Clinical trials: ALLOGRAFT
Primary Renal Allograft
Study to Evaluate Safety and Efficacy of Early Calcineurin Inhibitor Withdrawal in Primary Renal Allografts
Evaluate the safety and efficacy of early corticosteroid withdrawal and simultaneous calcineurin inhibitor withdrawal in recipients of primary renal allografts maintained long-term on MMF and sirolimus.
- Trial name
- NCT00374647
- Testing
- mycophenolate mofetil, sirolimus
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Cincinnati
Chronic Kidney Allograft Nephropathy
Renin Angiotensin System Blockade in Renal Transplant Patients With Presence of PECs in Urine
By means of a personalized medicine strategy, investigators are going to evaluate if the treatment with an angiotensin II receptor antagonist (ARAII) in renal transplant patients with the presence of renal progenitor cells (PECs)…
- Trial name
- NCT04769778
- Testing
- Valsartan 80Mg Oral Tablet
- Where
- Spain
- Volunteers
- 180 people
- Sponsor
- Josep M Cruzado
Antibody-mediated Rejection, Hyperacute Rejection of Cardiac Transplant
The De-novo Use of Eculizumab in Presensitized Patients Receiving Cardiac Transplantation
All individuals who receive a heart transplant are at risk for developing antibody-mediated rejection (AMR). An antibody is a protein produced by the body's immune system when it detects a foreign substance, called an antigen.
- Conditions
- Antibody-mediated Rejection, Hyperacute Rejection of Cardiac Transplant, Left Ventricular Dysfunction, Cardiac Allograft Vasculopathy
- Trial name
- DUET (NCT02013037)
- Testing
- Eculizumab
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Cedars-Sinai Medical Center
Cardiac Allograft Vasculopathy
A P2X7R Single Nucleotide Mutation Promotes Chronic Allograft Vasculopathy
Heart transplantation (HT) is a lifesaving procedure for patients with end-stage heart failure and provides a better survival and quality of life if compared to medical treatment.
- Trial name
- NCT02082821
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Failing Renal Allograft
Belatacept Therapy for the Failing Renal Allograft
The purpose of this study is to test the safety and effectiveness of belatacept (Nulojix®) in preventing antibody formation in patients with chronic failing kidney transplants.
- Trial name
- IM103-133 (NCT01921218)
- Testing
- Belatacept, Calcineurin inhibitor therapy, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Andrew B Adams
Heart Transplantation, Allograft Arteriopathy
Trajectories of Cardiac Allograft Vasculopathy After Heart Transplantation
This project aims: i) to identify Cardiac Allograft Vasculopathy (CAV) trajectories after heat transplantation using latent class mixed modeling, ii) to characterize the global and specific determinants of different trajectories…
- Trial name
- TRAJ-CAV (NCT04117152)
- Testing
- Latent class mixed modeling
- Where
- 3 sites in United States, Belgium and 1 more
- Volunteers
- 1,300 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Acute (Cellular) Renal Allograft Rejection
Single Dose rATG for Renal Allograft Rejection
Rabbit antithymocyte globulin (rATG) is approved for the treatment of acute rejection following kidney transplantation and is routinely administered as a series of 5-7 consecutive daily doses via central intravenous…
- Trial name
- NCT02102854
- Testing
- rATG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Methodist Hospital Research Institute
Cardiac Allograft Vasculopathy, Acute Cellular Graft Rejection
Cardiac Mitochondrial Function After Heart Transplantation
Studies have shown that cardiac function is affected immediately after heart transplantation (HTx), but seems to recover to some extent over the first year.
- Conditions
- Cardiac Allograft Vasculopathy, Acute Cellular Graft Rejection, Primary Graft Failure, Mitochondrial Function
- Trial name
- ENERGY-HTX (NCT04105803)
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- University of Aarhus
Liver Transplant, Liver Steatosis
Controlled Attenuation Parameter (CAP) in Liver Allografts
The primary aim is to determine the accuracy of CAP in the quantification of liver steatosis using liver biopsies as reference. Secondarily, investigators will correlate transient elastography (TE) and CAP results, analyze…
- Conditions
- Liver Transplant, Liver Steatosis, Liver Disease, Primary Non-function
- Trial name
- NCT02798861
- Testing
- Fibroscan 402/530
- Where
- 3 sites in United States
- Volunteers
- 160 people
- Sponsor
- Andres Duarte-Rojo
Skin Graft (Allograft)(Autograft) Failure
Presence of Fluorescence Signature to Predict Graft Failure Using MolecuLight i:X
This study will investigate whether the presence of a bacterial fluorescent signature captured by the MolecuLight i:X can predict a skin graft failure.
- Trial name
- NCT04185636
- Testing
- MolecuLight i:X imaging
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- MolecuLight Inc.
