Clinical trials: ALLOGRAFT
Laryngeal Cancer, Total Laryngectomy
Aortic Laryngeal Rehabilitation Graft
The larynx is a cartilaginous organ of the respiratory system located in the throat, which plays an essential role in respiratory function, swallowing and sound production.
- Trial name
- GRAAL (NCT04650919)
- Testing
- Total laryngectomy and reconstruction by stented aortic allograft (using human tissue and device).
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Strasbourg, France
Vasculopathy, Heart Transplant Failure
The Role of CD34 + Stem Cells and Biomarkers in the Development of CAV in HTX Patients
Coronary allograft vasculopathy represents one of the major limiting factors of long-term survival in heart transplant recipients.
- Trial name
- NCT05485467
- Testing
- coronary CT angiography
- Where
- Slovenia
- Volunteers
- 55 people
- Sponsor
- University Medical Centre Ljubljana
Chronic Allograft Injury, Calcineurin Inhibitor Toxicity
Mechanisms and Treatment of Chronic Allograft Injury (CAI) Due to Calcineurin Inhibitor (CNI) Toxicity
The purpose of this study is to find out how well the current drug regimen (including low Prograf dose and Myfortic, which is usually recommended to prevent any further deterioration in the kidney function) works and how safe it…
- Trial name
- NCT01473732
- Testing
- Everolimus, Tacrolimus, Mycophenolic acid
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Montefiore Medical Center
Genovarum
Results of Opening-wedge High Tibial Osteotomy Using Iliac Crest Allograft Compared to Iliac Crest Autograft
The purpose of this RCT is to determine the results of opening-wedge high tibial osteotomy in patients with genovarum deformity using iliac crest allograft compared to the results when using iliac crest autograft.
- Trial name
- NCT00595712
- Testing
- Iliac crest allograft, Iliac crest autograft
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Tehran University of Medical Sciences
Patellofemoral Dislocation
Clinical Study Relating to Patients Undergoing Medial Femoral Patellar Ligament Reconstruction
The objective of the present study will be to evaluate the clinical patellofemoral joint function (primary endpoint) and radiographically the patellofemoral arthritic degeneration (secondary endpoint) of of MPFL reconstruction…
- Trial name
- NCT04243265
- Testing
- MPFL reconstruction with fascia lata allograft
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- Istituto Ortopedico Rizzoli
Cardiac Allograft Vasculopathy
Comparing PCCT With ICA and IVUS in Detecting Cardiac Allograft Vasculopathy
In traditional coronary artery disease, patients often experience symptoms such as angina. However, heart transplant patients lack nerve connections in the transplanted heart and therefore usually do not notice any symptoms.
- Trial name
- CAVIAR (NCT07020039)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Pharmacokinetics, Tacrolimus
a Comparative Pharmacokinetic Study of Two Oral Formulations of Tacrolimus in Renal Allograft Recipients
The aim of this study is to identify the pharmacokinetic differences between two oral forms of Tacrolimus and consequent nephrotoxicity.
- Trial name
- NCT01055964
- Testing
- Tacrolimus
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Pelvic Organ Prolapse
Axis™ Allograft Dermis for Female Pelvic Floor Repair: a Prospective Post Market Study
This study is a prospective, single arm, multi-center, post-market study to evaluate the efficacy of Axis™ Allograft Dermis used for anterior, posterior or combined (anterior and posterior) pelvic organ prolapse repair.
- Trial name
- NCT01541748
- Testing
- Axis
- Where
- 5 sites in United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Coloplast A/S
Lung Transplant Failure and Rejection
Long Term Follow up of the LTOG Cohort
The purpose of the study is to follow participants who enrolled in the Lung Transplant Outcomes Group. Clinical data, functional assessments, and surveys will be collected to determine long term graft function and functional…
- Trial name
- LTOG (NCT04787822)
- Where
- 10 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- University of Pennsylvania
Coronary Artery Disease in Transplanted Heart (Diagnosis), Platelet Dysfunction
Coronary Artery Disease After Heart Transplantation
This study evaluates coronary artery disease after heart transplantation and its relation to platelet function. Furthermore, we will evaluate extracorporeal photopheresis as treatment of coronary artery disease after heart…
- Trial name
- ECP (NCT03583229)
- Testing
- Aspirin 75mg, Extracorporeal photopheresis
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Aarhus University Hospital
Graft-Versus-Host Disease
Bridging Pediatric and Adult Biomarkers in Graft-Versus-Host Disease
This study is designed to collect longitudinal biological samples from patients after hematopoietic cell transplantation (HCT) cared for at multiple bone marrow transplant centers to validate biomarkers of both acute and chronic…
- Trial name
- NCT02194439
- Where
- United States
- Volunteers
- 415 people
- Sponsor
- Indiana University
Anterior Cruciate Ligament Rupture
BioCleanse Tibialis Tendon Anterior Cruciate Ligament (ACL) Study
To compare the outcome of Anterior Cruciate Ligament (ACL) reconstruction performed using the tibialis allograft to historical outcomes of ACL reconstruction patients and to establish if any correlation exists between the age of…
- Trial name
- NCT00975845
- Testing
- BioCleanse Tibialis tendon
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- RTI Surgical
Brittle Type 1 Diabetes
Allogeneic Transplantation of Expanded Pancreatic Islet Cells
This study will evaluate the efficacy and safety of allogeneic pancreatic islet cells transplantation in patients with "brittle" type 1 diabetes.
