Clinical trials: ALLOGRAFT
Cytomegalovirus Disease
A Phase 3 Study of Brincidofovir Versus Valganciclovir for the Prevention of Cytomegalovirus Disease
To compare the efficacy of oral brincidofovir (BCV) to valganciclovir (vGCV) for the prevention of cytomegalovirus (CMV) disease in kidney transplant allograft recipients who are CMV seronegative pretransplant and received a…
- Trial name
- SUSTAIN (NCT02439970)
- Testing
- Brincidofovir, Valganciclovir
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Jazz Pharmaceuticals
Acute Myeloid Leukemia (AML)
"InDACtion" vs "3+7" Induction in AML
Older patients with acute myeloid leukemia (AML) have a small (< 10%) chance of long-term survival. Despite the treatment of elderly AML patients with intensive chemotherapy, the survival has not been improved during the last…
- Trial name
- NCT02172872
- Testing
- standard combination chemotherapy, decitabine
- Where
- 53 sites in Belgium, Bulgaria and 7 more
- Volunteers
- 606 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Knee Injury
Evaluation of the CR Plug for Repair of Defects Created at the Harvest Site From an Autograft in the Knee.
The main objective of this study is to test the ability of an allograft plug to provide a successful repair of an osteochondral defect left at the harvest site during OATS procedure.
- Trial name
- CRB (NCT00821873)
- Testing
- CR Plug
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- RTI Surgical
Graft Versus Host Disease, Leukemia
Stem Cell Transplant in Treating Patients With Hematological Cancer or Other Disorders
RATIONALE: Giving chemotherapy, such as fludarabine, busulfan, and cyclophosphamide, together with antithymocyte globulin before a donor stem cell transplant helps stop the growth of cancer and abnormal cells.
- Conditions
- Graft Versus Host Disease, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00740467
- Testing
- anti-thymocyte globulin, busulfan, cyclophosphamide
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Institut Paoli-Calmettes
Kidney Transplant, Rejection of Renal Transplant
Development and Validation of HistoMX, a Gene-Expression Platform for Molecular Interpretation of Kidney Allograft Biopsies
This retrospective multicentre observational study developed and validated HistoMX, an automated gene-expression-based platform for multidimensional molecular interpretation of kidney allograft biopsies.
- Conditions
- Kidney Transplant, Rejection of Renal Transplant, Antibody Mediated Rejection, BK Virus Nephropathy
- Trial name
- HistoMX (NCT07700563)
- Volunteers
- 2,410 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Acute Lymphoblastic Leukemia
A Phase 1b-2 Trial to Assess Venetoclax and Navitoclax Consolidation and Post-transplant Maintenance in High-risk Patients With T-ALL
This is a national, multicenter, phase II clinical trial to evaluate the potential benefit of pre-transplant consolidation and post-transplant maintenance with navitoclax and venetoclax in patients with T-ALL, LBL and MPAL T/M in…
- Trial name
- ITALLI001 (NCT05054465)
- Testing
- Navitoclax, Venetoclax
- Where
- 6 sites in Israel
- Volunteers
- 48 people
- Sponsor
- Israeli Medical Association
Cardiac Hypertrophy, Immunosuppression
Cardiac Allograft Remodeling and Effects of Sirolimus
Cardiac allograft remodeling causes poor quality of life, allograft failure and increased mortality after heart transplantation.
- Trial name
- CAR (NCT01889992)
- Testing
- Cardiac MRI, Coronary angiography with IVUS, Cardiac Allograft Remodeling
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Nebraska
Non-Hodgkin Lymphoma
Allogenic Stem Cell Transplantation (SCT) With Non-myeloablative Conditioning in Patients With Relapse Non-Hodgkin's Lymphoma (NHL)
To evaluate the use of ibritumomab tiuxetan (Zevalin) as part of the non myeloablative conditioning with melphalan, fludarabine and thiotepa in patients submitted to allogeneic transplantation of haematopoietic stem cells from…
- Trial name
- Z-RIC-Allo (NCT00644371)
- Testing
- Ibritumomab Tiuxetan (Zevalin)
- Where
- 14 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea
Disorder Related to Cardiac Transplantation
Assessment of Cardiac Allograft Vasculopathy by Optical Coherence Tomography
Cardiac allograft vasculopathy (CAV) is characterized by marked intimal proliferation and concentric vascular thickening and fibrosis. CAV remains the leading cause of late morbidity and mortality in heart transplant recipients.
- Trial name
- EARLY-OCT (NCT02503566)
- Testing
- Optical coherence tomography
- Where
- 2 sites in Czechia
- Volunteers
- 150 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Hepatitis B, Liver Transplantation
HepeX-B in Post Hepatic Allografts for Treatment of End Stage Liver Disease Due to Hepatitis B Infection
The purpose of this study is to compare the use of HepeX-B versus HBIg, two anti-viral drugs, in patients who have received liver transplants due to liver failure caused by Hepatitis B infection.
