIT) is non-invasive and provides functional imaging of the lung and it could be a useful tool to diagnose chronic lung allograft dysfunction (CLAD) and specially Bronchiolitis Obliterans Syndrome…
- Conditions
- Transplantation, Heart-Lung, Chronic Lung Allograft Dysfunction, Bronchiolitis Obliterans Syndrome
- Trial name
- CLAD (NCT02863835)
- Testing
- EIT, Salbutamol nebulisation and with CPAP
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Femur Fractures
Types of Fixation of Vancouver B1 Periprosthetic Fractures
The purpose of this study is to compare two different but standard treatments for the fixation of Vancouver B1 periprosthetic. The investigators aim to compare open reduction internal fixation using a locked plating system versus…
- Trial name
- NCT01354535
- Testing
- Isolated Locked Compression Plate, Cable Plating and Strut Allograft with Cerclage Wiring
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- Unity Health Toronto
Children Who Underwent Heart Transplantation Prior to Age 18, Received Care at Children's Healthcare of Atlanta
Allograft Fibrosis Following Pediatric Cardiac Transplantation
Transplantation is the preferred method of treating many forms of end-stage organ failure. While short-term results have improved, long-term outcomes remain inadequate.
- Trial name
- NCT00328185
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Children's Healthcare of Atlanta
Diabetic Foot Ulcer, DFU
Randomized Evaluation of Nonhealing Diabetic Foot Ulcers With Exclusive Wound Therapy
The goal of this study is to determine the between-arm difference in the proportion of subjects achieving complete closure of nonhealing diabetic foot ulcers with multiple CAMPs plus SOC versus matched controls over 12 weeks…
- Conditions
- Diabetic Foot Ulcer, DFU, Diabetic Foot Ulcer (DFU), Foot Ulcer Due to Type 1 Diabetes Mellitus
- Trial name
- RENEW (NCT07086443)
- Testing
- Activate™ Matrix, AmnioDefend™ FT Matrix, Palisade™ DM Matrix
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Sequence LifeScience, Inc.
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic Transplantation (BMT CTN 1702)
The purpose of this study is to determine if a search strategy of searching for an HLA-matched unrelated donor for allogeneic transplantation if possible then an alternative donor if an HLA-matched unrelated donor is not…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, Non-hodgkin Lymphoma
- Trial name
- BMT CTN 1702 (NCT03904134)
- Testing
- Donor Search Prognosis Score
- Where
- 52 sites in United States
- Volunteers
- 1,753 people
- Sponsor
- Center for International Blood and Marrow Transplant Research
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Chondrofix Osteochondral Allograft Prospective Study
The overall study objective is to evaluate Chondrofix Osteochondral Allograft ("Chondrofix") for the repair of osteochondral lesions in the knee.
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01410136
- Testing
- Chondrofix Osteochondral Allograft
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Patients Who Underwent Allograft
Treatment of Adenovirus Disseminated Infections in Hematopoietic Stem Cell Transplant Patients With Adenovirus Digestive Replication
Disseminated Adv infections are associated with high morbidity and mortality in HSCT pediatric patients. The most common source of Adv infection after pediatric HSCT is the host digestive tract where latent Adv are reactivated…
- Trial name
- ADENOCLEAR (NCT03481244)
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Long-Functioning Pancreas Allografts, Pancreas Transplant
Assessment of Insulin Production From Native Pancreas in Patients With Pancreas Transplants
This study will examine whether insulin-producing cells in the pancreas (beta cells) can recover in patients with type 1 diabetes who have had a pancreas transplant.
- Trial name
- NCT00246844
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Heart Transplantation, Kidney Transplantation
A Paediatric, Open, Follow up Study With Modigraf Examining Safety and Efficacy in de Novo Allograft Recipients
The purpose of this study, a follow up to study FG506-CL-0403, is to see how safe and effective Modigraf® is (Part A) and to see how safe and effective it is to change your child's medication from Modigraf® to Prograf® (Part B).
- Conditions
- Heart Transplantation, Kidney Transplantation, Liver Transplantation
- Trial name
- PROGRESSION (NCT01371344)
- Testing
- Tacrolimus granules, Tacrolimus capsules
- Where
- 12 sites in Belgium, France and 4 more
- Volunteers
- 47 people
- Sponsor
- Astellas Pharma Europe Ltd.
Pre-Pectoral Breast Reconstruction Following Mastectomy
Retrospective Study of AlloMend Acellular Dermal Matrix (ADM) Allograft and Pre-Pectoral Breast Reconstruction
This retrospective, single-site study will provide information regarding the efficiency of AlloMend® Acellular Dermal Matrix allograft in Pre-Pectoral Breast Reconstruction surgery following a single or double mastectomy.
- Trial name
- NCT06853964
- Testing
- AlloMend® Acellular Dermal Matrix allograft
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- AlloSource
Blood Cancer, Leukemia
Allogeneic Transplantation Using Total Lymphoid Irradiation (TLI) and Anti-Thymocyte Globulin (ATG) for Older Patients With Hematologic Malignancies
To measure how frequently and to what degree a complication of transplant cell acute graft versus host disease (GvHD) occurs.
- Trial name
- NCT00185640
- Testing
- Cyclosporine, Anti-thymocyte globulin (ATG), Mycophenolate mofetil (MMF)
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- Stanford University
Haematological Malignancy, Bone Marrow Transplant Complications
Nutrition and Metabolic Prehabilitation in HSCT Patients UK and ROI. BSBMT Multi-centre Survey.
To explore current practices of nutrition and metabolic screening, assessment and management prior to Haematopoietic Stem Cell Transplant (HSCT) in UK and ROI transplant centres.
- Conditions
- Haematological Malignancy, Bone Marrow Transplant Complications, Stem Cell Transplant Complications, Nutrition Aspect of Cancer
- Trial name
- NCT05352789
- Testing
- Non validated Survey
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Huntington Disease
Long Term Follow-up Grafted Huntington's Disease Patients
Long-term follow-up of Huntington's disease patients treated with intrastriatal allografts is essential to assess the benefit/risk ratio of grafts as well as their effectiveness.
- Trial name
- Post-MIGHD (NCT06194006)
- Testing
- Follow-up
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatitis B Virus, Allograft
Risk of Hepatitis B Virus Reactivation in Patients Undergoing Allografting
The purpose of this study is to evaluate the risk of hepatitis B reactivation in patients undergoing allografting.
- Conditions
- Hepatitis B Virus, Allograft, Hematological Malignancies
- Trial name
- NCT00876148
- Where
- Italy
- Sponsor
- Azienda Ospedaliera San Giovanni Battista
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