- Trial name
- NCT05990530
- Testing
- YD02-2022
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Transplanted Kidney Ischemia Reperfusion Injury
Limitation of Ischemic Injury of a Kidney Stored in Machine Perfusion in Hypothermia - Evaluation of the Impact on Kidney Allograft Function
The aims of this study are: 1. assessment of ischemia injury of kidney retrieved from standard and expanded criteria deceased donor before transplantation 2. assessment of efficacy of kidney ischemia injury decreasing 3.
- Trial name
- NCT01731457
- Testing
- etanercept
- Where
- Poland
- Volunteers
- 94 people
- Sponsor
- Medical University of Warsaw
Psychiatric Diagnosis, Cognition Disorders
Mood and Cognitive Outcome After Heart Transplantation (the MOODHEART Study)
The investigators aim at characterizing neuropsychiatric consequences of heart transplantation (HTX) and at assessing the impact of depressive symptoms after HTX on mortality and cardiac allograft vasculopathy (CAV).
- Trial name
- NCT02035865
- Where
- Norway
- Volunteers
- 74 people
- Sponsor
- Oslo University Hospital
Heart Transplantation, Kidney Transplantation
A Study to Compare How the Body Absorbs and Processes Two Different Formulations of the Anti-rejection Medication Tacrolimus (Advagraf® or Prograf®) in Children Receiving an Organ Transplant, and How Safe and Effective They Are Over a Longer Period of Time
The purpose of this study is to compare how the body absorbs and processes two different formulations of the anti-rejection medication tacrolimus (Advagraf® or Prograf®) in children receiving an organ transplant, and how safe and…
- Conditions
- Heart Transplantation, Kidney Transplantation, Liver Transplantation
- Trial name
- NCT01614665
- Testing
- Tacrolimus, Tacrolimus prolonged release
- Where
- 10 sites in Czechia, France and 3 more
- Volunteers
- 44 people
- Sponsor
- Astellas Pharma Europe Ltd.
Lumbar Degenerative Disc Disease
Radiographic and Clinical Outcomes of PureGen in Posterior Lumbar (PLIF) and Transforaminal Interbody Fusion (TLIF)
The purpose of this study is to assess the safety and efficacy of PureGen Osteoprogenitor Cell Allograft in patients undergoing Posterior Lumbar or Transforaminal Interbody Fusion.
- Trial name
- NCT01293981
- Testing
- PureGen Osteoprogenitor Cell Allograft
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- Alphatec Spine, Inc.
Type 1 Diabetes Mellitus
Efficacy of Islet After Kidney Transplantation
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00468117
- Testing
- Islet transplantation, Antithymocyte Globulin, Daclizumab or Basiliximab
- Where
- 10 sites in United States, Canada
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bone Neoplasms, Musculoskeletal Neoplasms
Predicting Allograft Volume in Orthopedic Oncology: Hemielipsoid Formula vs Intraoperative Fluid-Fill Measurement
Bone defects following primary musculoskeletal tumor resection are frequently reconstructed using structural allografts. Allograft availability is limited, and intraoperative waste due to oversized graft selection remains a…
- Conditions
- Bone Neoplasms, Musculoskeletal Neoplasms, Bone Transplantation
- Trial name
- PREDALL (NCT07653178)
- Testing
- Hemielipsoid Formula-Based Preoperative and Intraoperative Bone Defect Volume Estimation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Sakarya University
Alveolar Bone Resorption, Graft Overgrowth
Histological and Volumetric Evaluation of Customized Allograft Bone Blocks
Customized bone blocks need CBCT and digital software to design the block needed to rehabilitate. Some advantages are reduced surgical time and better adaptation of the graft, leading to less complications.
- Conditions
- Alveolar Bone Resorption, Graft Overgrowth, Resorption of Bone Graft, Graft Complication
- Trial name
- NCT05937035
- Testing
- Customized allogenic bone block surgery
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
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