- Trial name
- NCT00228592
- Testing
- HepeX-B, Hepatitis B Immune Globulin (HBIg)
- Where
- 20 sites in United States, France and 5 more
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Kidney Function, Kidney Transplant; Complications
Furosemide Stress Test Predicting Early Graft Function in Kidney Transplantation
Furosemide is an old drug that has been used frequently in the postoperative period of kidney transplantation, aiming to achieve adequate urine output.
- Conditions
- Kidney Function, Kidney Transplant; Complications, Delayed Graft Function
- Trial name
- FOSTIK (NCT03071536)
- Testing
- Furosemide Injection
- Where
- Thailand
- Volunteers
- 360 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Burn, Traumatic Implants
Long Term Evaluation of Human Acellular Dermal Matrix Allograft For Coverage of the Wound After Extensive Deep Burn
The present study was to retrospectively evaluate the long-term outcomes of the cograft acellular dermal matrix (ADM) with autologous thin split-thickness skin for coverage of functional regional wounds in burned patients.
- Trial name
- ADM (NCT01562119)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tang-Du Hospital
Alveolar Bone Loss
Histological Evaluation of Healing Following Ridge Preservation Using a Combined Cortical/Cancellous Mineralized Freeze-Dried Bone Allograft
The study is a 3-arm, parallel-design, randomized, prospective clinical trial.designed to examine histologic wound healing following ridge preservation using cortical bone allograft, cancellous bone allograft, or a combination of…
- Trial name
- NCT02275767
- Testing
- 50% cortical/50% cancellous FDBA, 100% cortical FDBA, 100% cancellous FDBA
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Allograft
Cooking Education and Adapted Physical Activity in Allografted Patients
Majority of patients after allo stem cell transplantation have malnutrition and decrease of physical activities. This state impacts on quality of life and on outcome of some complications like infections, graft versus host…
- Trial name
- NUTRITION (NCT03829072)
- Testing
- Cooking Education, adapted physical activity
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Disc Degeneration;Cervical
The NanoStrand Clinical Study
A prospective, multi-center, randomized, self-controlled, single-blinded, clinical study evaluating the NanoMetalene implant as compared to the PEEK and allograft implants in ACDF for the treatment of cervical degenerative disc…
- Trial name
- NCT03871400
- Testing
- Anterior cervical discectomy and fusion
- Where
- 11 sites in United States
- Volunteers
- 18 people
- Sponsor
- SeaSpine, Inc.
Antibody-mediated Rejection, Hyperacute Rejection of Cardiac Transplant
The De-novo Use of Eculizumab in Presensitized Patients Receiving Cardiac Transplantation
All individuals who receive a heart transplant are at risk for developing antibody-mediated rejection (AMR). An antibody is a protein produced by the body's immune system when it detects a foreign substance, called an antigen.
- Conditions
- Antibody-mediated Rejection, Hyperacute Rejection of Cardiac Transplant, Left Ventricular Dysfunction, Cardiac Allograft Vasculopathy
- Trial name
- DUET (NCT02013037)
- Testing
- Eculizumab
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Cedars-Sinai Medical Center
Signs and Symptoms, Respiratory
Respiratory Side Effects of Busulfan High Dose Chemotherapy in a Pediatric Population
Recently, several conditioning regimens did not include total body irradiation (TBI) anymore, especially in the case of young children due to cognitive sequelae and late effects on growth and height.
- Trial name
- NCT00328029
- Testing
- busulfan, respiratory function tests, pharmacokinetics, done during the treatment
- Where
- 2 sites in France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Strasbourg, France
Renal Transplant Rejection, Chronic Kidney Diseases
Pathology and Imaging in Kidney Allografts
This study will perform multi-parametric renal MRI in 70 patients with a renal transplant who are undergoing a clinically indicated biopsy of their transplant.
- Conditions
- Renal Transplant Rejection, Chronic Kidney Diseases, Fibrosis
- Trial name
- PIKA (NCT03780101)
- Testing
- Multi-parametric renal MRI
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- NHS Greater Glasgow and Clyde
Heart Transplanted Patients, Lung Transplanted Patients
Unraveling Mechanism of Action of Extracorporeal Photopheresis in Heart and Lung Transplant Patients
This is a prospective observational single center national study. Lung and heart transplant patients with a definite diagnosis of chronic lung allograft dysfunction (CLAD) or cardiac allograft vasculopathy (CAV) will be assigned…
- Conditions
- Heart Transplanted Patients, Lung Transplanted Patients, Chronic Lung Allograft Dysfunction (CLAD), Cardiac Allograft Vasculopathy
- Trial name
- URRAH (NCT06899828)
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Heart Transplantation
Advanced Cardiac Imaging in Cardiac Allograft Vasculopathy
Cardiac allograft vasculopathy (CAV) is a process of both immune and non-immune mediated thickening of the heart arteries of transplanted hearts.
- Trial name
- NCT01927614
- Testing
- Cardiac CT
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Nova Scotia Health Authority
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