Clinical trials: AMD and Macular Edema
Macular Edema, Retinal Vein Occlusion
Ranibizumab (Lucentis) for Macular Edema Secondary to Vein Occlusions
Central and branch retinal vein occlusions are major causes of visual loss. Hemorrhage and capillary nonperfusion, when they involve the macula, can contribute to visual loss, but the major cause is macular edema.
- Trial name
- LVO (NCT00407355)
- Testing
- Intravitreal injection of ranibizumab .3 dose, Intravitreal injection of Ranibizumab .5 dose
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Peter A Campochiaro, MD
Retinal Vein Occlusion (RVO)
Mecobalamin Combined With Anti-VEGF Intravitreal Injection for Retinal Vein Occlusion Treatment
Retinal vein occlusion (RVO), a common retinal vascular disease, is frequently treated with anti-vascular endothelial growth factor (anti-VEGF) agents as first-line therapy.
- Trial name
- NCT07133438
- Testing
- Anti-VEGF drug, Mecobalamin 5 MG
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Macular Edema, Diabetic Macular Edema
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of IVT MHU650 in Macular Edema Patients
This was an open-label, multi-center, FIH study with a single ascending dose (SAD) design that assessed the safety, tolerability and pharmacokinetics (PK) of a single IVT dose of MHU650 in up to 24 participants with macular edema.
- Conditions
- Macular Edema, Diabetic Macular Edema, Neovascular Age-related Macular Degeneration, Retinal Vein Occlusion
- Trial name
- NCT04635800
- Testing
- MHU650
- Where
- 6 sites in United States, Puerto Rico
- Volunteers
- 21 people
- Sponsor
- Novartis Pharmaceuticals
Uveitis, Iritis
Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications
Retinal optical coherence tomography (OCT) is an established technology which enables a detailed cross-sectional visualization of the retinal micro-anatomy, and an objective measurement of its thickness in-vivo.
- Conditions
- Uveitis, Iritis, Iridocyclitis, Anterior Uveitis
- Trial name
- NCT00476593
- Testing
- Diclofenac, Dexamethasone
- Where
- 2 sites in Norway
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Cornea, Retina
Spectral-domain Optical Coherence Tomography of the Eye
An increasing number of clinical studies on SD-OCT of ocular pathologies and potential new clinical applications has recently been published in the peer-reviewed literature.
- Conditions
- Cornea, Retina, Refractive Surgery, Macular Edema
- Trial name
- NCT02614625
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Augenabteilung Allgemeines Krankenhaus Linz
Diabetic Macular Edema
Visual Outcomes and the Predictive Factors in Chinese Patients With Diabetic Macular Edema Treated With Ranibizumab
The aim of this study is to evaluate the one-year visual outcome and prognostic factors after intraocular injections of ranibizumab under pro re nata treatment regimen for the patients with diabetic macular edema (DME).
- Trial name
- IVRDME (NCT03973138)
- Testing
- Ranibizumab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
Epiretinal Membrane, Macular Oedema
Evaluation of Retinal Parameters in Patients With Epiretinal Membrane After Vitrectomy
The goal of this interventional study is to assess the dynamics of structural and functional retinal changes in eyes with epiretinal membrane (ERM) after pars plana vitrectomy (PPV).
- Conditions
- Epiretinal Membrane, Macular Oedema, Macular Diseases, Retinal Diseases
- Trial name
- NCT07165626
- Testing
- Subtreshold micropulse laser therapy, Pars plana vitrectomy
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Pomeranian Medical University Szczecin
Macular Edema, Fibrosis of the Retina
Pro-permeability and Pro-fibrosis Factors in the Aqueous of Patients With Retinal Diseases
This study will examine potential factors in the aqueous humor that may contribute to the development or progression of macular edema or fibrosis (due to any underlying disease) in patients suffering from these conditions.
- Trial name
- P3F2 (NCT02688309)
- Testing
- Ozurdex, Surgery, Anterior Chamber (AC) Tap
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Johns Hopkins University
Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
Effect on Pain and Inflammation With DEXTENZA Treatment in Patients Undergoing Intravitreal Anti-VEGF Injections
This is an investigator initiated prospective open-label, within-patient, masked, randomized study in patients with neovascular AMD, DME, or RVO undergoing bilateral anti-VEGF injections.
- Conditions
- Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- DETeR (NCT04563299)
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Prednisolone Acetate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Retina Vitreous Associates of Florida
Uveitis, Intermediate, Macular Edema
Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis
The purpose of this study is to investigate if interferon beta is superior to the standard treatment with Methotrexate for the treatment of intermediate uveitis and macular edema.
- Conditions
- Uveitis, Intermediate, Macular Edema, Multiple Sclerosis
- Trial name
- NCT00344253
- Testing
- Interferon beta, Methotrexate
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- Heidelberg University
Uveitis, Macular Edema
Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis
The study is designed to evaluate the safety and efficacy of triamcinolone acetonide, CLS-TA, in subjects with macular edema following non-infectious uveitis.