Patients Who Underwent Allograft
Treatment of Adenovirus Disseminated Infections in Hematopoietic Stem Cell Transplant Patients With Adenovirus Digestive Replication
Disseminated Adv infections are associated with high morbidity and mortality in HSCT pediatric patients. The most common source of Adv infection after pediatric HSCT is the host digestive tract where latent Adv are reactivated…
- Trial name
- ADENOCLEAR (NCT03481244)
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bone Diseases, Infectious, Disease of Bone
Spinal Infection Management With Structural Allograft
Background. Bone infections can involve the vertebral column, intervertebral disc space, spinal canal and soft tissues, can generate neurological deficit in addition to the destruction of the bone that causes functional…
- Conditions
- Bone Diseases, Infectious, Disease of Bone, Syndrome, Spine Infection
- Trial name
- NCT03265561
- Testing
- Bone allograft, Bone auto and allograft group
- Where
- Mexico
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Nuevo Leon
Cardiac Allograft Vasculopathy
Phosphodiesterase-5 (PDE-5) Inhibition in Heart Transplant Recipients
Hypothesis 1: Treatment of heart transplant recipients with sildenafil, a PDE-5 inhibitor, will improve small artery elasticity (SAE) when compared to placebo.
- Trial name
- NCT01812434
- Testing
- Sildenafil
- Where
- United States
- Sponsor
- University of Minnesota
Cardiac Transplant Disorder, Cardiac Death
HEart trAnsplantation Registry of piTie-Salpetriere University Hospital
Heart transplantation (HTx) is a procedure which is hindered by several complications. The HEARTS registry aims to allow the analysis of risk factors of all post-HTx complications.
- Conditions
- Cardiac Transplant Disorder, Cardiac Death, Heart Failure, Acute Cellular Graft Rejection
- Trial name
- HEARTS (NCT03393793)
- Volunteers
- 566 people
- Sponsor
- Lee S Nguyen
Kidney; Complications, Allograft
Eculizumab Therapy for Chronic Complement-Mediated Injury in Kidney Transplantation
This study is designed to assess the effectiveness of eculizumab in recipients of kidney transplantation with donor-specific antibodies (DSA) and worsening kidney function and to assess if eculizumab improves endothelial cell…
- Trial name
- NCT01327573
- Testing
- eculizumab
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Sanjay Kulkarni
Lung Transplantation, Chronic Lung Allograft Dysfunction
Lung Clearance Index and Lung Allograft Dysfunction
The aim of this project is to evaluate the ability of the lung clearance index (LCI) to detect early chronic lung allograft failure (CLAD) in adult lung transplant recipients over a period of 3 years.
- Conditions
- Lung Transplantation, Chronic Lung Allograft Dysfunction, Rejection Lung Transplant
- Trial name
- NCT03850002
- Testing
- Early detection of CLAD by Lung Clearance Index (LCI)
- Sponsor
- University of Zurich
Cardiac Allograft Vasculopathy
Real Time Myocardial Perfusion Echocardiography for Coronary Allograft Vasculopathy
Is real-time myocardial perfusion echocardiography (RTMPE) a feasible and effective non-invasive method to detect significant Coronary Allograft Vasculopathy in pediatric and adult cardiac transplant recipients? Will perfusion…
- Trial name
- NCT02880137
- Testing
- Perflutren Lipid Microsphere, RTMPE
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Pancreas Transplantation
The Norwegian Pancreas Transplantation (PTx) Study
Several studies have shown acceptable results after Pancreas Transplantation (PTx) by substituting ATG with basiliximab, which is considered to convey a considerably lower number of adverse events.
- Conditions
- Diabetes Mellitus, Pancreas Transplantation, Allograft Rejection, Surgical Complication Nec
- Trial name
- PTx (NCT01957696)
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Cardiac Allograft Vasculopathy
A Study to Compare the Effectiveness of a Drug That Suppresses the Immune System Called Thymoglobulin® in Preventing the Development of a Disease That Affects the Majority of Heart Transplant Recipients Called Cardiac Allograft Vasculopathy (CAV)
The purpose of this study is to test the hypothesis that administering Thymoglobulin® induction therapy early after transplant prevents the development of cardiac allograft vasculopathy (CAV).
- Trial name
- NCT01157949
- Testing
- Thymoglobulin
- Where
- United States
- Sponsor
- Cedars-Sinai Medical Center
Cardiac Allograft Vasculopathy, Transplanted Heart Complication
Effect of Ivabradine on Exercise Capacity After Heart Transplantation
This study evaluates whether treatment with ivabradine compared to placebo can improve exercise capacity in long-term heart transplant recipients with cardiac allograft vasculopathy and elevated heart rate at rest.
- Trial name
- VANISH-CAV (NCT03405831)
- Testing
- Ivabradine
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Finn Gustafsson