- Conditions
- Uveitis, Macular Edema, Uveitis, Posterior, Uveitis, Anterior
- Trial name
- DOGWOOD (NCT02255032)
- Testing
- 4 mg CLS-TA, 0.8 mg CLS-TA
- Where
- 11 sites in United States
- Volunteers
- 22 people
- Sponsor
- Clearside Biomedical, Inc.
Vision Disorders
Usability of the Software MacuFix for the Categorization of Metamorphopsia
The usability of a novel test to categorize a distorted visual impression (metamorphopsia) is examined with the questionnaire "SUS"
- Trial name
- MacuFix (NCT04347564)
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Augenheilkunde Lindenthal
Macular Edema, Retinal Vein Occlusion
Effect of Intravitreal Ranibizumab Injection With Retinal Vein Occlusion (RVO)
The purpose of this study is to evaluate the effects of intravitreal Lucentis® (Ranibizumab) and investigate the anatomical and functional improvement following this treatment in patients with macular edema due to retinal vein…
- Trial name
- NCT00942864
- Testing
- ranibizumab
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Novartis Korea Ltd.
Diabetes Mellitus, Macular Edema
Laser and Medical Treatment of Diabetic Macular Edema
This study will compare the side effects of two laser treatments for diabetic macular edema, a common condition in patients with diabetes.
- Trial name
- NCT00027287
- Testing
- Vitamin E
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Macular Edema
Safety, Efficacy and Cost-efficacy of Ranibizumab (Monotherapy or Combination With Laser) in the Treatment of Diabetic Macular Edema (DME)
To evaluate, specifically within the Canadian medical environment, the efficacy, safety and cost-efficacy of ranibizumab administered either as combination therapy (ranibizumab plus laser photocoagulation), or as monotherapy in…
- Trial name
- RESPOND (NCT01135914)
- Testing
- ranibizumab, Laser
- Where
- 20 sites in Canada
- Volunteers
- 241 people
- Sponsor
- Novartis Pharmaceuticals
Branch Retinal Vein Occlusion
Efficacy and Safety of Ranibizumab With or Without Laser in Comparison to Laser in Branch Retinal Vein Occlusion
This study will generate comparative data for 0.5-mg ranibizumab using PRN dosing administered with or without adjunctive laser treatment versus laser photocoagulation (the current standard of care) up to Month 6 in patients with…
- Trial name
- BRIGHTER (NCT01599650)
- Testing
- Ranibizumab, Laser
- Where
- 82 sites in Australia, Canada and 15 more
- Volunteers
- 455 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Macular Edema, Age Related Macular Degeneration
Intravitreal Injections of Ziv-aflibercept for Macular Diseases
Diabetic macular edema (DME), wet-AMD and macular edema secondary to vein occlusions are the leading cause of blindness in developed countries.
- Conditions
- Diabetic Macular Edema, Age Related Macular Degeneration, Branch Retinal Vein Occlusion With Macular Edema, Central Retinal Vein Occlusion With Macular Edema
- Trial name
- NCT02556723
- Testing
- Intravitreal injections of ziv-aflibercept
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Retina Clinic, Sao Paulo, Brazil
Renal Function Disorder, Diabetic Macular Edema (DME)
Impact of Intravitreal Faricimab on Renal Function in Diabetic Patients
This study aims to investigate the impact of intravitreal injection of anti-vascular endothelial growth factor (anti VEGF) Faricimab on renal function of diabetic patients.
- Conditions
- Renal Function Disorder, Diabetic Macular Edema (DME), Neovascular Age Related Macular Degeneration
- Trial name
- NCT06929507
- Testing
- Intravitreal injection of Faricimab or Aflibercept 2 mg
- Where
- 2 sites in Greece
- Volunteers
- 60 people
- Sponsor
- University Hospital, Alexandroupolis
Macular Edema
Safety and Efficacy Study of Dexamethasone in the Treatment of Patients With Macular Edema Following Retinal Vein Occlusion (RVO)
This study will assess the safety and efficacy of 700 μg dexamethasone Posterior Segment Drug Delivery System (DEX PS DDS) Applicator System in patients with macular edema in a 6 month double-blind period versus sham followed by…
- Trial name
- NCT01660802
- Testing
- 700 μg Dexamethasone
- Where
- China
- Volunteers
- 262 people
- Sponsor
- Allergan
Retinal Vein Occlusion, Macular Edema
Study of Squalamine Lactate for the Treatment of Macular Edema Related to Retinal Vein Occlusion
This was a prospective, single center, open label, randomized study evaluating the biological effect of squalamine lactate ophthalmic solution, 0.2% combined with intravitreous ranibizumab in patients with macular edema secondary…
- Trial name
- NCT02614937
- Testing
- ranibizumab, Squalamine Lactate Ophthalmic Solution, 0.2%
- Volunteers
- 20 people
- Sponsor
- Ohr Pharmaceutical Inc.